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Contact Details

Phone
+64 21 0852 8847
Email
sandeepani.subasinghe@otago.ac.nz

University Links

Position
Senior Professional Practice Fellow
Department
Department of Anatomy
Qualifications
MD (Russia) MSc (Otago) PhD
Research summary
Characterisation of collagen fibre alterations in cornea following cross-linking (CXL) treatment
Teaching

Undergraduate teaching:

  • Professional courses: ELM 2, ELM 3 & ALM 5 (2nd, 3rd and 5th-year Medical), PHTY 250, (Physiotherapy 2nd year), DENT 262 (Dental 2nd year), Pharmacy 4th year
  • Science courses: ANAT 331, ANAT 101

Postgraduate teaching:

  • Postgraduate Diploma in Surgical Anatomy
  • Postgraduate Ophthalmology course
  • FRACS
    • Memberships
    • CARG
    • Australian and New Zealand Association of Clinical Anatomists
    • Anatomical Society, Faculty of Medicine, University of Colombo, Sri Lanka
    Clinical
    Clinical Education Research and Clinical Anatomy Research

    Research

    Keratoconus (KC) is a disease included in a wider range of diseases called corneal ectasia which leads to spontaneous, non-inflammatory, self-limiting ectasia of the cornea that results in localised corneal thinning with protrusion of the thinned cornea. Incidence of KC varies greatly within different ethnic groups with most estimates between 50 and 230 per 100,000 of population (approximately 1 per 2000) with a prevalence of 54.5 per 100.000 in early studies. In New Zealand, the prevalence of high incidence of keratoconus has been known for more than 30 years with a considerably high percentage in Maori and Pacific Islanders in contrast to European and Asian populations.

    In recent years, corneal crosslinking (CXL) treatment with ultraviolet light (UVA) and riboflavin has been introduced as a minimally invasive treatment option to arrest the progression of keratectasia and it has revolutionised the treatment of KC.

    Presently I am looking into long term effects and morphological changes of corneal stromal collagen fibres following crosslinking treatment.

    Publications

    Subasinghe, S. K. (2021). Biological characterisation of morphological alterations of the cornea following collagen cross-linking (CXL) treatment (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/12064 Awarded Doctoral Degree

    Subasinghe, S. K., Ogbuehi, K. C., Mitchell, L., & Dias, G. J. (2021). Morphological alterations of the cornea following Crosslinking Treatment (CXL). Clinical Anatomy, 34, 859-866. doi: 10.1002/ca.23728 Journal - Research Article

    Subasinghe, S. K., Ogbuehi, K. C., Mitchell, L., & Dias, G. J. (2021). Animal model with structural similarity to human corneal collagen fibrillar arrangement. Anatomical Science International, 96, 286-293. doi: 10.1007/s12565-020-00590-8 Journal - Research Article

    Subasinghe, S. K., Ogbuehi, K. C., Mitchell, L., & Dias, G. J. (2020). Morphological alterations of the porcine corneal collagen following collagen cross-linking (CXL) treatment. Clinical Anatomy, 33(2), (pp. E54). doi: 10.1002/ca.23426 Conference Contribution - Published proceedings: Abstract

    Subasinghe, S. K., Ogbuehi, K. C., & Dias, G. J. (2018). Current perspectives on corneal collagen crosslinking (CXL). Graefe's Archive for Clinical & Experimental Ophthalmology, 256(8), 1363-1384. doi: 10.1007/s00417-018-3966-0 Journal - Research Other

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