Professor Antony Braithwaite
MSc, PhDProfessor Antony Braithwaite is head of the Cell Transformational Unit at the Children's Medical Research Institute, based at the University of Sydney. He splits his time between Otago and Sydney.
Antony completed his Bachelor and Masters of Science degrees at the University of Auckland before embarking on his PhD at the Australian National University. Antony was awarded a Howard Florey Fellowship and worked at the Marie Curie Cancer Research Institute in the UK, before returning to the Australian National University to lead a team studying basic mechanisms in cancer cell formation. In 1996, he took up a personal Professorship in Pathology at Otago.
Antony's research is focused on the regulation of cell proliferation and cell survival and the role played by the tumour suppressor protein, p53.
Publications
Ray Das, S., Delahunt, B., Lasham, A., Li, K., Wright, D., Print, C., Slatter, T., Braithwaite, A., & Mehta, S. (2024). Combining TP53 mutation and isoform has the potential to improve clinical practice. Pathology. Advance online publication. doi: 10.1016/j.pathol.2024.02.003 Journal - Research Other
Wiles, A. K., Mehta, S., Millier, M., Woolley, A. G., Li, K., Parker, K., Kazantseva, M., Wilson, M., Young, K., Bowie, S., Ray, S., Slatter, T. L., Stamp, L. K., Hessian, P. A., & Braithwaite, A. W. (2023). Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis. Arthritis Research & Therapy, 25, 62. doi: 10.1186/s13075-023-03040-8 Journal - Research Article
Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267 Journal - Research Article
Reinhardt, L. S., Zhang, X., Groen, K., Morten, B. C., De Iuliis, G. N., Braithwaite, A. W., … Avery-Kiejda, K. A. (2022). Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage. Cell Death & Disease, 13, 907. doi: 10.1038/s41419-022-05349-9 Journal - Research Article
Polwatta, S. N., Boix De Jesús, A. N., Wang, D., Taha, A., Kazantseva, M., Zhou, J., Mehta, S., Saraiva, A. M., … Royds, J., … Braithwaite, A. W., Hung, N. A., & Slatter, T. L. (2022, August). The Δ 133p53 isoform enhances cell-surface trafficking to promote metastasis. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394 Journal - Research Other
Zhang, X., Groen, K., Morten, B. C., Reinhardt, L. S., Campbell, H. G., Braithwaite, A. W., … Avery-Kiejda, K. A. (2022). The effect of p53 and its N-terminally truncated isoform, Δ40p53, on breast cancer migration and invasion. Molecular Oncology, 16, 447-465. doi: 10.1002/1878-0261.13118 Journal - Research Article
Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., … Braithwaite, A. W. (2021). Adaptive homeostasis and the p53 isoform network. EMBO Reports, 22, e53085. doi: 10.15252/embr.202153085 Journal - Research Other
Arsic, N., Slatter, T., Gadea, G., Villain, E., Fournet, A., Kazantseva, M., … Mehta, S., … Braithwaite, A., & Roux, P. (2021). Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nature Communications, 12, 5463. doi: 10.1038/s41467-021-25550-2 Journal - Research Article
Lasham, A., Knowlton, N., Mehta, S. Y., Braithwaite, A. W., & Print, C. G. (2021). Breast cancer patient prognosis is determined by the interplay between TP53 mutation and alternative transcript expression: Insights from TP53 long amplicon digital PCR assays. Cancers, 13(7), 1531. doi: 10.3390/cancers13071531 Journal - Research Article
Chin, C. V., Antony, J., Ketharnathan, S., Labudina, A., Gimenez, G., Parsons, K. M., … Braithwaite, A., Guilford, P., … Horsfield, J. A. (2020). Cohesin mutations are synthetic lethal with stimulation of WNT signaling. eLIFE, 9, e61405. doi: 10.7554/eLife.61405 Journal - Research Article
Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3 Journal - Research Article
Mehta, S., Algie, M., Al-Jabry, T., McKinney, C., Kannan, S., Verma, C. S., … Parker, K., Henderson, L., Gould, M. L., Bhatia, P., Harfoot, R., … Kleffmann, T., … Woolley, A. G., … Braithwaite, A. (2020). Critical role for cold shock protein YB-1 in cytokinesis. Cancers, 12, 2473. doi: 10.3390/cancers12092473 Journal - Research Article
Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472 Journal - Research Article
Lasham, A., Tsai, P., Fitzgerald, S. J., Mehta, S. Y., Knowlton, N. S., Braithwaite, A. W., & Print, C. G. (2020). Accessing a new dimension in TP53 biology: Multiplex long amplicon digital PCR to specifically detect and quantitate individual TP53 transcripts. Cancers, 12(3), 769. doi: 10.3390/cancers12030769 Journal - Research Article
Mehta, S., McKinney, C., Algie, M., Verma, C. S., Kannan, S., Harfoot, R., … Gould, M. L., Parker, K., … Cunliffe, H. E., … Kleffmann, T., Braithwaite, A. W., & Woolley, A. G. (2020). Dephosphorylation of YB-1 is required for nuclear localisation during G2 phase of the cell cycle. Cancers, 12(2), 315. doi: 10.3390/cancers12020315 Journal - Research Article
Li, K., Wilson, M., Parker, K., Wiles, A., Schultz, M., Slatter, T., Baird, M., & Braithwaite, A. (2019). An Δ133p53-like isoform drives exaggerated immune responses to promote chronic inflammation. European Journal of Immunology, 49(Suppl. 3), (pp. 782). doi: 10.1002/eji.201970400 Conference Contribution - Published proceedings: Abstract
Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1 Journal - Research Article
Vennin, C., Mélénec, P., Rouet, R., Nobis, M., Cazet, A. S., Murphy, K. J., … Braithwaite, A. W., … Timpson, P. (2019). CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature Communications, 10, 3637. doi: 10.1038/s41467-019-10968-6 Journal - Research Article
