PhD, MPhil, MSc
Associate Professor
Contact details
Tel 64 4 806 1753
Email patries.herst@otago.ac.nz
Dr Herst has been employed by the University of Otago since 2001 and divides her time between undergraduate and postgraduate teaching, preclinical and clinical research. She has been a committee member of the Health and Disability Ethics Committee (HDEC) since 2012.
Research interests and activities
Preclinical Research
Dr Herst has been a visiting scientist at the Malaghan Institute since completion of her PhD in 2006. There, she conducts research into drug resistance of highly aggressive cancer cells in collaboration with Professor Mike Berridge. Her most recent research, in close collaboration with Dr McConnell at the University of Victoria, Wellington, focuses on radiosensitization of glioblastoma multiforme in vitro and in an orthotopic intracranial mouse glioma model.
Clinical Research
Dr Herst has conducted randomized controlled clinical trials in NZ hospitals that investigate management of radiation-induced side effects since 2008. To date 5 trials (3 skin trials, one cystitis trial and one oral mucositis trial) have been completed, analysed and published. A sixth trial on management of skin reactions in head and neck patients is currently recruiting in Christchurch and Dunedin.
This work was presented to the Otago Spotlight Series: Cancer Research symposium and is part of Cancer Research at Otago working to advance the prevention, detection and management of cancer in New Zealand, and beyond.
Publications
Herst, P. M., Carson, G. M., Eccles, D. A., & Berridge, M. V. (2022). Bioenergetic and metabolic adaptation in tumour progression and metastasis. Frontiers in Oncology, 12. doi: 10.3389/fonc.2022.857686
Stones, A. L., & Herst, P. M. (2021). Review of the Accident Compensation Corporation's radiation therapy injury claims. 1 July 2009-30 June 2019. New Zealand Medical Journal, 134(1543), 113-122. Retrieved from https://www.nzma.org.nz/journal
Tang, J. S., Cait, A., Li, Y., Abolins-Thompson, H., Gell, K., Herst, P. M., … Gasser, O. (2021). Practical approach to explore the effects of polyphenols on aryl hydrocarbon receptor regulated immune function. Journal of Agricultural & Food Chemistry, 69, 8625-8633. doi: 10.1021/acs.jafc.1c02095
Grasso, C., Eccles, D. A., Boukalova, S., Fabre, M.-S., Dawson, R. H., Neuzil, J., Herst, P. M., & Berridge, M. V. (2020). Mitochondrial DNA affects the expression of nuclear genes involved in immune and stress responses in a breast cancer model. Frontiers in Physiology, 11, 543962. doi: 10.3389/fphys.2020.543962
Herst, P. M., Grasso, C., Fabre, M.-S., Boukalova, S., Ezrova, Z., Neuzil, J., & Berridge, M. V. (2020). A simple indirect colorimetric assay for measuring mitochondrial energy metabolism based on uncoupling sensitivity. Biochemistry & Biophysics Reports, 24, 100858. doi: 10.1016/j.bbrep.2020.100858
Berridge, M. V., Herst, P. M., & Grasso, C. (2020). Mitochondrial movement between mammalian cells: An emerging physiological phenomenon. In G. Gasparre & A. M. Porcelli (Eds.), The human mitochondrial genome: From basic biology to disease. (pp. 515-546). London, UK: Academic Press. doi: 10.1016/B978-0-12-819656-4.00020-6
Chapter in Book - Research
Berridge, M. V., & Herst, P. M. (2015). Tumor cell complexity and metabolic flexibility in tumorigenesis and metastasis. In S. Mazurek & M. Shoshan (Eds.), Tumor cell metabolism: Pathways, regulation and biology. (pp. 23-43). Wien: Springer. doi: 10.1007/978-3-7091-1824-5
Chapter in Book - Research
Stones, A. L., & Herst, P. M. (2021). Review of the Accident Compensation Corporation's radiation therapy injury claims. 1 July 2009-30 June 2019. New Zealand Medical Journal, 134(1543), 113-122. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Tang, J. S., Cait, A., Li, Y., Abolins-Thompson, H., Gell, K., Herst, P. M., … Gasser, O. (2021). Practical approach to explore the effects of polyphenols on aryl hydrocarbon receptor regulated immune function. Journal of Agricultural & Food Chemistry, 69, 8625-8633. doi: 10.1021/acs.jafc.1c02095
Journal - Research Article
Grasso, C., Eccles, D. A., Boukalova, S., Fabre, M.-S., Dawson, R. H., Neuzil, J., Herst, P. M., & Berridge, M. V. (2020). Mitochondrial DNA affects the expression of nuclear genes involved in immune and stress responses in a breast cancer model. Frontiers in Physiology, 11, 543962. doi: 10.3389/fphys.2020.543962
