Contact Details
- Phone
- 64 3 479 5747
- paul.smith@otago.ac.nz
- Position
- Professor
- Department
- Department of Pharmacology and Toxicology
- Qualifications
- BA(Hons) PhD GradDipApplStat MApplStat(Hons) DSc AStat (SSAI)
- Research summary
- Vestibular and Auditory Neuroscience
- Teaching
- Neuropharmacology, Neuroscience
- Biostatistics
Research
Interests: vestibular and auditory systems; vestibular dysfunction and tinnitus; effects of vestibular damage on the hippocampus; applications of statistics to pharmacology; biostatistics in general.
My major research interest is in the vestibular and auditory systems and how damage to them can result in plastic changes in the brain. We study the effects of vestibular and auditory damage on the brainstem vestibular and cochlear nuclei, and also on other areas of the CNS such as the medial temporal lobe, especially the hippocampus and striatum.
Additional details
I am appointed to the HRC Standing Committee on Therapeutic Trials (SCOTT), the HRC Emerging Researcher First Grant Science Assessing CommitteeScientific Advisory Committee of the New Zealand Neurological Foundation, and to the Editorial Boards of the Journal of Vestibular Research, Frontiers in NeurologyNeuro-Otology (Associate Editor), Frontiers in Neuroscience, Frontiers in Psychology, Auris Nasus Larynx and the Springer Encyclopedia of Neuroscience (Field Editor for Neuropharmacology).
I am an Accredited Statistician (AStat) with the Statistical Society of Australia Inc. (SSAI) and a Fellow of the Royal Statistical Society, UK. I am also a Principal Investigator with the Brain Research New Zealand Centre of Research Excellence and with the Eisdell Moore Centre for Hearing and Balance Research, University of Auckland.
Publications
Zheng, Y., & Smith, P. F. (2024). Translating animal findings to humans in tinnitus research. In W. Schlee, B. Langguth, D. De Ridder, S. Vanneste, T. Kleinjung & A. R. Møller (Eds.), Textbook of tinnitus. (2nd ed.) (pp. 301-312). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-35647-6_24 Chapter in Book - Research
Tan, H. T., Smith, P. F., & Zheng, Y. (2024). Time-dependent effects of acoustic trauma and tinnitus on extracellular levels of amino acids in the inferior colliculus of rats. Hearing Research, 443, 108948. doi: 10.1016/j.heares.2024.108948 Journal - Research Article
Smith, P. F. (2023). Interpreting the meaning of changes in hippocampal volume associated with vestibular loss. Frontiers in Integrative Neuroscience, 17, 1254972. doi: 10.3389/fnint.2023.1254972 Journal - Research Other
Singh, A., Smith, P. F., & Zheng, Y. (2023). Targeting the limbic system: Insights into its involvement in tinnitus. International Journal of Molecular Sciences, 24, 9889. doi: 10.3390/ijms24129889 Journal - Research Other
McLaren, R., Smith, P. F., Taylor, R. L., Niazi, I. K., & Taylor, D. (2023). Scoping out noisy galvanic vestibular stimulation: A review of the parameters used to improve postural control. Frontiers in Neuroscience, 17, 1156796. doi: 10.3389/fnins.2023.1156796 Journal - Research Other
2024
Chapter in Book - Research
Zheng, Y., & Smith, P. F. (2024). Translating animal findings to humans in tinnitus research. In W. Schlee, B. Langguth, D. De Ridder, S. Vanneste, T. Kleinjung & A. R. Møller (Eds.), Textbook of tinnitus. (2nd ed.) (pp. 301-312). Cham, Switzerland: Springer. doi: 10.1007/978-3-031-35647-6_24
Journal - Research Article
Tan, H. T., Smith, P. F., & Zheng, Y. (2024). Time-dependent effects of acoustic trauma and tinnitus on extracellular levels of amino acids in the inferior colliculus of rats. Hearing Research, 443, 108948. doi: 10.1016/j.heares.2024.108948
2023
Journal - Research Article
Tashakori-Sabzevar, F., Vautrelle, N., Zheng, Y., & Smith, P. F. (2023). Vestibular modulation of the tail of the rat striatum. Scientific Reports, 13, 4443. doi: 10.1038/s41598-023-31289-1
Journal - Research Other
Smith, P. F. (2023). Interpreting the meaning of changes in hippocampal volume associated with vestibular loss. Frontiers in Integrative Neuroscience, 17, 1254972. doi: 10.3389/fnint.2023.1254972
Singh, A., Smith, P. F., & Zheng, Y. (2023). Targeting the limbic system: Insights into its involvement in tinnitus. International Journal of Molecular Sciences, 24, 9889. doi: 10.3390/ijms24129889
McLaren, R., Smith, P. F., Taylor, R. L., Niazi, I. K., & Taylor, D. (2023). Scoping out noisy galvanic vestibular stimulation: A review of the parameters used to improve postural control. Frontiers in Neuroscience, 17, 1156796. doi: 10.3389/fnins.2023.1156796
Conference Contribution - Published proceedings: Abstract
Kelly, G., Singh, A., Smith, P. F., & Zheng, Y. (2023). Effects of chronic tinnitus on long-term potentiation in the rat hippocampus. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
Sabzevar, F., Zheng, Y., Vautrelle, N., & Smith, P. (2023). Vestibular projections to the striatum: The mechanism of galvanic vestibular stimulation effects in Parkinson’s disease? Brain Stimulation, 16(1), (pp. 151-152). doi: 10.1016/j.brs.2023.01.114
2022
Journal - Research Article
Rana, Z., Rosengren, R., & Smith, P. (2022). Exploring the mechanism and suggesting combination therapies for HDAC inhibitors in androgen receptor-null prostate cancer using multivariate statistical analysis and data mining techniques. Bioinformatics & Biology Insights. Advance online publication. doi: 10.1177/11779322221145428
McLaren, R., Smith, P. F., Taylor, R. L., Ravindran, S., Rashid, U., & Taylor, D. (2022). Efficacy of nGVS to improve postural stability in people with bilateral vestibulopathy: A systematic review and meta-analysis. Frontiers in Neuroscience, 16, 1010239. doi: 10.3389/fnins.2022.1010239
Journal - Research Other
Curthoys, I. S., Smith, P. F., & Ramos de Miguel, A. (2022). Why should constant stimulation of saccular afferents modify the posture and gait of patients with bilateral vestibular dysfunction? The saccular substitution hypothesis. Journal of Clinical Medicine, 11(4), 1132. doi: 10.3390/jcm11041132
Smith, P. F. (2022). Hearing loss versus vestibular loss as contributors to cognitive dysfunction. Journal of Neurology, 269, 87-99. doi: 10.1007/s00415-020-10343-2
Conference Contribution - Published proceedings: Abstract
Tan, H.-T., Smith, P., Zheng, Y., & Reynolds, J. (2022). Stimulation-evoked dopamine release in the auditory cortex of anaesthetised rats. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 52). Retrieved from https://www.queenstownresearchweek.org
Conference Contribution - Poster Presentation (not in published proceedings)
Telang, R. S., Suzuki-Kerr, H., Vlajkovic, S. M., Smith, P. F., Zheng, Y., & Thorne, P. R. (2022, August-September). Insight into hearing loss through a metabolomics approach: A pilot comparison of inner ear fluid, cochlea and blood plasma. Poster session presented at the 16th New Zealand Medical Sciences Congress (MedSci), Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Tashakori Sabzevar, F., Vautrelle, N., Zheng, Y., & Smith, P. F. (2022, September). Effects of electrical vestibular stimulation on the local field potential in rat striatum. Verbal presentation at the Postgraduate & Early Career Researchers Committee (PERC) & Division of Health Sciences Early & Mid-Career Researcher (EMCR) Joint Research Symposium, Dunedin, New Zealand.
2021
Chapter in Book - Research
Searchfield, G. D., Zhang, J., Biswas, R., De Ridder, D., Deutsch, B., Hall, D. A., … Kleinstäuber, M., … Smith, P. F., … Zheng, Y. (2021). Emerging topics in the behavioral neuroscience of tinnitus. In G. D. Searchfield & J. Zhang (Eds.), The behavioral neuroscience of tinnitus: Current topics in behavioral neurosciences (Vol. 51). (pp. 461-484). Cham, Switzerland: Springer. doi: 10.1007/7854_2021_217
Zheng, Y., McTavish, J., & Smith, P. F. (2021). Pharmacological evaluation of drugs in animal models of tinnitus. In G. D. Searchfield & J. Zhang (Eds.), The behavioral neuroscience of tinnitus: Current topics in behavioral neurosciences (Vol. 51). (pp. 51-82). Cham, Switzerland: Springer. doi: 10.1007/7854_2020_212
He, J., Aa, J.-Y., Sun, J.-G., Smith, P. F., De Ridder, D., Wang, G.-J., & Zheng, Y. (2021). Metabolic changes in the brain and blood of rats following acoustic trauma, tinnitus and hyperacusis. In B. Langguth, T. Kleinjung, D. De Ridder, W. Schlee & S. Vanneste (Eds.), Tinnitus: An interdisciplinary approach towards individualized treatment: Towards understanding the complexity of tinnitus: Progress in brain research (Vol. 262). (pp. 399-430). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/bs.pbr.2020.09.002
Journal - Research Article
Smith, P. F., & Zheng, Y. (2021). Applications of multivariate statistical and data Mining analyses to the search for biomarkers of sensorineural hearing loss, tinnitus, and vestibular dysfunction. Frontiers in Neurology, 12, 627294. doi: 10.3389/fneur.2021.627294
Hitier, M., Zhang, Y.-F., Sato, G., Besnard, S., Zheng, Y., & Smith, P. F. (2021). Stratification of hippocampal electrophysiological activation evoked by selective electrical stimulation of different angular and linear acceleration sensors in the rat peripheral vestibular system. Hearing Research, 403, 108173. doi: 10.1016/j.heares.2021.108173
Journal - Research Other
McLaren, R., Smith, P. F., Lord, S., Kaur, P. K., Zheng, Y., & Taylor, D. (2021). Noisy galvanic vestibular stimulation combined with a multisensory balance program in older adults with moderate to high fall risk: Protocol for a feasibility study for a randomized controlled trial. JMIR Research Protocols, 10(10), e32085. doi: 10.2196/32085
Conference Contribution - Published proceedings: Abstract
Smith, P. F., Hitier, M., Zhang, Y.-F., Sato, G., Besnard, S., & Zheng, Y. (2021). The implications of vestibular and auditory dysfunction for dementia. New Zealand Medical Journal, 134(1539), (pp. 92). Retrieved from https://www.nzma.org.nz/journal
2020
Chapter in Book - Research
Agrawal, Y., Smith, P. F., & Merfeld, D. M. (2020). Dizziness, imbalance and age-related vestibular loss. In J. Stein (Ed.), Reference module in neuroscience and biobehavioral psychology. Elsevier. doi: 10.1016/B978-0-12-809324-5.23818-2
Journal - Research Article
Smith, P. F. (2020). Why the cerebellar shutdown/clampdown hypothesis of vestibular compensation is inconsistent with neurophysiological evidence. Journal of Vestibular Research, 30(5), 295-303. doi: 10.3233/ves-200715
Smith, P. F. (2020). Why dizziness is likely to increase the risk of cognitive dysfunction and dementia in elderly adults. New Zealand Medical Journal, 133(1522), 112-127. Retrieved from https://www.nzma.org.nz/journal
Jacob, A., Tward, D. J., Resnick, S., Smith, P. F., Lopez, C., Rebello, E., … Agrawal, Y. (2020). Vestibular function and cortical and sub-cortical alterations in an aging population. Heliyon, 6(8), e04728. doi: 10.1016/j.heliyon.2020.e04728
Logerot, P., Smith, P. F., Wild, M., & Kubke, M. F. (2020). Auditory processing in the zebra finch midbrain: Single unit responses and effect of rearing experience. PeerJ, 8, e9363. doi: 10.7717/peerj.9363
Kumari, N., Taylor, D., Rashid, U., Vandal, A. C., Smith, P. F., & Signal, N. (2020). Cerebellar transcranial direct current stimulation for learning a novel split-belt treadmill task: a randomised controlled trial. Scientific Reports, 10(1), 11853. doi: 10.1038/s41598-020-68825-2
Journal - Research Other
Smith, P. F., Truchet, B., Chaillan, F. A., Zheng, Y., & Besnard, S. (2020). Vestibular modulation of long-term potentiation and NMDA receptor expression in the hippocampus. Frontiers in Molecular Neuroscience, 13, 140. doi: 10.3389/fnmol.2020.00140
Hitier, M., Zhang, Y.-F., Sato, G., Besnard, S., Zheng, Y., & Smith, P. F. (2020). The effects of selective electrical stimulation of the rat cochlea on hippocampal field potentials [Short communication]. Hearing Research, 395, 108023. doi: 10.1016/j.heares.2020.108023
