Dr Mike Garratt

Gaillard, J.-M., Garratt, M., & Lemaître, J.-F. (2017). Senescence in mammalian life history traits. In R. P. Shefferson, O. R. Jones & R. Salguero-Gómez (Eds.), The evolution of senescence in the tree of life. (pp. 126-155). Cambridge, UK: Cambridge University Press. doi: 10.1017/9781139939867.007

Chapter in Book - Research

Agbor Epse Muluh, E., McCormack, J. C., Mo, Y., Garratt, M., & Peng, M. (2024). Gustatory and olfactory shifts during pregnancy and the postpartum period: a systematic review and meta-analysis. Physiology & Behavior, 273, 114388. doi: 10.1016/j.physbeh.2023.114388

Journal - Research Article

Garratt, M., Neyt, C., Ladyman, S. R., Pyrski, M., Zufall, F., & Leinders-Zufall, T. (2023). Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice. iScience, 26, 106455. doi: 10.1016/j.isci.2023.106455

Journal - Research Article

Herrera, J. J., Pifer, K., Louzon, S., Leander, D., Fiehn, O., Day, S. M., … Garratt, M. (2023). Early or late-life treatment with acarbose or rapamycin improves physical performance and affects cardiac structure in aging mice. Journals of Gerontology Series A, 78(3), 397-406. doi: 10.1093/gerona/glac221

Journal - Research Article

Garratt, M., Erturk, I., Alonso, R., Zufall, F., Leinders-Zufall, T., Pletcher, S. D., & Miller, R. A. (2022). Lifespan extension in female mice by early, transient exposure to adult female olfactory cues. eLIFE. Advance online publication. doi: 10.7554/eLife.84060

Journal - Research Article

Isola, J. V. V., Veiga, G. B., de Brito, C. R. C., Alvarado‑Rincón, J. A., Garcia, D. N., Zanini, B. M., … Garratt, M., … Stout, M. B. (2022). 17α-estradiol does not adversely affect sperm parameters or fertility in male mice: Implications for reproduction-longevity trade-offs. GeroScience. doi: 10.1007/s11357-022-00601-8

Journal - Research Article

Debarba, L. K., Jayarathne, H. S. M., Miller, R. A., Garratt, M., & Sadagurski, M. (2021). 17-a-estradiol has sex-specific effects on neuroinflammation that are partly reversed by gonadectomy. Journals of Gerontology Series A. doi: 10.1093/gerona/glab216

Journal - Research Article

Garratt, M., Try, H., & Brooks, R. C. (2021). Access to females and early life castration individually extend maximal but not median lifespan in male mice. GeroScience, 43, 1437-1446. doi: 10.1007/s11357-020-00308-8

Journal - Research Article

Sugrue, V. J., Zoller, J. A., Narayan, P., Lu, A. T., Ortega-Recalde, O. J., Grant, M. J., … Bond, D. M., … Garratt, M., … Hore, T. A., & Horvath, S. (2021). Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci. eLIFE, 10, e64932. doi: 10.7554/eLife.64932

Journal - Research Article

Garratt, M., Try, H., Smiley, K. O., Grattan, D. R., & Brooks, R. C. (2020). Mating in the absence of fertilization promotes a growth-reproduction versus lifespan trade-off in female mice. PNAS, 117(27), 15748-15754. doi: 10.1073/pnas.2003159117

Journal - Research Article

Herrera, J. J., Louzon, S., Pifer, K., Leander, D., Merrihew, G. E., Park, J. H., … Garratt, M. (2020). Acarbose has sex-dependent and -independent effects on age-related physical function, cardiac health, and lipid biology. JCI Insight, 5(21), e137474. doi: 10.1172/jci.insight.137474

Journal - Research Article

Lemaître, J.-F., Ronget, V., Tidière, N., Allainé, D., Berger, V., Cohas, A., … Garratt, M., … Gaillard, J.-M. (2020). Sex differences in adult lifespan and aging rates of mortality across wild mammals. PNAS, 117(15), 8546-8553. doi: 10.1073/pnas.1911999117

Journal - Research Article

Gale, T. J., Garratt, M., & Brooks, R. C. (2019). Female mice seek refuge from castrated males, but not intact or vasectomized males, mitigating a socially-induced glucocorticoid response. Physiology & Behavior, 211, 112678. doi: 10.1016/j.physbeh.2019.112678

Journal - Research Article

Garratt, M., Leander, D., Pifer, K., Bower, B., Herrera, J. J., Day, S. M., … Miller, R. A. (2019). 17-α estradiol ameliorates age-associated sarcopenia and improves late-life physical function in male mice but not in females or castrated males. Aging Cell, 18(2), e12920. doi: 10.1111/acel.12920

