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Dr Nick Green

Nick Green imageEmail nick.green@otago.ac.nz

Google Scholar Nicholas J Green

Website Green Group – Organic and biological chemistry

Research interests

The Nick Green research group is a synthetic and biological chemistry group. We are interested in exploring new chemical reactions and new chemical structures.

We have a particular interest in the chemistry of molecules of life, including nucleosides, peptides, and lipids. We investigate the synthesis of these molecules and derivatives with applications in organic and medicinal chemistry. We also evaluate the chemical and physical properties of these molecules, and potential routes to them that may have occurred on a primordial Earth, or other planets, which may inform our understanding on the origins of life and homochirality.

Professional background

  • 2022–present, Lecturer, University of Otago.
  • 2018–2022, Research Associate, Homerton College, University of Cambridge.
  • 2017–2022, Career Development Fellow, MRC Laboratory of Molecular Biology, Cambridge.
  • 2016–2017, Postdoctoral Fellow, University of Edinburgh.
  • 2015–2016, Postdoctoral Fellow, Australian National University.
  • 2011–2015, PhD (Organic Synthesis), Australian National University.

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Publications

Godfrey, R. C., Jones, H. E., Green, N. J., & Lawrence, A. L. (2022). Unified total synthesis of the brevianamide alkaloids enabled by chemical investigations into their biosynthesis. Chemical Science, 13(5), 1313-1322. doi: 10.1039/d1sc05801k

Rimmer, P. B., Thompson, S. J., Xu, J., Russell, D. A., Green, N. J., Ritson, D. J., … Queloz, D. P. (2021). Timescales for prebiotic photochemistry under realistic surface ultraviolet conditions. Astrobiology, 21(9), 1099-1120. doi: 10.1089/ast.2020.2335

Xu, J., Green, N. J., Russell, D. A., Liu, Z., & Sutherland, J. D. (2021). Prebiotic photochemical coproduction of purine ribo- and deoxyribonucleosides [Communication]. Journal of the American Chemical Society, 143, 14482-14486. doi: 10.1021/jacs.1c07403

Green, N. J., Xu, J., & Sutherland, J. D. (2021). Illuminating life's origins: UV photochemistry in abiotic synthesis of biomolecules. Journal of the American Chemical Society, 143, 7219-7236. doi: 10.1021/jacs.1c01839

Szabla, R., Zdrowowicz, M., Spisz, P., Green, N. J., Stadlbauer, P., Kruse, H., … Rak, J. (2021). 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions. Nature Communications, 12, 3018. doi: 10.1038/s41467-021-23300-y

Green, N. J., Saglam, M. F., & Sherburn, M. S. (2016). Synthesis of dendralenes. In H. Hopf & M. S. Sherburn (Eds.), Cross conjugation: Modern dendralene, radialene and fulvene chemistry. (pp. 1-38). Weinheim, Germany: Wiley-VCH. doi: 10.1002/9783527671182.ch1

Chapter in Book - Research

Godfrey, R. C., Jones, H. E., Green, N. J., & Lawrence, A. L. (2022). Unified total synthesis of the brevianamide alkaloids enabled by chemical investigations into their biosynthesis. Chemical Science, 13(5), 1313-1322. doi: 10.1039/d1sc05801k

Journal - Research Article

Green, N. J., Xu, J., & Sutherland, J. D. (2021). Illuminating life's origins: UV photochemistry in abiotic synthesis of biomolecules. Journal of the American Chemical Society, 143, 7219-7236. doi: 10.1021/jacs.1c01839

Journal - Research Article

Rimmer, P. B., Thompson, S. J., Xu, J., Russell, D. A., Green, N. J., Ritson, D. J., … Queloz, D. P. (2021). Timescales for prebiotic photochemistry under realistic surface ultraviolet conditions. Astrobiology, 21(9), 1099-1120. doi: 10.1089/ast.2020.2335

Journal - Research Article

Szabla, R., Zdrowowicz, M., Spisz, P., Green, N. J., Stadlbauer, P., Kruse, H., … Rak, J. (2021). 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions. Nature Communications, 12, 3018. doi: 10.1038/s41467-021-23300-y

Journal - Research Article

Bonfio, C., Russell, D. A., Green, N. J., Mariani, A., & Sutherland, J. D. (2020). Activation chemistry drives the emergence of functionalised protocells. Chemical Science, 11, 10688-10697. doi: 10.1039/d0sc04506c

Journal - Research Article

Godfrey, R. C., Green, N. J., Nichol, G. S., & Lawrence, A. L. (2020). Total synthesis of brevianamide A. Nature Chemistry, 12, 615-619. doi: 10.1038/s41557-020-0442-3

Journal - Research Article

Xu, J., Chmela, V., Green, N. J., Russell, D. A., Janicki, M. J., Góra, R. W., … Sutherland, J. D. (2020). Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides. Nature, 582, 60-66. doi: 10.1038/s41586-020-2330-9

Journal - Research Article

Xu, J., Green, N. J., Gibard, C., Krishnamurthy, R., & Sutherland, J. D. (2019). Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction. Nature Chemistry, 11, 457-462. doi: 10.1038/s41557-019-0225-x

Journal - Research Article

Xu, J., Green, N. J., Russell, D. A., Liu, Z., & Sutherland, J. D. (2021). Prebiotic photochemical coproduction of purine ribo- and deoxyribonucleosides [Communication]. Journal of the American Chemical Society, 143, 14482-14486. doi: 10.1021/jacs.1c07403

Journal - Research Other

Green, N. J., Connolly, C. A., Rietdijk, K. P. W., Nichol, G. S., Duarte, F., & Lawrence, A. L. (2018). Bio-inspired domino oxa-Michael/Diels–Alder/oxa-Michael dimerization of para-quinols [Communication]. Angewandte Chemie International Edition, 57(21), 6198-6202. doi: 10.1002/anie.201802125

Journal - Research Other

Cao, M.-H., Green, N. J., & Xu, S.-Z. (2017). Application of the aza-Diels-Alder reaction in the synthesis of natural products. Organic & Biomolecular Chemistry, 15, 3105-3129. doi: 10.1039/C6OB02761J

Journal - Research Other

Green, N. J., & Lawrence, A. L. (2016). [Review of the book Applications of domino transformations in organic synthesis]. Synthesis, 48, 4594. doi: 10.1055/s-0036-1589473

Journal - Research Other

Green, N. J., Willis, A. C., & Sherburn, M. S. (2016). Direct cross-couplings of propargylic diols [Communication]. Angewandte Chemie International Edition, 55(32), 9244-9248. doi: 10.1002/anie.201604527

Journal - Research Other

Green, N. J., & Sherburn, M. S. (2013). Multi-bond forming processes in efficient synthesis. Australian Journal of Chemistry, 66, 267-283. doi: 10.1071/CH13003

Journal - Research Other

Green, N. J., Lawrence, A. L., Bojase, G., Willis, A. C., Paddon-Row, M. N., & Sherburn, M. S. (2013). Domino cycloaddition organocascades of dendralenes [Communication]. Angewandte Chemie International Edition, 52(32), 8333-8336. doi: 10.1002/anie.201302185

Journal - Research Other

Green, N. (2019). DNA: Biotic invention, or prebiotic product? [Behind the paper]. Nature Portfolio Chemistry Community blog. Retrieved from https://chemistrycommunity.nature.com/posts/44786-the-rna-world-now-including-dna

Other Research Output

More publications...