Agrawal, Y., Merfeld, D. M., Horak, F. B., Redfern, M. S., Manor, B., Westlake, K. P., … Smith, P. F., … Lipsitz, L. A. (2020). Aging, vestibular function, and balance: Proceedings of a National Institute on Aging/National Institute on Deafness and Other Communication Disorders Workshop. Journals of Gerontology Series A, 75(12), 2471-2480. doi: 10.1093/gerona/glaa097
Agrawal, Y., Smith, P. F., & Rosenberg, P. B. (2020). Vestibular impairment, cognitive decline and Alzheimer's disease: Balancing the evidence. Aging & Mental Health, 24(5), 705-708. doi: 10.1080/13607863.2019.1566813
2019
Chapter in Book - Research
Smith, P. F. (2019). Vestibular compensation as a distributed process. In J. P. Stein (Ed.), Reference module in neuroscience and biobehavioral psychology. Elsevier. doi: 10.1016/B978-0-12-809324-5.23820-0
Journal - Research Article
Martey, O. N. K., Greish, K., Smith, P. F., & Rosengren, R. J. (2019). A multivariate statistical analysis of the effects of styrene maleic acid encapsulated RL71 in a xenograft model of triple negative breast cancer. Journal of Biological Methods, 6(4). doi: 10.14440/jbm.2019.306
Machado, M. L., Lefèvre, N., Philoxene, B., Le Gall, A., Madeleine, S., Fleury, P., Smith, P. F., & Besnard, S. (2019). New software dedicated to virtual mazes for human neurocognitive investigations. Journal of Neuroscience Methods, 327, 108388. doi: 10.1016/j.jneumeth.2019.108388
Le Gall, A., Hilber, P., Chesneau, C., Bulla, J., Toulouse, J., Machado, M. L., … Smith, P. F., & Besnard, S. (2019). The critical role of vestibular graviception during cognitivo-motor development. Behavioural Brain Research, 372, 112040. doi: 10.1016/j.bbr.2019.112040
Truchet, B., Benoit, A., Chaillan, F., Smith, P. F., Philoxene, B., Guillamin, M., … Besnard, S. (2019). Hippocampal LTP modulation and glutamatergic receptors following vestibular loss. Brain Structure & Function, 224, 699-711. doi: 10.1007/s00429-018-1792-0
Journal - Research Other
Smith, P. F. (2019). The growing evidence for the importance of the otoliths in spatial memory. Frontiers in Neural Circuits, 13, 66. doi: 10.3389/fncir.2019.00066
Smith, P. F., Agrawal, Y., & Darlington, C. L. (2019). Sexual dimorphism in vestibular function and dysfunction. Journal of Neurophysiology, 121, 2379-2391. doi: 10.1152/jn.00074.2019
Besnard, S., Tighilet, B., Chabbert, C., Hitier, M., Toulouse, J., Le Gall, A., … Smith, P. F. (2019). Reply to Micarelli et al. Commentary on the balance of sleep: Role of the vestibular sensory system. Sleep Medicine Reviews, 44, 87-88. doi: 10.1016/j.smrv.2018.12.003
Zheng, Y., & Smith, P. F. (2019). Cannabinoid drugs: Will they relieve or exacerbate tinnitus? Current Opinion in Neurology, 32, 131-136. doi: 10.1097/wco.0000000000000631
Conference Contribution - Published proceedings: Abstract
Smith, P. F., & Zheng, Y. (2019). Application of discriminant and principal component analyses to analysis of metabolomics data obtained from brain tissue. Proceedings of the New Zealand Statistical Association Conference. (pp. 37-38). Retrieved from https://www.otago.ac.nz/nzsa/programme-and-speakers/
Kumaria, N., Taylor, D., Rashid, U., Vandal, A. C., Smith, P. F., & Signal, N. (2019). Can cerebellar transcranial direct current stimulation influence motor learning in healthy adults? In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 66). Retrieved from http://www.otago.ac.nz/awcbr
Zheng, Y., Castro, S., Tan, H.-T., Jones, O., Smith, P. F., & Reynolds, J. N. (2019). Increased synaptic plasticity in the inferior colliculus of rats following acoustic trauma. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 38). Retrieved from http://www.otago.ac.nz/awcbr
2018
Journal - Research Article
Smith, P. F. (2018). Vestibular functions and Parkinson’s Disease. Frontiers in Neurology, 9, 1085. doi: 10.3389/fneur.2018.01085
Stiles, L., Zheng, Y., & Smith, P. F. (2018). The effects of electrical stimulation of the peripheral vestibular system on neurochemical release in the rat striatum. PLoS ONE, 13(10), e0205869. doi: 10.1371/journal.pone.0205869
Hitier, M., Sato, G., Zhang, Y.-F., Zheng, Y., Besnard, S., & Smith, P. F. (2018). Vestibular-related eye movements in the rat following selective electrical stimulation of the vestibular sensors. Journal of Comparative Physiology A, 204, 835-847. doi: 10.1007/s00359-018-1286-9
Stiles, L., Reynolds, J. N., Napper, R., Zheng, Y., & Smith, P. F. (2018). Single neuron activity and c-Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system. Physiological Reports, 6(13), e13791. doi: 10.14814/phy2.13791
Benoit, A., Besnard, S., Guillamin, M., Philoxene, B., Sola, B., Le Gall, A., … Smith, P. F. (2018). Differential regulation of NMDA receptor-expressing neurons in the rat hippocampus and striatum following bilateral vestibular loss demonstrated using flow cytometry. Neuroscience Letters, 683, 43-47. doi: 10.1016/j.neulet.2018.06.035
Hitier, M., Sato, G., Zhang, Y.-F., Besnard, S., & Smith, P. F. (2018). Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus. Neuroscience Letters, 677, 60-64. doi: 10.1016/j.neulet.2018.04.041
Benoit, A., Guillamin, M., Aitken, P., Smith, P. F., Sola, B., Poulain, L., … Besnard, S. (2018). Flow cytometry for receptor analysis from ex-vivo brain tissue in adult rat. Journal of Neuroscience Methods, 304, 11-23. doi: 10.1016/j.jneumeth.2018.04.005
Aitken, P., Zheng, Y., & Smith, P. F. (2018). The modulation of hippocampal theta rhythm by the vestibular system. Journal of Neurophysiology, 119(2), 548-562. doi: 10.1152/jn.00548.2017
Journal - Research Other
Besnard, S., Tighilet, B., Chabbert, C., Hitier, M., Toulouse, J., Le Gall, A., … Smith, P. F. (2018). The balance of sleep: Role of the vestibular sensory system. Sleep Medicine Reviews, 42, 220-228. doi: 10.1016/j.smrv.2018.09.001
Smith, P. F. (2018). On the application of multivariate statistical and data mining analyses to data in neuroscience. Journal of Undergraduate Neuroscience Education, 16(2), R20-R32. [Review].
Conference Contribution - Published proceedings: Abstract
Smith, P. F., Truchet, B., Benoit, A., Chaillan, F., Philoxene, B., Guillamin, M., … Besnard, S. (2018). The neurobiological basis of spatial memory deficits following vestibular dysfunction: Modulation of hippocampal long-term potentiation and NMDA receptors. Proceedings of the Combined New Zealand Society for Balance, Dizziness and Vertigo (NZSBDV) and the Neuro-Otology Society of Australia (NOTSA) Clinical and Scientific Meeting. (pp. 34). Retrieved from http://vertigosociety.nz/
Machado, M. L., Lefèvre, N., Philoxene, B., Le Gall, A., Madeleine, S., Fleury, P., Smith, P. F., & Besnard, S. (2018). New software dedicated to virtual mazes for human neurocognitive investigations. Proceedings of the Combined New Zealand Society for Balance, Dizziness and Vertigo (NZSBDV) and the Neuro-Otology Society of Australia (NOTSA) Clinical and Scientific Meeting. (pp. 33). Retrieved from http://vertigosociety.nz/
Le Gall, A., Chesneau, C., Hilber, P., Philoxene, B., Bulla, J., Besnard, S., & Smith, P. F. (2018). Evidence that the otoliths are critical for early development in mice. Proceedings of the Combined New Zealand Society for Balance, Dizziness and Vertigo (NZSBDV) and the Neuro-Otology Society of Australia (NOTSA) Clinical and Scientific Meeting. (pp. 32). Retrieved from http://vertigosociety.nz/
Zheng, Y., Aa, J., He, J., Wang, G., & Smith, P. F. (2018). Can metabolic changes in the blood predict changes in the brain in rats following acoustic trauma? In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 26). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Other Research Output
Smith, P. (2018, May). Lost in space: The significance of the vestibular system for space exploration. Department of Pharmacology & Toxicology, University of Otago, Dunedin, New Zealand. [Department Seminar].
2017
Journal - Research Article
Smith, P. F. (2017). Is hippocampal neurogenesis modulated by the sensation of self-motion encoded by the vestibular system? Neuroscience & Biobehavioral Reviews, 83, 489-495. doi: 10.1016/j.neubiorev.2017.09.013
Smith, P. F. (2017). Bionic balance organs: Progress in the development of vestibular prostheses. New Zealand Medical Journal, 130(1461), 56-65. Retrieved from http://www.nzma.org.nz/journal
Zheng, Y., Gliddon, C. M., Aitken, P., Stiles, L., Machado, M.-L., Philoxene, B., … Smith, P. F., & Besnard, S. (2017). Effects of acute altered gravity during parabolic flight and/or vestibular loss on cell proliferation in the rat dentate gyrus. Neuroscience Letters, 654, 120-124. doi: 10.1016/j.neulet.2017.06.033
Aitken, P., Zheng, Y., & Smith, P. F. (2017). Ethovision™ analysis of open field behaviour in rats following bilateral vestibular loss. Journal of Vestibular Research, 27, 89-101. doi: 10.3233/VES-170612
He, J., Zhu, Y., Aa, J., Smith, P. F., De Ridder, D., Wang, G., & Zheng, Y. (2017). Brain metabolic changes in rats following acoustic trauma. Frontiers in Neuroscience, 11, 148. doi: 10.3389/fnins.2017.00148
Aitken, P., Zheng, Y., & Smith, P. F. (2017). Effects of bilateral vestibular deafferentation in rat on hippocampal theta response to somatosensory stimulation, acetylcholine release, and cholinergic neurons in the pedunculopontine tegmental nucleus. Brain Structure & Function, 222(7), 3319-3332. doi: 10.1007/s00429-017-1407-1
Liu, P., Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Smith, P. F. (2017). Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum. Neuroscience, 348, 273-287. doi: 10.1016/j.neuroscience.2017.02.033
Smith, P. F. (2017). The vestibular system and cognition. Current Opinion in Neurology, 30(1), 84-89. doi: 10.1097/wco.0000000000000403
Abouzayd, M., Smith, P. F., Moreau, S., & Hitier, M. (2017). What vestibular tests to choose in symptomatic patients after a cochlear implant? A systematic review and meta-analysis. European Archives of Oto-Rhino-Laryngology, 274(1), 53-63. doi: 10.1007/s00405-016-4007-4
Journal - Research Other
Smith, P. F. (2017). A guerilla guide to common problems in 'neurostatistics': Essential statistical topics in neuroscience. Journal of Undergraduate Neuroscience Education, 16(1), R1-R12. [Review].
Conference Contribution - Published proceedings: Abstract
Tan, H., Smith, P. F., & Zheng, Y. (2017). Neurotransmitter changes in the auditory and non-auditory brain regions of rats following tinnitus-inducing acoustic trauma. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 54). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Smith, P. F., Hitier, M., Zhang, Y., Sato, G., Besnard, S., & Zheng, Y. (2017). Effects of selective electrical stimulation of semi-circular canal and otolithic vestibular receptors on field potential activity in the rat hippocampus. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 25). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Zheng, Y., Tan, H., & Smith, P. F. (2017). Effects of tinnitus-inducing acoustic trauma on neurotransmitter release in response to sound stimulation in the inferioir colliculus of rats: Preliminary results. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 24). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Tan, H. T., Smith, P. F., & Zheng, Y. (2017). Neurotransmitter changes in the auditory and non-auditory brain regions of rats following tinnitus-inducing acoustic trauma. New Zealand Medical Journal, 130(1461), (pp. 91). Retrieved from http://www.nzma.org.nz/journal
Conference Contribution - Verbal presentation and other Conference outputs
Aitken, P., Zheng, Y., & Smith, P. F. (2017, September). Effects of bilateral vestibular loss in the rat on the cholinergic theta pathways into the hippocampus. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Section (ASCEPT-NZ) Annual Scientific Meeting, Queenstown, New Zealand.
Smith, P. (2017, September). Neurostatistics: Common problems arising in statistical analyses in neuroscience. Verbal presentation at the Symposium in Honour of Associate Professor John Harraway, Dunedin, New Zealand.
