Accessibility Skip to Global Navigation Skip to Local Navigation Skip to Content Skip to Search Skip to Site Map Menu

Associate Professor Shieak YC Tzeng, Department of Surgery and Anaesthesia

photo-of-shieak-tzeng-surgery-deptMB ChB, PhD (Otago)
Associate Professor

Contact details

Department of Surgery & Anaesthesia
University of Otago, Wellington
PO Box 7343
Wellington South

Email shieak.tzeng@otago.ac.nz

Current roles

Scientific Director, Wellington Medical Technology Group
Theme Leader, Point of Care Technologies, Centre for Bioengineering & Nanomedicine
Council member, New Zealand Physiological Society
Research Co-Ordinator, Cerebral Autoregulation Research Network 

Research Expertise

Neuroprotection in acute brain injury
Cerebral microcirculation
Computational modelling 
Clinical monitoring technologies
Systems Physiology
Bioinformatics

^ Top of page

Publications

Fan, J.-L., O'Donnell, T., Gray, C. L., Croft, K., Noakes, A. K., Koch, H., & Tzeng, Y.-C. (2019). Dietary nitrate supplementation enhances cerebrovascular CO2 reactivity in a sex-specific manner. Journal of Applied Physiology. Advance online publication. doi: 10.1152/japplphysiol.01116.2018

Saleem, S., Sarafis, Z. K., Lee, A. H. X., Squair, J. W., Barak, O. F., Sober-Williams, E., … Tzeng, Y.-C., & Phillips, A. A. (2019). Spinal cord disruption is associated with a loss of Cushing-like blood pressure interactions [Short communication]. Journal of Neurotrauma, 36, 1487-1490. doi: 10.1089/neu.2018.5931

Allan, P. D., O'Donnell, T., & Tzeng, Y.-C. (2018). Agreement between finger plethysmography- and brachial oscillometry-derived blood pressure measurements. Clinical Physiology & Functional Imaging, 38(3), 439-446. doi: 10.1111/cpf.12435

Allan, P. D., Tzeng, Y.-C., Gowing, E. K., Clarkson, A. N., & Fan, J.-L. (2018). Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. Journal of Applied Physiology, 125(3), 862-869. doi: 10.1152/japplphysiol.01081.2017

Saleem, S., Vucina, D., Sarafis, Z., Lee, A. H. X., Squair, J. W., Barak, O. F., … Tzeng, Y.-C., & Phillips, A. A. (2018). Wavelet decomposition analysis is a clinically relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1108-H1114. doi: 10.1152/ajpheart.00152.2017

Journal - Research Article

Fan, J.-L., O'Donnell, T., Gray, C. L., Croft, K., Noakes, A. K., Koch, H., & Tzeng, Y.-C. (2019). Dietary nitrate supplementation enhances cerebrovascular CO2 reactivity in a sex-specific manner. Journal of Applied Physiology. Advance online publication. doi: 10.1152/japplphysiol.01116.2018

Allan, P. D., O'Donnell, T., & Tzeng, Y.-C. (2018). Agreement between finger plethysmography- and brachial oscillometry-derived blood pressure measurements. Clinical Physiology & Functional Imaging, 38(3), 439-446. doi: 10.1111/cpf.12435

Saleem, S., Vucina, D., Sarafis, Z., Lee, A. H. X., Squair, J. W., Barak, O. F., … Tzeng, Y.-C., & Phillips, A. A. (2018). Wavelet decomposition analysis is a clinically relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury. American Journal of Physiology: Heart & Circulatory Physiology, 314(5), H1108-H1114. doi: 10.1152/ajpheart.00152.2017

Allan, P. D., Tzeng, Y.-C., Gowing, E. K., Clarkson, A. N., & Fan, J.-L. (2018). Dietary nitrate supplementation reduces low frequency blood pressure fluctuations in rats following distal middle cerebral artery occlusion. Journal of Applied Physiology, 125(3), 862-869. doi: 10.1152/japplphysiol.01081.2017

Saito-Benz, M., Murphy, W. G., Tzeng, Y.-C., Atkinson, G., & Berry, M. J. (2018). Storage after gamma irradiation affects in vivo oxygen delivery capacity of transfused red blood cells in preterm infants. Transfusion. Advance online publication. doi: 10.1111/trf.14764

Saleem, S., Teal, P. D., Howe, C. A., Tymko, M. M., Ainslie, P. N., & Tzeng, Y.-C. (2018). Is Cushing mechanism a dynamic blood pressure stabilizing system? Insights from Granger causality analysis of spontaneous blood pressure and cerebral blood flow. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 315(3), R484-R495. doi: 10.1152/ajpregu.00032.2018

