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Contact Details

Email
anurag.singh@otago.ac.nz

University Links

Position
Research Fellow
Department
Department of Pharmacology and Toxicology
Qualifications
MSc PhD
Research summary
Auditory-limbic interaction in tinnitus generation and perception
Memberships
  • Vice President, Emerging Neuroscientists Group, University of Otago
  • Research Fellow Representative, Brain Health Research Centre Management Committee

Research

Tinnitus, a complex disorder, results from sentient cognisance of a sound without an external auditory stimulus. It is reported in children, adults, and older populations. Patients suffering from tinnitus often present with hearing loss, anxiety, depression, and sleep disruption in addition to hissing and ringing in the ear.

Human imaging study shows that tinnitus affects both auditory and limbic regions, and the interplay between the auditory-limbic system may be central to understanding and perhaps therapeutics for persistent tinnitus.

Using electrophysiological, imaging and behavioural approaches in rodents, my research brings attention to the role of synaptic plasticity in the limbic system such as the hippocampus, amygdala and others (and its interaction with the auditory system) in tinnitus development.

Publications

Wright, A. L., Konen, L. M., Mockett, B. G., Morris, G. P., Singh, A., Burbano, L. E., … Abraham, W. C., & Vissel, B. (2023). The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease. Molecular Neurodegeneration, 18(1), 65. doi: 10.1186/s13024-023-00632-5 Journal - Research Article

Singh, A., Smith, P. F., & Zheng, Y. (2023). Targeting the limbic system: Insights into its involvement in tinnitus. International Journal of Molecular Sciences, 24, 9889. doi: 10.3390/ijms24129889 Journal - Research Other

Kelly, G., Singh, A., Smith, P. F., & Zheng, Y. (2023). Effects of chronic tinnitus on long-term potentiation in the rat hippocampus. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 265th Otago Medical School Research Society (OMSRS) Meeting: Summer Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839 Conference Contribution - Published proceedings: Abstract

Singh, A., Sateesh, S., Jones, O. D., & Abraham, W. C. (2022). Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1. Scientific Reports, 12, 1746. doi: 10.1038/s41598-022-05844-1 Journal - Research Article

Sateesh, S., Singh, A., Jones, O. D., & Abraham, W. C. (2021). Astrocyte-mediated trans-regional regulation of synaptic plasticity in the hippocampus. New Zealand Medical Journal, 134(1547), (pp. 137-138). Retrieved from https://www.nzma.org.nz/journal Conference Contribution - Published proceedings: Abstract

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