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CHEM305 Biological Chemistry

Application of fundamental chemistry principles to an understanding of chemical reactions and molecular structure in biological systems.

CHEM 305 Biological Chemistry focuses on how the concepts and techniques from various fields of chemistry may be applied to interpret chemical transformations in biological systems and to determine the structure of biomolecules. The paper will evaluate frontiers in biological chemistry by identifying the underlying fundamental concepts of molecular transformation and structure.

Paper title Biological Chemistry
Paper code CHEM305
Subject Chemistry
EFTS 0.1500
Points 18 points
Teaching period First Semester
Domestic Tuition Fees (NZD) $1,018.05
International Tuition Fees (NZD) $4,320.00

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Prerequisite
18 200-level CHEM points
Recommended Preparation
CHEM 205
Schedule C
Science
Eligibility
CHEM 305 is an important paper for chemistry majors wishing to proceed to a career that involves biological chemistry and also for all general degree students requiring knowledge and understanding of biological chemistry.
Contact
Associate Professor Guy N. L. Jameson
Tel 64 3 479 8028
Location: Science II, 5C4
gjameson@chemistry.otago.ac.nz
Teaching staff
Course Co-ordinator: Assoc Prof Guy N. L. Jameson
Dr E.W.Tan
Dr Alan R. Hayman
Assoc Prof Steve Moratti
Paper Structure
  • Amino Acids and Peptides
    • The chemistry and reactivity of amino acids and peptides
    • Methods of isolation, purification and analysis of peptides and proteins
    • Strategies used in the chemical synthesis of peptides
  • Enzymes
    • The role and modes of action of enzymes in catalysing biological reactions
    • Structure activity relationships and kinetics of enzymes
    • Mechanisms of enzyme reactions using proteases as examples
    • Strategies for enzyme inhibition in drug design
  • Spectroscopy of Biological Systems
    • Spectroscopic investigations are integral to the study of biological systems. We will examine the principles and applications of NMR, EPR and M?Âssbauer spectroscopy to study metalloenzymes
  • Polymers
    • An overview of polymers and their properties
    • Chemical synthesis of natural polymers
    • Biocompatible and biodegradable polymers
    • Use of polymers in drug delivery and devices
Teaching Arrangements
Three lectures per week and one 4-hour lab class per week.
Textbooks
Recommended:
Jones, J. Amino acid and peptide synthesis, Oxford University Press

Bruice, P.Y. Organic Chemistry, (4th edn), Prentice-Hall

Fersht, A. Enzyme structure and mechanism, Freeman
Graduate Attributes Emphasised
Interdisciplinary perspective, Lifelong learning, Scholarship, Critical thinking, Self-motivation.
View more information about Otago's graduate attributes.
Learning Outcomes
Expectations at the completion of the paper:
  • An understanding of the scientific concepts underlying chemical transformation and structure determination involving biological molecules
  • An appreciation of the chemical factors controlling biological processes
  • An ability to identify fundamental concepts in chemistry underlying biological systems
  • Demonstrated expertise in the generic activities of information retrieval, critical analysis and presentation, logistical planning and cooperative teamwork
  • An understanding of how chemical knowledge is applied in a practical, problem-solving context

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Timetable

First Semester

Location
Dunedin
Teaching method
This paper is taught On Campus
Learning management system
Blackboard

Lecture

Stream Days Times Weeks
Attend
L1 Tuesday 09:00-09:50 9-12, 14-15, 18-22
Thursday 09:00-09:50 9-15, 17-22
Friday 09:00-09:50 9-14, 17-22

Practical

Stream Days Times Weeks
Attend one stream from
P1 Monday 14:00-17:50 10-15, 17-22
P2 Wednesday 14:00-17:50 10-15, 17-22

Application of fundamental chemistry principles to an understanding of chemical reactions and molecular structure in biological systems.

CHEM 305 Biological Chemistry focuses on how the concepts and techniques from various fields of chemistry may be applied to interpret chemical transformations in biological systems and to determine the structure of biomolecules. The paper will evaluate frontiers in biological chemistry by identifying the underlying fundamental concepts of molecular transformation and structure.

Paper title Biological Chemistry
Paper code CHEM305
Subject Chemistry
EFTS 0.1500
Points 18 points
Teaching period First Semester
Domestic Tuition Fees (NZD) $1,038.45
International Tuition Fees (NZD) $4,492.80

^ Top of page

Prerequisite
18 200-level CHEM points
Recommended Preparation
CHEM 205
Schedule C
Science
Eligibility
CHEM 305 is an important paper for chemistry majors wishing to proceed to a career that involves biological chemistry and also for all general degree students requiring knowledge and understanding of biological chemistry.
Contact
Dr Alan Hayman
Tel 64 3 479 7923
Location: Science II, 4n9
hayman@chemistry.otago.ac.nz
Teaching staff
Course Co-ordinator: Dr Alan. R. Hayman
Dr E.W.Tan
Assoc Prof Steve Moratti
Paper Structure
  • Amino Acids and Peptides
    • The chemistry and reactivity of amino acids and peptides
    • Methods of isolation, purification and analysis of peptides and proteins
    • Strategies used in the chemical synthesis of peptides
  • Enzymes
    • The role and modes of action of enzymes in catalysing biological reactions
    • Structure activity relationships and kinetics of enzymes
    • Mechanisms of enzyme reactions using proteases as examples
    • Strategies for enzyme inhibition in drug design
  • Spectroscopy of Biological Systems
    • Spectroscopic investigations are integral to the study of biological systems. We will examine the principles and applications of NMR and EPR spectroscopy to study metalloenzymes
  • Polymers
    • An overview of polymers and their properties
    • Chemical synthesis of natural polymers
    • Biocompatible and biodegradable polymers
    • Use of polymers in drug delivery and devices
Teaching Arrangements
Three lectures per week and one 4-hour lab class per week.
Textbooks
Recommended:
Jones, J. Amino acid and peptide synthesis, Oxford University Press

Bruice, P.Y. Organic Chemistry, (4th edn), Prentice-Hall

Fersht, A. Enzyme structure and mechanism, Freeman
Graduate Attributes Emphasised
Interdisciplinary perspective, Lifelong learning, Scholarship, Critical thinking, Self-motivation.
View more information about Otago's graduate attributes.
Learning Outcomes
Expectations at the completion of the paper:
  • An understanding of the scientific concepts underlying chemical transformation and structure determination involving biological molecules
  • An appreciation of the chemical factors controlling biological processes
  • An ability to identify fundamental concepts in chemistry underlying biological systems
  • Demonstrated expertise in the generic activities of information retrieval, critical analysis and presentation, logistical planning and cooperative teamwork
  • An understanding of how chemical knowledge is applied in a practical, problem-solving context

^ Top of page

Timetable

First Semester

Location
Dunedin
Teaching method
This paper is taught On Campus
Learning management system
Blackboard

Lecture

Stream Days Times Weeks
Attend
L1 Tuesday 09:00-09:50 9-13, 15-22
Thursday 09:00-09:50 9-13, 15-22
Friday 09:00-09:50 9-12, 15-22

Practical

Stream Days Times Weeks
Attend one stream from
P1 Monday 14:00-17:50 10-13, 15-16, 18-22
P2 Wednesday 14:00-17:50 10-13, 15-16, 18-22