Journal - Research Article
Herst, P. M., Aumata, A., Sword, V., Jones, R., Purdie, G., & Costello, S. (2020). Cranberry capsules are not superior to placebo capsules in managing acute non-haemorrhagic radiation cystitis in prostate cancer patients: A phase III double blinded randomised placebo controlled clinical trial. Radiotherapy & Oncology, 149, 117-123. doi: 10.1016/j.radonc.2020.05.006
Journal - Research Article
Herst, P. M., Grasso, C., Fabre, M.-S., Boukalova, S., Ezrova, Z., Neuzil, J., & Berridge, M. V. (2020). A simple indirect colorimetric assay for measuring mitochondrial energy metabolism based on uncoupling sensitivity. Biochemistry & Biophysics Reports, 24, 100858. doi: 10.1016/j.bbrep.2020.100858
Journal - Research Article
Yan, J., Yuan, L., Wang, J., Li, S., Yao, M., Wang, K., & Herst, P. M. (2020). Mepitel Film is superior to Biafine cream in managing acute radiation-induced skin reactions in head and neck cancer patients: A randomised intra-patient controlled clinical trial. Journal of Medical Radiation Sciences, 67(3), 208-216. doi: 10.1002/jmrs.397
Journal - Research Article
Herst, P. M., Grasso, C., & Berridge, M. V. (2018). Metabolic reprogramming of mitochondrial respiration in metastatic cancer. Cancer & Metastasis Reviews, 37, 643-653. doi: 10.1007/s10555-018-9769-2
Journal - Research Article
Leong, A., Herst, P., & Kane, P. (2018). VERT, a virtual clinical environment, enhances understanding of radiation therapy planning concepts. Journal of Medical Radiation Sciences, 65(2), 97-105. doi: 10.1002/jmrs.272
Journal - Research Article
Moore, S. J., Herst, P. M., & Louwe, R. J. W. (2018). Review of the patient positioning reproducibility in head-and-neck radiotherapy using Statistical Process Control. Radiotherapy & Oncology, 127(2), 183-189. doi: 10.1016/j.radonc.2018.01.006
Journal - Research Article
Wooding, H., Yan, J., Yuan, L., Chyou, T.-Y., Gao, S., Ward, I., & Herst, P. M. (2018). The effect of Mepitel Film on acute radiation-induced skin reactions in head and neck cancer patients: A feasibility study. British Journal of Radiology, 91(1081), 20170298. doi: 10.1259/bjr.20170298
Journal - Research Article
Castro, M. L., Carson, G. M., McConnell, M. J., & Herst, P. M. (2017). High dose ascorbate causes both genotoxic and metabolic stress in glioma cells. Antioxidants, 6(3), 58. doi: 10.3390/antiox6030058
Journal - Research Article
Feldman, L. A., Fabre, M.-S., Grasso, C., Reid, D., Broaddus, W. C., Lanza, G. M., … Herst, P. M. (2017). Perfluorocarbon emulsions radiosensitise brain tumors in carbogen breathing mice with orthotopic GL261 gliomas. PLoS ONE, 12(9), e0184250. doi: 10.1371/journal.pone.0184250
Journal - Research Article
Herst, P. M., Rowe, M. R., Carson, G. M., & Berridge, M. V. (2017). Functional mitochondria in health and disease. Frontiers in Endocrinology, 8, 296. doi: 10.3389/fendo.2017.00296
Journal - Research Article
Sutherland, A. E., Bennett, N. C., & Herst, P. M. (2017). Psychological stress affects the severity of radiation-induced acute skin reactions in breast cancer patients. European Journal of Cancer Care, 26(6), e12737. doi: 10.1111/ecc.12737
Journal - Research Article
Kane, P., Jasperse, M., Egan, R., McBain, L., McKinlay, E., Pullon, S., & Herst, P. (2016). Continuity of cancer patient care in New Zealand: The general practitioner perspective. New Zealand Medical Journal, 129(1440), 55-63. Retrieved from https://www.nzma.org.nz/journal
Journal - Research Article
Hamilton, K., Bennett, N. C., Purdie, G., & Herst, P. M. (2015). Standardized cranberry capsules for radiation cystitis in prostate cancer patients in New Zealand: A randomized double blinded, placebo controlled pilot study. Supportive Care in Cancer, 23(1), 95-102. doi: 10.1007/s00520-014-2335-8
Journal - Research Article
O'Donovan, A., Coleman, M., Harris, R., & Herst, P. (2015). Prophylaxis and management of acute radiation-induced skin toxicity: A survey of practice across Europe and the USA. European Journal of Cancer Care, 24(3), 425-435. doi: 10.1111/ecc.12213
Journal - Research Article
