Contact Details
- Phone
- +64 3 479 4960
- louise.parr-brownlie@otago.ac.nz
University Links
- Position
- Professor
- Department
- Department of Anatomy
- Qualifications
- BPhEd MSc PhD(Otago)
- Research summary
- Brain changes associated with Parkinson's disease and chronic pain
- Teaching
Current:
- ANAT335 Neurobiology
- NEUR452 Neurodegenerative disorders
Previous:
- HUBS191 (musculoskeletal)
- ANAT241 (musculoskeletal)
- ELM2 (musculoskeletal)
- Memberships
- Director Māori, Ageing Well National Science Challenge
- Māori Advisory Board for Brain Research New Zealand – Roro Rangahau Aotearoa Centre of Research Excellence
- Secretary of the International Basal Ganglia Society Council
Research
Professor Parr-Brownlie has internationally recognised expertise in understanding how activity in the motor thalamus, motor cortex and basal ganglia control normal movements and is altered in Parkinson's disease. Her team use a combination of optogenetic stimulation, electrophysiological recordings, electron and confocal microscopy to investigate brain function and structure. They have applied optogenetic stimulation to determine if there are better places and ways to stimulate the brain to improve movements in models of Parkinson's disease.
She has been an invited speaker at prestigious conferences in the United States, such as Howard Hughes Medical Institute (Janelia) and Gordon Research Conferences. Professor Parr-Brownlie has extended her research programme to (1) examine anatomical and physiological changes in the brain associated with chronic pain and (2) investigate Māori community perspectives of neurosurgical approaches to treat neurological disorders and traumatic brain injury.
Current staff in the laboratory are Dr Elodie Kip (ARF), Conor Underwood (PRF) and Mariana Te Pou (ARF). Current postgraduate students are Alexander Woolrych (PhD) and Lily Bentall (Hons).
Additional details
Dr Parr-Brownlie is Ngāti Maniapoto and Te Arawa.
Current funding includes Health Research Council of New Zealand, Brain Research New Zealand, and Marsden Fund. Other previous funding includes Neurological Foundation of New Zealand.
Lab staff alumni are:
- Dr Clementine Bosch-Bouju, postdoctoral fellow
- Dr Lisa Smith, postdoctoral fellow
- Dr Rachel Sizemore, postdoctoral fellow
- Dr Sonja Seeger-Armbruster, postdoctoral fellow
- Julia Prier, ARF
- Roseanna Smither, ARF
- Stella Cameron, ARF
- Niamh Cameron, ARF
Lab postgraduate alumni are:
- Dr Sophie Barnett (PhD)
- Dr Ashik Banstola (PhD)
- Dr Stella Cameron (PhD)
- Nikki Guy (MMedSc)
- James Miller (MSc and Hons)
- Shane Little (MSc and PGDipSc)
- Abby Johnson (Hons)
- Niamh Cameron (PGDipSc)
Publications
Parr-Brownlie, L. (2023, November-December). Weaving equity and innovation into Parkinson's research. Plenary presentation at the 10th Asia Pacific International Congress of Anatomists (APICA) and the 20th Australian & New Zealand Association of Clinical Anatomists (ANZACA) Conference: Reconnect, Ka Mua, Ka Muri, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs
Kukutai, T., Parr-Brownlie, L., & Pitama, S. (2023). A bridge between: Te Ao Māori and Te Ara Paerangi. New Zealand Science Review, 78(1-2). doi: 10.26686/nzsr.vi.8256 Journal - Research Article
Parr-Brownlie, L. (2023, March). Weaving equity and innovation into Parkinson’s research. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture]. Other Research Output
Seo, S., Parr-Brownlie, L., Bilkey, D., Hughes, S., & Oorschot, D. (2023, June). Opposite changes in midbrain dopamine microcircuitry in the repeated hypoxic rat model of ADHD-like hyperactivity/impulsivity versus the maternal immune activation rat model of schizophrenia: Potential bases for new therapies. Poster session presented at the International Basal Ganglia Society (IBAGS) XIV Meeting, Stockholm, Sweden. Conference Contribution - Poster Presentation (not in published proceedings)
Bentall, L., & Parr-Brownlie, L. (2023, June). Changes in SNpr activity underlying dyskinesia in PD model rats. Poster session presented at the International Basal Ganglia Society (IBAGS) XIV Meeting, Stockholm, Sweden. Conference Contribution - Poster Presentation (not in published proceedings)
2023
Journal - Research Article
Kukutai, T., Parr-Brownlie, L., & Pitama, S. (2023). A bridge between: Te Ao Māori and Te Ara Paerangi. New Zealand Science Review, 78(1-2). doi: 10.26686/nzsr.vi.8256
Kip, E., & Parr-Brownlie, L. (2023). Healthy lifestyles and wellbeing reduce neuroinflammation and prevent neurodegenerative and psychiatric disorders [Review]. Frontiers in Neuroscience, 17, 1092537. doi: 10.3389/fnins.2023.1092537
Conference Contribution - Poster Presentation (not in published proceedings)
Seo, S., Parr-Brownlie, L., Bilkey, D., Hughes, S., & Oorschot, D. (2023, June). Opposite changes in midbrain dopamine microcircuitry in the repeated hypoxic rat model of ADHD-like hyperactivity/impulsivity versus the maternal immune activation rat model of schizophrenia: Potential bases for new therapies. Poster session presented at the International Basal Ganglia Society (IBAGS) XIV Meeting, Stockholm, Sweden.