Trevarton, A. J., Zhou, Y., Yang, D., Rewcastle, G. W., Flanagan, J. U., Braithwaite, A., … Lasham, A. (2019). Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1. Acta Pharmaceutica Sinica B, 9(5), 997-1007. doi: 10.1016/j.apsb.2018.12.011 Journal - Research Article
Zeng, J., Thomson, M., Broadbent, J., Foster Page, L., Shalev, I., Moffitt, T., Caspi, A., Williams, S., Braithwaite, A., Robertson, S., & Poulton, R. (2018). Examining the association between telomere length and periodontal attachment loss in the Dunedin Study. Proceedings of the Australasian Applied Statistics (AASC) Conference. (pp. 32). Retrieved from https://www.aasc.nz/ Conference Contribution - Published proceedings: Abstract
Reily-Bell, A., Fisher, A., Devenish, C. J., Hung, N. A., Braithwaite, A. W., & Slatter, T. L. (2018, August). Investigating p53 isoforms in HPV positive cervical cancers and in the placenta. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Eiholzer, R. A., Kazantseva, M., Mehta, S., Roth, I., Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018, August). The role of the p53 isoform Δ133TPP53 in treatment resistance. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Ray, S., McKinney, C., Roth, L., Heinzel, S., Hodgkin, P., Mehta, S., Slatter, T. L., & Braithwaite, A. W. (2018, August). p53 does not cause growth arrest or death in normal B cells but only affects division rate. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Mehta, S., Algie, M., Al Jabri, T., McKinney, C., Verma, C., Weini, M., … Henderson, L., Gould, M., Parker, K., Bhatia, P., Harfoot, R., Kleffmann, T., … Woolley, A., & Braithwaite, A. (2018, August). RSK mediated YB-1 phosphorylation: A key event required for completion of cytokinesis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Slatter, T. L., Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., … Royds, J. A., Zhou, J., Hung, N. A., & Braithwaite, A. W. (2018, August). The TP53 isoform Δ133p53β in glioblastoma development. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Henderson, L., Mehta, S., Fleming, N., Eccles, M., Chatterjee, A., Print, C., … Braithwaite, A. (2018, August). p63 promotes proliferation in melanoma cell lines via regulation of AQP3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Braithwaite, A. W. (2018, August). Can the wild type p53 tumour suppressor cause cancer? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Munro, F. M., Gimenez, G., Shepherd, P. R., Braithwaite, A. W., McCall, J. L., & Fleming, N. I. (2018, August). Regulation of IL-6 is pivotal to outcome in colorectal cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Munro, F., Gimenez, G., Shepherd, P., Braithwaite, A., McCall, J., & Fleming, N. (2018). A common variation in the IL6 promoter predicts time to metastasis for colorectal cancer and may indicate the mechanisms involved. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/ Conference Contribution - Published proceedings: Abstract
Mehta, S. Y., Morten, B. C., Antony, J., Henderson, L., Lasham, A., Campbell, H., Cunliffe, H., Horsfield, J. A., … Braithwaite, A. W. (2018). Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget, 9(49), 29146-29161. doi: 10.18632/oncotarget.25635 Journal - Research Article
Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3 Journal - Research Article
Hibma, M., Zhang, T., Gimenez, G., Ly, K., Burn, C., Young, K., Wilson, M., … Tschirley, A., Braithwaite, A., & Baird, M. (2018). Human papillomavirus regulation of Langerhans cell function in the skin. European Journal of Immunology, 48(Suppl. 1), (pp. 96-97). doi: 10.1002/eji.201871000 Conference Contribution - Published proceedings: Abstract
Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111 Journal - Research Article
Zhang, J., Burn, C., Young, K., Wilson, M., Ly, K., Budhwani, M., Tschirley, A., Braithwaite, A., Baird, M., & Hibma, M. (2018). Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports, 8, 2373. doi: 10.1038/s41598-018-20779-2 Journal - Research Article
Campbell, H., Fleming, N., Roth, I., Mehta, S., Wiles, A., Williams, G., … Munro, F., McNoe, L., Black, M., McCall, J., Slatter, T. L., … Braithwaite, A. W. (2018). Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. Nature Communications, 9(1), 254. doi: 10.1038/s41467-017-02408-0 Journal - Research Article
Slatter, T. L., Kazantseva, M., Eiholzer, R., Mehta, S., Wiles, A., Bowie, S., Zhou, J., … Wilson, B. K. J., … Frampton, C. M., … Royds, J. A., … Hung, N. A., & Braithwaite, A. W. (2017). Elevated Δ133p53β correlates with a high tumor-associated macrophage content in glioblastoma with a poor patient outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 37). Retrieved from http://www.uib.no/en/ccbio Conference Contribution - Published proceedings: Abstract
Kazantseva, M., Mehta, S., Eiholzer, R. A., Roth, I., Bowie, S., Joruiz, S., Royds, J. A., Taha, A., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2017). Elevated Δ133p53β in prostate tumours correlates with an immune suppressive signature and poorer outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 29). Retrieved from http://www.uib.no/en/ccbio Conference Contribution - Published proceedings: Abstract
