MB ChB, PhD (Otago)
Associate Professor
Contact details
Department of Surgery & Anaesthesia
University of Otago, Wellington
PO Box 7343
Wellington South
Email shieak.tzeng@otago.ac.nz
Current roles
Scientific Director, Wellington Medical Technology Group
Theme Leader, Point of Care Technologies, Centre for Bioengineering & Nanomedicine
Council member, New Zealand Physiological Society
Research Co-Ordinator, Cerebral Autoregulation Research Network
Research Expertise
Neuroprotection in acute brain injury
Cerebral microcirculation
Computational modelling
Clinical monitoring technologies
Systems Physiology
Bioinformatics
Publications
Thomas, D., Harrison, F., Little, A., King, A., Sorby-Adams, A. J., Tzeng, S., … Obruchkov, S. (2022, May). Portable magnetic resonance based monitoring of MCA occlusion in an ovine sheep stroke model. Verbal presentation at the Joint Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) & the European Society for Magnetic Resonance in Medicine & Biology (ESMRMB) and the 31st Annual Meeting of the International Society for Magnetic Resonance Radiographers & Technologists (ISMRT), [Hybrid].
Little, A., Thomas, D., Tzeng, S., & Obruchkov, S. (2022, May). Continuous perfusion measurement with single sided low-field MR. Verbal presentation at the Joint Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) & the European Society for Magnetic Resonance in Medicine & Biology (ESMRMB) and the 31st Annual Meeting of the International Society for Magnetic Resonance Radiographers & Technologists (ISMRT), [Hybrid].
Thomas, D. G., Tzeng, Y.-C., Galvosas, P., Harrison, F. G., Berry, M. J., Teal, P. D., Galvin, S. D., & Obruchkov, S. I. (2022). Single-sided magnet system for quantitative MR relaxometry and preclinical in-vivo monitoring. IEEE Transactions on Biomedical Engineering. Advance online publication. doi: 10.1109/TBME.2022.3200626
Labrecque, L., Smirl, J. D., Tzeng, Y.-C., & Brassard, P. (2022). We should take the direction of blood pressure change into consideration for dynamic cerebral autoregulation quantification [Point/counterpoint]. Journal of Cerebral Blood Flow & Metabolism. Advance online publication. doi: 10.1177/0271678x221104868
Ali, H., Brooks, C., Tzeng, Y.-C., Crane, J., Beasley, R., Gibson, P., Pattemore, P., Stanley, T., Pearce, N., & Douwes, J. (2022). Heart rate variability as a marker of autonomic nervous system activity in young people with eosinophilic and non-eosinophilic asthma. Journal of Asthma. Advance online publication. doi: 10.1080/02770903.2022.2070763
Ali, H., Brooks, C., Tzeng, Y.-C., Crane, J., Beasley, R., Gibson, P., Pattemore, P., Stanley, T., Pearce, N., & Douwes, J. (2022). Heart rate variability as a marker of autonomic nervous system activity in young people with eosinophilic and non-eosinophilic asthma. Journal of Asthma. Advance online publication. doi: 10.1080/02770903.2022.2070763
Journal - Research Article
Thomas, D. G., Galvosas, P., Tzeng, Y.-C., Harrison, F. G., Berry, M. J., Teal, P. D., … Obruchkov, S. (2022). Oxygen saturation-dependent effects on blood transverse relaxation at low fields. Magnetic Resonance Materials in Physics, Biology & Medicine, 35, 805-815. doi: 10.1007/s10334-021-00993-2
Journal - Research Article
Thomas, D. G., Tzeng, Y.-C., Galvosas, P., Harrison, F. G., Berry, M. J., Teal, P. D., Galvin, S. D., & Obruchkov, S. I. (2022). Single-sided magnet system for quantitative MR relaxometry and preclinical in-vivo monitoring. IEEE Transactions on Biomedical Engineering. Advance online publication. doi: 10.1109/TBME.2022.3200626