Bentall, L., & Parr-Brownlie, L. (2023, June). Changes in SNpr activity underlying dyskinesia in PD model rats. Poster session presented at the International Basal Ganglia Society (IBAGS) XIV Meeting, Stockholm, Sweden.
Conference Contribution - Verbal presentation and other Conference outputs
Parr-Brownlie, L. (2023, November-December). Weaving equity and innovation into Parkinson's research. Plenary presentation at the 10th Asia Pacific International Congress of Anatomists (APICA) and the 20th Australian & New Zealand Association of Clinical Anatomists (ANZACA) Conference: Reconnect, Ka Mua, Ka Muri, Dunedin, New Zealand.
Other Research Output
Parr-Brownlie, L. (2023, March). Weaving equity and innovation into Parkinson’s research. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2022
Journal - Research Article
Kip, E., Bentall, L., Underwood, C. F., Hughes, S. M., & Parr-Brownlie, L. C. (2022). Patterned stimulation of the Chrimson opsin in glutamatergic motor thalamus neurons improves forelimb akinesia in parkinsonian rats. Neuroscience, 507, 64-78. doi: 10.1016/j.neuroscience.2022.10.026
Banstola, A., Young, C. K., Parr-Brownlie, L., & McNaughton, N. (2022). Dynamic interaction between hippocampus, orbitofrontal cortex, and subthalamic nucleus during goal conflict in the stop signal task in rats. Neuroscience Research, 182, 65-75. doi: 10.1016/j.neures.2022.06.006
Parr-Brownlie, L. C., Itoga, C. A., Walters, J. R., & Underwood, C. F. (2022). Oscillatory waveform sharpness asymmetry changes in motor thalamus and motor cortex in a rat model of Parkinson's disease. Experimental Neurology, 354, 114089. doi: 10.1016/j.expneurol.2022.114089
Kip, E. C., & Parr-Brownlie, L. C. (2022). Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson's disease. Ageing Research Reviews, 78, 101618. doi: 10.1016/j.arr.2022.101618
Journal - Research Other
Goins, R. T., Parr-Brownlie, L. C., & Radford, K. (2022). Indigenous aging. Frontiers in Public Health, 10, 1111672. doi: 10.3389/fpubh.2022.1111672
Conference Contribution - Published proceedings: Abstract
Kip, E., Bentall, L., Underwood, C. F., Hughes, S. M., & Parr-Brownlie, L. C. (2022). Patterned simulation of the chrimson opsin in glutamatergic motor thalamus neurons improves forelimb akinesia in a chronic rat model of Parkinson's disease. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 85). Retrieved from https://www.queenstownresearchweek.org
Other Research Output
Parr-Brownlie, L., Gillion, G., Sporle, A., Ogilvie, S., Sciascia, A., Te Kani, J., ... Awatere, S. (2022). Rauika Māngai submission on Te Ara Paerangi Future Pathways. Retrieved from http://www.rauikamangai.co.nz/resources-hub
Kukutai, T., Hutchings, J., Allen, J., Allport, T., Black, A., Boulton, A., ... Foster, M., ... Hapeta, J., ... Jackson, A. M., ... Paine, S-J., ..., Parr-Brownlie, L., ... Pitama, S., Poa, D., ... Ruru, J., ... Tipene-Leach, D., Walker, G., ... Wilson-Rooy, M. (2022). A Tiriti-based research, science and innovation system: Te Ara Paerangi: Future Pathways Green Paper submission from Te Pūtahitanga collective of Māori scientists and researchers. Retrieved from http://www.rauikamangai.co.nz/resources-hub
Potter, H. & Rauika Māngai, including Parr-Brownlie, L.C., Awatere, S., & Sporle, A. (2022). A Wai 262 best practice guide for science partnerships with kaitiaki for research involving taonga: Lessons from Māori voices in the New Zealand science sector. Dunedin, New Zealand: Rauika Māngai. Retrieved from http://www.rauikamangai.co.nz/resources-hub
2021
Journal - Research Article
Barnett, S. C., Parr-Brownlie, L. C., Perry, B. A. L., Young, C. K., Wicky, H. E., Hughes, S. M., McNaughton, N., & Dalrymple-Alford, J. C. (2021). Anterior thalamic nuclei neurons sustain memory. Current Research in Neurobiology, 2, 100022. doi: 10.1016/j.crneur.2021.100022