Wiles, A., Kazantseva, M., Li, K., Williams, M., Bowie, S., Jo, S., Millier, M., Hessian, P., Stamp, L., Baird, M. A., Slatter, T., & Braithwaite, A. (2017). The presence of Δ133p53β in the autoimmune disease rheumatoid arthritis. Proceedings of the 3rd International p53 Isoform Conference. P10. Retrieved from http://www.uib.no/en/ccbio Conference Contribution - Published proceedings: Abstract
Print, C., Lasham, A., Knowlton, N., Trevarton, A., Jebb, A., Blenkiron, C., … Harris, G., … Braithwaite, A., & Black, M. (2017). Bioinformatic prospecting for breast cancer drivers. In A. Blackman, L. Gillman, C. Oliver & D. Dantzic (Eds.), Proceedings of the Inaugural New Zealand Breast Cancer Symposium (NZBCS): United for a Cure through Research. (pp. 60). Auckland, New Zealand: Auckland University of Technology. [Abstract] Conference Contribution - Published proceedings: Abstract
Hale, T. K., Solomon, R., Bond, S. D., Mehta, S., Braithwaite, A., Wheeler, D., & Fitzsimons, H. (2017). Untethering the genome: Loss of HP1α enhances malignant cell invasion. In A. Blackman, L. Gillman, C. Oliver & D. Dantzic (Eds.), Proceedings of the Inaugural New Zealand Breast Cancer Symposium (NZBCS): United for a Cure through Research. (pp. 40). Auckland, New Zealand: Auckland University of Technology. [Abstract] Conference Contribution - Published proceedings: Abstract
Morten, B., Campbell, H., Braithwaite, A., Scott, R., & Avery-Kiejda, K. (2017). The Role of Δ 40P53 in the response to DNA damage in breast cancer cells. Asia-Pacific Journal of Clinical Oncology, 13(Suppl. 5), (pp. 19). doi: 10.1111/ajco.12813 Conference Contribution - Published proceedings: Abstract
Zhang, X., Morten, B., Campbell, H., Braithwaite, A., Thorne, R., Scott, R., & Avery-Kiejda, K. (2017). Δ40P53 inhibits migration/invasion in MCF-7 breast cancer cells. Asia-Pacific Journal of Clinical Oncology, 13(Suppl. 5), (pp. 19-20). doi: 10.1111/ajco.12813 Conference Contribution - Published proceedings: Abstract
Hibma, M., Zhang, J., Baird, M., & Braithwaite, A. (2017, July). Evaluating immune modulation of Langerhans cells by microparticles shed from human papillomavirus type 16-E7 expressing keratinocyctes. Verbal presentation at the New Zealand Branch of the Australasian Society for Immunology (NZ ASI) Annual Scientific Meeting, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6 Journal - Research Article
Leroy, B., Ballinger, M. L., Baran-Marszak, F., Bond, G. L., Braithwaite, A., Concin, N., … Soussi, T. (2017). Recommended guidelines for validation, quality control, and reporting of TP53 variants in clinical practice. Cancer Research, 77(6), 1250-1260. doi: 10.1158/0008-5472.can-16-2179 Journal - Research Article
Kazantseva, M., Hung, N., Mehta, S., Roth, I., Baird, M., Braithwaite, A., & Slatter, T. (2016, October). Mutant p53 promotes incorrect B cell differentiation and adverse outcome in DLBCL. Verbal presentation at the 7th International Mutant p53 Workshop, Melbourne, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Braithwaite, A., Slatter, T., Wilson, M., & Baird, M. (2016). D133p53 isoform: A novel adjuvant for tumour vaccination. European Journal of Immunology, 46(Suppl. 1), (pp. 1007). doi: 10.1002/eji.201670200 Conference Contribution - Published proceedings: Abstract
Zhang, T., Burn, C., Ly, K., Young, K., Wilson, M., Braithwaite, A., Baird, M., & Hibma, M. (2016). Immune modulation of Langerhans cells by microparticles from human papillomavirus type 16 E7 expressing keratinocytes. European Journal of Immunology, 46(Suppl. 1), (pp. 890-891). doi: 10.1002/eji.201670200 Conference Contribution - Published proceedings: Abstract
Mehta, S., Tsai, P., Lasham, A., Campbell, H., Reddel, R., Braithwaite, A., & Print, C. (2016). A study of TP53 RNA splicing illustrates pitfalls of RNA-seq methodology. Cancer Research, 76(24), 7151-7159. doi: 10.1158/0008-5472.can-16-1624 Journal - Research Article
Fleming, N. I., Henderson, L. E., Campbell, H. G., Antony, J., Print, C. G., Baird, M., & Braithwaite, A. W. (2016, August-September). A common variation within the IL6 promoter may alter its control by the p53 protein family and influence cancer progression. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Mehta, S., Lasham, A., Woolley, A., Algie, M., Al Jabry, T., Ma, W., Fleming, N., Young, K., Parker, K., … Braithwaite, A. (2016, August-September). Role of YB-1 in cell cycle. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Kazantseva, M., Hung, N., Mehta, S., Baird, M., Slatter, T., & Braithwaite, A. (2016, August-September). Investigating the association of Δ133p53 isoform expression and the inflammatory microenvironment in prostate tumours. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Campbell, H., Fleming, N., Roth, I., Vennin, C., McCall, J., Mehta, S., Wiles, A., Williams, G., … Baird, M., & Braithwaite, A. W. (2016, August-September). IL-6 signalling mediates tumorigenesis, invasion and metastasis driven by the Δ133p53 isoform. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Lasham, A., Mehta, S. Y., Fitzgerald, S. J., Woolley, A. G., Hearn, J. I., Hurley, D. G., Ruza, I., Algie, M., … Braithwaite, A. W., & Print, C. G. (2016). A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line. International Journal of Cancer, 139(5), 1157-1170. doi: 10.1002/ijc.30137 Journal - Research Article
Dasgupta, T., Antony, J., Braithwaite, A. W., & Horsfield, J. A. (2016). HDAC8 inhibition blocks SMC3 deacetylation and delays cell cycle progression without affecting cohesin-dependent transcription in MCF7 cancer cells. Journal of Biological Chemistry, 291(24), 12761-12770. doi: 10.1074/jbc.M115.704627 Journal - Research Article
