Dr Adele Woolley

Adele WoolleyBPhEd, BSc, DipSci, PhD

Dr Adele Woolley is a Research Fellow associated with the Cell Transformation Group (CTG) in the Department of Pathology.

Adele completed undergraduate degrees in Physical Education and Physiology. She went on to complete a postgraduate degree in neuroscience and a PhD in developmental neurobiology. Since 2006, she has been working in the CTG, under the mentorship of Professor Braithwaite.

Her research interests lie in the area of developmental pathways that are re-expressed in cancer. Adele is currently working on a number of projects including YBX-1 in breast cancer with a particular focus on epithelial to mesenchymal transition (EMT), BRCA1 signalling pathways in ovarian cell biology and is also investigating the interaction of p53 isoforms with p53 using a zebrafish model.

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Publications

Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., Woolley, A., … Fleming, N., Baird, M., & Braithwaite, A. W. (2016). The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene, 35, 4981-4989. doi: 10.1038/onc.2016.45

Lasham, A., Mehta, S. Y., Fitzgerald, S. J., Woolley, A. G., Hearn, J. I., Hurley, D. G., Ruza, I., Algie, M., … Braithwaite, A. W., & Print, C. G. (2016). A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line. International Journal of Cancer, 139(5), 1157-1170. doi: 10.1002/ijc.30137

Mehta, S., Lasham, A., Woolley, A., Algie, M., Al Jabry, T., Ma, W., Fleming, N., Young, K., Parker, K., … Braithwaite, A. (2016, August-September). Role of YB-1 in cell cycle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Fleming, J. S., Ruza, I., Thompson, B. A., Lee, K.-F., & Woolley, A. G. (2015). Effects of BRCA1 knockdown on CYP19a1/aromatase and steroid receptor expression in ovarian and tubal cells. Journal of Molecular & Genetic Medicine, 9(4), 185. doi: 10.4172/1747-0862.1000185

Lasham, A., Print, C. G., Woolley, A. G., Dunn, S. E., & Braithwaite, A. W. (2013). YB-1: Oncoprotein, prognostic marker and therapeutic target? Biochemical Journal, 449, 11-23. doi: 10.1042/bj20121323

Journal - Research Article

Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., Woolley, A., … Fleming, N., Baird, M., & Braithwaite, A. W. (2016). The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene, 35, 4981-4989. doi: 10.1038/onc.2016.45

Lasham, A., Mehta, S. Y., Fitzgerald, S. J., Woolley, A. G., Hearn, J. I., Hurley, D. G., Ruza, I., Algie, M., … Braithwaite, A. W., & Print, C. G. (2016). A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line. International Journal of Cancer, 139(5), 1157-1170. doi: 10.1002/ijc.30137

Fleming, J. S., Ruza, I., Thompson, B. A., Lee, K.-F., & Woolley, A. G. (2015). Effects of BRCA1 knockdown on CYP19a1/aromatase and steroid receptor expression in ovarian and tubal cells. Journal of Molecular & Genetic Medicine, 9(4), 185. doi: 10.4172/1747-0862.1000185

Lasham, A., Print, C. G., Woolley, A. G., Dunn, S. E., & Braithwaite, A. W. (2013). YB-1: Oncoprotein, prognostic marker and therapeutic target? Biochemical Journal, 449, 11-23. doi: 10.1042/bj20121323

Awasthi, A., Woolley, A. G., Lecomte, F. J., Hung, N., Baguley, B. C., Wilbanks, S. M., Jeffs, A. R., & Tyndall, J. D. A. (2013). Variable expression of GLIPR1 correlates with invasive potential in melanoma cells. Frontiers in Oncology, 3, 225. doi: 10.3389/fonc.2013.00225

Lasham, A., Samuel, W., Cao, H., Patel, R., Mehta, R., Stern, J. L., … Woolley, A. G., … Black, M. A., Shelling, A. N., Print, C. G., & Braithwaite, A. W. (2012). YB-1, the E2F Pathway, and regulation of tumor cell growth. Journal of the National Cancer Institute, 104(2), 133-146. doi: 10.1093/jnci/djr512

Woolley, A. G., Algie, M., Samuel, W., Harfoot, R., Wiles, A., Hung, N. A., … Royds, J. A., Perez, D., Yoon, H.-S., … Braithwaite, A. W. (2011). Prognostic association of YB-1 expression in breast cancers: A matter of antibody. PLoS ONE, 6(6), e20603. doi: 10.1371/journal.pone.0020603

Sheard, P. W., Bewick, G. S., Woolley, A. G., Shaw, J., Fisher, L., Fong, S. W., & Duxson, M. J. (2010). Investigation of neuromuscular abnormalities in neurotrophin-3-deficient mice. European Journal of Neuroscience, 31(1), 29-41. doi: 10.1111/j.1460-9568.2009.07032.x

