Dr Margaret Ryan

2023

Journal - Research Other

Mockett, B. G., & Ryan, M. M. (2023). The therapeutic potential of the neuroactive peptides of soluble amyloid precursor protein-alpha in Alzheimer’s disease and related neurological disorders. Seminars in Cell & Developmental Biology, 139, 93-101. doi: 10.1016/j.semcdb.2022.05.014

2022

Conference Contribution - Published proceedings: Abstract

Cawood, S., Neehoff, S., Glue, P., Williams, J., Ryan, M., Russell, B., & Harrison, O. (2022). Investigating the relationship between microRNA expression, brain structure and biochemistry in anxiety disorders and their potential treatment with ketamine. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 82). Retrieved from https://www.queenstownresearchweek.org

2021

Journal - Research Article

Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757

2019

Journal - Research Article

Sweetman, E., Ryan, M., Edgar, C., MacKay, A., Vallings, R., & Tate, W. (2019). Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome. International Journal of Immunopathology & Pharmacology, 33, 1-8. doi: 10.1177/2058738418820402

Journal - Research Other

Sweetman, E., Noble, A., Edgar, C., Mackay, A., Helliwell, A., Vallings, R., Ryan, M., & Tate, W. (2019). Current research provides insight into the biological basis and diagnostic potential for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Diagnostics, 9(3), 73. doi: 10.3390/diagnostics9030073

2018

Journal - Research Article

Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNAs are altered with amyloidosis in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease, 66(2), 835-852. doi: 10.3233/jad-180385

Conference Contribution - Published proceedings: Abstract

Ryan, M. M., Guévremont, D., Mockett, B., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNA are altered with amyloidosis in a mouse model of Alzheimer's disease. Proceedings of the Society for Neuroscience 48th Annual Meeting. 132.17/S12. SfN. Retrieved from https://www.sfn.org

2017

Conference Contribution - Published proceedings: Abstract

Sweetman, E. C., Tate, W. P., & Ryan, M. (2017). Investigating molecular diagnostic biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome. New Zealand Medical Journal, 130(1467), (pp. 106). Retrieved from http://www.nzma.org.nz/journal

Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2017). Changes in circulating microRNA during disease progession in a mouse model of Alzheimer's disease. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 26). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

2016

Conference Contribution - Published proceedings: Full paper

Tate, W. P., Sweetman, E. C., Noble, A. J. K., Edgar, C. D., Bateman, G., MacKay, A., Ryan, M. M., … Vallings, R. (2016). Tackling ME/CFS in New Zealand by the principles of precision medicine. Journal of Iimer, 10(1), (pp. 46-55). Retrieved from http://publizr.com/investinmeresearch/journal-of-iime-vol-10-issue-1#/0

2015

Journal - Research Article

Nido, G. S., Ryan, M. M., Benuskova, L., & Williams, J. M. (2015). Dynamical properties of gene regulatory networks involved in long-term potentiation. Frontiers in Molecular Neuroscience, 8, 42. doi: 10.3389/fnmol.2015.00042

Ryan, M. M., Guévremont, D., Luxmanan, C., Abraham, W. C., & Williams, J. M. (2015). Aging alters long-term potentiation—related gene networks and impairs synaptic protein synthesis in the rat hippocampus. Neurobiology of Aging, 36(5), 1868-1880. doi: 10.1016/j.neurobiolaging.2015.01.012

Conference Contribution - Published proceedings: Abstract

Ryan, M., Mockett, B., Guevremont, D., Abraham, W. C., & Williams, J. (2015). Distinct microma expression in a transgenic mouse model of Alzheimer's disease. Journal of Neurochemistry, 134(Suppl. 1), (pp. 328). doi: 10.1111/jnc.13189

2013

Journal - Research Article

Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013). Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics, 14, 376. doi: 10.1186/1471-2164-14-376

2012

Journal - Research Article

Ryan, M. M., Ryan, B., Kyrke-Smith, M., Logan, B., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS ONE, 7(7), e40538. doi: 10.1371/journal.pone.0040538

Conference Contribution - Published proceedings: Abstract

Williams, J., Joilin, G., Ryan, B., Guevremont, D., Ryan, M., Logan, B., & Abraham, W. (2012). Rapid down-regulation of microRNA following induction of long-term potentiation in vivo. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 49). Retrieved from http://www.ans.org.au/ans-annual-conference/