Faulkner, J., Tzeng, Y.-C., Lambrick, D., Woolley, B., Allan, P. D., O'Donnell, T., Lanford, J., Wong, L., & Stoner, L. (2017). A randomized controlled trial to assess the central hemodynamic response to exercise in patients with transient ischaemic attack and minor stroke. Journal of Human Hypertension, 31, 172-177. doi: 10.1038/jhh.2016.72

Malenfant, S., Brassard, P., Paquette, M., Le Blanc, O., Chouinard, A., Nadeau, V., Allan, P. D., Tzeng, Y.-C., … Provencher, S. (2017). Compromised cerebrovascular regulation and cerebral oxygenation in pulmonary arterial hypertension. Journal of the American Heart Association, 6(10), e006126. doi: 10.1161/jaha.117.006126

Saleem, S., Tzeng, Y.-C., Kleijn, W. B., & Teal, P. D. (2017). Detection of impaired sympathetic cerebrovascular control using functional biomarkers based on principal dynamic mode analysis. Frontiers in Physiology, 7, 685. doi: 10.3389/fphys.2016.00685

Phillips, A. A., Squair, J., Currie, K., Tzeng, Y.-C., Ainslie, P., & Krassioukov, A. V. (2017). 2015 ParaPan American Games: Autonomic function, but not physical activity, is associated with vascular-cognitive impairment in spinal cord injury. Journal of Neurotrauma, 34(6), 1283-1288. doi: 10.1089/neu.2016.4751

Witter, T., Tzeng, Y.-C., O'Donnell, T., Kusel, J., Walker, B., Berry, M., & Taylor, C. E. (2017). Inter-individual relationships between sympathetic arterial baroreflex function and cerebral perfusion control in healthy males. Frontiers in Neuroscience, 11, 457. doi: 10.3389/fnins.2017.00457

Saleem, S., Teal, P. D., Kleijn, W. B., Ainslie, P. N., & Tzeng, Y.-C. (2016). Identification of human sympathetic neurovascular control using multivariate wavelet decomposition analysis. American Journal of Physiology: Heart & Circulatory Physiology, 311(3), H837-H848. doi: 10.1152/ajpheart.00254.2016

Smirl, J. D., Hoffman, K., Tzeng, Y.-C., Hansen, A., & Ainslie, P. N. (2016). The relationship between blood pressure and cerebral blood flow during supine cycling: Influence of aging. Journal of Applied Physiology, 120(5), 552-563. doi: 10.1152/japplphysiol.00667.2015

Saleem, S., Teal, P. D., Kleijn, W. B., O'Donnell, T., Witter, T., & Tzeng, Y.-C. (2015). Non-linear characterisation of cerebral pressure-flow dynamics in humans. PLoS ONE, 10(9), e0139470. doi: 10.1371/journal.pone.0139470

Horsman, H. M., Peebles, K. C., & Tzeng, Y. C. (2015). Interactions between breathing rate and low-frequency fluctuations in blood pressure and cardiac intervals. Journal of Applied Physiology, 119, 793-798. doi: 10.1152/japplphysiol.00525.2015

Rickards, C. A., Sprick, J. D., Colby, H. B., Kay, V., & Tzeng, Y.-C. (2015). Coupling between arterial pressure, cerebral blood velocity, and cerebral tissue oxygenation with spontaneous and forced oscillations. Physiological Measurement, 36(4), 785-801. doi: 10.1088/0967-3334/36/4/785

Smirl, J. D., Hoffman, K., Tzeng, Y.-C., Hansen, A., & Ainslie, P. N. (2015). Methodological comparison of active- and passive-driven oscillations in blood pressure: Implications for the assessment of cerebral pressure-flow relationships. Journal of Applied Physiology, 119(5), 487-501. doi: 10.1152/japplphysiol.00264.2015

Allan, P. D., Faulkner, J., O'Donnell, T., Lanford, J., Wong, L., Saleem, S., … Tzeng, Y.-C. (2015). Hemodynamic variability and cerebrovascular control after transient cerebral ischemia. Physiological Reports, 3(11), e12602. doi: 10.14814/phy2.12602

Rickards, C. A., & Tzeng, Y.-C. (2014). Arterial pressure and cerebral blood flow variability: Friend or foe? A review. Frontiers in Physiology, 5, 120. doi: 10.3389/fphys.2014.00120

Meel-van den Abeelen, A. S. S., Simpson, D. M., Wang, L. J. Y., Slump, C. H., Zhang, R., Tarumi, T., … Tzeng, Y.-C., … Claassen, J. A. H. R. (2014). Between-centre variability in transfer function analysis, a widely used method for linear quantification of the dynamic pressure-flow relation: The CARNet study. Medical Engineering & Physics, 36(5), 620-627. doi: 10.1016/j.medengphy.2014.02.002