Castro, M. L., McConnell, M. J., & Herst, P. M. (2014). Radio-sensitisation by pharmacological ascorbate in glioblastoma multiforme cells, human glial cells, and HUVECs depends on their antioxidant and DNA repair capabilities and is not cancer specific. Free Radical Biology & Medicine, 74, 200-209. doi: 10.1016/j.freeradbiomed.2014.06.022
Journal - Research Article
Coleman, K., Jasperse, M., Herst, P., & Yielder, J. (2014). Establishing radiation therapy advanced practice in New Zealand. Journal of Medical Radiation Sciences, 61, 38-44. doi: 10.1002/jmrs.33
Journal - Research Article
Grasso, C., Fabre, M.-S., Collis, S. V., Castro, M. L., Field, C. S., Schleich, N., McConnell, M. J., & Herst, P. M. (2014). Pharmacological doses of daily ascorbate protect tumors from radiation damage after a single dose of radiation in an intracranial mouse glioma model. Frontiers in Oncology, 4, 356. doi: 10.3389/fonc.2014.00356
Journal - Research Article
Herst, P. M. (2014). Protecting the radiation-damaged skin from friction: A mini review. Journal of Medical Radiation Sciences, 61(2), 119-125. doi: 10.1002/jmrs.46
Journal - Research Article
Herst, P. M., Bennett, N. C., Sutherland, A. E., Peszynski, R. I., Paterson, D. B., & Jasperse, M. L. (2014). Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients. Radiotherapy & Oncology, 110(1), 137-143. doi: 10.1016/j.radonc.2014.01.005
Journal - Research Article
Jasperse, M., Herst, P., & Dungey, G. (2014). Evaluating stress, burnout and job satisfaction in New Zealand radiation oncology departments. European Journal of Cancer Care, 23(1), 82-88. doi: 10.1111/ecc.12098
Journal - Research Article
Kane, P., Jasperse, M., Boland, P., & Herst, P. (2014). A pathway to empowerment: Evaluating a cancer education and support programme in New Zealand. European Journal of Cancer Care, 23(5), 668-674. doi: 10.1111/ecc.12188
Journal - Research Article
McConnell, M. J., & Herst, P. M. (2014). Ascorbate combination therapy: New tool in the anticancer toolbox? Science Translational Medicine, 6(222), 222fs6. doi: 10.1126/scitranslmed.3008488
Journal - Research Article
Herst, P. M., & Berridge, M. V. (2013). Cell hierarchy, metabolic flexibility and systems approaches to cancer treatment. Current Pharmaceutical Biotechnology, 14(3), 289-299.
Journal - Research Article
Herst, P. M., Broadley, K. W. R., Harper, J. L., & McConnell, M. J. (2012). Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest. Free Radical Biology & Medicine, 52(8), 1486-1493. doi: 10.1016/j.freeradbiomed.2012.01.021
Journal - Research Article
Jasperse, M. L., Herst, P. M., & Kane, J. P. (2012). Evaluation of the training and support received by facilitators of a cancer education and support programme in New Zealand. European Journal of Cancer Care, 21(2), 224-232. doi: 10.1111/j.1365-2354.2011.01303.x
Journal - Research Article
Leong, A. G., Herst, P. M., & Harper, J. L. (2012). Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities. Innate Immunity, 18(3), 459-466. doi: 10.1177/1753425911422263
Journal - Research Article
Parsons, E., Begley, A., & Herst, P. (2012). Manuka honey mouthwash does not affect oral mucositis in head and neck cancer patients in New Zealand. Journal of Radiotherapy in Practice, 11, 249-256. doi: 10.1017/S1460396911000410
Journal - Research Article
Paterson, D. B., Poonam, P., Bennett, N. C., Peszynski, R. I., Van Beekhuizen, M. J., Jasperse, M. L., & Herst, P. M. (2012). Randomized intra-patient controlled trial of Mepilex Lite dressings versus aqueous cream in managing radiation-induced skin reactions post-mastectomy. Journal of Cancer Science & Therapy, 4(11), 347-356. doi: 10.4172/1948-5956.1000166
Journal - Research Article
Broadley, K., Larsen, L., Herst, P. M., Smith, R. A. J., Berridge, M. V., & McConnell, M. J. (2011). The novel phloroglucinol PMT7 kills glycolytic cancer cells by blocking autophagy and sensitizing to nutrient stress. Journal of Cellular Biochemistry, 112(7), 1869-1879. doi: 10.1002/jcb.23107
Journal - Research Article
Herst, P. M., Howman, R. A., Neeson, P. J., Berridge, M. V., & Ritchie, D. S. (2011). The level of glycolytic metabolism in acute myeloid leukemia blasts at diagnosis is prognostic for clinical outcome. Journal of Leukocyte Biology, 89(1), 51-55. doi: 10.1189/jlb.0710417
Journal - Research Article
Jasperse, M., Herst, P., & Dungey, G. (2011). Workplace challenges and coping strategies in a small cohort of radiation therapists in New Zealand: A pilot study. Shadows, 54(3), 4-9.
