Associate Professor Joanna Williams

Contact Details

Phone: +64 3 479 8821
Email: joanna.williams@otago.ac.nz

University Links

Position: Associate Professor
Department: Department of Anatomy
Qualifications: BSc MSc PhD (Otago)
Research summary: Molecular Neurobiology

Research

Our research covers three main areas:

Memory mechanisms: Using modern molecular biological, bioinformatics and proteomic techniques we have built up a portfolio of studies focused on the regulation of key glutamate receptors involved in memory processes as well as how gene and microRNA expressions are altered in response to memory events. Understanding how memories are formed will lead to a greater understanding of the molecular pathology underlying aging-related memory loss and diseases of the brain.

Amyloid precursor protein: The lab is intensively researching a protein called sAPPα. Unlike amyloid-?, the pathological agent in Alzheimer's Disease, sAPPα, has neuroprotective and memory enhancing functions and the group aims to uncover both molecular mechanisms underlying these positive functions and the specific regions within sAPPα which confer these properties as these may have therapeutic potential.

Biomarkers Discovery: We have added a new dimension to our research portfolio which aims to identify biomarkers within plasma which may be predictive of neurological diseases. Currently this work focuses on Alzheimer's Disease, Schizophrenia and Parkinson's disease.

Joanna's research expertise includes molecular profiling - Western blotting, qPCR, qPCR arrays, microarrays, epigenetics assay, bioinformatics, human and animal models of Alzheimer's disease.

For more details:
Neuroscience Research Group

Publications

Guévremont, D., Roy, J., Cutfield, N. J., & Williams, J. M. (2023). MicroRNAs in Parkinson's disease: A systematic review and diagnostic accuracy meta-analysis. Scientific Reports, 13(1), 16272. doi: 10.1038/s41598-023-43096-9 Journal - Research Article

Tippett, L. J., Cawston, E. E., Morgan, C. A., Melzer, T. R., Brickell, K. L., Ilse, C., … Le Heron, C., Buchanan, S., … Anderson, T. J., Williams, J. M., Cutfield, N. J., Dalrymple-Alford, J. C., … the NZ-DPRC. (2023). Dementia Prevention Research Clinic: A longitudinal study investigating factors influencing the development of Alzheimer’s disease in Aotearoa, New Zealand. Journal of the Royal Society of New Zealand, 53(4), 489-510. doi: 10.1080/03036758.2022.2098780 Journal - Research Article

Ryan, B., O'Mara Baker, A., Ilse, C., Brickell, K. L., Kersten, H. M., Williams, J. M., … Curtis, M. A. (2023). The New Zealand Genetic Frontotemporal Dementia Study (FTDGeNZ): A longitudinal study of pre-symptomatic biomarkers. Journal of the Royal Society of New Zealand, 53(4), 511-531. doi: 10.1080/03036758.2022.2101483 Journal - Research Article

Spoelstra, H. E., Westlake, C. M., & Williams, J. M. (2022). The relationship between secreted amyloid precursor protein alpha (sAPPα) and the cell surface expression of NMDA glutamate receptors: A time-course study. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 264th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839 Conference Contribution - Published proceedings: Abstract

Lamichhane, R., Williams, J., Fouille, R., Tirand, C., Wedlock, L., Hannaway, R., & Ussher, J. E. (2022, August). Co-stimulatory function of 4-1BB during MAIT cell activation by bacteria. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)

2023

Journal - Research Article

2022

Journal - Research Article

Chu, A. J., & Williams, J. M. (2022). Astrocytic microRNA in ageing, inflammation, and neurodegenerative disease. Frontiers in Physiology, 12, 826697. doi: 10.3389/fphys.2021.826697

Guévremont, D., Tsui, H., Knight, R. G., Fowler, C. J., Masters, C. L., Martins, R. N., Abraham, W. C., Tate, W. P., Cutfield, N. J., & Williams, J. M. (2022). Plasma microRNA vary in association with the progression of Alzheimer's disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 14, e12251. doi: 10.1002/dad2.12251

Potemkin, N., Cawood, S. M. F., Treece, J., Guévremont, D., Rand, C. J., McLean, C., Stanton, J.-A. L., & Williams, J. M. (2022). A method for simultaneous detection of small and long RNA biotypes by ribodepleted RNA-Seq. Scientific Reports, 12(621). doi: 10.1038/s41598-021-04209-4

Conference Contribution - Published proceedings: Abstract

Cawood, S., Neehoff, S., Glue, P., Williams, J., Ryan, M., Russell, B., & Harrison, O. (2022). Investigating the relationship between microRNA expression, brain structure and biochemistry in anxiety disorders and their potential treatment with ketamine. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 82). Retrieved from https://www.queenstownresearchweek.org

Conference Contribution - Poster Presentation (not in published proceedings)

2021

Journal - Research Article

Livingstone, R. W., Elder, M. K., Singh, A., Westlake, C. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2021). Secreted amyloid precursor protein-alpha enhances LTP through the synthesis and trafficking of Ca²⁺-permeable AMPA receptors. Frontiers in Molecular Neuroscience, 14, 660208. doi: 10.3389/fnmol.2021.660208

Kyrke-Smith, M., Logan, B., Abraham, W. C., & Williams, J. M. (2021). Bilateral histone deacetylase 1 and 2 activity and enrichment at unique genes following induction of long-term potentiation in vivo. Hippocampus, 31, 389-407. doi: 10.1002/hipo.23297

Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757

Conference Contribution - Published proceedings: Abstract

Westlake, C. M., Livingstone, R. W., Peppercorn, K., Tate, W. P., & Williams, J. M. (2021). Secreted amyloid precursor protein alpha (sAPPα) regulates surface expression of GluA1-containing glutamate receptors in primary hippocampal neurons. New Zealand Medical Journal, 134(1535), (pp. 98). Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Chu, A. J., Connor, B., & Williams, J. M. (2021, September). Developing novel therapeutics for Alzheimer's disease in Aotearoa: Effects of secreted amyloid precursor protein-alpha on astrocytes and reprogrammed human neural cultures. Poster session presented at the Achieving Health Equity from Research Conference [Otago Spotlight Series], Wellington, New Zealand.