Journal - Research Article
Ali, H., Brooks, C., Crane, J., Beasley, R., Holgate, S., Gibson, P., Pattemore, P., Tzeng, Y.-C., Stanley, T., … Douwes, J. (2021). Enhanced airway sensory nerve reactivity in non-eosinophilic asthma. BMJ Open Respiratory Research, 8, e000974. doi: 10.1136/bmjresp-2021-000974
Journal - Research Article
Barclay, H., Mukerji, S., Kayser, B., O'Donnell, T., Tzeng, Y.-C., Hill, S., … Fan, J.-L. (2021). Respiratory alkalinization and posterior cerebral artery dilatation predict acute mountain sickness severity during 10 h normobaric hypoxia. Experimental Physiology, 106, 175-190. doi: 10.1113/EP088938
Journal - Research Article
Fan, J.-L., O'Donnell, T., Lanford, J., Croft, K., Watson, E., Smyth, D., … Tzeng, Y.-C. (2020). Dietary nitrate reduces blood pressure and cerebral artery velocity fluctuations and improve cerebral autoregulation in transient ischemic attack patients. Journal of Applied Physiology, 129, 547-557. doi: 10.1152/japplphysiol.00160.2020
Journal - Research Article
Fan, J.-L., O'Donnell, T., Gray, C. L., Croft, K., Noakes, A. K., Koch, H., & Tzeng, Y.-C. (2019). Dietary nitrate supplementation enhances cerebrovascular CO2 reactivity in a sex-specific manner. Journal of Applied Physiology, 127, 760-769. doi: 10.1152/japplphysiol.01116.2018
Journal - Research Article
Allan, P. D., O'Donnell, T., & Tzeng, Y.-C. (2018). Agreement between finger plethysmography- and brachial oscillometry-derived blood pressure measurements. Clinical Physiology & Functional Imaging, 38(3), 439-446. doi: 10.1111/cpf.12435
Journal - Research Article
Allan, P. D., Tzeng, Y.-C., Gowing, E. K., Clarkson, A. N., & Fan, J.-L. (2018). Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. Journal of Applied Physiology, 125(3), 862-869. doi: 10.1152/japplphysiol.01081.2017
Journal - Research Article
Saleem, S., Teal, P. D., Howe, C. A., Tymko, M. M., Ainslie, P. N., & Tzeng, Y.-C. (2018). Is Cushing mechanism a dynamic blood pressure stabilizing system? Insights from Granger causality analysis of spontaneous blood pressure and cerebral blood flow. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 315(3), R484-R495. doi: 10.1152/ajpregu.00032.2018
Journal - Research Article
Saleem, S., Vucina, D., Sarafis, Z., Lee, A. H. X., Squair, J. W., Barak, O. F., … Tzeng, Y.-C., & Phillips, A. A. (2018). Wavelet decomposition analysis is a clinically relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1108-H1114. doi: 10.1152/ajpheart.00152.2017
Journal - Research Article
Faulkner, J., Tzeng, Y.-C., Lambrick, D., Woolley, B., Allan, P. D., O'Donnell, T., Lanford, J., Wong, L., & Stoner, L. (2017). A randomized controlled trial to assess the central hemodynamic response to exercise in patients with transient ischaemic attack and minor stroke. Journal of Human Hypertension, 31, 172-177. doi: 10.1038/jhh.2016.72
Journal - Research Article
Malenfant, S., Brassard, P., Paquette, M., Le Blanc, O., Chouinard, A., Nadeau, V., Allan, P. D., Tzeng, Y.-C., … Provencher, S. (2017). Compromised cerebrovascular regulation and cerebral oxygenation in pulmonary arterial hypertension. Journal of the American Heart Association, 6(10), e006126. doi: 10.1161/jaha.117.006126
Journal - Research Article
Phillips, A. A., Squair, J., Currie, K., Tzeng, Y.-C., Ainslie, P., & Krassioukov, A. V. (2017). 2015 ParaPan American Games: Autonomic function, but not physical activity, is associated with vascular-cognitive impairment in spinal cord injury. Journal of Neurotrauma, 34(6), 1283-1288. doi: 10.1089/neu.2016.4751