Cohen, S. B., Ma, W., Valova, V. A., Algie, M., Harfoot, R., Woolley, A. G., … Braithwaite, A. W. (2010). Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing. Oncogene, 29, 403-410. doi: 10.1038/onc.2009.321

Jeffs, A. R., Glover, A. C., Slobbe, L. J., Wang, L., He, S., Hazlett, J. A., Awasthi, A., Woolley, A. G., … Print, C. G., … Eccles, M. R. (2009). A gene expression signature of invasive potential in metastatic melanoma cells. PLoS ONE, 4(12), e8461. doi: 10.1371/journal.pone.0008461

Woolley, A. G., Tait, K. J., Hurren, B. J., Fisher, L., Sheard, P. W., & Duxson, M. J. (2008). Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells. GLIA, 56(3), 306-317. doi: 10.1002/glia.20614

Woolley, A. G., Sheard, P. W., & Duxson, M. J. (2005). Neurotrophin-3 null mutant mice display a postnatal motor neuropathy. European Journal of Neuroscience, 21, 2100-2110.

Woolley, A., Sheard, P. W., Dodds, K. G., & Duxson, M. J. (1999). Alpha motoneurons are present in normal numbers but with reduced soma size in neurotrophin-3 knockout mice. Neuroscience Letters, 272, 107-110.

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Conference Contribution - Published proceedings: Abstract

Tait, K. J., Woolley, A. G., & Duxson, M. J. (2005). Neurotrophin-3 loss in vivo does not affect myelination at birth, but reduces myelination at three weeks in mice. New Zealand Medical Journal, 118(1225). Retrieved from http://journal.nzma.org.nz/journal/118-1225/1740/content.pdf

Woolley, A. G., Tait, K. J., Fisher, L., Kirschner, D. A., & Duxson, M. J. (2005). Role of neurotrophin-3 in the regulation of peripheral myelination in vivo. Mechanisms of Development. 122(Suppl.), (pp. S113). [Abstract]

Woolley, A., Sheard, P. W., & Duxson, M. J. (2002). Effects of NT-3 deficit on mouse neuromuscular development. Proceedings of the Third (2002) Asia Pacific Symposium on Neural Regeneration. (pp. 64). [Abstract]

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Conference Contribution - Poster Presentation (not in published proceedings)

Fleming, J. S., Ruza, I., Lee, K.-F., & Woolley, A. (2011, September). Aromatase/CYP19 and steroid receptor expression in response to BRCA1 knockdown in MCF-7 breast cancer cells and reproductive tract epithelial cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Jeffs, A., Glover, A., He, S., Woolley, A., Eccles, M., & Baguley, B. (2008, August-September). Gene expression signatures of invasion in melanoma. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Li, C., Jeffs, A., He, S., Woolley, A., & Eccles, M. (2007, May). Is there cooperation, interference, or no interaction at all between PAX genes in promoting tumorigenesis? Poster session presented at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.

Glover, A., He, S., Ineson, J., Jeffs, A., Woolley, A., Marshall, E., … Eccles, M. (2007, August). The role of PAX3 in malignant melanoma. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Woolley, A., Hazlett, J., Li, G., & Eccles, M. (2007, May). Is PAX8 involved in the regulation of cell proliferation in ovarian cancer? Poster session presented at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.

Woolley, A., Hazlett, J., Li, C., & Eccles, M. (2007, August). Is PAX8 involved in the regulation of cell proliferation in ovarian cancer? Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Glover, A., He, S., Ineson, J., Jeffs, A., Woolley, A., Marshall, E., … Eccles, M. (2007, May). The role of PAX3 in malignant melanoma. Poster session presented at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.

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Conference Contribution - Verbal presentation and other Conference outputs

Mehta, S., Lasham, A., Woolley, A., Algie, M., Al Jabry, T., Ma, W., Fleming, N., Young, K., Parker, K., … Braithwaite, A. (2016, August-September). Role of YB-1 in cell cycle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Algie, M., Jeffs, A., Woolley, A., Kleffmann, T., & Braithwaite, A. (2012, August). Identification of binding partners of the oncoprotein Y-box binding protein (YBX1) in breast cancer cell-line. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Woolley, A. (2011, March). Prognostic association of YB-1 expression in breast cancers: A matter of antibody. Verbal presentation at the New Zealand/Singapore Cancer Symposium, Dunedin, New Zealand.

Glover, A., He, S., Ineson, J., Jeffs, A., Woolley, A., Marshall, E., … Eccles, M. (2007, September). Expression profiling, characterisation, and the role of PAX3 in the NZM panel of metastatic melanoma cell lines. Verbal presentation at the Joint Meeting of the 10th Annual Microarray and Gene Expression Data Society (MGED) Meeting and the 7th Annual Australasian Microarray and Associated Technologies (AMATA) Conference, Brisbane, Australia.

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Awarded Doctoral Degree

Woolley, A. G. (2003). Development and perinatal maintenance of the neuromuscular system in neurotrophin-3 null mutant mice (PhD). University of Otago, Dunedin, New Zealand. 312p.

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