Woolrych, A., Vautrelle, N., Reynolds, J. N. J., & Parr-Brownlie, L. C. (2021). Throwing open the doors of perception: The role of dopamine in visual processing. European Journal of Neuroscience, 54, 6135-6146. doi: 10.1111/ejn.15408
Seo, S., Sizemore, R. J., Reader, K. L., Smither, R. A., Wicky, H. E., Hughes, S. M., Bilkey, D. K., Parr-Brownlie, L. C., & Oorschot, D. E. (2021). A schizophrenia risk factor induces marked anatomical deficits at GABAergic-dopaminergic synapses in the rat ventral tegmental area: Essential evidence for new targeted therapies. Journal of Comparative Neurology, 529, 3946-3973. doi: 10.1002/cne.25225
Journal - Research Other
Marie, A., Darricau, M., Touyarot, K., Parr-Brownlie, L. C., & Bosch-Bouju, C. (2021). Role and mechanism of vitamin A metabolism in the pathophysiology of Parkinson's disease. Journal of Parkinson's Disease, 11, 949-970. doi: 10.3233/jpd-212671
Underwood, C. F., & Parr-Brownlie, L. C. (2021). Primary motor cortex in Parkinson’s disease: Functional changes and opportunities for neurostimulation. Neurobiology of Disease, 147, 105159. doi: 10.1016/j.nbd.2020.105159
Conference Contribution - Published proceedings: Abstract
Kip, E., Bentall, L., Underwood, C. F., Hughes, S. M., & Parr-Brownlie, L. C. (2021). Specific patterns of optogenetic stimulation of glutamatergic motor thalamus neurons improve akinesia in a chronic rat model of Parkinson's disease. New Zealand Medical Journal, 134(1539), (pp. 88). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Verbal presentation and other Conference outputs
Mann, J., & Parr-Brownlie, L. (2021, September). Realising the dream for equity: The contribution of National Science Challenges. Verbal presentation at the Achieving Health Equity from Research Conference [Otago Spotlight Series], Wellington, New Zealand.
Parr-Brownlie, L. (2021, September). Reframing biomedical research for equitable brain health outcomes. Verbal presentation at the Achieving Health Equity from Research Conference [Otago Spotlight Series], Wellingotn, New Zealand.
Other Research Output
Parr-Brownlie, L. (2021, February). Stimulating the brain to recover movements. Australasian Neuroscience Society (ANS) Australasian Course in Advanced Neuroscience (ACAN) Alumni Symposia, [Online]. [Research Presentation].
Basak, I. & Parr-Brownlie, L. (2021, March). How to detect Parkinson's disease. University of the 3rd Age (U3A), Alexandra, New Zealand. [Public Seminar].
2020
Journal - Research Article
Jackson, A.-M., Rewi, T., Hakopa, H., Phillips, C., Russell, P., Parr-Brownlie, L. C., Hulbe, C., Leoni, G., Mita, N., Hepburn, C., Wikaira, J., … Elder, H. (2020). Towards building an Indigenous Science Tertiary Curriculum (Part 2). New Zealand Science Review, 76(1-2), 25-31.
Parr-Brownlie, L. C., Waters, D. L., Neville, S., Neha, T., & Muramatsu, N. (2020). Aging in New Zealand: Ka haere ki te ao pakeketanga. Gerontologist, 60(5), 812-820. doi: 10.1093/geront/gnaa032
Other Research Output
Martin, W.-J., Hazel, J.-A., on behalf of Rauika Māngai, including Sporle, A., Harwood, M., Parr-Brownlie, L., Foster, M., Awatere, S. (2020). A guide to vision Mātauranga: Lessons from Māori voices in the New Zealand science sector. Wellington, New Zealand: Rauika Māngai. Retrieved from http://www.rauikamangai.co.nz/resources-hub
2019
Journal - Research Article
Jackson, A.-M., Hakopa, H., Phillips, C., Parr-Brownlie, L. C., Russell, P., Hulbe, C., Rewi, T., Leoni, G., Mita, N., Jackson, S., Poa, D., Hepburn, C., Wikaira, J., … Elder, H. (2019). Towards building an Indigenous Science Tertiary Curriculum. New Zealand Science Review, 75(4), 69-73.
