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Contact Details

Phone
+64 3 479 4219
Email
shane.ohline@otago.ac.nz
Position
Research Fellow
Department
Department of Physiology
Research summary
The role of ryanodine receptors in Alzheimer's disease

Research

The ryanodine receptor has been shown to be faulty in both Alzheimer’s (AD) and heart disease.

We study the receptor in neurons by determining how it is organised and trafficked in a mouse model of AD. Additionally, we will study the effects of already approved heart medications on the brain of this model mouse using patch clamp electrophysiology.

We aim to understand the function, and dysfunction, of this receptor in the brain and to find some way to restore its normal function in AD.

Publications

Chan, J. A., Ohline, S. M., Munro, M. L., & Jones, P. P. (2023, August). Ryanodine type II receptor clustering in Alzheimer's disease. Verbal presentation at the 17th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022, August-September). Altered membrance properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APPswe/PS1dE9 model of Alzheimer's disease. Verbal presentation at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Ohline, S. M., Liu, X., Ibrahim, M. F., Mockett, B. G., Empson, R. M., Abraham, W. C., Iremonger, K. J., & Jones, P. P. (2022). Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APPswe/PS1dE9 model of Alzheimer’s disease. Frontiers in Cellular Neuroscience, 16, 958876. doi: 10.3389/fncel.2022.958876 Journal - Research Article

Ohline, S. M., Hughes, S. M., & Abraham, W. C. (2022). Immediate early gene expression and intrinsic excitability are not linked in adult-born hippocampal neurons. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 62). Retrieved from https://www.queenstownresearchweek.org Conference Contribution - Published proceedings: Abstract

Mathiesen, S. N., Schoderboeck, L., Ohline, S. M., Mockett, B. G., Abraham, W. C., & Hughes, S. M. (2022). Peripheral administration of AAV-PHP.eB encoding TFEB causes toxicity in mice. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 55). Retrieved from https://www.queenstownresearchweek.org Conference Contribution - Published proceedings: Abstract

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