Journal - Research Article
Saleem, S., Tzeng, Y.-C., Kleijn, W. B., & Teal, P. D. (2017). Detection of impaired sympathetic cerebrovascular control using functional biomarkers based on principal dynamic mode analysis. Frontiers in Physiology, 7, 685. doi: 10.3389/fphys.2016.00685
Journal - Research Article
Witter, T., Tzeng, Y.-C., O'Donnell, T., Kusel, J., Walker, B., Berry, M., & Taylor, C. E. (2017). Inter-individual relationships between sympathetic arterial baroreflex function and cerebral perfusion control in healthy males. Frontiers in Neuroscience, 11, 457. doi: 10.3389/fnins.2017.00457
Journal - Research Article
Saleem, S., Teal, P. D., Kleijn, W. B., Ainslie, P. N., & Tzeng, Y.-C. (2016). Identification of human sympathetic neurovascular control using multivariate wavelet decomposition analysis. American Journal of Physiology: Heart & Circulatory Physiology, 311(3), H837-H848. doi: 10.1152/ajpheart.00254.2016
Journal - Research Article
Smirl, J. D., Hoffman, K., Tzeng, Y.-C., Hansen, A., & Ainslie, P. N. (2016). The relationship between blood pressure and cerebral blood flow during supine cycling: Influence of aging. Journal of Applied Physiology, 120(5), 552-563. doi: 10.1152/japplphysiol.00667.2015
Journal - Research Article
Allan, P. D., Faulkner, J., O'Donnell, T., Lanford, J., Wong, L., Saleem, S., … Tzeng, Y.-C. (2015). Hemodynamic variability and cerebrovascular control after transient cerebral ischemia. Physiological Reports, 3(11), e12602. doi: 10.14814/phy2.12602
Journal - Research Article
Horsman, H. M., Peebles, K. C., & Tzeng, Y. C. (2015). Interactions between breathing rate and low-frequency fluctuations in blood pressure and cardiac intervals. Journal of Applied Physiology, 119, 793-798. doi: 10.1152/japplphysiol.00525.2015
Journal - Research Article
Rickards, C. A., Sprick, J. D., Colby, H. B., Kay, V., & Tzeng, Y.-C. (2015). Coupling between arterial pressure, cerebral blood velocity, and cerebral tissue oxygenation with spontaneous and forced oscillations. Physiological Measurement, 36(4), 785-801. doi: 10.1088/0967-3334/36/4/785
Journal - Research Article
Saleem, S., Teal, P. D., Kleijn, W. B., O'Donnell, T., Witter, T., & Tzeng, Y.-C. (2015). Non-linear characterisation of cerebral pressure-flow dynamics in humans. PLoS ONE, 10(9), e0139470. doi: 10.1371/journal.pone.0139470
Journal - Research Article
Smirl, J. D., Hoffman, K., Tzeng, Y.-C., Hansen, A., & Ainslie, P. N. (2015). Methodological comparison of active- and passive-driven oscillations in blood pressure: Implications for the assessment of cerebral pressure-flow relationships. Journal of Applied Physiology, 119(5), 487-501. doi: 10.1152/japplphysiol.00264.2015
Journal - Research Article
Berry, M., Tzeng, Y., & Marsland, C. (2014). Percutaneous transtracheal ventilation in an obstructed airway model in post-apnoeic sheep. British Journal of Anaesthesia, 113(6), 1039-1045. doi: 10.1093/bja/aeu188
Journal - Research Article
Horsman, H. M., Tzeng, Y. C., Galletly, D. C., & Peebles, K. C. (2014). The repeated sit-to-stand manoeuvre is a superior method for cardiac baroreflex assessment: A comparison with the modified Oxford method and Valsalva manoeuvre. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 307(11), R1345-R1352. doi: 10.1152/ajpregu.00376.2014
Journal - Research Article