Hyland, B. I., Seeger-Armbruster, S., Smither, R. A., & Parr-Brownlie, L. C. (2019). Altered recruitment of motor cortex neuronal activity during the grasping phase of skilled reaching in a chronic rat model of unilateral Parkinsonism. Journal of Neuroscience, 39(48), 9660-9672. doi: 10.1523/jneurosci.0720-19.2019
Journal - Research Other
Smith, L. M., & Parr-Brownlie, L. C. (2019). A neuroscience perspective of the gut theory of Parkinson's disease. European Journal of Neuroscience, 49(6), 817-823. doi: 10.1111/ejn.13869
Conference Contribution - Published proceedings: Abstract
Kwakowsky, A., Chawdhary, B., Kim, S., Hughes, S., Parr-Brownlie, L., Waldvogel, H., & Faull, R. (2019). Miniaturized wireless optoelectronic subdermal implants: A novel device for the optogenetic stimulation of hippocampal neurons. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 12508. Retrieved from https://www.ans.org.au
Chawdhary, B., Kim, S. H., Hughes, S., Parr-Brownlie, L., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019). Miniaturized wireless optolectronic subdermal implants: A novel device for the optogenetic stimulation of hippocampal neurons. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 53). Retrieved from http://www.otago.ac.nz/awcbr
Barnett, S. C., Young, C. K., Perry, B. A. L., McNaughton, N., Hughes, S. M., Parr-Brownlie, L. C., & Dalrymple-Alford, J. C. (2019). Optogenetic stimulation of the anterior thalamic nuclei ameliorates impaired spatial memory in rats with mammillothalamic tract lesions. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 27). Retrieved from http://www.otago.ac.nz/awcbr
2018
Journal - Research Other
Swain, N., Parr-Brownlie, L. C., Lennox Thompson, B., Darlow, B., Mani, R., & Baxter, D. (2018). Six things you need to know about pain. New Zealand Medical Journal, 131(1486), 5-8. Retrieved from https://www.nzma.org.nz/journal
Barnett, S. C., Perry, B. A. L., Dalrymple-Alford, J. C., & Parr-Brownlie, L. C. (2018). Optogenetic stimulation: Understanding memory and treating deficits. Hippocampus, 28(7), 457-470. doi: 10.1002/hipo.22960
Conference Contribution - Published proceedings: Abstract
Chen, F. B., Smither, R. A., Parr-Brownlie, L., McCormick, D., Malpas, S., & Budgett, D. M. (2018). Long-term use of a fully implantable optogenetic device in rat studies. Proceedings of the Society for Neuroscience 48th Annual Meeting. 112.09. SfN. Retrieved from https://www.sfn.org
Parr-Brownlie, L. C., Sizemore, R. J., Smither, R. A., Hughes, S. M., & Bosch-Bouju, C. (2018). Substania nigra pars reticulata-ventroanterior motor thalamus synpases are altered in parkinsonian rats. Proceedings of the Society for Neuroscience 48th Annual Meeting. 146.13/II17. SfN. Retrieved from https://www.sfn.org
Cameron, S., & Parr-Brownlie, L. C. (2018). Pathophysiological and anatomical changes of the deep cerebellar nuclei in a chronic rat model of Parkinson's disease. Proceedings of the Society for Neuroscience 48th Annual Meeting. 134.05/T14. SfN. Retrieved from https://www.sfn.org
Parr-Brownlie, L. C., Smither, R. A., Sizemore, R. J., Wicky, H. E., Hughes, S. M., & Bosch-Bouju, C. (2018). Anatomical and physiological changes at basal ganglia-motor thalamus synapses in rat model of Parkinson's disease. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 67). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Seo, S., Sizemore, R. J., Bilkey, D. K., Hughes, S. M., Parr-Brownlie, L. C., & Oorschot, D. E. (2018). Changes in midbrain dopamine circuitry in the maternal immune activation rat model of schizophrenia. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 30). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Oorschot, D. E., Seo, S., Bilkey, D. K., Hughes, S. M., Parr-Brownlie, L. C., & Sizemore, R. J. (2018). Synaptic triad arrangement within an aversive pathway in the normal uninjured brain. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 29). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
2017
Conference Contribution - Poster Presentation (not in published proceedings)
Seeger-Armbruster, S., Smither, R. A., Bosch-Bouju, C., Hyland, B. I., & Parr-Brownlie, L. C. (2017, March ). Reaching-related motor cortex activity is impaired in chronically parkinsonian rats. Poster session presented at the 12th International Basal Ganglia Society Meeting (IBAGS XII), Mérida, Mexico.
2016
Journal - Research Article
Smith, L. M., Parr-Brownlie, L. C., Duncan, E. J., Black, M. A., Gemmell, N. J., Dearden, P. K., & Reynolds, J. N. J. (2016). Striatal mRNA expression patterns underlying peak dose L-DOPA-induced dyskinesia in the 6-OHDA hemiparkinsonian rat. Neuroscience, 324, 238-251. doi: 10.1016/j.neuroscience.2016.03.012
Sizemore, R. J., Seeger-Armbruster, S., Hughes, S. M., & Parr-Brownlie, L. C. (2016). Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology. Journal of Neurophysiology, 115, 2124-2146. doi: 10.1152/jn.01131.2015
Sizemore, R. J., Zhang, R., Lin, N., Goddard, L., Wastney, T., Parr-Brownlie, L. C., Reynolds, J. N. J., & Oorschot, D. E. (2016). Marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons and striatal spiny projection neurons in the rat. Journal of Comparative Neurology, 524(5), 1062-1080. doi: 10.1002/cne.23891
Conference Contribution - Published proceedings: Abstract
Seo, S., Goddard, L., Parr-Brownlie, L. C., Sizemore, R. J., & Oorschot, D. E. (2016). Marked differences in the number and type of synapses innervating the primary dendrites of nigral versus ventral tegmental dopaminergic neurons, and nigral dopaminergic versus striatal spiny projection neurons, in the rat. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 28). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
2015
Chapter in Book - Research
Parr-Brownlie, L. C., & Reynolds, J. N. J. (2015). Basal ganglia. In K. Rogers (Ed.), Encyclopædia Britannica. (Online ed.) Encyclopædia Britannica. Retrieved from https://www.britannica.com
Journal - Research Article
Parr-Brownlie, L. C., Bosch-Bouju, C., Schoderboeck, L., Sizemore, R. J., Abraham, W. C., & Hughes, S. M. (2015). Lentiviral vectors as tools to understand central nervous system biology in mammalian model organisms. Frontiers in Molecular Neuroscience, 8, 14. doi: 10.3389/fnmol.2015.00014