Slatter, T. L., Wilson, M., Tang, C., Campbell, H. G., Ward, V. K., Young, V. L., … Fleming, N. I., Braithwaite, A. W., & Baird, M. A. (2016). Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12. OncoImmunology, 5(3), e1112941. doi: 10.1080/2162402X.2015.1112941 Journal - Research Article
Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., Woolley, A., … Fleming, N., Baird, M., & Braithwaite, A. W. (2016). The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene, 35, 4981-4989. doi: 10.1038/onc.2016.45 Journal - Research Article
Thomson, W. M., Zeng, J., Broadbent, J. M., Foster Page, L. A., Shalev, I., Moffitt, T. E., … Williams, S. M., Braithwaite, A. W., Robertson, S. P., & Poulton, R. (2016). Telomere length and periodontal attachment loss: A prospective cohort study. Journal of Clinical Periodontology, 43(2), 121-127. doi: 10.1111/jcpe.12499 Journal - Research Article
Kazantseva, M., Slatter, T., Hung, N., & Braithwaite, A. (2015, September). Altered regulation of Δ133p53 isoforms expression in prostate tumours. Verbal presentation at the 2nd International p53 Isoform Workshop, Aix-en-Provence, France. Conference Contribution - Verbal presentation and other Conference outputs
Sun, Y., Bell, J. L., Carter, D., Gherardi, S., Poulos, R. C., Milazzo, G., … Braithwaite, A., & Liu, T. (2015). WDR5 supports an N-Myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma. Cancer Research, 75(23), 5143-5154. doi: 10.1158/0008-5472.CAN-15-0423 Journal - Research Article
Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., … Fleming, N., Baird, M., & Braithwaite, A. (2015, October). Does a variant of the tumour suppressor P53 play a role in tumour metastasis? Poster session presented at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Braithwaite, A. (2015, October). The gene that stops cancer. Verbal presentation at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Fleming, N., Henderson, L. E., Print, C. G., Baird, M. A., & Braithwaite, A. W. (2015, August). Tumour suppression mechanisms and pro-migratory signals. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Braithwaite, A. (2015, August). The p53 tumour supressor and human cancer. Invited presentation at the Inaugural Dunedin School of Medicine Symposium, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Slatter, T. L., Hung, N., Bowie, S., Campbell, H., Rubio, C., Speidel, D., Wilson, M., Baird, M., Royds, J. A., & Braithwaite, A. W. (2015). Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell Death & Disease, 6, e1783. doi: 10.1038/cddis.2015.149 Journal - Research Article
Sawhney, S., Hood, K., Shaw, A., Braithwaite, A. W., Stubbs, R., Hung, N. A., Royds, J. A., & Slatter, T. L. (2015). Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a Δ133p53α mimic. PLoS ONE, 10(2), e0116270. doi: 10.1371/journal.pone.0116270 Journal - Research Article
Thomson, W. M., Broadbent, J. M., Poulton, R., Moffitt, T. E., Braithwaite, A. W., & Zeng, J. (2014). Telomere erosion and periodontal attachment loss by age 38. Journal of Dental Research, 93(Spec Iss B), 988. Retrieved from http://www.iadr.org Conference Contribution - Published proceedings: Abstract
Braithwaite, A. (2014, August). Role of YB1 in cancer. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Roth, I., Rubio, C., Campbell, H., Fleming, N., Baird, M., & Braithwaite, A. (2014, September). The Δ133p53 isoform promotes secreted cytokine-dependent cell migration. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Hung, N., Chen, Y.-J., Taha, A., Olivecrona, M., Boet, R., Wiles, A., … Shaw, A., Eiholzer, R., Baguley, B. C., Eccles, M. R., Braithwaite, A. W., MacFarlane, M., Royds, J. A., & Slatter, T. (2014). Increased paired box transcription factor 8 has a survival function in Glioma. BMC Cancer, 14, 159. doi: 10.1186/1471-2407-14-159 Journal - Research Article
Shalev, I., Moffitt, T. E., Braithwaite, A. W., Danese, A., Fleming, N. I., Goldman-Mellor, S., … Poulton, R., Robertson, S. P., … Caspi, A. (2014). Internalizing disorders and leukocyte telomere erosion: A prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. Molecular Psychiatry, 19, 1163-1170. doi: 10.1038/mp.2013.183 Journal - Research Article
Bildsoe, H., Loebel, D. A. F., Jones, V. J., Hor, A. C. C., Braithwaite, A. W., Chen, Y.-T., … Tam, P. P. L. (2013). The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Developmental Biology, 374, 295-307. doi: 10.1016/j.ydbio.2012.12.004 Journal - Research Article
Braithwaite, A. (2013, December). p53 in inflammatory diseases. Verbal presentation at the University of Otago Triple Theme Research Meeting: The Kidney in Health and Disease, Gut Health Network, Arthritis Research, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Harfoot, R., Fleming, S., Braithwaite, A., & Mercer, A. A. (2013). A retinoblastoma-associated protein (pRB) binding protein from orf virus. Proceedings of the Australasian Virology Society (AVS) Meeting. Retrieved from http://www.avs.org.au/scientific-program/ Conference Contribution - Published proceedings: Abstract
Neilsen, P. M., Braithwaite, A. W., Gamell, C., Haupt, S., Janic, A., Strasser, A., … Haupt, Y. (2013). Stimulating p53 down-under: A report from the 1st Australian p53 Workshop. Cell Death & Differentiation, 20(12), 1753-1756. doi: 10.1038/cdd.2013.2 Journal - Professional & Other Non-Research Articles
