Professor Ian Morison

Professor Ian MorisonMB ChB, BMedSc, PhD, FRCPA(Haem)

Professor Ian Morison is a research haematologist and Head of the Department of Pathology at the University of Otago.

Ian’s research interests are focused around genetic and epigenetic aspects of haematology and blood cancers, as well as the role of epigenetics in development. His work includes: studying childhood acute lymphoblastic leukaemia and its molecular origins; studying the epigenetics of myelodysplastic syndrome; identifying epigenetic differences between individuals; and the biochemical mechanisms behind familial thrombocytopenia.

After graduating from Otago with a medical degree, Ian took up a residency in clinical pathology at the University of Washington. It was during this time that he recognised the potential for research in all areas of pathology and laboratory medicine. In the years since, he has built a career as both a diagnostic haematologist and a researcher, maximising the synergies between the two.

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Publications

Chai, K. Y., Boyke Berahmana, A. A., & Morison, I. M. (2019). Haematologists usually over-estimate the percentage of CD138+ plasma cells in marrow biopsies. Pathology, 51(6), 647-648. doi: 10.1016/j.pathol.2019.05.010

Sneyd, M. J., Cox, B., & Morison, I. M. (2019). Trends in myeloma incidence, mortality and survival in New Zealand (1985–2016). Cancer Epidemiology, 60, 55-59. doi: 10.1016/j.canep.2019.03.006

Halliday, B. J., Fukuzawa, R., Markie, D. M., Grundy, R. G., Ludgate, J. L., Black, M. A., … Weeks, R. J., … Morison, I. M. (2018). Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genetics, 14(6), e1007399. doi: 10.1371/journal.pgen.1007399

Ledgerwood, E. C., Dunstan-Harrison, C., Ong, L., & Morison, I. M. (2019). CYCS gene variants associated with thrombocytopenia. Platelets, 30(5), 672-674. doi: 10.1080/09537104.2018.1543866

Ong, L., Morison, I. M., & Ledgerwood, E. C. (2017). Megakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes. British Journal of Haematology, 176(2), 268-279. doi: 10.1111/bjh.14421

Other Research Output

Morison, I. (2015) Catalogue of parent of origin effects: Imprinted genes and related effects, University of Otago, Dunedin, New Zealand. Retrieved from http://igc.otago.ac.nz/home.html

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Journal - Research Article

Sneyd, M. J., Cox, B., & Morison, I. M. (2019). Trends in myeloma incidence, mortality and survival in New Zealand (1985–2016). Cancer Epidemiology, 60, 55-59. doi: 10.1016/j.canep.2019.03.006

Halliday, B. J., Fukuzawa, R., Markie, D. M., Grundy, R. G., Ludgate, J. L., Black, M. A., … Weeks, R. J., … Morison, I. M. (2018). Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genetics, 14(6), e1007399. doi: 10.1371/journal.pgen.1007399

Fukuzawa, R., Anaka, M. R., Morison, I. M., & Reeve, A. E. (2017). The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour. PLoS ONE, 12(10), e0186333. doi: 10.1371/journal.pone.0186333

Macaulay, E. C., Chatterjee, A., Cheng, X., Baguley, B. C., Eccles, M. R., & Morison, I. M. (2017). The genes of life and death: A potential role for placental-specific genes in cancer: Active retrotransposons in the placenta encode unique functional genes that may also be used by cancer cells to promote malignancy. BioEssays, 39(11), 1700091. doi: 10.1002/bies.201700091

Ong, L., Morison, I. M., & Ledgerwood, E. C. (2017). Megakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes. British Journal of Haematology, 176(2), 268-279. doi: 10.1111/bjh.14421

Weeks, R. J., Ludgate, J. L., LeMée, G., & Morison, I. M. (2016). TESTIN induces rapid death and suppresses proliferation in childhood B acute lymphoblastic leukaemia cells. PLoS ONE, 11(3), e0151341. doi: 10.1371/journal.pone.0151341

Chatterjee, A., Macaulay, E. C., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., Devenish, C. J., & Morison, I. M. (2016). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Genes Genomes Genetics, 6(7), 1911-1921. doi: 10.1534/g3.116.030379