Seeger-Armbruster, S., Bosch-Bouju, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2015). Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced Parkinsonian rats. Journal of Neuroscience, 35(3), 1211-1216. doi: 10.1523/jneurosci.3277-14.2015
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L. C., Smither, R. A., & Little, S. T. C. (2015). Rostral reticular thalamus activity is altered in anaesthetized Parkinsonian rats. Proceedings of the Society for Neuroscience 45th Annual Meeting. 398.09/E32. SfN. Retrieved from https://www.sfn.org/
Cameron, S. H., Hyland, B. I., & Parr-Brownlie, L. C. (2015). Pathophysiology of the cerebellothalamic pathway in a chronic rat model of Parkinson's disease. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 73). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Miller, J. C. D., Smither, R. A., & Parr-Brownlie, L. C. (2015). Characterising the target innervations of glutamatergic neurons in the reticular thalamic nucleus. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 56). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Smither, R. A., Seeger-Armbruster, S., Hughes, S., Hyland, B., & Parr-Brownlie, L. C. (2015). Characterising ventroanterior motor thalamus inputs to motor cortex. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 45). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Sizemore, R. J., Parr-Brownlie, L. C., Hughes, S. M., & Oorschot, D. E. (2015). Complex GABAergic innervation onto ventral tegmental dopamine neurons. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 30). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Seeger-Armbruster, S., Bosch-Bouju, C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2015). Optogenetic stimulation of motor thalamic terminals modulates motor cortex activity in freely moving Parkinsonian rats. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 30). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Oorschot, D., Zhang, R., Lin, N., Wastney, T., Parr-Brownlie, L. C., Reynolds, J. N. J., & Sizemore, R. J. (2015). A stereological transmission electron microscopy study: Marked differences in the number and type of synapses innervating the somata and primary dendrites of three neuronal subtypes in the rat brain. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html
2014
Journal - Research Article
Bosch-Bouju, C., Smither, R. A., Hyland, B. I., & Parr-Brownlie, L. C. (2014). Reduced reach-related modulation of motor thalamus neural activity in a rat model of Parkinson's disease. Journal of Neuroscience, 34(48), 15836-15850. doi: 10.1523/jneurosci.0893-14.2014
Conference Contribution - Published proceedings: Abstract
Seeger-Armbruster, S., Bosch, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2014). Physiological patterns of optogenetic stimulation in the motor thalamus restore reaching in parkinsonian rats. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts
Seeger-Armbruster, S., Bosch, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2014). Does optogenetic stimulation of motor thalamus improve reaching in Parkinsonian rats? In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 33). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Parr-Brownlie, L. C., Sizemore, R. J., Hughes, S. M., & Oorschot, D. E. (2014). Virus infects electron microscopy: Combining techniques for enhanced imaging of brain circuitry. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 83). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Miller, J. C. D., Smither, R. A., & Parr-Brownlie, L. C. (2014). Establishing a rodent model of complex regional pain syndrome. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 60). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Cameron, S. H., Hyland, B. I., & Parr-Brownlie, L. C. (2014). Cerebellar neural activity in a chronic rat model of Parkinson's disease. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 59). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Little, S. T. C., & Parr-Brownlie, L. C. (2014). Changes in reticular thalamic nucleus neuronal activity in anaesthetized parkinsonian rats. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 53). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Conference Contribution - Verbal presentation and other Conference outputs
Parr-Brownlie, L. (2014, August). Virus infects electron microscopy: Combining techniques for enhanced imaging of brain circuitry. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2013
Journal - Research Article
Bosch-Bouju, C., Hyland, B. I., & Parr-Brownlie, L. C. (2013). Motor thalamus integration of cortical, cerebellar and basal ganglia information: Implications for normal and Parkinsonian conditions. Frontiers in Computational Neuroscience, 7, 163. doi: 10.3389/fncom.2013.00163
Conference Contribution - Published proceedings: Abstract
Little, S. T. C., Bosch-Bouju, C., & Parr-Brownlie, L. C. (2013). Neuronal activity in reticular thalamic nucleus in urethane-anaesthetized rats. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 56). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Bosch-Bouju, C., Prier, J., Smither, R., Hughes, S., Hyland, B., & Parr-Brownlie, L. (2013). Optogenetic stimulation of basal ganglia inputs to motor thalamus affects reaching in parkinsonian rats. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 40). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Bosch, C., Hyland, B., & Parr-Brownlie, L. (2013). Movement-related neuronal activity in the motor thalamus is strongly impaired in a Parkinson's disease rat model. New Zealand Medical Journal, 126(1377). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Verbal presentation and other Conference outputs
Sizemore, R. J., Parr-Brownlie, L., Lin, N., Zhang, R., & Oorschot, D. E. (2013, March). Number and type of synapses on the somata and primary dendrites of dopaminergic neurons in the rat ventral tegmental area. Verbal presentation at the 11th Triennial Meeting of the International Basal Ganglia Society (IBAGS-XI), Eilat, Israel.