Journal - Research Article

Harrison, D. E., Strong, R., Alavez, S., Astle, C. M., DiGiovanni, J., Fernandez, E., … Garratt, M., … Miller, R. A. (2019). Acarbose improves health and lifespan in aging HET3 mice. Aging Cell, 18(2), e12898. doi: 10.1111/acel.12898

Journal - Research Article

Tyshkovskiy, A., Bozaykut, P., Borodinova, A. A., Gerashchenko, M. V., Ables, G. P., Garratt, M., … Gladyshev, V. N. (2019). Identification and application of gene expression signatures associated with lifespan extension. Cell Metabolism, 30(3), 573-593. doi: 10.1016/j.cmet.2019.06.018

Journal - Research Article

Gale, T., Garratt, M., & Brooks, R. C. (2018). Perceived threats of infanticide reduce maternal allocation during lactation and lead to elevated oxidative damage in offspring. Functional Ecology, 32(9), 2158-2169. doi: 10.1111/1365-2435.13146

Journal - Research Article

Garratt, M., Lagerborg, K. A., Tsai, Y.-M., Galecki, A., Jain, M., & Miller, R. A. (2018). Male lifespan extension with 17‐α estradiol is linked to a sex‐specific metabolomic response modulated by gonadal hormones in mice. Aging Cell, 17(4), e12786. doi: 10.1111/acel.12786

Journal - Research Article

Ronget, V., Gaillard, J.-M., Coulson, T., Garratt, M., Gueyffier, F., Lega, J.-C., & Lemaître, J.-F. (2018). Causes and consequences of variation in offspring body mass: Meta-analyses in birds and mammals. Biological Reviews, 93(1), 1-27. doi: 10.1111/brv.12329

Journal - Research Article

Brooks, R. C., & Garratt, M. G. (2017). Life history evolution, reproduction, and the origins of sex-dependent aging and longevity. Annals of the New York Academy of Sciences, 1389(1), 92-107. doi: 10.1111/nyas.13302

Journal - Research Article

Cady, G., Landeryou, T., Garratt, M., Kopchick, J. J., Qi, N., Garcia-Galiano, D., … Sadagurski, M. (2017). Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Molecular Metabolism, 6(5), 393-405. doi: 10.1016/j.molmet.2017.03.001

Journal - Research Article

Garratt, M., Bower, B., Garcia, G. G., & Miller, R. A. (2017). Sex differences in lifespan extension with acarbose and 17-α estradiol: Gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling. Aging Cell, 16(6), 1256-1266. doi: 10.1111/acel.12656

Journal - Research Article

Garratt, M., Nakagawa, S., & Simons, M. J. P. (2017). Life-span extension with reduced somatotrophic signaling: Moderation of aging effect by signal type, sex, and experimental cohort. Journals of Gerontology Series A, 72(12), 1620-1626. doi: 10.1093/gerona/glx010

Journal - Research Article

Ronget, V., Garratt, M., Lemaître, J.-F., & Gaillard, J.-M. (2017). The ‘evo-demo’ implications of condition-dependent mortality. Trends in Ecology & Evolution, 32(12), 909-921. doi: 10.1016/j.tree.2017.09.003

Journal - Research Article

Garratt, M., Kee, A. J., Palme, R., & Brooks, R. C. (2016). Male presence can increase body mass and induce a stress-response in female mice independent of costs of offspring production. Scientific Reports, 6(23538). doi: 10.1038/srep23538

Journal - Research Article

Garratt, M., Nakagawa, S., & Simons, M. J. P. (2016). Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction. Aging Cell, 15(4), 737-743. doi: 10.1111/acel.12489

Journal - Research Article

Garratt, M., & Brooks, R. C. (2015). A genetic reduction in antioxidant function causes elevated aggression in mice. Journal of Experimental Biology, 218(2), 223-227. doi: 10.1242/jeb.112011

Journal - Research Article

Garratt, M., Lemaître, J.-F., Douhard, M., Bonenfant, C., Capron, G., Warnant, C., … Gaillard, J.-M. (2015). High juvenile mortality is associated with sex-specific adult survival and lifespan in wild roe deer. Current Biology, 25(6), 759-763. doi: 10.1016/j.cub.2014.11.071

Journal - Research Article

Gibson, A. B., Garratt, M., & Brooks, R. C. (2015). Experimental evidence that litter size imposes an oxidative challenge to offspring. Journal of Experimental Biology, 218(24), 3911-3918. doi: 10.1242/jeb.116327

Journal - Research Article

Garratt, M., Pichaud, N., Glaros, E. N., Kee, A. J., & Brooks, R. C. (2014). Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice. PNAS, 111(22), 8119-8124. doi: 10.1073/pnas.1322282111

Journal - Research Article

Aloise King, E. D., Garratt, M., & Brooks, R. (2013). Manipulating reproductive effort leads to changes in female reproductive scheduling but not oxidative stress. Ecology & Evolution, 3(12), 4161-4171. doi: 10.1002/ece3.786