2016
Journal - Research Article
Aitken, P., Benoit, A., Zheng, Y., Philoxene, B., Le Gall, A., Denise, P., … Smith, P. F. (2016). Hippocampal and striatal M1-muscarinic acetylcholine receptors are down-regulated following bilateral vestibular loss in rats. Hippocampus, 26(12), 1509-1514. doi: 10.1002/hipo.22651
Smith, P. F., Renner, R. M., & Haslett, S. J. (2016). Compositional data in neuroscience: If you've got it, log it! Journal of Neuroscience Methods, 271, 154-159. doi: 10.1016/j.jneumeth.2016.07.008
Tranter-Entwistle, I., Dawes, P., Darlington, C. L., Smith, P. F., & Cutfield, N. (2016). Video head impulse in comparison to caloric testing in unilateral vestibular schwannoma. Acta Oto-Laryngologica, 136(11), 1110-1114. doi: 10.1080/00016489.2016.1185540
Hitier, M., Sato, G., Zhang, Y.-f., Zheng, Y., Besnard, S., Smith, P. F., & Curthoys, I. S. (2016). Anatomy and surgical approach of rat’s vestibular sensors and nerves. Journal of Neuroscience Methods, 270, 1-8. doi: 10.1016/j.jneumeth.2016.05.013
Smith, P. F. (2016). Age-related neurochemical changes in the vestibular nuclei. Frontiers in Neurology, 7, 20. doi: 10.3389/fneur.2016.00020
Balabhadrapatruni, S., Zheng, Y., Napper, R., & Smith, P. F. (2016). Basal dendritic length is reduced in the rat hippocampus following bilateral vestibular deafferentation. Neurobiology of Learning & Memory, 131, 56-60. doi: 10.1016/j.nlm.2016.03.009
Smith, P. F., & Zheng, Y. (2016). Cannabinoids, cannabinoid receptors and tinnitus. Hearing Research, 332, 210-216. doi: 10.1016/j.heares.2015.09.014
Conference Contribution - Published proceedings: Abstract
Zheng, Y., Aa, J., He, J., Zhu, Y., Vagal, S., Wang, G., & Smith, P. F. (2016). Long-term brain metabolic changes in rats following tinnitus-inducing acoustic trauma: A pilot study. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 25). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
2015
Chapter in Book - Research
Vidal, P. P., Cullen, K., Curthoys, I. S., Du Lac, S., Holstein, G., Idoux, E., … Smith, P. (2015). The vestibular system. In G. Paxinos (Ed.), The rat nervous system. (4th ed.) (pp. 805-864). London, UK: Academic Press. doi: 10.1016/B978-0-12-374245-2.00028-0
Journal - Research Article
Zheng, Y., Smithies, H., Aitken, P., Gliddon, C., Stiles, L., Darlington, C. L., & Smith, P. F. (2015). Cell proliferation in the cochlear nucleus following acoustic trauma in rat. Neuroscience, 303, 524-534. doi: 10.1016/j.neuroscience.2015.07.033
Zheng, Y., McPherson, K., Reid, P., & Smith, P. F. (2015). The anti-inflammatory selective melanocortin receptor subtype 4 agonist, RO27-3225, fails to prevent acoustic trauma-induced tinnitus in rats. European Journal of Pharmacology, 761, 206-210. doi: 10.1016/j.ejphar.2015.05.007
Zheng, Y., Reid, P., & Smith, P. F. (2015). Cannabinoid CB1 receptor agonists do not decrease, but may increase, acoustic trauma-induced tinnitus in rats. Frontiers in Neurology, 6, 60. doi: 10.3389/fneur.2015.00060
Stiles, L., & Smith, P. F. (2015). The vestibular-basal ganglia connection: Balancing motor control. Brain Research, 1597, 180-188. doi: 10.1016/j.brainres.2014.11.063
Zheng, Y., Dixon, S., McPherson, K., & Smith, P. F. (2015). Glutamic acid decarboxylase levels in the cochlear nucleus of rats with acoustic trauma-induced chronic tinnitus. Neuroscience Letters, 586, 60-64. doi: 10.1016/j.neulet.2014.11.047
Journal - Research Other
Besnard, S., Lopez, C., Brandt, T., Denise, P., & Smith, P. F. (2015). The vestibular system in cognitive and memory processes in mammalians. Frontiers in Integrative Neuroscience, 9, 55. doi: 10.3389/fnint.2015.00055
Conference Contribution - Published proceedings: Abstract
Gliddon, C. M., Zheng, Y., Aitken, P., Stiles, L., Hitier, M., Machado, M.-L., … Smith, P., Darlington, C., & Besnard, S. (2015). Effects of vestibular loss and parabolic flight on cell proliferation in the rat dentate gyrus. Proceedings of the Society for Neuroscience 45th Annual Meeting. 335.02/T13. SfN. Retrieved from https://www.sfn.org
Stiles, L., Zheng, Y., Napper, R. M., & Smith, P. F. (2015). Changes in c-Fos expression in the striatum following electrical stimulation of the peripheral vestibular system. Proceedings of the Society for Neuroscience 45th Annual Meeting. 236.02/L21. SfN. Retrieved from https://www.sfn.org/
Aitken, P., Zheng, Y., & Smith, P. F. (2015). Bilateral vestibular lesions increase sensitivity to non-vestibular induced theta rhythm in rats. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 68). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
2014
Journal - Research Article
Smith, P. F., Darlington, C. L., & Zheng, Y. (2014). The effects of complete vestibular deafferentation on spatial memory and the hippocampus in rat: The Dunedin experience. Multisensory Research, 28(5-6), 461-485. doi: 10.1163/22134808-00002469
Smith, P. F., & Zheng, Y. (2014). Cannabis, cannabinoids and tinnitus. Journal of Pharmacology & Drug Metabolism, 1, 1-6. Retrieved from http://www.jscholaronline.org/journals/journal-of-pharmacology-and-drug-metabolism/jhome.php
Zheng, Y., Stiles, L., Chien, Y.-T., Darlington, C. L., & Smith, P. F. (2014). The effects of acute stress-induced sleep disturbance on acoustic trauma-induced tinnitus in rats. BioMed Research International, 2014, 724195. doi: 10.1155/2014/724195
Hitier, M., Besnard, S., & Smith, P. F. (2014). Vestibular pathways involved in cognition. Frontiers in Integrative Neuroscience, 8, 59. doi: 10.3389/fnint.2014.00059
Rivers-Auty, J. R., Smith, P. F., & Ashton, J. C. (2014). The cannabinoid CB2 receptor agonist GW405833 does not ameliorate brain damage induced by hypoxia-ischemia in rats. Neuroscience Letters, 569, 104-109. doi: 10.1016/j.neulet.2014.03.077
Zheng, Y., Geddes, L., Sato, G., Stiles, L., Darlington, C. L., & Smith, P. F. (2014). Galvanic vestibular stimulation impairs cell proliferation and neurogenesis in the rat hippocampus but not spatial memory. Hippocampus, 24(5), 541-552. doi: 10.1002/hipo.22247
Zheng, Y., McPherson, K., & Smith, P. F. (2014). Effects of early and late treatment with L-baclofen on the development and maintenance of tinnitus caused by acoustic trauma in rats. Neuroscience, 258, 410-421. doi: 10.1016/j.neuroscience.2013.11.032
Journal - Research Other
Hornibrook, J., & Smith, P. F. (2014). Dizziness caused by medications. New Zealand Medical Journal, 127(1388). Retrieved from http://www.nzma.org.nz/journal
Journal - Professional & Other Non-Research Articles
Ashton, J. C., Zheng, Y., Darlington, C., Baek, J.-H., & Smith, P. F. (2014). Cannabinoid CB2 receptor immunolabelling in the healthy brain—still a live possibility. Naunyn-Schmiedeberg's Archives of Pharmacology, 387(3), 301. doi: 10.1007/s00210-013-0948-y
Conference Contribution - Published proceedings: Abstract
Zheng, Y., Smithies, H., Aitken, P., Darlington, C. L., & Smith, P. F. (2014). Neurogenesis in the rat cochlear nucleus and the effects of acoustic trauma. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 78). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html
Cutfield, N., Tranter-Entwistle, I., Smith, P., Darlington, C., & Dawes, P. (2014). Video head impulse testing in comparison to caloric testing in pre-surgical vestibular Schwannoma University of Otago, Dunedin, New Zealand. Journal of Vestibular Research, 24(2-3 (Special Issue)), (pp. 224-225). doi: 10.3233/VES-140514
2013
Journal - Research Article
Smith, P. F., & Zheng, Y. (2013). From ear to uncertainty: Vestibular contributions to cognitive function. Frontiers in Integrative Neuroscience, 7, 84. doi: 10.3389/fnint.2013.00084
Smith, P. F., Ganesh, S., & Liu, P. (2013). A comparison of random forest regression and multiple linear regression for prediction in neuroscience. Journal of Neuroscience Methods, 220(1). doi: 10.1016/j.jneumeth.2013.08.024
Smith, P. F., & Zheng, Y. (2013). Principal component analysis suggests subtle changes in glutamate receptor subunit expression in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience Letters, 548, 265-268. doi: 10.1016/j.neulet.2013.05.036
Baek, J.-H., Darlington, C. L., Smith, P. F., & Ashton, J. C. (2013). Antibody testing for brain immunohistochemistry: Brain immunolabeling for the cannabinoid CB2 receptor. Journal of Neuroscience Methods, 216(2), 87-95. doi: 10.1016/j.jneumeth.2013.03.021
Smith, P. F., Haslett, S., & Zheng, Y. (2013). A multivariate statistical and data mining analysis of spatial memory–related behaviour following bilateral vestibular loss in the rat. Behavioural Brain Research, 246, 15-23. doi: 10.1016/j.bbr.2013.02.033
Zheng, Y., Wilson, G., Stiles, L., & Smith, P. F. (2013). Glutamate receptor subunit and calmodulin kinase II expression, with and without T maze training, in the rat hippocampus following bilateral vestibular deafferentation. PLoS ONE, 8(2), e54527. doi: 10.1371/journal.pone.0054527
Journal - Research Other
Smith, P. F. (2013). Vestibular dysfunction and Alzheimer’s disease. Medical Hypotheses, 81(6), 1169-1170. doi: 10.1016/j.mehy.2013.09.034
Smith, P. F., & Darlington, C. L. (2013). Personality changes in patients with vestibular dysfunction. Frontiers in Human Neuroscience, 7, 678. doi: 10.3389/fnhum.2013.00678
Conference Contribution - Published proceedings: Abstract
Hitier, M., Zhang, Y. F., Sato, G., Zheng, Y., Denise, P., Besnard, S., & Smith, P. F. (2013). Eye movements during selective electrical vestibular stimulation in rat. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 76). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Zhang, Y. F., Sato, G., Hitier, M., Zheng, Y., Denise, P., Besnard, S., & Smith, P. F. (2013). Functional relations between the vestibular system and hippocampus. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 59). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Sato, G., Sekine, K., Matsuda, K., Takeda, N., & Smith, P. F. (2013). Risk factors for poor outcome of a single Epley maneuver and residual positional vertigo in patients with benign paroxysmal positional vertigo. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 57). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Smith, P. F., Geddes, L. H., Stiles, L., Sato, G., Darlington, C. L., & Zheng, Y. (2013). The effects of galvanic vestibular stimulation on cell proliferation in the rat hippocampus and spatial memory. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 30). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Zheng, Y., McPherson, K., Stiles, L., Darlington, C. L., & Smith, P. F. (2013). Effects of early treatment with L-baclofen on the development of tinnitus induced by acoustic trauma in rats. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 28). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Zheng, Y., McNamara, E., Aitken, P., & Smith, P. F. (2013). Cell proliferation in the rat cochlear nucleus following noise exposure. Proceedings of the 7th International Tinnitus Research Initiative (TRI) Conference: Tinnitus: A Treatable Disease. (pp. 47). Retrieved from http://www.tinnitusresearch.org/
Zheng, Y., McPherson, K., Stiles, L., Darlington, C. L., & Smith, P. F. (2013). Effect of early treatment with L-baclofen on the development of tinnitus induced by acoustic trauma in rats. Proceedings of the 7th International Tinnitus Research Initiative (TRI) Conference: Tinnitus: A Treatable Disease. (pp. 23). Retrieved from http://www.tinnitusresearch.org/
2012
Journal - Research Article
Zheng, Y., McNamara, E., Stiles, L., Darlington, C. L., & Smith, P. F. (2012). Evidence that memantine reduces chronic tinnitus caused by acoustic trauma in rats. Frontiers in Neurology, 3, 127. doi: 10.3389/fneur.2012.00127