Chatterjee, A., Stockwell, P. A., Rodger, E. J., Duncan, E. J., Parry, M. F., Weeks, R. J., & Morison, I. M. (2015). Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation. Scientific Reports, 5, 17328. doi: 10.1038/srep17328

Hodgson, T. O., Ruskova, A., Shugg, C. J., McCallum, V. J., & Morison, I. M. (2015). Green neutrophil and monocyte inclusions: Time to acknowledge and report. British Journal of Haematology, 170, 229-235. doi: 10.1111/bjh.13434

Josephs, T. M., Morison, I. M., Day, C. L., Wilbanks, S. M., & Ledgerwood, E. C. (2014). Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: Implications for the peroxidase mechanism and cytochrome c release. Biochemical Journal, 458(2), 259-265. doi: 10.1042/BJ20131386

Stockwell, P. A., Chatterjee, A., Rodger, E. J., & Morison, I. M. (2014). DMAP: Differential methylation analysis package for RRBS and WGBS data. Bioinformatics, 30(13), 1814-1822. doi: 10.1093/bioinformatics/btu126

Rodger, E. J., Chatterjee, A., & Morison, I. M. (2014). 5-hydroxymethylcytosine: A potential therapeutic target in cancer. Epigenomics, 6(5), 503-514. doi: 10.2217/epi.14.39

Macaulay, E. C., Roberts, H. E., Cheng, X., Jeffs, A. R., Baguley, B. C., & Morison, I. M. (2014). Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene. PLoS ONE, 9(4), e95840. doi: 10.1371/journal.pone.0095840

Chatterjee, A., Ozaki, Y., Stockwell, P. A., Horsfield, J. A., Morison, I. M., & Nakagawa, S. (2013). Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing. Epigenetics, 8(9), 979-989. doi: 10.4161/epi.25797

Chatterjee, A., Stockwell, P. A., Rodger, E. J., & Morison, I. M. (2012). Comparison of alignment software for genome-wide bisulphite sequence data. Nucleic Acids Research, 40(10), e79. doi: 10.1093/nar/gks150

Rodger, E. J., & Morison, I. M. (2012). Myelodysplastic syndrome in New Zealand and Australia. Internal Medicine Journal, 42(11), 1235-1242. doi: 10.1111/j.1445-5994.2011.02619.x

Chatterjee, A., Rodger, E. J., Stockwell, P. A., Weeks, R. J., & Morison, I. M. (2012). Technical considerations for reduced representation bisulfite sequencing with multiplexed libraries. Journal of Biomedicine & Biotechnology, 2012, 741542. doi: 10.1155/2012/741542

Macaulay, E. C., Weeks, R. J., Andrews, S., & Morison, I. M. (2011). Hypomethylation of functional retrotransposon-derived genes in the human placenta. Mammalian Genome, 22, 722-735. doi: 10.1007/s00335-011-9355-1

Weeks, R. J., Kees, U. R., Song, S., & Morison, I. M. (2010). Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Molecular Cancer, 9, 163. doi: 10.1186/1476-4598-9-163

Morison, I. M., Cramer Bordé, E. M., Cheesman, E. J., Cheong, P. L., Holyoake, A. J., Fichelson, S., Weeks, R. J., Lo, A., Davies, S. M. K., Wilbanks, S. M., Fagerlund, R. D., Ludgate, M. W., da Silva Tatley, F. M., Coker, M. S. A., Bockett, N. A., Hughes, G., Pippig, D. A., Smith, M. P., … Ledgerwood, E. C. (2008). A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nature Genetics, 40(4), 387-389. doi: 10.1038/ng.103

Morison, I. M., Ramsay, J. P., & Spencer, H. G. (2005). A census of mammalian imprinting. Trends in Genetics, 21(8), 457-465.

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Journal - Research Other

Chai, K. Y., Boyke Berahmana, A. A., & Morison, I. M. (2019). Haematologists usually over-estimate the percentage of CD138+ plasma cells in marrow biopsies. Pathology, 51(6), 647-648. doi: 10.1016/j.pathol.2019.05.010

Ledgerwood, E. C., Dunstan-Harrison, C., Ong, L., & Morison, I. M. (2019). CYCS gene variants associated with thrombocytopenia. Platelets, 30(5), 672-674. doi: 10.1080/09537104.2018.1543866

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