Dr Caroline Beck

Dr Caroline BeckBSc (Hons), PhD

Dr Caroline Beck is a developmental biologist in the Department of Zoology at the University of Otago.

She is interested in understanding the complex gene regulation required to “build” an animal from a single cell. Caroline’s research lab has a particular interest in the development of organs, such as the vertebrate limb and eye, and the ability of some vertebrates to regenerate these organs. The work relies heavily on model animals to reveal how complex structures are built and – in the case of regeneration after injury – rebuilt. While most of the work uses amphibian models, such as Xenopus laevis (clawed frogs), the zebrafish fin is also used for complementary studies on regeneration.

Caroline gained a BSc (Hons) in Medical Biochemistry at the University of Birmingham and a PhD in Biological Sciences at the University of Warwick, before undertaking a postdoctoral fellowship at the University of Bath. She has been at Otago since 2004.

Further information

Further information about Caroline is available on the Department of Zoology website.

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Publications

Beck, C. (2018). Recovering what was lost: Can morphogens scale to enable regeneration? In D. M. Gardiner (Ed.), Regenerative engineering and developmental biology: Principles and applications. (pp. 207-227). Boca Raton, FL: CRC Press.

Taylor, A., Beck, C., & Bicknell, L. (2017). Modelling rare disease in Xenopus laevis using CRISPR/Cas9. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 689. Retrieved from http://gen2017.w.events4you.currinda.com

Jones, M., Beck, C., & Hore, T. (2017). The role of DNA hypomethylation in Zebrafish cell reprogramming during tail fin regeneration. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 40-41). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Keenan, S. R., & Beck, C. W. (2016). Xenopus limb bud morphogenesis. Developmental Dynamics, 245(3), 233-243. doi: 10.1002/dvdy.24351

Beck, C. W. (2016). Manipulating carbohydrate metabolism to enhance regeneration. BioEssays, 38(12), 1192. doi: 10.1002/bies.201600196

Chapter in Book - Research

Beck, C. (2018). Recovering what was lost: Can morphogens scale to enable regeneration? In D. M. Gardiner (Ed.), Regenerative engineering and developmental biology: Principles and applications. (pp. 207-227). Boca Raton, FL: CRC Press.

Beck, C. W. (2012). Studying regeneration in Xenopus. In S. Hoppler & P. D. Vize (Eds.), Xenopus protocols: Post-genomic approaches: Methods in molecular biology (Vol. 917). (pp. 525-539). New York: Springer. doi: 10.1007/978-1-61779-992-1_30

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Journal - Research Article

Keenan, S. R., & Beck, C. W. (2016). Xenopus limb bud morphogenesis. Developmental Dynamics, 245(3), 233-243. doi: 10.1002/dvdy.24351

Wang, Y.-H., Keenan, S. R., Lynn, J., McEwan, J. C., & Beck, C. W. (2015). Gremlin1 induces anterior–posterior limb bifurcations in developing Xenopus limbs but does not enhance limb regeneration. Mechanisms of Development, 138, 256-267. doi: 10.1016/j.mod.2015.10.003

Beck, C. W. (2015). Development of the vertebrate tailbud. Wiley Interdisciplinary Reviews: Developmental Biology, 4(1), 33-44. doi: 10.1002/wdev.163

Wang, Y.-H., & Beck, C. (2015). Distinct patterns of endosulfatase genes expression during Xenopus laevis limb development and regeneration. Regeneration, 2(1), 19-25. doi: 10.1002/reg2.27

Wang, Y.-H., & Beck, C. W. (2014). Distal expression of sprouty (spry) genes during Xenopus laevis limb development and regeneration. Gene Expression Patterns, 15(1), 61-66. doi: 10.1016/j.gep.2014.04.004

Pietak, A., Ma, S., Beck, C. W., & Stringer, M. D. (2013). Fundamental ratios and logarithmic periodicity in human limb bones. Journal of Anatomy, 222(5), 526-537. doi: 10.1111/joa.12041

Jones, T. E. M., Day, R. C., & Beck, C. W. (2013). Attenuation of bone morphogenetic protein signaling during amphibian limb development results in the generation of stage-specific defects. Journal of Anatomy, 223(5), 474-488. doi: 10.1111/joa.12098

Taylor, A. J., & Beck, C. W. (2012). Histone deacetylases are required for amphibian tail and limb regeneration but not development. Mechanisms of Development, 129(9-12), 208-218. doi: 10.1016/j.mod.2012.08.001

Day, R. C., & Beck, C. W. (2011). Transdifferentiation from cornea to lens in Xenopus laevis depends on BMP signalling and involves upregulation of Wnt signalling. BMC Developmental Biology, 11, 54. doi: 10.1186/1471-213x-11-54

Lynch, J., McEwan, J., & Beck, C. W. (2011). Analysis of the expression of retinoic acid metabolising genes during Xenopus laevis organogenesis. Gene Expression Patterns, 11(1-2), 112-117. doi: 10.1016/j.gep.2010.10.003