Smith, P. F. (2012). Dyscalculia and vestibular function. Medical Hypotheses, 79(4), 493-496. doi: 10.1016/j.mehy.2012.06.032
Zheng, Y., Cheung, I., & Smith, P. F. (2012). Performance in anxiety and spatial memory tests following bilateral vestibular loss in the rat and effects of anxiolytic and anxiogenic drugs. Behavioural Brain Research, 235(1), 21-29. doi: 10.1016/j.bbr.2012.07.025
Zheng, Y., Balabhadrapatruni, S., Baek, J. H., Chung, P., Gliddon, C., Zhang, M., Darlington, C. L., Napper, R., … Smith, P. F. (2012). The effects of bilateral vestibular loss on hippocampal volume, neuronal number, and cell proliferation in rats. Frontiers in Neurology, 3, 20. doi: 10.3389/fneur.2012.00020
Stiles, L., Zheng, Y., Darlington, C. L., & Smith, P. F. (2012). The D2 dopamine receptor and locomotor hyperactivity following bilateral vestibular deafferentation in the rat. Behavioural Brain Research, 227(1), 150-158. doi: 10.1016/j.bbr.2011.11.006
Stiles, L., Zheng, Y., Darlington, C. L., & Smith, P. F. (2012). The effects of the D2 dopamine receptor antagonist, eticlopride, on attention following bilateral vestibular deafferentation in the rat. Neuroscience Letters, 506(2), 193-197. doi: 10.1016/j.neulet.2011.11.003
Zheng, Y., Vagal, S., McNamara, E., Darlington, C. L., & Smith, P. F. (2012). A dose–response analysis of the effects of L-baclofen on chronic tinnitus caused by acoustic trauma in rats. Neuropharmacology, 62, 940-946. doi: 10.1016/j.neuropharm.2011.09.027
Neo, P., Carter, D., Zheng, Y., Smith, P., Darlington, C., & McNaughton, N. (2012). Septal elicitation of hippocampal theta rhythm did not repair cognitive and emotional deficits resulting from vestibular lesions. Hippocampus, 22(5), 1176-1187. doi: 10.1002/hipo.20963
Journal - Research Other
Smith, P. F. (2012). A note on the advantages of using linear mixed model analysis with maximal likelihood estimation over repeated measures ANOVAs in psychopharmacology: Comment on Clark et al. (2012). Journal of Psychopharmacology, 26(12), 1605-1607. doi: 10.1177/0269881112463471
Smith, P. F. (2012). Statistical analysis in pharmacology is not always BO. Trends in Pharmacological Sciences, 33(11), 565-566. doi: 10.1016/j.tips.2012.08.006
Smith, P. F. (2012). Interactions between the vestibular nucleus and the dorsal cochlear nucleus: Implications for tinnitus [Short communication]. Hearing Research, 292(1-2), 80-82. doi: 10.1016/j.heares.2012.08.006
Smith, P. F., Zheng, Y., & Darlington, C. L. (2012). Revisiting baclofen for the treatment of severe chronic tinnitus. Frontiers in Neurology, 3, 34. doi: 10.3389/fneur.2012.00034
Conference Contribution - Published proceedings: Abstract
Machado, M. L., Lelong-Boulouard, V., Smith, P., Freret, T., Philoxene, B., Denise, P., & Besnard, S. (2012). Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat. Fundamental & Clinical Pharmacology, 26(Suppl. s1), (pp. 61). doi: 10.1111/j.1472-8206.2012.01032.x
2011
Chapter in Book - Research
Smith, P. F. (2011). The endocannabinoid system in the cochlear nucleus and its implications for tinnitus treatment. In A. R. Møller, B. Langguth, D. De Ridder & T. Kleinjung (Eds.), Textbook of tinnitus. (pp. 639-647). New York: Springer. doi: 10.1007/978-1-60761-145-5_79
Journal - Research Article
Zheng, Y., Balabhadrapatruni, S., Masumura, C., Darlington, C. L., & Smith, P. F. (2011). Effects of the putative cognitive-enhancing ampakine, CX717, on attention and object recognition memory. Current Alzheimer Research, 8(8), 876-882. doi: 10.2174/156720511798192709
Hüfner, K., Strupp, M., Smith, P., Brandt, T., & Jahn, K. (2011). Spatial separation of visual and vestibular processing in the human hippocampal formation. Annals of the New York Academy of Sciences, 1233, 177-186. doi: 10.1111/j.1749-6632.2011.06115.x
Zheng, Y., Hamilton, E., McNamara, E., Smith, P. F., & Darlington, C. L. (2011). The effects of chronic tinnitus caused by acoustic trauma on social behaviour and anxiety in rats. Neuroscience, 193, 143-153. doi: 10.1016/j.neuroscience.2011.07.026
Zheng, Y., Hamilton, E., Begum, S., Smith, P. F., & Darlington, C. L. (2011). The effects of acoustic trauma that can cause tinnitus on spatial performance in rats. Neuroscience, 186, 48-56. doi: 10.1016/j.neuroscience.2011.04.052
Zheng, Y., Hamilton, E., Stiles, L., McNamara, E., de Waele, C., Smith, P. F., & Darlington, C. L. (2011). Acoustic trauma that can cause tinnitus impairs impulsive control but not performance accuracy in the 5-choice serial reaction time task in rats. Neuroscience, 180, 75-84. doi: 10.1016/j.neuroscience.2011.02.040
Zheng, Y., Begum, S., Zhang, C., Fleming, K., Masumura, C., Zhang, M., Smith, P., & Darlington, C. (2011). Increased BrdU incorporation reflecting DNA repair, neuronal de-differentiation or possible neurogenesis in the adult cochlear nucleus following bilateral cochlear lesions in the rat. Experimental Brain Research, 210(3-4), 477-487. doi: 10.1007/s00221-010-2491-0
Baek, J. H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2011). Cannabinoid CB1 receptor expression and affinity in the rat hippocampus following bilateral vestibular deafferentation. Neuroscience Letters, 487(3), 330-334. doi: 10.1016/j.neulet.2010.10.050
Conference Contribution - Published proceedings: Abstract
McNamara, E. J., Zheng, Y., Darlington, C. L., & Smith, P. F. (2011). Memantine: A promising treatment for acoustic trauma-induced tinnitus. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29 , 8.7. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Cheung, I. C. W., Smith, P. F., Darlington, C. L., & Zheng, Y. (2011). Do rats with bilateral vestibular lesions experience anxiety? In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.37. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Stiles, L., Zheng, Y., Darlington, C. L., & Smith, P. F. (2011). The effects of D2 dopamine receptor antagonism on behavioural changes in bilateral vestibular deafferented rats. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.36. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Balabhadrapatruni, S., Napper, R., Zheng, Y., Darlington, C. L., & Smith, P. F. (2011). Effects of bilateral vestibular deafferentation on the dendritic morphology of CA1 pyramidal neurones: A Golgi study. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.35. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Conference Contribution - Verbal presentation and other Conference outputs
Smith, P. (2011, May). Vestibular and auditory influences on the hippocampus. Verbal presentation at the Spring Hippocampal Research Conference, Verona, Italy.
2010
Journal - Research Article
Baek, J. H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2010). Evidence that spatial memory deficits following bilateral vestibular deafferentation in rats are probably permanent. Neurobiology of Learning & Memory, 94(3), 402-413. doi: 10.1016/j.nlm.2010.08.007
Goddard, M., Smith, P. F., & Ashton, J. C. (2010). Behavioural effects of co-administration of Δ9-tetrahydrocannabinol with fluoxetine in rats. Pharmacology, 86(2), 125-128. doi: 10.1159/000317059
Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019
Zheng, Y., Stiles, L., Hamilton, E., Smith, P. F., & Darlington, C. L. (2010). The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats. Hearing Research, 268(1-2), 145-150. doi: 10.1016/j.heares.2010.05.015
Zheng, Y., Mason-Parker, S. E., Logan, B., Darlington, C. L., Smith, P. F., & Abraham, W. C. (2010). Hippocampal synaptic transmission and LTP in vivo are intact following bilateral vestibular deafferentation in the rat. Hippocampus, 20(4), 461-468. doi: 10.1002/hipo.20645
Smith, P. F. (2010). New approaches in the management of spasticity in multiple sclerosis patients: Role of cannabinoids. Therapeutics & Clinical Risk Management, 6, 59-63.
Zheng, Y., Vagal, S., Zhu, X.-X., de Waele, C., Smith, P. F., Wang, G., Zhang, M., & Darlington, C. L. (2010). The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats. Journal of Ethnopharmacology, 128(2), 545-548. doi: 10.1016/j.jep.2010.01.053
Smith, P. F., & Darlington, C. L. (2010). A possible explanation for dizziness following SSRI discontinuation. Acta Oto-Laryngologica, 130, 981-983. doi: 10.3109/00016481003602082
Zheng, Y., Masumura, C., Chung, P., Darlington, C. L., & Smith, P. F. (2010). Cell proliferation and survival in the vestibular nucleus following bilateral vestibular deafferentation in the adult rat. Neuroscience Letters, 468(1), 85-88. doi: 10.1016/j.neulet.2009.10.070
Journal - Research Other
Smith, P. F., Geddes, L. H., Baek, J.-H., Darlington, C. L., & Zheng, Y. (2010). Modulation of memory by vestibular lesions and galvanic vestibular stimulation. Frontiers in Neurology, 1, 141. doi: 10.3389/fneur.2010.00141
Smith, P. F., Darlington, C. L., & Zheng, Y. (2010). Move it or lose it: Is stimulation of the vestibular system necessary for normal spatial memory? Hippocampus, 20(1), 36-43. doi: 10.1002/hipo.20588
Conference Contribution - Published proceedings: Full paper
Smith, P. F., Zheng, Y., & Darlington, C. L. (2010). Promising medications for tinnitus. New Zealand Medical Journal, 123(1311). Retrieved from http://journal.nzma.org.nz/journal/123-1311/4040/content.pdf
Darlington, C. L., Smith, P. F., & Zheng, Y. (2010). Animal models of tinnitus. New Zealand Medical Journal, 123(1311). Retrieved from http://journal.nzma.org.nz/journal/123-1311/4040/content.pdf
Conference Contribution - Published proceedings: Abstract
Balabhadrapatruni, S., Zheng, Y., Darlington, C. L., Napper, R., & Smith, P. F. (2010). Long-term effects of bilateral vestibular deafferentation on the total number of neurons in the subregions of the hippocampus estimated using the optical fractionator. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 29). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Zheng, Y., Hamilton, E., Stiles, L., Smith, P. F., & Darlington, C. L. (2010). Inducing and assessing chronic tinnitus in rats using unilateral acoustic trauma and a frequency-specific shift in discrimination function with a conditioned lick suppression paradigm. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 45). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Hamilton, E., Zheng, Y., Darlington, C. L., & Smith, P. F. (2010). Effects of chronic tinnitus on attention and impulsive behavior in rats. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 46). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Vagal, S., Zheng, Y., Hamilton, E., Darlington, C. L., & Smith, P. F. (2010). Effects of baclofen on chronic tinnitus induced by acoustic trauma. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 46). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Stiles, L., Zheng, Y., Hamilton, E., Smith, P. F., & Darlington, C. L. (2010). Effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 47). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Baek, J.-H., Zheng, Y., Darlington, C., & Smith, P. (2010). Permanent spatial memory deficits after bilateral vestibular deafferentation and the effects of cannabinoids. New Zealand Medical Journal, 123(1321). Retrieved from http://journal.nzma.org.nz/journal/123-1321/4329/content.pdf
2009
Chapter in Book - Research
Darlington, C. L., Zheng, Y., & Smith, P. F. (2009). Herbal medicinal products for tinnitus: Perspectives and evaluation. In P. Houghton & P. K. Mukherjee (Eds.), Evaluation of herbal medicinal products. (pp. 314-321). London: Pharmaceutical Press.
Smith, P. F., Darlington, C. L., & Zheng, Y. (2009). Cognitive deficits following complete bilateral loss of vestibular function and their relationship to the hippocampus. In A. Lindqvist & G. Nyman (Eds.), Dizziness: Vertigo, disequilibrium and lightheadedness. New York: Nova Science.