2011

Journal - Research Article

Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2011). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo. Hippocampus, 21(5), 541-553. doi: 10.1002/hipo.20770

Conference Contribution - Published proceedings: Abstract

Ryan, M. M., Morris, G., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2011). Secreted amyloid precursor protein-alpha regulates hippocampal gene expression. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 163). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf

Morris, G. P., Ryan, M. M., Bourne, K., & Tate, W. P. (2011). Understanding how secreted amyloid precursor protein-α (SAPPα) signals changes in gene expression in neurons. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 160). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf

Joilin, G., Ryan, B., Guévremont, D., Logan, B., Ryan, M. M., Abraham, W. C., & Williams, J. M. (2011). Rapid down-regulation of a microRNA controller of gene expression, microRNA-132, following induction of long-term potentiation in vivo. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.28. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Joilin, G., Guévremont, D., Logan, B., Ryan, M., Abraham, W., & Williams, J. (2011). Rapid down-regulation of microRNA following induction of long-term potentiation in vivo. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf

Morris, G., Ryan, M., Bourne, K., & Tate, W. (2011). Secreted amyloid precursor protein-α mediates gene expression. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf

Ryan, B., Guévremont, D., Ryan, M., Logan, B., Abraham, W., & Williams, J. (2011). Plasticity-related down-regulation of microRNA regulators of gene expression. New Zealand Medical Journal. 124(1335). Retrieved from http://www.nzma.org.nz/journal/124-1335/4693/content.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Ryan, M. (2011, July). sAPPα: A protein to remember. Verbal presentation at the Brain Health Research Centre Conference, Dunedin, New Zealand.

Abraham, C., Ryan, M., Logan, B., & Williams, J. (2011, May). LTP-associated gene expression: NFkappaB as a potential hub of activity. Verbal presentation at the Spring Hippocampal Research Conference, Verona, Italy.

2010

Journal - Research Article

Giger, T., Khaitovich, P., Somel, M., Lorenc, A., Lizano, E., Harris, L. W., Ryan, M. M., … Pääbo, S. (2010). Evolution of neuronal and endothelial transcriptomes in primates. Genome Biology & Evolution, 2, 284-292. doi: 10.1093/gbe/evq018

2009

Conference Contribution - Published proceedings: Abstract

Ryan, M. M., Morris, G., Bourne, K., Mockett, B. G., Abraham, W. C., Tate, W. P., & Williams, J. M. (2009). Regulation of gene expression by sAPPα and RER derivative in differentiated neuroblastoma cells. Alzheimer's & Dementia, 5(4, Suppl. 1), (pp. P421). doi: 10.1016/j.jalz.2009.04.938

2008

Journal - Research Article

Harris, L. W., Wayland, M., Lan, M., Ryan, M., Giger, T., Lockstone, H., … Bahn, S. (2008). The cerebral microvasculature in schizophrenia: A laser capture microdissection study. PLoS ONE, 3(12), e3964. doi: 10.1371/journal.pone.0003964

Conference Contribution - Published proceedings: Abstract

Renshaw, J. A., Ryan, M., Williams, J., & Tate, W. (2008). Recombinant sAPPα causes specific changes in gene expression in neuroblastoma cells and rat hippocampal cell slices. New Zealand Medical Journal, 121(1274). Retrieved from http://journal.nzma.org.nz/journal/121-1274/3078/content.pdf

Luxmanan, C., Ryan, M., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2008). Age-related changes in LTP-associated gene expression profiles in the dentate gyrus. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 21). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Tate, W., Bourne, K., Turner, P. R., Claasen, A., Ryan, M., Taylor, C., Ireland, D., Ballagh, I., Marechal, N., Bilkey, D., Williams, J., & Abraham, W. (2008, November-December). Secreted amyloid precursor protein alpha: A mammalian memory molecule. Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

2007

Journal - Research Article

Tkachev, D., Mimmack, M. L., Huffaker, S. J., Ryan, M., & Bahn, S. (2007). Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia. International Journal of Neuropsychopharmacology, 10, 557-563. doi: 10.1017/S1461145706007334

Conference Contribution - Published proceedings: Abstract

Ryan, M. M., Luxmanan, C., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2007). Profiling early gene expression changes during LTP in-vivo. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp

Conference Contribution - Poster Presentation (not in published proceedings)

Luxmanan, C., Ryan, M. M., Gill, A., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2007, November). Evidence for ageing-related attenuation of LTP-inducible transcription-related gene expression in rats. Poster session presented at the Society for Neuroscience 37th Annual Meeting, San Diego, California.