Meel-van den Abeelen, A. S. S., Simpson, D. M., Wang, L. J. Y., Slump, C. H., Zhang, R., Tarumi, T., … Tzeng, Y.-C., … Claassen, J. A. H. R. (2014). Between-centre variability in transfer function analysis, a widely used method for linear quantification of the dynamic pressure-flow relation: The CARNet study. Medical Engineering & Physics, 36(5), 620-627. doi: 10.1016/j.medengphy.2014.02.002
Journal - Research Article
Rickards, C. A., & Tzeng, Y.-C. (2014). Arterial pressure and cerebral blood flow variability: Friend or foe? A review. Frontiers in Physiology, 5, 120. doi: 10.3389/fphys.2014.00120
Journal - Research Article
Smirl, J. D., Haykowsky, M. J., Nelson, M. D., Tzeng, Y.-C., Marsden, K. R., Jones, H., & Ainslie, P. N. (2014). Relationship between cerebral blood flow and blood pressure in long-term heart transplant recipients. Hypertension, 64, 1314-1320. doi: 10.1161/hypertensionaha.114.04236
Journal - Research Article
Smirl, J. D., Tzeng, Y. C., Monteleone, B. J., & Ainslie, P. N. (2014). Influence of cerebrovascular resistance on the dynamic relationship between blood pressure and cerebral blood flow in humans. Journal of Applied Physiology, 116(12), 1614-1622. doi: 10.1152/japplphysiol.01266.2013
Journal - Research Article
Taylor, C. E., Willie, C. K., Ainslie, P. N., & Tzeng, Y.-C. (2014). Assessment of human baroreflex function using carotid ultrasonography: What have we learnt? Acta Physiologica, 211(2), 297-313. doi: 10.1111/apha.12302
Journal - Research Article
Tzeng, Y. C., MacRae, B. A., Ainslie, P. N., & Chan, G. S. H. (2014). Fundamental relationships between blood pressure and cerebral blood flow in humans. Journal of Applied Physiology, 117(9), 1037-1048. doi: 10.1152/japplphysiol.00366.2014
Journal - Research Article
Tzeng, Y.-C., & Ainslie, P. N. (2014). Blood pressure regulation IX: Cerebral autoregulation under blood pressure challenges. European Journal of Applied Physiology, 114(3), 545-559. doi: 10.1007/s00421-013-2667-y
Journal - Research Article
Willie, C. K., Tzeng, Y.-C., Fisher, J. A., & Ainslie, P. N. (2014). Integrative regulation of human brain blood flow. Journal of Physiology, 592(5), 841-859. doi: 10.1113/jphysiol.2013.268953
Journal - Research Article
Horsman, H. M., Peebles, K. C., Galletly, D. C., & Tzeng, Y.-C. (2013). Cardiac baroreflex gain is frequency dependent: Insights from repeated sit-to-stand maneuvers and the modified Oxford Method. Applied Physiology, Nutrition & Metabolism, 38(7), 753-759. doi: 10.1139/apnm-2012-0444
Journal - Research Article
Peebles, K. C., Horsman, H., & Tzeng, Y.-C. (2013). The influence of tobacco smoking on the relationship between pressure and flow in the middle cerebral artery in humans. PLoS ONE, 8(8), e72624. doi: 10.1371/journal.pone.0072624
Journal - Research Article
Tan, C. O., Tzeng, Y.-C., Hamner, J. W., Tamisier, R., & Taylor, J. A. (2013). Alterations in sympathetic neurovascular transduction during acute hypoxia in humans. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 304(11), R959-R965. doi: 10.1152/ajpregu.00071.2013
Journal - Research Article
Taylor, C. E., Willie, C. K., Atkinson, G., Jones, H., & Tzeng, Y.-C. (2013). Postural influences on the mechanical and neural components of the cardiovagal baroreflex. Acta Physiologica, 208(1), 66-73. doi: 10.1111/apha.12087
Journal - Research Article
Tzeng, Y.-C., & MacRae, B. A. (2013). Interindividual relationships between blood pressure and cerebral blood flow variability with intact and blunted cerebrovascular control. Journal of Applied Physiology, 114(7), 888-895. doi: 10.1152/japplphysiol.01388.2012