Journal - Research Article
Baek, J. h., Zheng, Y., Darlington, C. L., & Smith, P. F. (2009). The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. Neuroscience Letters, 464(1), 71-73. doi: 10.1016/j.neulet.2009.08.008
Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2009). Long-term deficits on a foraging task after bilateral vestibular deafferentation in rats. Hippocampus, 19(5), 480-486. doi: 10.1002/hipo.20533
Darlington, C. L., Goddard, M., Zheng, Y., & Smith, P. F. (2009). Anxiety-related behavior and biogenic amine pathways in the rat following bilateral vestibular lesions. Annals of the New York Academy of Sciences, 1164(1), 134-139. doi: 10.1111/j.1749-6632.2008.03725.x
Smith, P. F., Brandt, T., Strupp, M., Darlington, C. L., & Zheng, Y. (2009). Balance before reason in rats and humans. Annals of the New York Academy of Sciences, 1164(1), 127-133. doi: 10.1111/j.1749-6632.2008.03726.x
Zheng, Y., Balabhadrapatruni, S., Masumura, C., Munro, O., Darlington, C. L., & Smith, P. F. (2009). Bilateral vestibular deafferentation causes deficits in a 5-choice serial reaction time task in rats. Behavioural Brain Research, 203, 113-117. doi: 10.1016/j.bbr.2009.04.027
Alexander, A., Smith, P. F., & Rosengren, R. J. (2009). Cannabinoids in the treatment of cancer. Cancer Letters, 285(1), 6-12. doi: 10.1016/j.canlet.2009.04.005
Conference Contribution - Published proceedings: Abstract
Alexander, A., Baek, J., Stuart, E. C., Taurin, S., Smith, P. F., & Rosengren, R. J. (2009). A CB1 specific agonist, JWH-133 accelerates tumor growth in a xenograft model of estrogen receptor negative breast cancer. The Toxicologist. [CD-ROM], 108(1), (pp. 346). [Abstract]
Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2009). The effect of the cannabinoid agonist, WIN 55212-2 on object recognition memory in rats. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx
Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2009). Aging alters agmatine levels in memory-associated brain structures. Journal of Neurochemistry. 109(Suppl. 1), (pp. 304). doi: 10.1111/j.1471-4159.2009.05927.x
Conference Contribution - Poster Presentation (not in published proceedings)
Vagal, S., Darlington, C. L., Smith, P. F., & Zheng, Y. (2009, September). Effects of a Chinese herbal mixture (EMF01) in an animal model of tinnitus. Poster session presented at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2009, September). The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Smith, P. F., Devaraj, R., Zhang, H., Ganesalingham, G., & Liu, P. (2009, September). Multivariate analysis of neurochemical changes in the aging rat brain. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
2008
Journal - Research Article
Liu, P., Smith, P. F., & Darlington, C. L. (2008). Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Synapse, 62, 834-841. doi: 10.1002/syn.20563
Goddard, M., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Synaptic protein expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss. Hippocampus, 18(5), 440-444. doi: 10.1002/hipo.20416
Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2008). Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus, 18, 853-856. doi: 10.1002/hipo.20448
Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2008). Effects of bilateral vestibular deafferentation on anxiety-related behaviours in Wistar rats. Behavioural Brain Research, 193(1), 55-62. doi: 10.1016/j.bbr.2008.04.018
Goddard, M., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Monoamine transporter and enzyme expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss. Neuroscience Letters, 437(2), 107-110. doi: 10.1016/j.neulet.2008.03.073
Goddard, M., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Locomotor and exploratory behavior in the rat following bilateral vestibular deafferentation. Behavioral Neuroscience, 122(2), 448-459. doi: 10.1037/0735-7044.122.2.448
Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Cannabinoid CB2 receptor expression in the rat brainstem cochlear and vestibular nuclei. Acta Oto-Laryngologica, 128(9), 961-967. doi: 10.1080/00016480701796944
Ashton, J. C., Smith, P. F., & Darlington, C. L. (2008). The effect of Δ9-tetrahydrocannabinol on the extinction of an adverse associative memory. Pharmacology, 81(1), 18-20. doi: 10.1159/000107663
Smith, P. F. (2008). Inflammation in Parkinson's disease: An update. Current Opinion in Investigational Drugs, 9(5), 478-484.
Zheng, Y., Hooton, K., Smith, P. F., & Darlington, C. L. (2008). Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatments in rats. Acta Oto-Laryngologica, 128(1), 48-52. doi: 10.1080/00016480701361939
Conference Contribution - Published proceedings: Abstract
Zhang, C., Zheng, Y., Smith, P., & Zhang, M. (2008). Increased cell proliferation in the cochlear nucleus following bilateral cochlear lesions. New Zealand Medical Journal, 121(1274). Retrieved from http://journal.nzma.org.nz/journal/121-1274/3078/content.pdf
Darlington, C., Zhang, C., Zhang, M., Fleming, K., Smith, P. F., & Zheng, Y. (2008). Cell proliferation in the cochlear nucleus following bilateral cochlear lesions. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf
Zheng, Y., Balabhadrapatruni, S., Masumura, C., Darlington, C. L., & Smith, P. F. (2008). Effects of CX717 on attentional performance in rats with bilateral vestibular deafferentation. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf
Smith, P. F., Goddard, M., Masumura, C., Chung, P., Darlington, C. L., & Zheng, Y. (2008). Balance before reason. Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting. ASCEPT. Retrieved from http://phal.otago.ac.nz/ascept_docos/programme%202008.pdf
Balabhadrapatruni, S., Zheng, Y., Masumura, C., Darlington, C. L., & Smith, P. F. (2008). Effects of bilateral vestibular deafferentation on attentional performance in a five-choice serial reaction time task in rats. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 68). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Zheng, Y., Chung, P., Masumura, C., Darlington, C. L., Brandt, T., Strupp, M., Zhang, M., & Smith, P. F. (2008). Time course changes in hippocampal cell proliferation following bilateral vestibular damage in rats. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 61). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Ashton, J., Goddard, M., & Smith, P. (2008). Interaction between 5-HT pathways and the endocannabinoid system in the regulation of anxiety. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 54). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2008). Changes in hippocampal cannabinoid CB2 receptor expression following the bilateral vestibular deafferentation. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 46). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Masumura, C., Hooton, K., Horii, A., Zheng, Y., Smith, P. F., & Darlington, C. L. (2008). Evaluating cannabinoid receptor agonist for the treatment of salicylate induced tinnitus in rats. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 32). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2008, June-July). Aging alters agmatine levels in memory-associated brain structures. Poster session presented at the Third International Society for Neurochemistry Special Neurochemistry Conference: 8th International Meeting on Brain Energy Metabolism, Beijing, China.
2007
Chapter in Book - Research
Ashton, J. C., & Smith, P. F. (2007). Bcl-2 and mitochondrial control of apoptosis as a mechanism for regulating neural plasticity. In L. B. Shultz (Ed.), Cell Apoptosis: Regulation and Environmental Factors. (pp. 1-23). New York: Nova Science.
Smith, P. F., Zheng, Y., Goddard, M., & Darlington, C. L. (2007). Cognitive impairment due to inner ear damage. In H. C. Sentowski (Ed.), Cognitive Disorders Research Trends. (pp. 231-243). New York: Nova Science.
Journal - Research Article
Ashton, J. C., & Smith, P. F. (2007). Cannabinoids and cardiovascular disease: The outlook for clinical treatments. Current Vascular Pharmacology, 5(3), 175-184.
Smith, P. F. (2007). Will medicinal cannabinoids prove to be useful clinically? Current Drug Therapy, 2(2), 143-150.
Smith, P. F. (2007). Symptomatic treatment of multiple sclerosis using cannabinoids: Recent advances. Expert Review of Neurotherapeutics, 7(9), 1157-1163.
Zheng, Y., Baek, J.-H., Smith, P. F., & Darlington, C. L. (2007). Cannabinoid receptor down-regulation in the ventral cochlear nucleus in a salicylate model of tinnitus. Hearing Research, 228, 105-111.
Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2007). Bilateral vestibular deafferentation impairs performance in a spatial forced alternation task in rats. Hippocampus, 17, 253-256.
Darlington, C. L., & Smith, P. F. (2007). Drug treatments for tinnitus. Progress in Brain Research, 166, 249-262. doi: 10.1016/s0079-6123(07)66023-3
Conference Contribution - Published proceedings: Abstract
Darlington, C. L., Hooton, K., Smith, P. F., & Zheng, Y. (2007). Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatment in rats. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 56). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
Masumura, C., Horii, A., Darlington, C. L., & Smith, P. F. (2007). The effects of a calcineurin inhibitor on vestibular compensation. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 38). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
Baek, J.-H., Zheng, Y., Darlington, C. L., & Smith, P. F. (2007). Expression of cannabinoid receptors in the hindbrain. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 51). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2007). Effects of bilateral vestibular deafferentation on open field activity in rats. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 55). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
Smith, P. F., Goddard, M., Darlington, C. L., & Zheng, Y. (2007). Neurochemical changes in the hippocampus following bilateral vestibular damage. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 55). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
Baek, J.-H., Zheng, Y., Ashton, J. C., Darlington, C. L., & Smith, P. F. (2007). Abundant expression of the cannabinoid CB2 receptors in the rat cerebellum. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp
Liu, P., Devaraj, R., Collie, N. D., Chary, S., Bilkey, D. K., Smith, P. F., Darlington, C. L., & Zhang, H. (2007). Effects of aging on agmatine levels in memory-associated brain structures. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 26). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
2006
Journal - Research Article
Zheng, Y., Darlington, C. L., & Smith, P. F. (2006). Impairment and recovery on a food foraging task following unilateral vestibular deafferentation in rats. Hippocampus, 16, 368-378.
Zheng, Y., Lee, H. S., Smith, P. F., & Darlington, C. L. (2006). Neuronal nitric oxide synthase expression in the cochlear nucleus in a salicylate model of tinnitus. Brain Research, 1123, 201-206.
Ashton, J. C., Darlington, C. L., & Smith, P. F. (2006). Co-distribution of the cannabinoid CB1 receptor and the 5-HT transporter in the rat amygdale. European Journal of Pharmacology, 537, 70-71.
Smith, P. F., Ashton, J. C., & Darlington, C. L. (2006). The endocannabinoid system: A new player in the neurochemical control of vestibular function? Audiology & Neurotology, 11, 207-212.
Russell, N. A., Horii, A., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2006). Lesions of the vestibular system disrupt hippocampal theta rhythm in the rat. Journal of Neurophysiology, 96, 4-14.
Fergusson, D. M., Poulton, R., Smith, P. F., & Boden, J. M. (2006). Cannabis and psychosis. BMJ, 332, 172-175. doi: 10.1136/bmj.332.7534.172
Ashton, J. C., Friberg, D., Darlington, C. L., & Smith, P. F. (2006). Expression of the cannabinoid CB2 receptor in the rat cerebellum: An immunohistochemical study. Neuroscience Letters, 396, 113-116.
Conference Contribution - Published proceedings: Abstract
Liu, P., Smith, P. F., & Darlington, C. L. (2006). Effects of aging on NMDA receptor subunits in memory-associated brain structures. In J. G. Anson (Ed.), Proceedings of the 24th International Australasian Winter Conference on Brain Research. 24, (pp. 57). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2006Abstracts.pdf
Liu, P., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2006). Effects of perirhinal nitric oxide synthase inhibition in the water maze task. Acta Pharmacologica Sinica. 27(Suppl.), (pp. 371). [Abstract]
2005
Chapter in Book - Research
Smith, P. F. (2005). Medicinal use of cannabis: Implications for lung cancer. In R. L. Carafaro (Ed.), Focus on lung cancer research. (pp. 193-209). New York, NY: Nova Science Publishers.
Smith, P. F. (2005). Cannabis and cannabinoids for the symptomatic treatment of multiple sclerosis. In F. Columbus (Ed.), Treatment and management of multiple sclerosis. (pp. 155-167). New York, NY: Nova Science Publishers.
Journal - Research Article
Smith, P. F., Zheng, Y., & Darlington, C. L. (2005). Ginkgo biloba extracts for tinnitus: More hype than hope? Journal of Ethnopharmacology, 100, 95-99.
Zhang, R., Smith, P. F., & Darlington, C. L. (2005). Immunocytochemical and stereological study of glucocorticoid receptors in rat medial vestibular nucleus neurons and the effects of unilateral vestibular deafferentation. Acta Oto-Laryngologica, 125, 1258-1264.
Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2005). GABAA receptor subunit expression in the guinea pig vestibular nucleus complex during the development of vestibular compensation. Experimental Brain Research, 166, 71-77. doi: 10.1007/s00221-005-2344-4
Ashton, J. C., Little, E., Muir, M., Smith, P. F., & Darlington, C. L. (2005). Mitochondrial ultrastructure and apoptotic protein expression in the vestibular nucleus complex following unilateral labyrinthectomy. Brain Research, 1055, 165-170.
Brandt, T., Schautzer, F., Hamilton, D. A., Brüning, R., Markowitsch, H. J., Kalla, R., Darlington, C., Smith, P., & Strupp, M. (2005). Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain, 128(11), 2732-2741. doi: 10.1093/brain/awh617
Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2005). GABAergic systems in the vestibular nucleus and their contribution to vestibular compensation. Progress in Neurobiology, 75, 53-81. doi: 10.1016/j.pneurobio.2004.11.001
Zhang, R., Ashton, J., Horii, A., Darlington, C. L., & Smith, P. F. (2005). Immunocytochemical and stereological analysis of GABAB receptor subunit expression in the rat vestibular nucleus following unilateral vestibular deafferentation. Brain Research, 1037(1-2), 107-113. doi: 10.1016/j.brainres.2005.01.018
Smith, P. F., Zheng, Y., Horii, A., & Darlington, C. L. (2005). Does vestibular damage cause cognitive dysfunction in humans? [Review]. Journal of Vestibular Research, 15, 1-9.