Ryan, M. M., Luxmanan, C., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2007, July). Profiling early gene expression changes in an LTP-model of learning. Poster session presented at the 7th International Brain Research Organization World Congress of Neuroscience, Melbourne, Australia.

2006

Journal - Research Article

Ryan, M. M., Lockstone, H. E., Huffaker, S. J., Wayland, M. T., Webster, M. J., & Bahn, S. (2006). Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. Molecular Psychiatry, 11, 965-978. doi: 10.1038/sj.mp.4001875

2005

Journal - Research Article

Franz, H., Ullmann, C., Becker, A., Ryan, M., Bahn, S., Arendt, T., & … (2005). Systematic analysis of gene expression in human brains before and after death. Genome Biology, 6(13).

2004

Journal - Research Article

Prabakaran, S., Swatton, J. E., Ryan, M. M., Huffaker, S. J., Huang, J. T.-J., Griffin, J. L., & et al (2004). Mitochondrial dysfunction in schizophrenia: Evidence for compromised brain metabolism and oxidative stress. Molecular Psychiatry, 9, 684-697.

Wilson, K. E., Ryan, M. M., Prime, J. E., Pashby, D. P., Orange, P. R., O'Beirne, G., … Morris, C. M. (2004). Functional genomics and proteomics: Application in neurosciences. Journal of Neurology, Neurosurgery & Psychiatry, 75, 529-538. doi: 10.1136/jnnp.2003.026260

Ryan, M. M., Huffaker, S. J., Webster, M. J., Wayland, M., Freeman, T., & Bahn, S. (2004). Application and optimization of microarray technologies for human postmortem brain studies. Biological Psychiatry, 55, 329-336.

2003

Journal - Research Article

Tkachev, D., Mimmack, M. L., Ryan, M. M., Wayland, M., Freeman, T., Jones, P. B., & … (2003). Oligodendrocyte dysfunction in schizoprenia and bipolar disorder. Lancet, 362, 798-805.

Marchbanks, R. M., Ryan, M., Day, I. N. M., Owen, M., McGuffin, P., & Whatley, S. A. (2003). A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophrenia Research, 65, 33-38.

Conference Contribution - Poster Presentation (not in published proceedings)

Tkachev, D., Mimmack, M. L., Ryan, M. M., Wayland, M., Freeman, T., Webster, M. J., & ... (2003, November). Profound metabolic abnormalities in schizophrenia. Poster session presented at the Society for Neuroscience Annual Meeting, New Orleans, LA.

Huffaker, S. J., Ryan, M., Sudhakaran, P., Webster, M., Goedert, M., & Bahn, S. (2003, November). Large scale genechip analysis of post-mortem brains from schizophrenia and bipolar affective disorder patients. Poster session presented at the Society for Neuroscience Annual Meeting, New Orleans, LA.

2002

Journal - Research Article

Mimmack, M. L., Ryan, M., Baba, H., Navarro-Ruiz, J., Iritani, S., Faull, R. M. L., & ... (2002). Gene expression analysis in schizophrenia: Reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22. PNAS, 99(7), 4680-4685.

Bahn, S., Mimmack, M., Ryan, M., Caldwell, M. A., Jauniaux, E., Starkey, M., & Svendsen, C. N. (2002). Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: A gene expression study. Lancet, 359, 310-315.

Conference Contribution - Poster Presentation (not in published proceedings)

Ryan, M. M., Mimmack, M. L., Jones, P. B., Emson, P. C., Starkey, M., & Bahn, S. (2002, November). Gene expression analysis in schizophrenia: Reproducible upregulation of several members of the apolipoprotein L family located in a high susceptibility locus for schizophrenia on chromosome 22. Poster session presented at the Society for Neuroscience Annual Meeting, Orlando, FL.

2001

Journal - Research Article

Ryan, M., Starkey, M., Faull, R., Emson, P., & Bahn, S. (2001). Indexing-based differential display: Studies on post-mortem Alzheimer's brain. Molecular Brain Research, 88, 199-202.

Bahn, S., Augood, S. J., Ryan, M., Standaert, D. G., Starkey, M., & Emson, P. C. (2001). Gene expression profiling in the post-mortem human brain: No cause for dismay. Journal of Chemical Neuroanatomy, 22, 79-94.