Dr Michael Garelja

2024

Journal - Research Article

Rees, T. A., Tasma, Z., Garelja, M. L., O'Carroll, S. J., Walker, C. S., & Hay, D. L. (2024). Calcitonin receptor, calcitonin gene-related peptide and amylin distribution in C1/2 dorsal root ganglia. Journal of Headache & Pain, 25, 36. doi: 10.1186/s10194-024-01744-z

Mazzini, G., Le Foll, C., Boyle, C. N., Garelja, M. L., Zhyvoloup, A., Miller, M. E. T., Hay, D. L., … Lutz, T. A. (2024). The processing intermediate of human amylin, pro-amylin(1–48) has in vivo and in vitro bioactivity. Biophysical Chemistry. Advance online publication. doi: 10.1016/j.bpc.2024.107201

Garelja, M. L., Alexander, T. I., Bennie, A., Nimick, M., Petersen, J., Walker, C. S., & Hay, D. L. (2024). Pharmacological characterisation of erenumab, Aimovig, at two calcitonin gene-related peptide responsive receptors. British Journal of Pharmacology, 181, 142-161. doi: 10.1111/bph.16218

2023

Journal - Research Other

Garelja, M. L., Hay, D., Poyner, D. R., & Walker, C. S. (2023). Calcitonin receptors in GtoPdb v.2023.1 [Citation summary]. IUPHAR/BPS Guide to Pharmacology CITE, (1). doi: 10.2218/gtopdb/F11/2023.1

Conference Contribution - Published proceedings: Abstract

Garelja, M. L., Rees, T. A., & Hay, D. L. (2023). Investigation of CGRP and AMY₁ receptor subunit expression using RNA-fluorescence in situ hybridization in migraine associated tissue. Cephalalgia, 43(1 Suppl.), (pp. 32-33). doi: 10.1177/03331024231189112

Leen, A. J., Garelja, M. L., Forrester, L. M., & Hay, D. L. (2023). Identifying a new migraine-relevant receptor: Potential paracrine interaction between calcitonin gene-related peptide and the amylin 1 receptor in the parabrachial nucleus. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Conference Contribution - Edited volume of conference proceedings

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 268th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours/Postgraduate Diploma Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 266th Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Milne, T., Anwar, M., Burga, L., Harcombe, H., Garelja, M., Middleton, A., Ribeiro, D. C., Fleming, N., Ogbuehi, K., & Bahn, A. (Eds.). (2023). Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

2022

Journal - Research Article

Hendrikse, E. R., Rees, T. A., Tasma, Z., Garelja, M. L., Siow, A., Harris, P. W. R., … Hay, D. L. (2022). Characterization of antibodies against receptor activity-modifying protein 1 (RAMP1): A cautionary tale. International Journal of Molecular Sciences, 23, 16035. doi: 10.3390/ijms232416035

Garelja, M. L., & Hay, D. L. (2022). A narrative review of the calcitonin peptide family and associated receptors as migraine targets: Calcitonin gene-related peptide and beyond. Headache, 62(9), 1093-1104. doi: 10.1111/head.14388

Garelja, M. L., Bower, R. L., Brimble, M. A., Chand, S., Harris, P. W. R., Jamaluddin, M. A., … Hay, D. L. (2022). Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared to human receptors. British Journal of Pharmacology, 179, 416-434. doi: 10.1111/bph.15628

Conference Contribution - Edited volume of conference proceedings

Wilson, L., Harcombe, H., Jayakaran, P., Burga, L., Antony, J., Morgaine, K., Garelja, M., Middleton, A., Anwar, M., & Milne, T. (Eds.). (2022). Proceedings of the 264th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Wilson, L., Harcombe, H., Jayakaran, P., Burga, L., Antony, J., Morgaine, K., Garelja, M., Middleton, A., Anwar, M., & Milne, T. (Eds.). (2022). Proceedings of the 263rd Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Wilson, L., Harcombe, H., Jayakaran, P., Burga, L., Antony, J., Morgaine, K., Garelja, M., Middleton, A., Anwar, M., & Milne, T. (Eds.). (2022). Proceedings of the 262nd Otago Medical School Research Society (OMSRS) Meeting: Research Staff Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Conference Contribution - Verbal presentation and other Conference outputs

Alexander, T. I., Garelja, M. L., Gingell, J. J., & Hay, D. L. (2022, September). Differential interaction of β-arrestin for two CGRP-responsive receptors. Verbal presentation at the Postgraduate & Early Career Researchers Committee (PERC) & Division of Health Sciences Early & Mid-Career Researcher (EMCR) Joint Research Symposium, Dunedin, New Zealand.