Berry, M., Tzeng, Y., & Marsland, C. (2014). Percutaneous transtracheal ventilation in an obstructed airway model in post-apnoeic sheep. British Journal of Anaesthesia, 113(6), 1039-1045. doi: 10.1093/bja/aeu188

Smirl, J. D., Tzeng, Y. C., Monteleone, B. J., & Ainslie, P. N. (2014). Influence of cerebrovascular resistance on the dynamic relationship between blood pressure and cerebral blood flow in humans. Journal of Applied Physiology, 116(12), 1614-1622. doi: 10.1152/japplphysiol.01266.2013

Horsman, H. M., Tzeng, Y. C., Galletly, D. C., & Peebles, K. C. (2014). The repeated sit-to-stand manoeuvre is a superior method for cardiac baroreflex assessment: A comparison with the modified Oxford method and Valsalva manoeuvre. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 307(11), R1345-R1352. doi: 10.1152/ajpregu.00376.2014

Tzeng, Y.-C., & Ainslie, P. N. (2014). Blood pressure regulation IX: Cerebral autoregulation under blood pressure challenges. European Journal of Applied Physiology, 114(3), 545-559. doi: 10.1007/s00421-013-2667-y

Willie, C. K., Tzeng, Y.-C., Fisher, J. A., & Ainslie, P. N. (2014). Integrative regulation of human brain blood flow. Journal of Physiology, 592(5), 841-859. doi: 10.1113/jphysiol.2013.268953

Tzeng, Y. C., MacRae, B. A., Ainslie, P. N., & Chan, G. S. H. (2014). Fundamental relationships between blood pressure and cerebral blood flow in humans. Journal of Applied Physiology, 117(9), 1037-1048. doi: 10.1152/japplphysiol.00366.2014

Smirl, J. D., Haykowsky, M. J., Nelson, M. D., Tzeng, Y.-C., Marsden, K. R., Jones, H., & Ainslie, P. N. (2014). Relationship between cerebral blood flow and blood pressure in long-term heart transplant recipients. Hypertension, 64, 1314-1320. doi: 10.1161/hypertensionaha.114.04236

Taylor, C. E., Willie, C. K., Ainslie, P. N., & Tzeng, Y.-C. (2014). Assessment of human baroreflex function using carotid ultrasonography: What have we learnt? Acta Physiologica, 211(2), 297-313. doi: 10.1111/apha.12302

Taylor, C. E., Willie, C. K., Atkinson, G., Jones, H., & Tzeng, Y.-C. (2013). Postural influences on the mechanical and neural components of the cardiovagal baroreflex. Acta Physiologica, 208(1), 66-73. doi: 10.1111/apha.12087

Horsman, H. M., Peebles, K. C., Galletly, D. C., & Tzeng, Y.-C. (2013). Cardiac baroreflex gain is frequency dependent: Insights from repeated sit-to-stand maneuvers and the modified Oxford Method. Applied Physiology, Nutrition, & Metabolism, 38(7), 753-759. doi: 10.1139/apnm-2012-0444

Tzeng, Y.-C., & MacRae, B. A. (2013). Interindividual relationships between blood pressure and cerebral blood flow variability with intact and blunted cerebrovascular control. Journal of Applied Physiology, 114(7), 888-895. doi: 10.1152/japplphysiol.01388.2012

Tan, C. O., Tzeng, Y.-C., Hamner, J. W., Tamisier, R., & Taylor, J. A. (2013). Alterations in sympathetic neurovascular transduction during acute hypoxia in humans. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 304(11), R959-R965. doi: 10.1152/ajpregu.00071.2013

Peebles, K. C., Horsman, H., & Tzeng, Y.-C. (2013). The influence of tobacco smoking on the relationship between pressure and flow in the middle cerebral artery in humans. PLoS ONE, 8(8), e72624. doi: 10.1371/journal.pone.0072624

Willie, C. K., Ainslie, P. N., Taylor, C. E., Eves, N. D., & Tzeng, Y.-C. (2013). Maintained cerebrovascular function during post-exercise hypotension. European Journal of Applied Physiology, 113(6), 1597-1604. doi: 10.1007/s00421-012-2578-3

Peebles, K. C., Ball, O. G., MacRae, B. A., Horsman, H. M., & Tzeng, Y. C. (2012). Sympathetic regulation of the human cerebrovascular response to carbon dioxide. Journal of Applied Physiology, 113(5), 700-706. doi: 10.1152/japplphysiol.00614.2012

Gelinas, J. C., Marsden, K. R., Tzeng, Y. C., Smirl, J. D., Smith, K. J., Willie, C. K., … Ainslie, P. N. (2012). Influence of posture on the regulation of cerebral perfusion. Aviation, Space, & Environmental Medicine, 83(8), 751-757. doi: 10.3357/asem.3269.2012

