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Professor David Bilkey

Director, Brain Health Research Centre (BHRC)

David Bilkey

Email dbilkey@psy.otago.ac.nz
Phone 64 3 479 7633

Professor David Bilkey’s general research area is systems neuroscience, with a particular focus on the role of the temporal cortex regions of the brain in memory and learning processes. This work involves using a combination of electrophysiological and behavioral procedures to determine how these temporal area structures function and interact with regions such as the prefrontal cortex.

More recently he has been investigating how the function of the hippocampus is altered in schizophrenia using an animal model of the disorder. His research has been funded by the Health Research Council and Marsden Fund. He is an author on over 90 articles published in high-impact international journals. He is a past recipient of an Alexander von Humboldt Fellowship and has served on several major funding panels. He is actively involved in promoting science in schools and is the current director of the Brain Health Research Centre (BHRC).

David received a PhD from the University of Otago in 1987. After working as a postdoctoral fellow at the University of Washington in 1988 he returned to Otago as a lecturer, and served as the Head of Department from 2009 to 2013.

Teaching

Research Interests

  • Systems neuroscience
  • The role of the temporal cortex regions of the brain in memory and learning processes
  • How the function of the hippocampus is altered in schizophrenia

Find out more about Professor Bilkey's research interests

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Publications

Hillman, K. L., & Bilkey, D. K. (2012). Neural encoding of competitive effort in the anterior cingulate cortex. Nature Neuroscience, 15(9), 1290-1298. doi: 10.1038/nn.3187

Douglas, K. M., & Bilkey, D. K. (2007). Amusia is associated with deficits in spatial processing. Nature Neuroscience, 10(7), 915-921. doi: 10.1038/nn1925

Dickerson, D. D., Wolff, A. R., & Bilkey, D. K. (2010). Abnormal long-range neural synchrony in a maternal immune activation animal model of schizophrenia. Journal of Neuroscience, 30(37), 12424-12431. doi: 10.1523/JNEUROSCI.3046-10.2010

Hillman, K. L., & Bilkey, D. K. (2010). Neurons in the rat anterior cingulate cortex dynamically encode cost-benefit in a spatial decision-making task. Journal of Neuroscience, 30(22), 7705-7713. doi: 10.1523/JNEUROSCI.1273-10.2010

Clearwater, J. M., & Bilkey, D. K. (2012). Place, space, and taste: Combining context and spatial information in a hippocampal navigation system. Hippocampus, 22(3), 442-454. doi: 10.1002/hipo.20911

Journal - Research Article

Dickerson, D. D., Overeem, K. A., Wolff, A. R., Williams, J. M., Abraham, W. C., & Bilkey, D. K. (2014). Association of aberrant neural synchrony and altered GAD67 expression following exposure to maternal immune activation, a risk factor for schizophrenia. Translational Psychiatry, 4, e418. doi: 10.1038/tp.2014.64

Savanthrapadian, S., Wolff, A. R., Logan, B. J., Eckert, M. J., Bilkey, D. K., & Abraham, W. C. (2013). Enhanced hippocampal neuronal excitability and LTP persistence associated with reduced behavioral flexibility in the maternal immune activation model of schizophrenia. Hippocampus, 23(12), 1395-1409. doi: 10.1002/hipo.22193

Hillman, K. L., & Bilkey, D. K. (2012). Neural encoding of competitive effort in the anterior cingulate cortex. Nature Neuroscience, 15(9), 1290-1298. doi: 10.1038/nn.3187

Munn, R. G. K., & Bilkey, D. K. (2012). The firing rate of hippocampal CA1 place cells is modulated with a circadian period. Hippocampus, 22, 1325-1337. doi: 10.1002/hipo.20969

Dickerson, D. D., Restieaux, A. M., & Bilkey, D. K. (2012). Clozapine administration ameliorates disrupted long-range synchrony in a neurodevelopmental animal model of schizophrenia. Schizophrenia Research, 135, 112-115. doi: 10.1016/j.schres.2011.12.016

Clearwater, J. M., & Bilkey, D. K. (2012). Place, space, and taste: Combining context and spatial information in a hippocampal navigation system. Hippocampus, 22(3), 442-454. doi: 10.1002/hipo.20911