2012
Conference Contribution - Published proceedings: Abstract
Smith, L. M., Duncan, E. J., Parr-Brownlie, L. C., Black, M. A., Dearden, P. K., & Reynolds, J. N. J. (2012). Transcriptome analysis of levodopa-induced dyskinesias in the 6-hydroxydopamine hemiparkinsonian rat. Proceedings of the Society for Neuroscience 42nd Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2012
Smith, L., Duncan, E., Parr-Brownlie, L., Black, M., Dearden, P., & Reynolds, J. (2012). Understanding the mechanisms behind levodopa-induced dyskinesias. New Zealand Medical Journal, 125(1364). Retrieved from http://www.nzma.org.nz/journal
Wilson, J., & Parr-Brownlie, L. C. (2012). The challenges and benefits of building Māori capacity in the biomedical sciences. Proceedings of the Hui Whakapiripiri: Translating Knowledge into Māori Health Gains. Retrieved from http://hui.hrc.govt.nz/
Bosch, C., Prier, J., Hughes, S., Hyland, B., & Parr-Brownlie, L. (2012). New light-activated protein constructs to dissect the function of GABAergic neurons in the brain. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 42). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Sizemore, R., Parr-Brownlie, L., & Oorschot, D. (2012). Number and type of synapses on the somata and primary dendrites of dopaminergic neurons in the rat ventral tegmental area. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 41). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Conference Contribution - Verbal presentation and other Conference outputs
Parr-Brownlie, L. C., Hughes, S. M., & Hyland, B. I. (2012, August). Highlighting a novel treatment for Parkinson's disease. Verbal presentation at the Hui Poutama: Māori Research Symposium: Ka Haere Whakamua, Ka Titiro Whakamuri, Dunedin, New Zealand.
2011
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L. C., Wickens, J. R., Hutchison, M. A., & Hyland, B. I. (2011). Levodopa selectively increases high gamma power in the globus pallidus during functional but not dyskinetic movements in the hemiparkinsonian rat. In SfN (Ed.), Proceedings of the Society for Neuroscience 41st Annual Meeting. Retrieved from http://www.sfn.org/am2011/index.aspx?pagename=abstracts_main
Parr-Brownlie, L. C., & Walters, J. R. (2011). Motor cortex, but not motor thalamus, activity is impaired in anaesthetised Parkinsonian rats. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 47). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Oral%20Abstracts.pdf
Parr-Brownlie, L. C., Wickens, J. R., Hutchison, M. A., & Hyland, B. I. (2011). Globus pallidus neuronal activity does not underlie L-dopa induced dyskinesias in Parkinsonian rats. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 2.6. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Daly, E., Smith, L., Gray, J., Parr-Brownlie, L., Nagaraja, R., & Reynolds, J. (2011). A dose-response study of L-DOPA-induced dyskinesias in a unilateral 6-OHDA rat model of Parkinson’s disease. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf
Other Research Output
Parr-Brownlie, L. (2011, March). Shedding light on Parkinson’s disease. Brain Day Dunedin, University of Otago, New Zealand. [Public Seminar].
2010
Journal - Research Article
Avila, I., Parr-Brownlie, L. C., Brazhnik, E., Castañeda, E., Bergstrom, D. A., & Walters, J. R. (2010). Beta frequency synchronization in basal ganglia output during rest and walk in a hemiparkinsonian rat. Experimental Neurology, 221(2), 307-319. doi: 10.1016/j.expneurol.2009.11.016
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L. C. (2010). Lack of effects of L-dopa or an adenosine (A2A) receptor antagonist on globus pallidus neuronal activity in dyskinetic Parkinsonian rats. Proceedings of the 10th Triennial Meeting of the International Basal Ganglia Society (IBAGS X). (pp. 47). Retrieved from http://www.ibags.info/
2009
Journal - Research Article
Parr-Brownlie, L., Poloskey, S. L., Bergstrom, D. A., & Walters, J. R. (2009). Parafascicular thalamic nucleus activity in a rat model of Parkinson's disease. Experimental Neurology, 217(2), 269-281. doi: 10.1016/j.expneurol.2009.02.010
Conference Contribution - Published proceedings: Abstract
Avila, I., Bergstrom, D. A., Brazhnik, E., Parr-Brownlie, L. C., Castañeda, E., & Walters, J. R. (2009). Correlations between basal ganglia substantia nigra pars reticulata (SNpr) neuronal output and motor activity in a rodent model of Parkinson's disease. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2009
2008
Journal - Research Article
Aravamuthan, B. R., Bergstrom, D. A., French, R. A., Taylor, J. J., Parr-Brownlie, L. C., & Walters, J. R. (2008). Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease. Experimental Neurology, 213, 268-280. doi: 10.1016/j.expneurol.2008.05.023
Conference Contribution - Published proceedings: Abstract
Avila, I., Parr-Brownlie, L. C., Bergstrom, D. A., Castañeda, E., & Walters, J. R. (2008). Beta and low gamma frequency synchronization in basal ganglia output during rest and walk in the hemiparkinsonian rat. Movement Disorders, 23(Suppl. 1), (pp. S299-S300). doi: 10.1002/mds.22133