Lasham, A., Print, C. G., Woolley, A. G., Dunn, S. E., & Braithwaite, A. W. (2013). YB-1: Oncoprotein, prognostic marker and therapeutic target? Biochemical Journal, 449, 11-23. doi: 10.1042/bj20121323 Journal - Research Article
Campbell, H. G., Mehta, R., Neumann, A. A., Rubio, C., Baird, M., Slatter, T. L., & Braithwaite, A. W. (2013). Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD). Oncogene, 32(7), 827-836. doi: 10.1038/onc.2012.102 Journal - Research Article
Huschtscha, L. I., Napier, C. E., Noble, J. R., Bower, K., Au, A. Y. M., Campbell, H. G., Braithwaite, A. W., & Reddell, R. R. (2012). Enhanced isolation of fibroblasts from human skin explants. Biotechniques, 53(4), 239-244. doi: 10.2144/0000113939 Journal - Research Article
Al Jabry, T. S., Cohen, S. B., & Braithwaite, A. W. (2012, August). Characterising the functions of YB-1 phosphorylation. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Fitzgerald, S., Braithwaite, A., Shelling, A., Print, C., & Lasham, A. (2012, August). The role of YB-1 in resistance to chemotherapeutics in triple negative breast cancer. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Campbell, H. G., Rubio, C., Slatter, T. L., Jeffs, A. R., Baird, M., & Braithwaite, A. W. (2012, August). The p53 isoform, Δ133p53 binds to and inhibits the p53 family members, p63 and p73. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Algie, M., Jeffs, A., Woolley, A., Kleffmann, T., & Braithwaite, A. (2012, August). Identification of binding partners of the oncoprotein Y-box binding protein (YBX1) in breast cancer cell-line. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Braithwaite, A. W., Baird, M. A., Campbell, H. G., Hung, N. A., Jeffs, A. R., Print, C. G., & Slatter, T. L. (2012, August). Isoforms of the p53 tumour suppressor, inflammation, and cancer. Invited presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Campbell, H. G., Slatter, T. L., Jeffs, A., Mehta, R., Rubio, C., Baird, M., & Braithwaite, A. W. (2012). Does Δ133p53 isoform trigger inflammation and autoimmunity? Cell Cycle, 11(3), 446-450. doi: 10.4161/cc.11.3.19054 Journal - Research Article
Lasham, A., Samuel, W., Cao, H., Patel, R., Mehta, R., Stern, J. L., … Woolley, A. G., … Black, M. A., Shelling, A. N., Print, C. G., & Braithwaite, A. W. (2012). YB-1, the E2F Pathway, and regulation of tumor cell growth. Journal of the National Cancer Institute, 104(2), 133-146. doi: 10.1093/jnci/djr512 Journal - Research Article
Royds, J. A., Al Nadaf, S., Ahn, A., Chen, Y.-J., Wiles, A., Jellinek, D., Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). Older patients with glioma have a high frequency of a rare CDKN2A P14/16 allele. Neuro-Oncology, 13(Suppl. 2), 50, (pp. ii10). doi: 10.1093/neuonc/nor144 Conference Contribution - Published proceedings: Abstract
Royds, J. A., Al Nadaf, S., Wiles, A. K., Chen, Y.-J., Ahn, A., Shaw, A., Bowie, S., … Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival. PLoS ONE, 6(10), e26737. doi: 10.1371/journal.pone.0026737 Journal - Research Article
Joshi, S., Braithwaite, A. W., Robinson, P. J., & Chircop, M. (2011). Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression. Molecular Cancer, 10, 78. doi: 10.1186/1476-4598-10-78 Journal - Research Article
Woolley, A. G., Algie, M., Samuel, W., Harfoot, R., Wiles, A., Hung, N. A., … Royds, J. A., Perez, D., Yoon, H.-S., … Braithwaite, A. W. (2011). Prognostic association of YB-1 expression in breast cancers: A matter of antibody. PLoS ONE, 6(6), e20603. doi: 10.1371/journal.pone.0020603 Journal - Research Article
Li, C. G., Nyman, J. E., Braithwaite, A. W., & Eccles, M. R. (2011). PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene, 30, 4824-4834. doi: 10.1038/onc.2011.190 Journal - Research Article
Eccles, M. R., Li, C. G., Nyman, J. E., & Braithwaite, A. W. (2011). A role for PAX8 in promoting tumor cell type-specific proliferation through positively regulating E2F1 transcription and stabilizing RB protein. Proceedings of the American Association for Cancer Research (AACR) 102nd Annual Meeting. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx Conference Contribution - Published proceedings: Abstract
Slatter, T. L., Hung, N., Campbell, H., Rubio, C., Mehta, R., Renshaw, P., Williams, G., Wilson, M., … Jeffs, A., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2011). Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform. Blood, 117(19), 5166-5177. doi: 10.1182/blood-2010-11-321851 Journal - Research Article
Heinlein, C., Deppert, W., Braithwaite, A. W., & Speidel, D. (2010). A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry. Cell Cycle, 9(17), 3584-3590. doi: 10.4161/cc.9.17.12831 Journal - Research Article
Joshi, S., Perera, S., Gilbert, J., Smith, C. M., Mariana, A., Gordon, C. P., … Braithwaite, A. W., & Chircop, M. (2010). The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Molecular Cancer Therapeutics, 9(7), 1995-2006. doi: 10.1158/1535-7163.MCT-10-0161 Journal - Research Article
Joshi, S., Gaddipatti, S., Gilbert, J., . . ., Braithwaite, A. W., & Chircop, M. (2010). Dynamin inhibition: A new therapeutic approach for the treatment of cancer. Proceedings of the American Association for Cancer Research (AACR) 101st Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/ Conference Contribution - Published proceedings: Abstract
Cohen, S. B., Ma, W., Valova, V. A., Algie, M., Harfoot, R., Woolley, A. G., … Braithwaite, A. W. (2010). Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing. Oncogene, 29, 403-410. doi: 10.1038/onc.2009.321 Journal - Research Article
Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2010). p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death & Differentiation, 17, 540-550. doi: 10.1038/cdd.2009.136 Journal - Research Article
Tang, C., Slatter, T., Wilson, M., Braithwaite, A., & Baird, M. (2009). Dendritic cells from mice lacking p53, in contrast to those from mutant p53 and wild type mice, fail to induce Th1 immune responses and do not suppress tumour growth. Proceedings of the Australasian Society for Immunology 39th Annual Scientific Meeting. ASI. Retrieved from http://www.asi2009.org/ Conference Contribution - Published proceedings: Abstract
Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Tang, C. W., Baird, M. A., & Braithwaite, A. W. (2009, June). New roles for p53-mediated apoptosis in B cell development and in dendritic cell function. Verbal presentation at the New Zealand Australasian Society for Immunology (NZ ASI) Branch Meeting, Wellington, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Jiang, W.-Q., Zhong, Z.-H., Nguyen, A., Henson, J. D., Toouli, C. D., Braithwaite, A. W., & Reddel, R. (2009). Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. Journal of Cell Biology, 185(5), 797-810. doi: 10.1083/jcb.200810084 Journal - Research Article
Braithwaite, A. (2009, August). Cancer prediposition in mice expressing an isoform of the p53 tumour suppressor. Verbal presentation at the International MDM2 Workshop V, Ghent, Belgium. Conference Contribution - Verbal presentation and other Conference outputs
Hancox, R. J., Poulton, R., Welch, D., Olova, N., McLachlan, C. R., Greene, J. M., … Moffitt, T. E., Robertson, S. P., & Braithwaite, A. W. (2009). Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms. Human Genetics, 126(4), 559-565. doi: 10.1007/s00439-009-0704-z Journal - Research Article
Hibma, M. H., Real, N. C., Wiles, A., Dobson-Le, D., Dix, B. R., Wynford-Thomas, D., Braithwaite, A. W., & Royds, J. A. (2009). Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells. Virus Research, 145(1), 112-120. doi: 10.1016/j.virusres.2009.06.016 Journal - Research Article
Huschtscha, L., Moore, J. D., Noble, J. R., Campbell, H. G., Royds, J. A., Braithwaite, A. W., & Reddel, R. R. (2009). Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1. Journal of Cell Science, 122(16), 2989-2995. doi: 10.1242/jcs.044107 Journal - Research Article
Humar, B., McNoe, L., Dunbier, A., Heathcott, R., Braithwaite, A. W., & Reeve, A. E. (2008). Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition. Biologics, 2(2), 329-337. Journal - Research Article
Chen, Y.-J., Campbell, H. G., Wiles, A. K., Eccles, M. R., Reddel, R. R., Braithwaite, A. W., & Royds, J. A. (2008). PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Research, 68(14), 5724-5732. doi: 10.1158/0008-5472.CAN-08-0058 Journal - Research Article
Wiles, A., Hibma, M., Russell, A., Braithwaite, A., & Royds, J. A. (2007, December). Factors affecting efficiency of Onco-viral therapy involving the adenovirus ONYX-015. Verbal presentation at the 4th Australian Virology Group Meeting, Fraser Island, Australia. Conference Contribution - Verbal presentation and other Conference outputs
Chen, Y.-J., Wiles, A., Braithwaite, A., Eccles, M., Baguley, B., & Royds, J. A. (2007, August). PAX provides molecular clues to gliomagenesis. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Li, C., Jeffs, A., He, S., Marshall, E., Baguley, B., Braithwaite, A., & Eccles, M. (2007, August). Is there cooperation, interference, or no interaction at all between PAX genes in promoting tumorigenesis? Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Chen, Y.-J., Braithwaite, A. W., Eccles, M. R., & Royds, J. A. (2006). Fetal oncoproteins, PAX2 and PAX8, activate telomerase in glioma. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2062/content.pdf Conference Contribution - Published proceedings: Abstract
Chen, Y.-J., Eccles, M., Braithwaite, A., & Royds, J. (2006, May). p53 modulates the survival factor pax in gliomas. Poster session presented at the 13th International p53 Workshop, New York. Conference Contribution - Poster Presentation (not in published proceedings)
Yang, C.-Y. O., Sheffield, .., Braithwaite, A. W., & Royds, J. A. (2006, August - September). Molecular features of ALT glioblastoma associated with lower invasiveness and favourable prognosis. Poster session presented at the Queenstown Molecular Biology Conference, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)
Chen, Y.-J., Eccles, M., Braithwaite, A., & Royds, J. (2006). Silencing of PAX8 transcription factor reduced the viability of glioma cells. European Journal of Cancer Supplements, 4(12), (pp. 104-105). [Abstract] Conference Contribution - Published proceedings: Abstract
Chen, Y.-J., Braithwaite, A. W., Eccles, M. R., & Royds, J. A. (2006). Upregulation of PAX2, 5, and 8 in glioma and their novel function in telomerase activation. Proceedings of the Centro Nacional de Investigaciones Oncológicas Cancer Conference. (pp. 52). Madrid, Spain: CNIO. [Abstract] Conference Contribution - Published proceedings: Abstract