McEwan, J., Lynch, J., & Beck, C. W. (2011). Expression of key retinoic acid modulating genes suggests active regulation during development and regeneration of the amphibian limb. Developmental Dynamics, 240(5), 1259-1270. doi: 10.1002/dvdy.22555

Malloch, E. L., Perry, K. J., Fukui, L., Johnson, V. R., Wever, J., Beck, C. W., … Henry, J. J. (2009). Gene expression profiles of lens regeneration and development in Xenopus laevis. Developmental Dynamics, 238(9), 2340-2356. doi: 10.1002/dvdy.21998

Beck, C. W., Izpisúa Belmonte, J. C., & Christen, B. (2009). Beyond early development: Xenopus as an emerging model for the study of regenerative mechanisms. Developmental Dynamics, 238(6), 1226-1248. doi: 10.1002/dvdy.21890

Barker, D. M., & Beck, C. W. (2009). Overexpression of the transcription factor msx1 is insufficient to drive complete regeneration of refractory stage Xenopus laevis hindlimbs. Developmental Dynamics, 238(6), 1366-1378. doi: 10.1002/dvdy.21923

Pearl, E. J., Barker, D., Day, R. C., & Beck, C. W. (2008). Identification of genes associated with regenerative success of Xenopus laevis hindlimbs. BMC Developmental Biology, 8, 66. doi: 10.1186/1471-213X-8-66

Jarikji, Z. H., Vanamala, S., Beck, C. W., Wright, C. V. E., Leach, S. T., & Horb, M. E. (2007). Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Developmental Biology, 304, 786-799.

Beck, C. W., Christen, B., Barker, D., & Slack, J. M. W. (2006). Temporal requirement for bone morphogenetic proteins in regeneration of the tail and limb of Xenopus tadpoles. Mechanisms of Development, 123, 674-688.

Beck, C., Christen, B., & Slack, J. M. W. (2003). Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate. Developmental Cell, 5, 429-439.

Avaron, F., Thaeron-Antono, C., Beck, C., Borday-Birraux, V., Geraudie, J., Casane, D., & Laurenti, P. (2003). Comparison of even-skipped related gene expression pattern in vertebrates shows an association between expression domain loss and modification of selective constraints on sequences. Evolution & Development, 5(2), 145-156.

Christen, B., Beck, C., Lombardo, A., & Slack, J. M. W. (2003). Regeneration-specific expression pattern of three posterior hox genes. Developmental Dynamics, 226, 349-355.

Beck, C. W., & Slack, J. M. W. (2002). Notch is required for outgrowth of the Xenopus tail bud. International Journal of Developmental Biology, 46, 255-258.

Beck, C. W., & Slack, J. M. W. (2001). An amphibian with ambition: A new role for Xenopus in the 21st century [Minireview]. Genome Biology, 2(10), 1029.1-1029.5. Retrieved from http://genomebiology.com/2001/2/10/reviews/1029

Beck, C. W., Whitman, M., & Slack, J. M. W. (2001). The role of BMP signaling in outgrowth and patterning of the Xenopus tail bud. Developmental Biology, 238, 303-314.

Chalmers, A. D., Slack, J. M. W., & Beck, C. W. (2000). Regional gene expression in the epithelia of the Xenopus tadpole gut. Mechanisms of Development, 96, 125-128.

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Journal - Research Other

Beck, C. W. (2016). Manipulating carbohydrate metabolism to enhance regeneration. BioEssays, 38(12), 1192. doi: 10.1002/bies.201600196

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Conference Contribution - Published proceedings: Full paper

Slack, J. M. W., Beck, C. W., Gargioli, C., & Christen, B. (2004). Cellular and molecular mechanisms of regeneration in Xenopus. In B. Heap (Ed.), Philosophical Transactions: Biological Sciences. 359(1445), (pp. 745-751). London: The Royal Society. [Full Paper]

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Conference Contribution - Published proceedings: Abstract

Taylor, A., Beck, C., & Bicknell, L. (2017). Modelling rare disease in Xenopus laevis using CRISPR/Cas9. Proceedings of the Annual Conference of the Genetics Society of Australasia (GSA) with the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB). 689. Retrieved from http://gen2017.w.events4you.currinda.com

Jones, M., Beck, C., & Hore, T. (2017). The role of DNA hypomethylation in Zebrafish cell reprogramming during tail fin regeneration. Proceedings of the University of Otago Student Research Symposium: Te Wānaka Rakahau: Ākoka. (pp. 40-41). Retrieved from http://www.otago.ac.nz/graduate-research/scholarships/otago643219.html

Dearden, P. K., Duncan, E., Tidswell, O., & Beck, C. (2016). Linking Noggin and terminal patterning. Proceedings of the European Society for Evolutionary Developmental Biology (EED) 6th Meeting. (pp. 100). Retrieved from http://evodevo.eu/

Beck, C. W., & Miles, L. (2005). Pleiotropic actions of BMP signalling in Xenopus laevis development. Mechanisms of Development. 122, (pp. S165-S166). [Abstract]

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Conference Contribution - Verbal presentation and other Conference outputs

Beck, C. W., & Bishop, T. (2016, August-September). Understanding how regeneration is regulated in a vertebrate model: The clawed frog Xenopus. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

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