Zhang, R., Smith, P. F., & Darlington, C. L. (2005). Immunocytochemical and stereological studies of the rat vestibular nucleus: Optimal research methods using glucocorticoid receptors as an example. Journal of Neuroscience Methods, 144, 99-106.
Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2005). Effects of chronic infusion of a GABAA receptor agonist or antagonist into the vestibular nuclear complex on vestibular compensation in the guinea pig. Journal of Pharmacology & Experimental Therapeutics, 313(3), 1126-1135. doi: 10.1124/jpet.104.082172
Smith, P. F. (2005). Cannabinoids as potential anti-epileptic drugs. Current Opinion in Investigational Drugs, 6(7), 680-685.
Smith, P. F., & Darlington, C. L. (2005). Drug treatments for subjective tinnitus: Serendipitous discovery versus rational drug design. Current Opinion in Investigational Drugs, 6(7), 712-716.
Smith, P. F. (2005). The safety of cannabinoids for the treatment of multiple sclerosis. Expert Opinion on Drug Safety, 4(3), 443-456.
Ashton, J. C., Khalessi, A., Kapoor, M., Clarkson, A., Sammut, I. A., Darlington, C. L., & Smith, P. F. (2005). Characterization of mitochondrial respiratory chain energetics in the vestibular nucleus complex [Short Communication]. Acta Oto-Laryngologica, 125, 422-425.
Lindsay, L., Liu, P., Gliddon, C., Zheng, Y., Smith, P. F., & Darlington, C. L. (2005). Cytosolic glucocorticoid receptor expression in the rat vestibular nucleus and hippocampus following unilateral vestibular deafferentation. Experimental Brain Research, 162, 309-314. doi: 10.1007/s00221-004-2168-7
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2005). Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits. Hippocampus, 15, 642-655.
Smith, P. F., Horii, A., Russell, N., Bilkey, D. K., Zheng, Y., Liu, P., Kerr, D. S., & Darlington, C. L. (2005). The effects of vestibular lesions on hippocampal function in rats. Progress in Neurobiology, 75, 391-405.
Conference Contribution - Published proceedings: Abstract
Liu, P., Chen, G., Appleton, I., Smith, P. F., & Darlington, C. L. (2005). Regional variations and age-related changes in cyclooxygenase in memory-associated brain structures. Proceedings of the 23rd International Australasian Winter Conference on Brain Research. (pp. 55). [Abstract]
2004
Journal - Research Article
Horii, A., Masumura, C., Smith, P. F., Darlington, C. L., Kitahara, T., Uno, A., … Kubo, T. (2004). Microarray analysis of gene expression in the rat vestibular nucleus complex following unilateral vestibular deafferentation. Journal of Neurochemistry, 91, 975-982.
Smith, P. F. (2004). GW-1000 GW Pharmaceuticals. Current Opinion in Investigational Drugs, 5(7), 748-754.
Smith, P. F. (2004). Medicinal cannabis extracts for the treatment of multiple sclerosis. Current Opinion in Investigational Drugs, 5(7), 727-730.
Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2004). Rapid vestibular compensation in guinea pig even with prolonged anesthesia. Neuroscience Letters, 371, 138-141.
Zheng, Y., Darlington, C. L., & Smith, P. F. (2004). Bilateral labyrinthectomy causes long-term deficit in object recognition in rat. NeuroReport, 15, 1913-1916.
Ashton, J. C., Appleton, I., Darlington, C. L., & Smith, P. F. (2004). Cannabinoid CB1 receptor protein expression in the rat choroid plexus: A possible involvement of cannabinoids in the regulation of cerebrospinal fluid. Neuroscience Letters, 364, 40-42.
Ashton, J. C., Appleton, I., Darlington, C. L., & Smith, P. F. (2004). Immunohistochemical localization of cannabinoid CB1 receptor in inhibitory interneurons in the cerebellum. Cerebellum, 3, 222-226.
Ashton, J. C., Appleton, I., Darlington, C. L., & Smith, P. F. (2004). Immunohistochemical localization of cerebrovascular cannabinoid CB1 receptor protein. Journal of Cardiovascular Pharmacology, 44(5), 517-519.
Horii, A., Russell, N. A., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2004). Vestibular influences on CA1 neurons in the rat hippocampus: An electrophysiological study in vivo. Experimental Brain Research, 155(2), 245-250.
Liu, P., Gliddon, C. M., Lindsay, L., Darlington, C. L., & Smith, P. F. (2004). Nitric oxide synthase and arginase expression changes in the rat perirhinal and entorhinal cortices following unilateral vestibular damage: A link to deficits in object recognition? Journal of Vestibular Research, 14, 411-417.
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004). Potential involvement of NOS and arginase in age-related behavioural impairments. Experimental Gerontology, 39(8), 1207-1222.
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004). Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortex. Neurobiology of Aging, 25(4), 547-552.
Ashton, J. C., Zheng, Y., Liu, P., Darlington, C. L., & Smith, P. F. (2004). Immunohistochemical characterisation and localisation of cannabinoid CB1 receptor protein in the rat vestibular nucleus complex and the effects of unilateral vestibular deafferentation. Brain Research, 1021, 264-271.
Conference Contribution - Verbal presentation and other Conference outputs
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004, August). Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits. Verbal presentation at the 22nd International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
Commissioned Report for External Body
Smith, P. F. (2004). Drug Report for: GW-1000. Thomson Current Drugs. 19p.
2003
Journal - Research Article
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2003). Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus. Neuroscience, 119(3), 679-687.
Zheng, Y., Smith, P. F., Pearce, J. M., Vann, S. D., Good, M., Jenkins, T. A., & Aggleton, J. P. (2003). Using idiothetic cues to swim a path with a fixed trajectory and distance: Necessary involvement of the hippocampus, but not the retrosplenial cortex. Behavioral Neuroscience, 117(6), 1363-1377.
Smith, P. F. (2003). Neuroprotection against hypoxia-ischemia by insulin-like growth factor-I (IGF-I). IDrugs, 6(12), 1173-1177.
Smith, P. F. (2003). Therapeutic N-methyl-D-aspartate receptor antagonists: Will reality meet expectation. Current Opinion in Investigational Drugs, 4(7), 826-832.
Smith, P. F. (2003). Cannabinoids for the treatment of multiple sclerosis: No smoke without fire? Expert Review of Neurotherapeutics, 3(3), 327-334.
Russell, N. A., Horii, A., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2003). Bilateral peripheral vestibular lesions produce long-term changes in spatial learning in the rat. Journal of Vestibular Research, 13(1), 9-16.
Darlington, C. L., & Smith, P. F. (2003). Vestibulotoxicity following aminoglycoside antibiotics and its prevention. Current Opinion in Investigational Drugs, 4(7), 841-846.
Russell, N. A., Horii, A., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2003). Long-term effects of permanent vestibular lesions on hippocampal spatial firing. Journal of Neuroscience, 23(16), 6490-6498.
Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2003). Activation of the hypothalamic-pituitary-adrenal axis following vestibular deafferentation in pigmented guinea pig. Brain Research, 964, 306-310.
Ashton, J. C., Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2003). Effect of low body temperature during unilateral labyrinthectomy on vestibular compensation in the guinea pig. Acta Oto-Laryngologica, 123, 448-452.
Liu, P., Bilkey, D. K., Darlington, C. L., & Smith, P. F. (2003). Cannabinoid CB1 receptor protein expression in the rat hippocampus and entorhinal, perirhinal, postrhinal and temporal cortices: Regional variations and age-related changes. Brain Research, 979(1-2), 235-239.
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2003). Nitric oxide synthase and arginase in the rat hippocampus and the entorhinal, perirhinal, postrhinal, and temporal cortices: Regional variations and age-related changes. Hippocampus, 13, 859-867.
Gliddon, C. M., Smith, P. F., & Darlington, C. L. (2003). Interaction between the hypothalamic-pituitary-adrenal axis and behavioural compensation following unilateral vestibular deafferentation. Acta Oto-Laryngologica, 123(9), 1013-1021.
Horii, A., Kitahara, T., Smith, P. F., Darlington, C. L., Masumura, C., & Kubo, T. (2003). Effects of unilateral labyrinthectomy on GAD, GATI and GABA receptor gene expression in the rat vestibular nucleus. NeuroReport, 14, 2359-2363.
Liu, P., Zheng, Y., King, J., Darlington, C. L., & Smith, P. F. (2003). Long-term changes in hippocampal N-methyl-D-aspartate receptor subunits following unilateral vestibular damage in rat. Neuroscience, 117, 965-970.
Zheng, Y., Kerr, D. S., Darlington, C. L., & Smith, P. F. (2003). Unilateral inner ear damage results in lasting changes in hippocampal CA1 field potentials in vitro. Hippocampus, 13, 873-878.
Liu, P., Zheng, Y., King, J., Darlington, C. L., & Smith, P. F. (2003). Nitric oxide synthase and arginase expression in the vestibular nucleus and hippocampus following unilateral vestibular deafferentation in the rat. Brain Research, 966, 19-25.
Maclennan, K. M., Zheng, Y., Sheard, P. W., Williams, S. M., Darlington, C. L., & Smith, P. F. (2003). Adrenalectomy-induced cell death in the dentate gyrus: Further characterisation using TUNEL and effects of the Ginkgo biloba extract, EGb 761 and ginkgolide B. Hippocampus, 13, 212-225.
Liu, P., Zheng, Y., Smith, P. F., & Bilkey, D. K. (2003). Changes in NOS protein expression and activity in the rat hippocampus, entorhinal and postrhinal cortices after unilateral electrolytic perirhinal cortex lesions. Hippocampus, 13, 561-571.
Conference Contribution - Published proceedings: Abstract
Liu, P., Bilkey, D. K., Darlington, C. L., & Smith, P. F. (2003). Age-related changes in glucocorticoid receptor protein expression in the rat hippocampus and parahippocampal region. In J. G. Anson & J. Wickens (Eds.), Proceedings of the 21st International Australasian Winter Conference on Brain Research. (pp. 53). Queenstown: AWCBR. [Abstract]
Ashton, J. C., Khalessi, A., Kapoor, M., Clarkson, A., Darlington, C. L., Smith, P. F., & Sammut, I. A. (2003). Mitochondria respiratory chain activity in the vestibular nucleus and cerebellum. Proceedings of the 21st International Australasian Winter Conference on Brain Research. 21, (pp. 45). University of Otago, Dunedin: AWCBR. [Abstract]
2002
Authored Book - Research
Smith, P. F. (2002). Cannabis on the Brain. Palmerston North: Dunmore Press, 228p.
Journal - Research Article
Smith, P. F. (2002). The therapeutic applications of cannabinoids in the treatment of pain and spasticity in multiple sclerosis. Current Opinion in Investigational Drugs, 3, 1472-1477.
Darlington, C. L., Dutia, M. B., & Smith, P. F. (2002). The contribution of the intrinsic properties of vestibular nucleus neurones to recovery from vestibular damage. European Journal of Neuroscience, 15, 1719-1727.
King, J., Zheng, Y., Liu, P., Darlington, C. L., & Smith, P. F. (2002). NMDA and AMPA receptor subunit protein expression in the rat vestibular nucleus following unilateral labyrinthectomy. NeuroReport, 13(12), 1541-1545.
Horii, A., Smith, P. F., & Darlington, C. L. (2002). Application of real-time quantitative polymerase chain reaction to quantification of glutamate receptor gene expression in the vestibular brainstem and cerebellum. Brain Research Protocols, 9(1), 77-83. doi: 10.1016/S1385-299X(01)00139-8
Nicholson, M., King, J., Smith, P. F., & Darlington, C. L. (2002). Vestibulo-ocular, optokinetic and postural function in diabetes mellitus. NeuroReport, 13(1), 1-5.
Maclennan, K. M., Darlington, C. L., & Smith, P. F. (2002). The CNS effects of Ginkgo biloba extracts and ginkgolide B. Progress in Neurobiology, 67, 235-257.
King, J., Young, C., Highton, J., Smith, P. F., & Darlington, C. L. (2002). Vestibulo-ocular, optokinetic and postural function in humans with rheumatoid arthritis. Neuroscience Letters, 328, 77-80.