Journal - Research Article
Berridge, M. V., Herst, P. M., & Tan, A. S. (2010). Metabolic flexibility and cell heirarchy in metastatic cancer. Mitochondrion, 10(6), 584-588. doi: 10.1016/j.mito.2010.08.002
Journal - Research Article
Diggelmann, K. V., Zytkovicz, A. E., Tuaine, J. M., Bennett, N. C., Kelly, L. E., & Herst, P. M. (2010). Mepilex Lite dressings for the management of radiation-induced erythema: A systematic inpatient controlled clinical trial. British Journal of Radiology, 83(995), 971-978. doi: 10.1259/bjr/62011713
Journal - Research Article
Jasperse, M., Herst, P., & Coleman, K. (2010). Evaluation of an 'in house' RT-led treatment review programme. Shadows, 53(2), 4-7.
Journal - Research Article
Berridge, M. V., Herst, P. M., & Lawen, A. (2009). Targeting mitochondrial permeability in cancer drug development. Molecular Nutrition & Food Research, 53(1), 76-86. doi: 10.1002/mnfr.200700493
Journal - Research Article
Coleman, K., Herst, P., & Sycamore, C. (2009). Role extension for radiation therapists in New Zealand: A survey of radiation oncologists and radiation therapists. Shadows, 52(1), 11-18.
Journal - Research Article
Herst, P. M., Davis, J. E., Neeson, P., Berridge, M. V., & Ritchie, D. S. (2009). The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells. Haematologica, 94(7), 928-934. doi: 10.3324/haematol.2008.003996
Journal - Research Article
Martin, W. J., Herst, P. M., Chia, E. W., & Harper, J. L. (2009). Sesquiterpene dialdehydes inhibit MSU crystal-induced superoxide production by infiltrating neutrophils in an in vivo model of gouty inflammation. Free Radical Biology & Medicine, 47(5), 616-621. doi: 10.1016/j.freeradbiomed.2009.05.035
Journal - Research Article
Herst, P. M., Hesketh, E. L., Ritchie, D. S., & Berridge, M. V. (2008). Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60rho0 cells. Leukemia Research, 32(2), 327-333.
Journal - Research Article
Herst, P. M., Perrone, G. G., Dawes, I. W., Bircham, P. W., & Berridge, M. V. (2008). Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits. FEMS Yeast Research, 8(6), 897-905.
Journal - Research Article
Herst, P. M., & Berridge, M. V. (2007). Cell surface oxygen consumption: A major contributor to cellular oxygen consumption in glycolytic cancer cell lines. Biochimica et Biophysica Acta: Bioenergetics, 1767, 170-177.
Journal - Research Article
Herst, P. M., Petersen, T., Jerram, P., Baty, J., & Berridge, M. V. (2007). The antiproliferative effects of phenoxodiol are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells. Biochemical Pharmacology, 74(11), 1587-1595.
Journal - Research Article
Herst, P. M., & Berridge, M. V. (2006). Plasma membrane electron transport: A new target for cancer drug development. Current Molecular Medicine, 6, 895-904.
Journal - Research Article
Berridge, M. V., Herst, P. M., & Tan, A. S. (2005). Tetrazolium dyes as tools in cell biology: New insights into their cellular reduction. Biotechnology Annual Review, 11, 127-152. doi: 10.1016/S1387-2656(05)11004-7
Journal - Research Article
Herst, P. M., Levine, D. M., & Berridge, M. V. (2005). Mitochondrial gene knockout HL60ρ0 cells show preferential differentiation into monocytes/macrophages. Leukemia Research, 29(10), 1163-1170. doi: 10.1016/j.leukres.2005.03.013
Journal - Research Article