Garelja, M. L., Alexander, T., Walker, C. S., & Hay, D. L. (2022, August-September). Extracellular bimolecular fluorescence complementation assays for investigating receptor dimerization: A proof of concept with receptors for calcitonin gene-related peptide. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

2021

Journal - Research Other

Garelja, M. L., Walker, C. S., & Hay, D. L. (2021). CGRP receptor antagonists for migraine: Are they also AMY₁ receptor antagonists? British Journal of Pharmacology, 179, 454-459. doi: 10.1111/bph.15585

Conference Contribution - Published proceedings: Abstract

Garelja, M., Walker, C., & Hay, D. (2021). Pharmacological characterisation of mouse calcitonin and calcitonin receptor-like receptors reveals differences compared to human receptors. Cephalalgia, 41(1 Suppl.), (pp. 72). doi: 10.1177/03331024211034005

Conference Contribution - Verbal presentation and other Conference outputs

Garelja, M. (2021, December). CGRP blocking drugs for migraine: Towards a better understanding of mechanisms of action. Verbal presentation at the Pain@Otago Research Symposium, [Online].

2020

Journal - Research Article

Garelja, M. L., Au, M., Brimble, M. A., Gingell, J. J., Hendrikse, E. R., Lovell, A., … Hay, D. L. (2020). Molecular mechanisms of class B GPCR activation: Insights from adrenomedullin receptors. ACS Pharmacology & Translational Science, 3(2), 246-262. doi: 10.1021/acsptsci.9b00083

2019

Journal - Research Article

Musa, H., Hendrikse, E. R., Brimble, M. A., Garelja, M. L., Watkins, H. A., Harris, P. W. R., & Hay, D. L. (2019). Pharmacological characterization and investigation of N-terminal loop amino acids of adrenomedullin 2 that are important for receptor activation. Biochemistry, 58(32), 3468-3474. doi: 10.1021/acs.biochem.9b00571

Yule, L. R., Garelja, M. L., Hendrikse, E. R., Gingell, J. J., Poyner, D. R., Harris, P. W. H., Brimble, M. A., & Hay, D. L. (2019). A potent fluorescent calcitonin gene-related peptide analogue enables visualization of receptor internalization. Peptide Science, 111(6), e2416. doi: 10.1002/pep2.24126

Awarded Doctoral Degree

Garelja, M. (2019). Molecular insights into the signalling of calcitonin receptor-like receptor: Receptor activity-modifying protein complexes (PhD). University of Auckland, Auckland, New Zealand. Retrieved from http://hdl.handle.net/2292/50390

2018

Journal - Research Article

Garelja, M. L., Walker, C. A., Siow, A., Yang, S. H., Harris, P. W. R., Brimble, M. A., … Hay, D. L. (2018). Receptor activity modifying proteins have limited effects on the class B G protein-coupled receptor calcitonin receptor-like receptor stalk. Biochemistry, 57(8), 1410-1422. doi: 10.1021/acs.biochem.7b01180

Simms, J., Uddin, R., Sakmar, T. P., Gingell, J. J., Garelja, M. L., Hay, D. L., … Poyner, D. R. (2018). Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the CalcitoninRreceptor-Like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) complex. Biochemistry, 57(32), 4915-4922. doi: 10.1021/acs.biochem.8b00502

Journal - Research Other

Hay, D. L., Garelja, M. L., Poyner, D. R., & Walker, C. S. (2018). Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. British Journal of Pharmacology, 175(1), 3-17. doi: 10.1111/bph.14075

Conference Contribution - Published proceedings: Abstract

Walker, C. S., Garelja, M., Rees, T. A., & Hay, D. (2018). Profiling calcitonin gene-related peptide receptor dignalling in transfected cells and trigeminal ganglia neurons. Headache, 58(Suppl. 2), (pp. 69-70). doi: 10.1111/head.13306

2017

Journal - Research Article

Woolley, M. J., Reynolds, C. A., Simms, J., Walker, C. S., Mobarec, J. C., Garelja, M. L., … Hay, D. L. (2017). Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochemical Pharmacology, 142, 96-110. doi: 10.1016/j.bcp.2017.07.005

2016

Journal - Research Article

Watkins, H. A., Chakravarthy, M., Abhayawardana, R. S., Gingell, J. J., Garelja, M. L., Pardamwar, M., … Hay, D. L. (2016). Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties. Journal of Biological Chemistry, 291(22), 11657-11675. doi: 10.1074/jbc.M115.688218