Journal - Research Article
Willie, C. K., Ainslie, P. N., Taylor, C. E., Eves, N. D., & Tzeng, Y.-C. (2013). Maintained cerebrovascular function during post-exercise hypotension. European Journal of Applied Physiology, 113(6), 1597-1604. doi: 10.1007/s00421-012-2578-3
Journal - Research Article
Ainslie, P. N., Lucas, S. J. E., Fan, J.-L., Thomas, K. N., Cotter, J. D., Tzeng, Y. C., & Burgess, K. R. (2012). Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans. Journal of Applied Physiology, 113(7), 1058-1067. doi: 10.1152/japplphysiol.00463.2012
Journal - Research Article
Gelinas, J. C., Marsden, K. R., Tzeng, Y. C., Smirl, J. D., Smith, K. J., Willie, C. K., … Ainslie, P. N. (2012). Influence of posture on the regulation of cerebral perfusion. Aviation, Space, & Environmental Medicine, 83(8), 751-757. doi: 10.3357/asem.3269.2012
Journal - Research Article
Hamner, J. W., Tan, C. O., Tzeng, Y.-C., & Taylor, J. A. (2012). Cholinergic control of the cerebral vasculature in humans. Journal of Physiology, 590(24), 6343-6352. doi: 10.1113/jphysiol.2012.245100
Journal - Research Article
Marsden, K. R., Haykowsky, M. J., Smirl, J. D., Jones, H., Nelson, M. D., Altamirano-Diaz, L. A., … Tzeng, Y. C., … Ainslie, P. N. (2012). Aging blunts hyperventilation-induced hypocapnia and reduction in cerebral blood flow velocity during maximal exercise. Age, 34(3), 725-735. doi: 10.1007/s11357-011-9258-9
Journal - Research Article
Peebles, K. C., Ball, O. G., MacRae, B. A., Horsman, H. M., & Tzeng, Y. C. (2012). Sympathetic regulation of the human cerebrovascular response to carbon dioxide. Journal of Applied Physiology, 113(5), 700-706. doi: 10.1152/japplphysiol.00614.2012
Journal - Research Article
Sin, P. Y. W., Webber, M. R., Galletly, D. C., & Tzeng, Y. C. (2012). Relationship between cardioventilatory coupling and pulmonary gas exchange. Clinical Physiology & Functional Imaging, 32(6), 476-480. doi: 10.1111/j.1475-097X.2012.01144.x
Journal - Research Article
Tzeng, Y. C., Ainslie, P. N., Cooke, W. H., Peebles, K. C., Willie, C. K., MacRae, B. A., … Horsman, H. M., & Rickards, C. A. (2012). Assessment of cerebral autoregulation: The quandary of quantification. American Journal of Physiology: Heart & Circulatory Physiology, 303(6), H658-H671. doi: 10.1152/ajpheart.00328.2012
Journal - Research Article
Willie, C. K., Macleod, D. B., Shaw, A. D., Smith, K. J., Tzeng, Y. C., Eves, N. D., … Ainslie, P. N. (2012). Regional brain blood flow in man during acute changes in arterial blood gases. Journal of Physiology, 590(14), 3261-3275. doi: 10.1113/jphysiol.2012.228551
Journal - Research Article
Atkinson, G., Batterham, A. M., Jones, H., Taylor, C. E., Willie, C. K., & Tzeng, Y.-C. (2011). Appropriate within-subjects statistical models for the analysis of baroreflex sensitivity. Clinical Physiology & Functional Imaging, 31(1), 80-82. doi: 10.1111/j.1475-097X.2010.00974.x
Journal - Research Article
Bellapart, J., Chan, G. S. H., Tzeng, Y.-C., Ainslie, P. N., Dunster, K. R., Barnett, A. G., … Fraser, J. F. (2011). The effect of ventricular assist devices on cerebral blood flow and blood pressure fractality. Physiological Measurement, 32(9), 1361-1372. doi: 10.1088/0967-3334/32/9/001
Journal - Research Article
Bellapart, J., Chan, G. S., Tzeng, Y.-C., Ainslie, P., Barnett, A. G., Dunster, K. R., … Fraser, J. F. (2011). The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study. BMC Anesthesiology, 11, 4. doi: 10.1186/1471-2253-11-4
Journal - Research Article