Huschtscha, L. I., Moore, J., Noble, J., Royds, J., Campbell, H., Braithwaite, A., & Reddel, R. (2006, February). Paradoxical interaction of tumour supressor genes p53 and p16 in human mammary epithelial cells. Poster session presented at the 18th Lorne Cancer Conference, Lorne, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Huschtscha, L., Moore, J., Noble, J., Campbell, H., Royds, J., Braithwaite, A., & Reddel, R. (2006, May). Paradoxical interaction of tumor supressor genes p53 and p16 in human mammary epithelial cells. Poster session presented at the 13th International p53 Workshop, New York. Conference Contribution - Poster Presentation (not in published proceedings)
Braithwaite, A. W., Del Sal, G., & Lu, X. (2006). Some p53-binding proteins that can function as arbiters of life and death. Cell Death & Differentiation, 13, 984-993. Journal - Research Article
Braithwaite, A. W., & Prives, C. L. (2006). p53: More research and more questions. Cell Death & Differentiation, 13, 877-880. Journal - Research Article
Chen, Y.-J., Hakin-Smith, V., Teo, M., Xinarianos, G. E., Jellinek, D. A., Carroll, T., … Braithwaite, A. W., … Royds, J. A. (2006). Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. Cancer Research, 66(13), 6473-6476. Journal - Research Article
Royds, J. A., Hibma, M., Dix, B. R., Hananeia, L., Russell, I. A., Wiles, A., … Braithwaite, A. W. (2006). p53 promotes adenoviral replication and increases late viral gene expression. Oncogene, 25, 1509-1520. Journal - Research Article
Homer, C., Knight, D. A., Hananeia, L., Sheard, P., Risk, J., Lasham, A., Royds, J. A., & Braithwaite, A. W. (2005). Y-box factor YB1 controls p53 apoptotic function. Oncogene, 24, 8314-8325. Retrieved from http://www.nature.com/onc/journal/v24/n56/abs/1208998a.html Journal - Research Article
He, S.-J., Stevens, G., Braithwaite, A. W., & Eccles, M. R. (2005). Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin-induced cytotoxicity. Molecular Cancer Therapeutics, 4(6), 996-1003. Journal - Research Article
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., … Braithwaite, A., Poulton, R., & Craig, I. W. (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction. Biological Psychiatry, 57(10), 1117-1127. Journal - Research Article
Braithwaite, A. W., Royds, J. A., & Jackson, P. (2005). The p53 story: Layers of complexity. Carcinogenesis, 26(7), 1161-1169. Journal - Research Other
Eccles, M. R., He, S. J., Braithwaite, A., Royds, J., & Baguley, B. (2004, June). A 'from the ground up' approach to the development of novel strategic genetic targets and methodologies for cancer gene therapy. Verbal presentation at the New Zealand Society for Oncology Conference, Christchurch, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Tong, S., Inglis, E., Nooijen, A., Wynford-Thomas, D., Braithwaite, A., & Hibma, M. (2004, February). Evasion of host immunity by human papillomavirus mediated Fas (CD95) down-regulation. Poster session presented at the 21st International Papillomavirus Conference and Clinical Workshop, Mexico City. Conference Contribution - Poster Presentation (not in published proceedings)
Russell, A., Royds, J. A., & Braithwaite, A. W. (2004). Exploitation of cell cycle and cell death controls by Adenoviruses: The road to a productive infection. In C. Alonso (Ed.), Progress in molecular and subcellular biology: Viruses and apoptosis. (pp. 207-243). Berlin: Springer. Chapter in Book - Research
Braithwaite, A. W., & Edwards, S. J. (2003). The p53 pathway, cancer and aging. In S. C. Kaul & R. Wadhwa (Eds.), Aging of cells in and outside the body. (pp. 121-149). UK: Kluwer Academic. Chapter in Book - Research
Lasham, A., Moloney, S., Hale, T., Homer, C., Zhang, Y. F., Murison, J. G., Braithwaite, A. W., & Watson, J. (2003). The Y-box-binding protein, YB1, is a potential negative regulator of the p53 tumor suppressor. Journal of Biological Chemistry, 278(37), 35516-35523. Journal - Research Article
Edwards, S. J., Hananeia, L., Eccles, M. R., Zhang, Y.-F., & Braithwaite, A. (2003). The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions. Oncogene, 22(29), 4517-4523. Journal - Research Article
Hall, R. J., Merriman, M. E., Green, R. A., Markham, V. H., Smyth, D. J., Heward, J. M., … Braithwaite, A., … Darlow, B. A., … Harrison, A. A., Highton, J., Hunt, P. J., Manning, P. J., … Scott, R. S., Taylor, B. J., Willis, J., … Merriman, T. R. (2003). The Deleted in Colorectal Carcinoma (DCC) gene 201 R → G polymorphism: No evidence for genetic association with autoimmune disease. European Journal of Human Genetics, 11, 840-844. Journal - Research Article
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., … Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-389. doi: 10.1126/science.1083968 Journal - Research Article
Tyers, N., Royds, J. A., & Braithwaite, A. (2003, February). Effect of thrombospondin on angiogenesis (relationship between P53 and TSP-1). Poster session presented at the 15th Lorne Cancer Conference, Lorne, Australia. Conference Contribution - Poster Presentation (not in published proceedings)
Zhang, Y.-F., Homer, C., Edwards, S. J., Hananeia, L., Lasham, A., Royds, J., Sheard, P., & Braithwaite, A. W. (2003). Nuclear localization of Y-box factor YB1 requires wild-type p53. Oncogene, 22, 2782-2794. doi: 10.1038/sj.onc.1206357 Journal - Research Article
Mill, J. S., Caspi, A., McClay, J., Sugden, K., Purcell, S., Asherson, P., … Braithwaite, A., Poulton, R., & Moffitt, T. E. (2002). The dopamine D4 receptor and the hyperactivity phenotype: A developmental-epidemiological study. Molecular Psychiatry, 7(4), 383-391. doi: 10.1038/sj.mp.4000984 Journal - Research Article