Avila, I., Bergstrom, D. A., Parr-Brownlie, L. C., Ahluwalia, J., Castañeda, E., & Walters, J. R. (2008). Basal ganglia output during akinesia and l-dopa-induced rotation and dyskinesias in the hemiparkinsonian rat. Proceedings of the Society for Neuroscience Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2008
Parr-Brownlie, L. C., Poloskey, S. L., Bergstrom, D. A., & Walters, J. R. (2008). Increased oscillatory activity in basal ganglia output nuclei after dopamine cell lesion does not directly drive oscillatory activity in ventroanterior-ventrolateral and parafascicuclar thalamic nuclei in anesthetized rats. Proceedings of the Society for Neuroscience Annual Meeting. SfN. Retrieved from http://www.sfn.org/index.aspx?pagename=abstracts_am2008
Conference Contribution - Verbal presentation and other Conference outputs
Parr-Brownlie, L. (2008, June). The role of the thalamus in Parkinson's disease: Passive relay nucleus or integrator of basal ganglia output? Verbal presentation at the Brain Health and Repair Research Centre 2nd Annual Conference, Dunedin, New Zealand.
2007
Journal - Research Article
Walters, J. R., Hu, D., Itoga, C. A., Parr-Brownlie, L. C., & Bergstrom, D. A. (2007). Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine. Neuroscience, 144, 762-776.
Parr-Brownlie, L. C., Poloskey, S. L., Flanagan, K. K., Eisenhofer, G., Bergstrom, D. A., & Walters, J. R. (2007). Dopamine lesion-induced change in subthalamic nucleus activity are not associated with alterations in firing rate or pattern in layer V neurons of the anterior cingulate cortex in anesthetized rats. European Journal of Neuroscience, 26, 1925-1939.
Conference Contribution - Published proceedings: Abstract
Aravamuthan, B. R., Parr-Brownlie, L. C., Taylor, J. J., Bergstrom, D. A., & Walters, J. R. (2007). The temporal relationship between neuronal activitiy in the pedunculopontine nucleas and the motor cortex is altered in a rodent model of Parkinson's disease. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp
Avila, I., Parr-Brownlie, L. C., Bergstrom, D. A., Gonzales, K. K., Poloskey, S. L., Castañeda, E., & Walters, J. R. (2007). Firing rate and local field potential changes in a basal ganglia output nucleaus during walking and rest in the hemiparkinsonian rat. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp
Conference Contribution - Poster Presentation (not in published proceedings)
Walters, J. R., Hu, D., Parr-Brownlie, L. C., Tierney, P. L., Itoga, C. A., & Bergstrom, D. A. (2007, September). Emergence of oscillatory activity in the basal ganglia network in awake and anesthetized rodent models of Parkinson's disease. Poster session presented at the 9th Triennial Meeting of the International Basal Ganglia Society, Egmond aan Zee, the Netherlands.
Aravamuthan, B., Aziz, T., Bergstrom, D., Johansen-Berg, H., Parr-Brownlie, L., Stein, J., & Walters, J. (2007, July). Comparing the pedunculopontine and subthalamic nuclei: Implications for deep brain stimulation in Parkinson's disease. Poster session presented at the 22nd Annual MD/PhD Student Conference, Keystone, USA.
Parr-Brownlie, L. C., Poloskey, S. L., Bergstrom, D. A., & Walters, J. R. (2007, September). Investigation of the impact of cortical and thalamic neuronal activity on firing pattern in the subthalamic nucleus in the parkinsonian rat. Poster session presented at the 9th Triennial Meeting of the International Basal Ganglia Society, Egmond aan Zee, the Netherlands.
2006
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L. C., Bergstrom, D. A., Itoga, C. A., & Walters, J. R. (2006). Passage of oscillatory activity in basal ganglia-thalamocortical pathways in parkinsonism. Movement Disorders, 21(Suppl. 13), (pp. S77). doi: 10.1002/mds.20870
Parr-Brownlie, L. C., Poloskey, S. L., Bergstrom, D. A., Gonzales, K. K., & Walters, J. R. (2006). Dopamine cell lesion-induced changes in neuronal activity in motor and anterior cingulate cortices in urethane anesthetized rats. FENS Abstracts. 3, A147.14. FENS. Retrieved from http://fens2006.neurosciences.asso.fr/abstracts/R5/A147_14.html
Parr-Brownlie, L. C., Poloskey, S. L., Bergstrom, D. A., Gonzales, K. K., & Walters, J. R. (2006). Contribution of cortical activity to changes in firing rate and pattern of subthalamic neurons in a rodent model of Parkinson's disease. Proceedings of the Society for Neuroscience Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76-28AF-4C1C-8AE8-4F73B56247A7%7D
2005
Chapter in Book - Research
Walters, J. R., Hu, D., Itoga, C. A., Parr-Brownlie, L. C., & Bergstrom, D. A. (2005). Do local field potentials reflect synchronized spiking activity of neuronal populations in the basal ganglia? Studies in a rodent model of Parkinson's disease. In J. P. Bolam, C. A. Ingham & P. J. Magill (Eds.), The basal ganglia VIII. (pp. 37-46). New York, NY: Springer Science+Business Media.