Conference Contribution - Published proceedings: Abstract
Darlington, C. L., King, J., Zheng, Y., Liu, P., & Smith, P. F. (2002). Nitric oxide synthase and arginase expression in the rat vestibular nucleus following unilateral vestibular deafferentation. 20th International Australasian Winter Conference on Brain Research. 20, (pp. 38). [Abstract]
Gliddon, C. M., Darlington, C. L., & Smith, P. F. (2002). Activation of the hypothalamic-pituitary-adrenal axis following vestibular deafferentation in pigmented Guinea Pig. 20th International Australasian Winter Conference on Brain Research. 20, (pp. 36). [Abstract]
Khalessi, A., Ashton, J. C., Sammut, I. A., Smith, P. F., & Darlington, C. L. (2002). Mitochondrial function in the vestibular nucleus complex. 20th International Australasian Winter Conference on Brain Research. 20, (pp. 36). [Abstract]
King, J., Zheng, Y., Darlington, C. L., Smith, P. F., & Liu, P. (2002). NMDA and AMPA receptor subunit protein expression in the rat vestibular nucleus following unilateral labyrinthectomy. 20th International Australasian Conference on Brain Research. 20, (pp. 37). [Abstract]
Smith, P. F., King, J., Zheng, Y., Liu, P., & Darlington, C. L. (2002). Nitric Oxide Synthase and Arginase expression in the rat hippocampus following unilateral vestibular deafferentation. 20th International Australasian Winter Conference on Brain R. 20, (pp. 34). [Abstract]
Zheng, Y., Pearce, J., Smith, P. F., & Aggleton, J. P. (2002). Contribution of visual cues and vestibular cues to egocentric spatial memory in the morris water maze. 20th International Australian Winter Conference on Brain Research. 20, (pp. 35). [Abstract]
Ashton, J. C., Smith, P. F., Darlington, C. L., & Gliddon, C. M. (2002). The effect of low body temperature at unilateral deafferentation on vestibular compensation. 20th International Australasian Winter Conference on Brain Research. 20, (pp. 37). Dept of Psychology: AWCBR. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Liu, P., Zheng, Y., King, J., Darlington, C., & Smith, P. (2002). NMDA and AMPA receptor subunit protein expression in the rat hippocampus following unilateral labyrinthectomy. Verbal presentation at the Twentieth International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
2001
Journal - Research Article
Zheng, Y., Horii, A., Smith, P. F., & Darlington, C. L. (2001). Differences in NOS protein expression and activity in the rat vestibular nucleus following unilateral labyrinthectomy. Molecular Brain Research, 88, 166-170.
Smith, P. F. (2001). New evidence that nicotine affects eye movement and balance in susceptible individuals. NeuroReport, 12, A31-A32.
Todd, L., King, J., Darlington, C. L., & Smith, P. F. (2001). Optokinetic reflex dysfunction in multiple sclerosis. NeuroReport, 12(7), 1399-1402.
Horii, A., Smith, P. F., & Darlington, C. L. (2001). Quantitative changes in gene expression of glutamate receptor subunits/subtypes in the vestibular nucleus, inferior olive and flocculus before and following unilateral labyrinthectomy in the rat: Real-time quantitative PCR method. Experimental Brain Research, 139, 188-200.
Smith, P. F., Zheng, Y., Paterson, S., & Darlington, C. L. (2001). The contribution of nitric oxide to vestibular compensation: Are there species differences? Acta Oto-Laryngologica, 121(545), 57-60. doi: 10.1080/000164801750388126
Zheng, Y., Horii, A., Appleton, I., Darlington, C. L., & Smith, P. F. (2001). Damage to the vestibular inner ear causes long-term changes in nitric oxide synthase expression in the rat hippocampus. Neuroscience, 105(1), 1-5.
Darlington, C. L., Ross, A., King, J., & Smith, P. F. (2001). Menstrual cycle effects on postural stability but not optokinetic function. Neuroscience Letters, 307, 147-150.
Conference Contribution - Published proceedings: Abstract
Richmond, J., Liu, P., Bilkey, D., & Smith, P. F. (2001). Changes in NOS activity and protein expression in the rat hippocampus and entorhinal and postrhinal cortoces following unilateral perirhinal lesions. Society for Neuroscience Abstracts. 27. [Abstract]
Zheng, Y., Horii, A., Darlington, C. L., Kerr, D. S., & Smith, P. F. (2001). Differential changes in hippocampal nitric oxide synthase activity and protein expression following unilateral labrynthectomy in rat. 31st Annual Meeting of the Society for Neuroscience. 27. San Diego, USA: Society for Neuroscience. [Abstract]
Zheng, Y., Horii, A., Appleton, I., Darlington, C. L., Kerr, D. S., & Smith, P. F. (2001). Differential changes in hippocampal nitric oxide synthase activity and protein expression following unilateral labyrinthectomy in rat. Society for Neuroscience Abstracts. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Russell, N. A., Liu, P., Darlington, C. L., Bilkey, D. K., Horii, A., & Smith, P. F. (2001). Hippocampal neuron firing rate correlations with angular velocity and angular acceleration in rats with vestibular lesions. Verbal presentation at the 19th International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
Commissioned Report for External Body
Smith, P. F. (2001). How Safe is Cannabis? Commissioned by The Health Select Committee On Legal and Safety Issues Relating to Cannabis. Ministry of Health, Wellington. Wellington: New Zealand Government. 15p.
2000
Chapter in Book - Research
Smith, P. F., & Darlington, C. L. (2000). The contributions of excitatory and inhibitory amino acid neurotransmitters to vestibular plasticity. In A. J. Beitz & J. H. Anderson (Eds.), Neurochemistry of the Vestibular System. (pp. 381-401). New York: CRC Press.
Journal - Research Article
Alexander, H., Sansom, A. J., Kerr, D. R., Smith, P. F., Dragunow, M., & Darlington, C. L. (2000). An antisense oligonucleotide for c-fos does not delay vestibular compensation of the static symptoms following unilateral vestibular deafferention in guinea pig. Neuroscience Research Communications, 26(2), 123-128.
Gliddon, C. M., Sansom, A. J., Smith, P. F., & Darlington, C. L. (2000). Effects of intra-vestibular nucleus injection of the Group I metabotropic glutamate receptor antagonist AIDA on vestibular compensation in guinea pigs. Experimental Brain Research, 134(1), 74-80. doi: 10.1007/s002210000437
Paterson, S., Zheng, Y., Smith, P. F., & Darlington, C. L. (2000). The effects of L-NAME on vestibular compensation and NOS activity in the vestibular nucleus, cerebellum and cortex of the guinea pig. Brain Research, 879, 148-155.
Sansom, A. J., Smith, P. F., Darlington, C. L., & Laverty, R. (2000). The effects of protein kinase C and calmodulin kinase II inhibitors on vestibular compensation in the guinea pig. Brain Research, 882(1-2), 45-54.
Darlington, C. L., Erasmus, J., Nicholson, M., King, J., & Smith, P. F. (2000). Comparison of visual-vestibular interaction in insulin-dependent and non-insulin-dependent diabetes mellitus. NeuroReport, 11(3), 487-490.
Alexander, H., Sansom, A. J., Kerr, D. R., Smith, P. F., Dragunow, M., & Darlington, C. L. (2000). Effects of c-fos antisense and mis-sense oligonucleotides on Fos expression in the vestibular nucleus and vestibular compensation following unilateral labyrinthectomy. Neuroscience Research Communications, 26(2), 123-128.
Zheng, Y., Appleton, I., Smith, P. F., & Darlington, C. L. (2000). Subregional variation in the effects of unilateral vestibular deafferentation on nitric oxide synthase activity and nitrite formation in the guinea pig hippocampus. Neuroscience Research Communications, 27(2), 109-116.
Gowans, J., Matheson, A. J., Darlington, C. L., & Smith, P. F. (2000). The effects of scopolamine and cyclizine on visual-vestibular interaction in humans. Journal of Vestibular Research, 10, 87-92.
Peters, K., Darlington, C. L., & Smith, P. F. (2000). The effects of repeated optokinetic stimulation on human autonomic function. Journal of Vestibular Research, 10, 139-142.
Kerr, D. R., Sansom, A. J., Smith, P. F., & Darlington, C. L. (2000). Comparison of protein kinase activity and protein phosphorylation in the medial vestibular nucleus and prepositus hypoglossi in labyrinthine-intact and labyrinthectomized guinea pigs. Journal of Vestibular Research, 10(2), 107-117.
Sansom, A. J., Smith, P. F., Darlington, C. L., & Laverty, R. (2000). Vestibular nucleus N-methyl-D-aspartate receptors contribute to spontaneous nystagmus generation following unilateral labyrinthectomy in guinea pigs. Neuroscience Letters, 283(2), 117-120.
Smith, P. F. (2000). A neuroscientist looks at philosophy: Response to Beedle (1999). Journal of Neuroscience Research, 60, 281-283.
Smith, P. F. (2000). Pharmacology of the vestibular system. Current Opinion in Neurology, 13, 31-37.
Smith, P. F. (2000). Are vestibular hair cells excited to death by aminoglycoside antibiotics? Journal of Vestibular Research, 10(1), 1-5.
Maingay, M., Sansom, A. J., Kerr, D. R., Smith, P. F., & Darlington, C. L. (2000). The effects of intra-vestibular nucleus administration of brain-derived neurotrophic factor (BDNF) on recovery from peripheral vestibular damage in guinea pig. NeuroReport, 11(11), 2429-2432.
Smith, P. F. (2000). Cannabis on the brain: Is it neurotoxic or neuroprotective? New Zealand Journal of Psychology, 29(1), 36-39.
Journal - Research Other
Smith, P. F., & Darlington, C. L. (2000). The development of drugs targeting the HIV cognitive-motor complex. Current Opinion in Anti-inflammatory & Immunomodulatory Investigational Drugs. [Review].
Darlington, C. L., & Smith, P. F. (2000). Molecular mechanisms of recovery from vestibular damage in mammals: Recent advances. Progress in Neurobiology, 62, 313-325. doi: 10.1016/S0301-0082(00)00002-2
Conference Contribution - Published proceedings: Abstract
Russell, N. A., Horii, A., Liu, P., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2000). Hippocampal place fields have decreased stability in rats with bilateral vestibular labyrinthectomies. Proceedings of the Society for Neuroscience. 26, (pp. 471). [Abstract]
Zheng, Y., Horii, A., Smith, P. F., & Darlington, C. L. (2000). Time course changes of hippocampal nitric oxide synthase following unilateral vestibular deafferentation in rats. 18th International Australasian Winter Conference on Brain Research. Queenstown, New Zealand. [Abstract]
Zheng, Y., Appleton, I., Smith, P. F., & Darlington, C. L. (2000). Subregional variation in the effects of unilateral deafferentation on nitric oxide synthase activity and nitrite formation in the guinea pig hippocampus. European Journal of Neuroscience. 12(Suppl 11), (pp. 34). [Abstract]
Smith, P. F., Pateson, S., Zheng, Y., & Darlington, C. L. (2000). The effects of the NOS inhibitor, L-Name, on vestibular compensation in Guinea Pig. 18th International Australasian Winter Conference on Brain Research. Queenstown, New Zealand. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Russell, N., Horii, A., Liu, P., Smith, P., Darlington, C., & Bilkey, D. K. (2000). Hippocampal theta rhythm has decreased power in rats with bilateral vestibular labyrinthectomies. Verbal presentation at the Eighteenth International Australasian Winter Conference on Brain Research, Queenstown.
1999
Chapter in Book - Research
Darlington, C. L., Smith, P. F., & Maclennan, K. M. (1999). The neuroprotective properties of ginkgo extracts. In T. A. Van Beek (Ed.), Medicinal and Aromatic Plants - Industrial Profiles: Ginkgo Biloba. (pp. 331-344). Amsterdam: Harwood Academic Publishers.
Journal - Research Article
Kerr, D. R., Sansom, A. J., Smith, P. F., & Darlington, C. L. (1999). Comparison of protein kinase activity and protein phosphorylation in the medical vastibular nucleus and prepositus hypoglossi in labyrinthine-intact and labyrinthectomized guinea pigs. Journal of Vestibular Research, 1, 1-11.
Matheson, A. J., Darlington, C. L., & Smith, P. F. (1999). Incidence of dizziness in the elderly: Correlation with ocular motor, optokinetic and postural function. New Zealand Journal of Psychology, 17-22.
Matheson, A. J., Darlington, C. L., & Smith, P. F. (1999). Further evidence for age-related deficits in human postural control. Journal of Vestibular Research, 9, 261-264.
Schlatter, M., Kerr, D. R., Darlington, C. L., & Smith, P. F. (1999). Evidence that the Ginkgo biloba extract, EGb 761, neither accelerates nor enhances rapid compensation of the static symptoms of unilateral vestibular deafferentation in guinea pig. Journal of Vestibular Research, 9, 111-118.
Darlington, C. L., Matheson, A. J., Menenti, E. C., & Smith, P. F. (1999). Vestibular dysfunction in multiple sclerosis. Australian Journal of Otolaryngology, 3, 257-258.