Morgan, K., Meredith, J., Kuo, J.-Y. A., Bilkey, D. K., & McLennan, I. S. (2011). The sex bias in novelty preference of preadolescent mouse pups may require testicular Müllerian inhibiting substance. Behavioural Brain Research, 221(1), 304-306. doi: 10.1016/j.bbr.2011.02.048

Morgan, K., Dennis, N. A., Ruffman, T., Bilkey, D. K., & McLennan, I. S. (2011). The stature of boys is inversely correlated to the levels of their Sertoli cell hormones: Do the testes restrain the maturation of boys? PLoS ONE, 6(6), e20533. doi: 10.1371/journal.pone.0020533

Wolff, A. R., Cheyne, K. R., & Bilkey, D. K. (2011). Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia. Behavioural Brain Research, 225, 382-387. doi: 10.1016/j.bbr.2011.07.033

Wolff, A. R., & Bilkey, D. K. (2010). The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss. Behavioural Brain Research, 213, 323-327. doi: 10.1016/j.bbr.2010.05.008

Lu, X., & Bilkey, D. K. (2010). The velocity-related firing property of hippocampal place cells is dependent on self-movement. Hippocampus, 20(5), 573-583. doi: 10.1002/hipo.20666

Eckert, M. J., Bilkey, D. K., & Abraham, W. C. (2010). Altered plasticity in hippocampal CA1, but not dentate gyrus, following long-term environmental enrichment. Journal of Neurophysiology, 103(6), 3320-3329. doi: 10.1152/jn.01037.2009

Hillman, K. L., & Bilkey, D. K. (2010). Neurons in the rat anterior cingulate cortex dynamically encode cost-benefit in a spatial decision-making task. Journal of Neuroscience, 30(22), 7705-7713. doi: 10.1523/JNEUROSCI.1273-10.2010

Dickerson, D. D., Wolff, A. R., & Bilkey, D. K. (2010). Abnormal long-range neural synchrony in a maternal immune activation animal model of schizophrenia. Journal of Neuroscience, 30(37), 12424-12431. doi: 10.1523/JNEUROSCI.3046-10.2010

Nerad, L., Liu, P., & Bilkey, D. K. (2009). Bilateral NMDA lesions centered on the postrhinal cortex have minimal effects on hippocampal place cell firing. Hippocampus, 19(3), 221-227. doi: 10.1002/hipo.20517

Taylor, C. J., Ireland, D. R., Ballagh, I., Bourne, K., Marechal, N. M., Turner, P. R., Bilkey, D. K., Tate, W. P., & Abraham, W. C. (2008). Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiology of Disease, 31(2), 250-260. doi: 10.1016/j.nbd.2008.04.011

Wolff, A. R., & Bilkey, D. K. (2008). Immune activation during mid-gestation disrupts sensorimotor gating in rat offspring. Behavioural Brain Research, 190(1), 156-159. doi: 10.1016/j.bbr.2008.02.021

Bilkey, D. K. (2007). Space and context in the temporal cortex. Hippocampus, 17, 813-825. doi: 10.1002/hipo.20318

Oorschot, D. E., Voss, L., Covey, M. V., Bilkey, D. K., & Saunders, S. E. (2007). ADHD-like hyperactivity, with no attention deficit, in adult rats after repeated hypoxia during the equivalent of extreme prematurity. Journal of Neuroscience Methods, 166, 315-322.

Douglas, K. M., & Bilkey, D. K. (2007). Amusia is associated with deficits in spatial processing. Nature Neuroscience, 10(7), 915-921. doi: 10.1038/nn1925

Futter, J. E., Davies, M., Bilkey, D. K., & Aggleton, J. P. (2006). The effects of cytotoxic perirhinal cortex lesions on spatial learning by rats: A comparison of the Dark Agouti and Sprague-Dawley strains. Behavioral Neuroscience, 120, 150-161.

Russell, N. A., Horii, A., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2006). Lesions of the vestibular system disrupt hippocampal theta rhythm in the rat. Journal of Neurophysiology, 96, 4-14.

More publications...