Marsden, K. R., Haykowsky, M. J., Smirl, J. D., Jones, H., Nelson, M. D., Altamirano-Diaz, L. A., … Tzeng, Y. C., … Ainslie, P. N. (2012). Aging blunts hyperventilation-induced hypocapnia and reduction in cerebral blood flow velocity during maximal exercise. Age, 34(3), 725-735. doi: 10.1007/s11357-011-9258-9

Tzeng, Y. C., Ainslie, P. N., Cooke, W. H., Peebles, K. C., Willie, C. K., MacRae, B. A., … Horsman, H. M., & Rickards, C. A. (2012). Assessment of cerebral autoregulation: The quandary of quantification. American Journal of Physiology: Heart & Circulatory Physiology, 303(6), H658-H671. doi: 10.1152/ajpheart.00328.2012

Willie, C. K., Macleod, D. B., Shaw, A. D., Smith, K. J., Tzeng, Y. C., Eves, N. D., … Ainslie, P. N. (2012). Regional brain blood flow in man during acute changes in arterial blood gases. Journal of Physiology, 590(14), 3261-3275. doi: 10.1113/jphysiol.2012.228551

Ainslie, P. N., Lucas, S. J. E., Fan, J.-L., Thomas, K. N., Cotter, J. D., Tzeng, Y. C., & Burgess, K. R. (2012). Influence of sympathoexcitation at high altitude on cerebrovascular function and ventilatory control in humans. Journal of Applied Physiology, 113(7), 1058-1067. doi: 10.1152/japplphysiol.00463.2012

Hamner, J. W., Tan, C. O., Tzeng, Y.-C., & Taylor, J. A. (2012). Cholinergic control of the cerebral vasculature in humans. Journal of Physiology, 590(24), 6343-6352. doi: 10.1113/jphysiol.2012.245100

Sin, P. Y. W., Webber, M. R., Galletly, D. C., & Tzeng, Y. C. (2012). Relationship between cardioventilatory coupling and pulmonary gas exchange. Clinical Physiology & Functional Imaging, 32(6), 476-480. doi: 10.1111/j.1475-097X.2012.01144.x

Willie, C. K., Ainslie, P. N., Taylor, C. E., Jones, H., Sin, P. Y. W., & Tzeng, Y.-C. (2011). Neuromechanical features of the cardiac baroreflex after exercise. Hypertension, 57, 927-933. doi: 10.1161/HYPERTENSIONAHA.110.164616

Tzeng, Y.-C., & Chan, G. S. H. (2011). Unraveling the human cerebral circulation: Insights from cerebral blood pressure and flow recordings. Journal of Applied Physiology, 111(2), 349-350. doi: 10.1152/japplphysiol.00715.2011

Chan, G. S. H., Ainslie, P. N., Willie, C. K., Taylor, C. E., Atkinson, G., Jones, H., … Tzeng, Y.-C. (2011). Contribution of arterial Windkessel in low-frequency cerebral hemodynamics during transient changes in blood pressure. Journal of Applied Physiology, 110(4), 917-925. doi: 10.1152/japplphysiol.01407.2010

Lewis, N. C. S., Atkinson, G., Lucas, S. J. E., Grant, E. J. M., Jones, H., Tzeng, Y. C., Horsman, H., & Ainslie, P. N. (2011). Is there diurnal variation in initial and delayed orthostatic hypotension during standing and head-up tilt? Chronobiology International, 28(2), 135-145. doi: 10.3109/07420528.2010.536283

Bellapart, J., Chan, G. S., Tzeng, Y.-C., Ainslie, P., Barnett, A. G., Dunster, K. R., … Fraser, J. F. (2011). The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study. BMC Anesthesiology, 11, 4. doi: 10.1186/1471-2253-11-4

Atkinson, G., Batterham, A. M., Jones, H., Taylor, C. E., Willie, C. K., & Tzeng, Y.-C. (2011). Appropriate within-subjects statistical models for the analysis of baroreflex sensitivity. Clinical Physiology & Functional Imaging, 31(1), 80-82. doi: 10.1111/j.1475-097X.2010.00974.x

Bellapart, J., Chan, G. S. H., Tzeng, Y.-C., Ainslie, P. N., Dunster, K. R., Barnett, A. G., … Fraser, J. F. (2011). The effect of ventricular assist devices on cerebral blood flow and blood pressure fractality. Physiological Measurement, 32(9), 1361-1372. doi: 10.1088/0967-3334/32/9/001

Willie, C. K., Colino, F. L., Bailey, D. M., Tzeng, Y. C., Binsted, G., Jones, L. W., … Lucas, S. J., … Ainslie, P. N. (2011). Utility of transcranial Doppler ultrasound for the integrative assessment of cerebrovascular function. Journal of Neuroscience Methods, 196(2), 221-237. doi: 10.1016/j.jneumeth.2011.01.011

More publications...