Bolger, C., Sansom, A. J., Smith, P. F., & Darlington, C. L. (1999). An antisense oligonucleotide to brain-derived neurotrophic factor delays postural compensation following unilateral labyrinthectomy in guinea pig. NeuroReport, 10(7), 1485-1488.
McDermott, K. H., Matheson, A. J., Titov, N., Darlington, C. L. M., & Smith, P. F. (1999). Does habitual, vigorous optokinetic stimulation alter optokinetic nystagmus and sensitivity to circularvection? Journal of Vestibular Research, 9, 59-61.
Zheng, Y., Smith, P. F., & Darlington, C. L. (1999). Temporal bone surgery causes reduced nitric oxide synthase activity in the ipsilateral guinea pig hippocampus. Neuroscience Letters, 259, 130-132.
Zheng, Y., Smith, P. F., & Darlington, C. L. (1999). Noradrenaline and serotonin levels in the guinea pig hippocampus following unilateral vestibular deafferentation. Brain Research, 836, 199-202.
Zheng, Y., Smith, P. F., & Darlington, C. L. (1999). Subregional analysis of amino acid levels in the guinea pig hippocampus following unilateral vestibular deafferentation. Journal of Vestibular Research, 9, 335-345.
Smith, P. F., & Maclennan, K. M. (1999). The neuroprotective effects of platelet activating factor (PAF) receptor antagonists in CNS disorders. Current Opinion in Anti-inflammatory & Immunomodulatory Investigational Drugs, 1, 205-218.
Journal - Research Other
Matheson, A. J., Darlington, C. L., & Smith, P. F. (1999). Dizziness in the elderly and age-related degeneration in the vestibular system. New Zealand Journal of Psychology, 28(1), 10-16. [Review].
Smith, P. F., & Darlington, C. L. (1999). Recent developments in drug therapy for multiple sclerosis. Multiple Sclerosis, 5, 110-120. doi: 10.1177/135245859900500208
Conference Contribution - Published proceedings: Abstract
Zheng, Y., Smith, P. F., & Darlington, C. L. (1999). Effects of peripheral vestibular damage on monoamine and amino acid levels in the guinea pig hippocampus. Proc. Univ. Otago Medical School. 77(17). [Abstract]
Kerr, D. R., Sansom, A. J., Darlington, C. L., & Smith, P. F. (1999). Calmodulin Kinase (CaMK) activity and Protein Kinase C (PKC) activity in guinea pig medial vestibular nucleus (MVN) and prepositus hypoglossi (PH). Australasian Winter Conference on Brain Research 1999. [Abstract]
Kerr, D. R., Sansom, A. J., Darlington, C. L., Smith, P. F., & Watson, J. A. (1999). Protein Phosphorylation in vitro in the guinea pig medial vestibular nucleus (MVN) compared to prepositus hypoglossi (PH) following unilateral vestibular deafferentiation. Society for Neuroscience 29th Annual Meeting. Abstract 7. [Abstract]
1998
Chapter in Book - Research
Smith, P. F., & Darlington, C. L. (1998). Neural mechanisms of psychiatric disturbances in patients with epilepsy. In H. McDonnell & P. Snyder (Eds.), Psychiatric co-morbidity in epilepsy: Basic mechanisms, diagnosis and treatment. (pp. 15-35). Washington DC: American Psychiatric Press.
Journal - Research Article
Darlington, C. L., & Smith, P. F. (1998). Drug treatment for vertigo and dizziness. New Zealand Medical Journal, Sept 11, 332-334.
Paul, C. A., Sansom, A. J., Maclennan, K., Darlington, C. L., & Smith, P. F. (1998). The effects of steroids on vestibular compensation and vestibular nucleus neuronal activity in guinea pig. Journal of Vestibular Research, 8(3), 201-207.
Smith, P. F., Darlington, C. L., Yan, Y., & Dragunow, M. (1998). Unilateral vestibular deafferentation induces brain-derived neurotrophic factor (BDNF) protein expression in the guinea pig lateral, but not medial, vestibular nuclei. Journal of Vestibular Research, 8, 443-447.
Darlington, C. L., & Smith, P. F. (1998). Further evidence for gender differences in circularvection. Journal of Vestibular Research, 8(2), 151-153.
Newsham-West, D., Darlington, C. L., & Smith, P. F. (1998). Potent effects of a selective cannabinoid receptor agonist on some guinea pig medial vestibular nucleus neurons. European Journal of Pharmacology, 348(May 1), R1-R2.
Anderson, T. V., Moulton, A., Sansom, A. J., Kerr, D. R., Laverty, R., Darlington, C. L., & Smith, P. F. (1998). Evidence for reduced nitric oxide synthase (NOS) activity in the ipsilateral medial vestibular nucleus and bilateral prepositus hypoglossi following unilateral vestibular deafferentation in the guinea pig. Brain Research, 787(2), 311-314.
Matheson, A. J., Darlington, C. L., & Smith, P. F. (1998). Age-related changes in human optokinetic sensitivity. NeuroReport, 9, 2175-2177.
Journal - Research Other
Maclennan, K., Smith, P. F., & Darlington, C. L. (1998). Adrenalectomy-induced neuronal degeneration. Progress in Neurobiology, 54, 481-498. doi: 10.1016/S0301-0082(97)00076-2
Conference Contribution - Published proceedings: Abstract
Zheng, Y., Smith, P. F., & Darlington, C. L. (1998). Temporal bone trauma causes reduced nitric oxide synthase (NOS) activity in the ipsilateral guinea pig hippocampus. Proceedings of the University of Otago Medical School. 76(35). Dunedin: University of Otago. [Abstract]
1997
Chapter in Book - Research
Darlington, C. L., Smith, P. F., & Maclennan, K. M. (1997). Effects of Ginkgo biloba extract (EGb 761) on recovery from peripheral vestibular deafferentation (vestibular compensation). In V. Papadopoulos, K. Drieu & Y. Christen (Eds.), Advances in Ginkgo biloba Research, Vol. 6. (pp. 47-58). Paris: Elsevier.
Journal - Research Article
Sansom, A. J., Brent, V. A., Jarvie, P. E., Darlington, C. L., Smith, P. F., Laverty, R., & Rostas, J. A. P. (1997). In vitro phosphorylation of medial vestibular nucleus and prepositus hypoglossi proteins during behavioural recovery from unilateral vestibular deafferentation in guinea pig. Brain Research, 778(1), 166-177.
Smith, P. F. (1997). Vestibular-hippocampal interactions. Hippocampus, 7(5), 465-471.
Smith, P. F., & Darlington, C. L. (1997). The contribution of N-methyl-D-aspartate receptors to lesion-induced plasticity in the vestibular nucleus. Progress in Neurobiology, 53(5), 517-531.
1996
Authored Book - Research
Smith, P. F., & Darlington, C. L. (1996). Clinical Psychopharmacology: A Primer. New York: Lawrence Erlbaum Associates, 143p.
Chapter in Book - Research
Darlington, C., & Smith, P. (1996). What neurotransmitters are important in the vestibular system? In R. Baloh & G. M. Halmagyi (Eds.), Disorders of the Vestibular System. (pp. 140-144). New York: Oxford University Press.
Journal - Research Article
Maclennan, K., Smith, P. F., & Darlington, C. L. M. (1996). The effects of ginkgolide B (BN52021) on guinea pig vestibular nucleus neurons in vitro: importance of controlling for effects of dimethylsulphoxide (DMSO) vehicles. Neuroscience Research, 26(4), 395-399.
Hutchinson, M. A., Smith, P. F., & Darlington, C. L. M. (1996). The behavioural and neuronal effects of the chronic administration of benzodiazepine anxiolytic and hypnotic drugs. Progress in Neurobiology, 49(1), 73-97.
Smith, P. F., & Darlington, C. L. (1996). Recent advances in the pharmacology of the vestibulo-ocular reflex system. Trends in Pharmacological Sciences, 17(11), 421-427.
Maclennan, K. M., Smith, P. F., & Darlington, C. L. (1996). Platelet-activating factor in the CNS. Progress in Neurobiology, 50(5-6), 585-596.
Darlington, C. L. M., & Smith, P. F. (1996). Circularvection: visually-induced illusion of self-rotation. New Zealand Journal of Psychology, 25(2), 20-23.
Darlington, C. L. M., & Smith, P. F. (1996). Oscillopsia and dizziness resulting from gentamicin antibiotic treatment: a clinical note on the beneficial effects of vestibular rehabilitation therapy. New Zealand Journal of Psychology, 25(2), 24-28.
Darlington, C. L., Gilchrist, D. P. D., & Smith, P. F. (1996). Melanocortins and lesion-induced plasticity in the CNS: a review. Brain Research Reviews, 22(3), 245-257.
Darlington, C. L. M., Lawlor, P., Smith, P. F., & Dragunow, M. (1996). Temporal relationship between the expression of Fos, Jun and Krox-24 in the guinea pig vestibular nuclei during the development of vestibular compensation for unilateral vestibular deafferentation. Brain Research, 735, 173-176.
Darlington, C. L. M., & Smith, P. F. (1996). Recovery of static vestibular function following peripheral vestibular lesions (vestibular compensation) in mammals: the intrinsic mechanism hypothesis. Journal of Vestibular Research, 6, 185-201.
Dutia, M. B., Gilchrist, D. P. D., Sansom, A. J. J., Smith, P. F., & Darlington, C. L. M. (1996). The opioid receptor antagonist, naloxone, enhances ocular motor compensation following peripheral vestibular deafferentation in guinea pig. Experimental Neurology, 141, 141-144.
Jerram, A., Smith, P. F., & Darlington, C. L. (1996). Comparison of the effects of SKF 10047 and ketamine hydrochloride on stereotyped behavior, locomotor activity and ataxia in guinea pig. European Journal of Pharmacology, 307, 269-272.
Gilchrist, D. P. D., Darlington, C. L., & Smith, P. F. (1996). An in vitro investigation of the effects of the ACTH/MSH-(4-9) analogue, Org 2766, on guinea pig medial vestibular nucleus neurons. Peptides, 17, 681-688.
Gilchrist, D. P. D., Darlington, C. L., & Smith, P. F. (1996). Evidence that short ACTH fragments enhance vestibular compensation via direct action on the ipsilateral vestibular nucleus. NeuroReport, 7, 1489-1492.
Hutchinson, M., Smith, P. F., & Darlington, C. L. (1996). The behavioral and neuronal effects of the chronic administration of benzodiazepine anxiolytic and hypnotic drugs. Progress in Neurobiology, 49, 73-97.
Hutchinson, M., Smith, P. F., & Darlington, C. L. (1996). Tolerance to the ataxic effects of diazepam in guinea pig is not associated with a reduced sensitivity of GABAa receptors in the vestibular nucleus. European Journal of Pharmacology, 301, 83-90.
Jerram, A., Smith, P. F., & Darlington, C. L. (1996). A dose-response analysis of the behavioral effects of (+)MK-801 in guinea pig: comparison with CPP. Pharmacology Biochemistry & Behavior, 53, 799-807.
Martin, J., Gilchrist, D. P. D., Smith, P. F., & Darlington, C. L. (1996). Early diazepam treatment following unilateral labyrinthectomy does not impair vestibular compensation of spontaneous hystagmus in guinea pig. Journal of Vestibular Research, 6, 135-139.
Sansom, A. J. J., Smith, P. F., & Darlington, C. L. (1996). Fentazin anesthesia for labyrinthine surgery in guinea pigs. Journal of Vestibular Research, 6, 49-52.
Smith, P. F., & Darlington, C. L. (1996). Epistemological realism in psychology: Kant or won't? New Zealand Journal of Psychology, 25, 13-20.
Smith, P. F., & Darlington, C. L. (1996). The development of psychosis in epilepsy: a re-examination of the Kindling hypothesis. Behavioural Brain Research, 75, 59-66.
Smith, P. F., McLennan, K., & Darlington, C. L. (1996). The neuroprotective properties of the Ginkgo Biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). Journal of Ethnopharmacology, 50, 131-139.
Smith, P. F., & Darlington, C. L. (1996). Cannabis: uses and abuses. New Ethicals, 33, 79-83.
Conference Contribution - Published proceedings: Full paper
Darlington, C. L., Lawlor, P., Smith, P. F., & Dragunow, M. (1996). Expression of immediate early gene proteins in the brainstem vestibular nucleus following unilateral vestibular deafferentation. Proceedings of the University of Otago Medical School. 74, (pp. 3-4). [Full Paper]
1995
Journal - Research Article
Smith, P. F., Darlington, C. L., & Maclennan, K. (1995). Ginko Biloba: An ancient Chinese tree with neuroprotective properties. Asia Pacific Journal of Pharmacology, 10, 3-4.