Journal - Research Article
Parr-Brownlie, L. C., & Hyland, B. I. (2005). Bradykinesia induced by dopamine D2 receptor blockade is associated with reduced motor cortex activity in the rat. Journal of Neuroscience, 25(24), 5700-5709.
2003
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L., & Hyland, B. I. (2003). Loss of burst firing and synchronisation in rat sensorimotor cortex during periods of parkinsonian bradykinesia. Proceedings of the 33rd Annual Meeting of the Society for Neuroscience. Washington, DC: Society for Neuroscience. Retrieved from http://sfn.scholarone.com/itin2003
2002
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L. C., & Hyland, B. I. (2002). Decreases in rat motor cortex activity precede acute Parkinsonian movement deficits. Abstracts of Australasian Winter Conference on Brain Research. 20. Retrieved from http://www.awcbr.org/
Parr-Brownlie, L. C., & Hyland, B. I. (2002). Changes in motor cortex activity in an acute rat model of Parkinsonian bradykinesia. Proceedings of the Physiological Society of New Zealand. 21, (pp. 56). Auckland. [Abstract]
2001
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L., & Hyland, B. I. (2001). Effect of prior information on motor preparation in the rat. International Journal of Neuroscience. 108, (pp. 242). [Abstract]
Anson, J. G., Hyland, B. I., Mohagheghi, A., Parr-Brownlie, L., Bowe, S., Jordan, K., & Wickens, J. (2001). Simple reaction time: just remember this. International Journal of Neuroscience. 109, (pp. 196). [Abstract]
Parr-Brownlie, L. C., Anson, J. G., & Hyland, B. I. (2001). Reduced motor cortical activation in a rat model of Parkinsonian bradykinesia. Society for Neuroscience Abstracts. 27. Retrieved from http://sfn.ScholarOne.com/itin2001/
Hyland, B. I., & Parr-Brownlie, L. C. (2001). Reduced motor cortical activation in a rat model of Parkinsonian bradykinesia. Proceedings of the Physiological Society of New Zealand. 20, (pp. 65). [Abstract]
2000
Conference Contribution - Published proceedings: Abstract
Anson, J. G., Hyland, B. I., Mohagheghi, A., Parr-Brownlie, L., Bowe, S., Jordan, K., & Wickens, J. (2000). Memory and simple reaction time. In P. Treffner & S. Morrison (Eds.), Abstracts, 5th Biennial Motor Control & Human Skill Research Workshop. (pp. 23). Gold Coast, Queensland: Griffith University. [Abstract]
1998
Journal - Research Article
Parr-Brownlie, L. C., Wickens, J., Anson, J. G., & Hyland, B. I. (1998). Does having to remember the position of a target improve reaction time? Motor Control, 2, 142-147.
Mohagheghi, A. A., Anson, J. G., Hyland, B. I., Parr-Brownlie, L. C., & Wickens, J. (1998). Foreperiod length, but not memory, affects human reaction time in a precued, delayed response. Motor Control, 2, 133-141.
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L. C., Wickens, J., Anson, J. G., & Hyland, B. I. (1998). Effect of a memory requirement on human reaction time in a precued, delayed response time. Cahiers de Psychologie Cognitive. 17(4-5), (pp. 1066). [Abstract]
Mohagheghi, A. A., Anson, G., Hyland, B. I., Parr-Brownlie, L., & Wickens, J. (1998). Foreperiod length, but not memory, effects human reaction time in a pre-cued, delayed response task. International Journal of Neuroscience. 94. [Abstract]
Parr-Brownlie, L. C., Hyland, B. I., Anson, G., & Wickens, J. R. (1998). Do you react faster if you have to remember what to do? International Journal of Neuroscience. 94, (pp. 102). [Abstract]
1997
Conference Contribution - Published proceedings: Abstract
Parr-Brownlie, L., & Hyland, B. I. (1997). Equipotent dose comparison for haloperidol and raclopride during a learnt motor task. International Journal of Neuroscience. 89, (pp. 89). [Abstract]
Anson, J. G., Hyland, B. I., Wickens, J. R., Mohagheghi, A. A., & Parr-Brownlie, L. C. (1997). Effects of Memory and Foreperiod Length on Human Reaction Time in a Pre-cued Delayed Response Task. Society for Neuroscience Abstracts. 23(1), (pp. 204). New Orleans: Society for Neuroscience. [Abstract]