Edwards, S. J., Dix, B. R., Myers, C. J., Dobson-Le, D., Huschtscha, L., Hibma, M., Royds, J., & Braithwaite, A. W. (2002). Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14ARF tumor suppressor genes. Journal of Virology, 76(24), 12483-12490. doi: 10.1128/JVI.76.24.12483-12490.2002 Journal - Research Article
Hibma, M. H., Wiles, A., Jales, L., Wynford-Thomas, D., & Braithwaite, A. (2001). The influence of p53 and E1b55k on cell cycle following adenovirus type 5 infection. Verbal presentation at the DNA Tumour Virus Meeting, UK. Conference Contribution - Verbal presentation and other Conference outputs
Wiles, A., Hibma, M. H., Wynford-Thomas, D., Royds, J. A., & Braithwaite, A. (2001). p53 co-operates with adenovirus early protein E1b 55k to induce cell death. Lorne Conference. [Abstract] Conference Contribution - Published proceedings: Abstract
Dobson-Le, D. P., Edwards, S. J., Royds, J. A., & Braithwaite, A. (2001). SV40 Small T antigen and cell death. Lorne Conference. [Abstract] Conference Contribution - Published proceedings: Abstract
Russell, A., Royds, J. A., & Braithwaite, A. (2001). Rad51 may be required for adenoviral infection. Lorne Conference. [Abstract] Conference Contribution - Published proceedings: Abstract
Royds, J. A., Hibma, M. H., Wiles, A., Jales, L., Wynford-Thomas, D., & Braithwaite, A. (2001). Adenovirus early proten -E1b 55k, p53 and cell death. Lorne Conference. [Abstract] Conference Contribution - Published proceedings: Abstract
Dix, B. R., Edwards, S. J., & Braithwaite, A. W. (2001). Does the anti-tumour adenovirus, ONYX-015/dl1520 selectively target cells defective in the p53 pathway? Journal of Virology, 75(12), 5443-5447. doi: 10.1128/JVI.75.12.5443-5447.2001 Journal - Research Article
Thomson, W. M., Edwards, S. J., Dobson-Le, D. P., Tompkins, G. R., Poulton, R., Knight, D. A., … Braithwaite, A. W. (2001). IL-1 genotype and adult periodontitis among young New Zealanders. Journal of Dental Research, 80, 1700-1703. Journal - Research Article
Tyers, N., & Braithwaite, A. (2001). The effects of thrombospondin on angiogeneses (relationship between p53 and TSP-1). Abstracts of the Australasian Society of Clinical and Experimental Pharmacology and Toxicology. 9, (pp. 27). Dunedin. [Abstract] Conference Contribution - Published proceedings: Abstract
Mill, J., Caspi, A., McClay, J., Poulton, R., Braithwaite, A., Asherson, P., & Moffitt, T. E. (2001). The dopamine D4 receptor (DRD4) gene, behaviour, and psychopathology: A developmental-epidemiological study. In R. Todd, C. Paparozzi & L. E. DeLisi (Eds.), American Journal of Medical Genetics: Abstracts for the IXth World Congress of Psychiatric Genetics. 105(7), (pp. O47). [Abstract] Conference Contribution - Published proceedings: Abstract
Braithwaite, A. W., & Russell, I. A. (2001). Induction of cell death by adenoviruses. Apoptosis, 6, 359-370. Journal - Research Article
Hibma, M., & Braithwaite, A. (2001). Viruses to the rescue: p53-based therapies in the fight against cancer. New Zealand Medical Journal, 114(1133), 266-269. Journal - Research Article
Hale, T. K., Myers, C., Maitra, R., Kolzau, T., Nishizawa, M., & Braithwaite, A. W. (2000). Maf transcriptionally activates the mouse p53 promoter and causes a p53-dependent cell death. Journal of Biological Chemistry, 275(24), 17991-17999. Journal - Research Article
O'Carroll, S. J., Hall, A. R., Myers, C. J., Braithwaite, A. W., & Dix, B. R. (2000). Quantifying adenoviral titers by spectrophotometry. Biotechniques, 28, 408-410. Journal - Research Article
Dix, B. R., O'Carroll, S. J., Myers, C. J., Edwards, S. J., & Braithwaite, A. W. (2000). Efficient induction of cell death by adenoviruses requires binding of E1B55k and p53. Cancer Research, 60, 2666-2672. Journal - Research Article
Kolzau, T., Hansen, R. S., Zahra, D., Reddel, R. R., & Braithwaite, A. W. (1999). Inhibition of SV40 large T antigen induced apoptosis by small T antigen. Oncogene, 18(40), 5598-5603. Journal - Research Article
Hale, T. K., & Braithwaite, A. W. (1999). The adenovirus oncoprotein E1a stimulates binding of the transcription factor ETF to transcriptionally activate the p53 gene. Journal of Biological Chemistry, 274, 23777-23786. doi: 10.1074/jbc.274.34.23777 Journal - Research Article
Hall, A. R., O'Carroll, S. J., Dix, B. R., & Braithwaite, A. W. (1998). p53 dependent cell death/apoptosis is required for a productive adenovirus infection. Nature Medicine, 4, 1068-1072. Journal - Research Article
Ridgway, P. J., Hall, A. R., Myers, C. J., & Braithwaite, A. W. (1997). p53/E1b58kDa complex regulates adenovirus replication. Virology, 237, 404-413. Journal - Research Article
Braithwaite, A., & Poulton, R. (1997). Relevance in health research funding: reality or myth? New Zealand Medical Journal, 110, 361-362. Journal - Research Article
Hall, A. R., & Braithwaite, A. W. (1997). From clinical significance to significance in the clinic? New Zealand Medical Journal, 110, 347-348. Journal - Research Article
Hansen, R. S., & Braithwaite, A. (1996). The growth inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by E1a and ras. Oncogene, 13(5), 995-1007. Journal - Research Article
Sedger, L., Ramshaw, I., Condie, A., Medvecsky, J., Braithwaite, A., & Ruby, J. (1996). Vaccinia virus replication is independent of cellular HSP72 expression which is induced during virus infection. Virology, 225(2), 423-427. Journal - Research Article
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