Journal - Research Article

Garratt, M., Bathgate, R., de Graaf, S. P., & Brooks, R. C. (2013). Copper-zinc superoxide dismutase deficiency impairs sperm motility and in vivo fertility. Reproduction, 146(4), 297-304. doi: 10.1530/REP-13-0229

Journal - Research Article

Garratt, M., Gaillard, J.-M., Brooks, R. C., & Lemaître, J.-F. (2013). Diversification of the eutherian placenta is associated with changes in the pace of life. PNAS, 110(19), 7760-7765. doi: 10.1073/pnas.1305018110

Journal - Research Article

Garratt, M., Pichaud, N., Aloise King, E. D., & Brooks, R. C. (2013). Physiological adaptations to reproduction. I. Experimentally increasing litter size enhances aspects of antioxidant defence but does not cause oxidative damage in mice. Journal of Experimental Biology, 216(15), 2879-2888. doi: 10.1242/jeb.082669

Journal - Research Article

Pichaud, N., Garratt, M., Ballard, J. W. O., & Brooks, R. C. (2013). Physiological adaptations to reproduction. II. Mitochondrial adjustments in livers of lactating mice. Journal of Experimental Biology, 216(15), 2889-2895. doi: 10.1242/jeb.082685

Journal - Research Article

Garratt, M., McArdle, F., Stockley, P., Vasilaki, A., Beynon, R. J., Jackson, M. J., & Hurst, J. L. (2012). Tissue-dependent changes in oxidative damage with male reproductive effort in house mice. Functional Ecology, 26(2), 423-433. doi: 10.1111/j.1365-2435.2011.01952.x

Journal - Research Article

Garratt, M., Stockley, P., Armstrong, S. D., Beynon, R. J., & Hurst, J. L. (2011). The scent of senescence: Sexual signalling and female preference in house mice. Journal of Evolutionary Biology, 24(11), 2398-2409. doi: 10.1111/j.1420-9101.2011.02367.x

Journal - Research Article

Garratt, M., Vasilaki, A., Stockley, P., McArdle, F., Jackson, M., & Hurst, J. L. (2011). Is oxidative stress a physiological cost of reproduction? An experimental test in house mice. Proceedings of the Royal Society B, 278(1708), 1098-1106. doi: 10.1098/rspb.2010.1818

Journal - Research Article

McCormack, J. C., Roberts, R., Garratt, M., Wang, T., Hayes, J., & Peng, M. (2023). Longitudinal study of Energy, Neurosensory and Eating Responses durinG pregnancY (ENERGY cohort): A study protocol. Clinical Nutrition ESPEN. Advance online publication. doi: 10.1016/j.clnesp.2023.01.033

Journal - Research Other

Garratt, M. (2020). Why do sexes differ in lifespan extension? Sex-specific pathways of aging and underlying mechanisms for dimorphic responses. Nutrition & Healthy Aging, 5, 247-259. doi: 10.3233/NHA-190067

Journal - Research Other

Lemaître, J.-F., Garratt, M., & Gaillard, J.-M. (2020). Going beyond lifespan in comparative biology of aging. Advances in Geriatric Medicine & Research, 2(2), e200011. doi: 10.20900/agmr20200011

Journal - Research Other

Garratt, M., & Stout, M. B. (2018). Hormone actions controlling sex-specific life-extension. Aging, 10(3), 293-294. doi: 10.18632/aging.101396

Journal - Research Other

Dantzer, B., & Garratt, M. (2017). Sex differences in telomeres and lifespan in Soay sheep: From the beginning to the end. Molecular Ecology, 26(12), 3090-3092. doi: 10.1111/mec.14129

Journal - Research Other

Garratt, M., Brooks, R. C., Lemaître, J.-F., & Gaillard, J.-M. (2014). Female promiscuity and maternally dependent offspring growth rates in mammals [Brief communication]. Evolution, 68(4), 1207-1215. doi: 10.1111/evo.12333

Journal - Research Other

Speakman, J. R., & Garratt, M. G. (2014). Oxidative stress as a cost of reproduction: Beyond the simplistic trade-off model. BioEssays, 36(1), 93-106. doi: 10.1002/bies.201300108

Journal - Research Other

Gale, T., Gibson, A. B., Brooks, R. C., & Garratt, M. (2013). Exposure to a novel male during late pregnancy influences subsequent growth of offspring during lactation [Short communication]. Journal of Evolutionary Biology, 26(9), 2057-2062. doi: 10.1111/jeb.12192

Journal - Research Other

Garratt, M., & Brooks, R. C. (2012). Oxidative stress and condition-dependent sexual signals: More than just seeing red. Proceedings of the Royal Society B, 279(1741), 3121-3130. doi: 10.1098/rspb.2012.0568

Journal - Research Other