Working Paper; Discussion Paper; Technical Report

Potemkin, N., Cawood, S. M. F., Treece, J., Guévremont, D., Rand, C. J., McLean, C., Stanton, J.-A. L., & Williams, J. M. (2021). A workflow for simultaneous detection of coding and non-coding transcripts by ribosomal RNA-depleted RNA-Seq. bioRxiv. doi: 10.1101/2021.01.04.425201

2020

Journal - Research Article

Loehfelm, A., Elder, M. K., Boucsein, A., Jones, P. P., Williams, J. M., & Tups, A. (2020). Docosahexaenoic acid prevents palmitate-induced insulin-dependent impairments of neuronal health. FASEB Journal, 34, 4635-4652. doi: 10.1096/fj.201902517R

Conference Contribution - Published proceedings: Abstract

Guévremont, D., Tsui, H., Knight, R., Fowler, C. J., Masters, C. L., Martins, R. N., Abraham, W. C., Tate, W. P., Cutfield, N., & Williams, J. M. (2020). Plasma microRNA vary in association with the progression in Alzheimer's disease. Proceedings of the Alzheimer's Association International Conference (AAIC). ODO2-09-06. Retrieved from https://alz.confex.com/alz/20amsterdam/meetingapp.cgi/Home/0

2019

Journal - Research Article

Livingstone, R. W., Elder, M. K., Barrett, M. C., Westlake, C. M., Peppercorn, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2019). Secreted amyloid precursor protein-alpha promotes arc protein synthesis in hippocampal neurons. Frontiers in Molecular Neuroscience, 12, 198. doi: 10.3389/fnmol.2019.00198

Ryan, B., Williams, J. M., & Curtis, M. A. (2019). Plasma microRNAs are altered early and consistently in a mouse model of tauopathy. Neuroscience, 411, 164-176. doi: 10.1016/j.neuroscience.2019.05.036

Mockett, B. G., Guévremont, D., Elder, M. K., Parfitt, K. D., Peppercorn, K., Morrissey, J., Singh, A., Hintz, T. J., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2019). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Journal of Neuroscience, 39(17), 3188-3203. doi: 10.1523/jneurosci.1826-18.2019

Ryan, B., & Williams, J. M. (2019). Novel microRNA revealed by systematic analysis of the microRNA transcriptome in dentate gyrus granule cells. Neuroscience Letters, 707, 132280. doi: 10.1016/j.neulet.2016.09.003

Conference Contribution - Published proceedings: Abstract

Roy, J., Guevremont, D., Garvey, A., Cutfield, N. J., & Williams, J. M. (2019). MicroRNA expression in the diagnosis of Parkinson's disease. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 13197. Retrieved from https://www.ans.org.au

Chu, A. J., Peppercorn, K., Tate, W. P., Erlandsson, A., & Williams, J. M. (2019). Secreted amyloid precursor protein-alpha enhances amyloid-beta protofibril degradation in primary murine astrocytes. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 12828. Retrieved from https://www.ans.org.au

Kyrke-Smith, M., Abraham, W., & Williams, J. (2019). Bilateral regulation of histone deacetylase activity and gene expression is associated with an intermediate form long-term potentiation in vivo. Proceedings of the 39th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 11708. Retrieved from https://www.ans.org.au

Livingstone, R., Elder, M. K., Barrett, M., Westlate, C., Peppercorn, K., Tate, W., Abraham, W. C., & Williams, J. M. (2019). Arc protein synthesis is promoted by secreted amyloid precursor protein-alpha in primary hippocampal neurons. Proceedings of the Society for Neuroscience Annual Meeting. 286.17/C27. SfN. Retrieved from https://www.sfn.org

Roy, J., Guévremont, D., Garvey, A., Cutfield, N., & Williams, J. (2019). MicroRNA expression in the diagnosis of Parkinson's disease. Movement Disorders, 34(Suppl. 2), (pp. S297). doi: 10.1002/mds.27795

2018

Journal - Research Article

Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNAs are altered with amyloidosis in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease, 66(2), 835-852. doi: 10.3233/jad-180385

Kyrke-Smith, M., & Williams, J. M. (2018). Bridging synaptic and epigenetic maintenance mechanisms of the engram. Frontiers in Molecular Neuroscience, 11, 369. doi: 10.3389/fnmol.2018.00369

Journal - Research Other

Ryan, B., Baker, A., Ilse, C., Brickell, K. L., Kersten, H. M., Danesh-Meyer, H. V., Williams, J. M., … Curtis, M. A. (2018). Diagnosing pre-clinical dementia: The NZ Genetic Frontotemporal Dementia Study (FTDGeNZ). New Zealand Medical Journal, 1476(131), 88-91. Retrieved from https://www.nzma.org.nz/journal

Conference Contribution - Published proceedings: Abstract

Garvey, A., Cutfield, N., & Williams, J. (2018). Is there a role for miRNA in the diagnosis of PD? Movement Disorders, 33(Suppl. 2), (pp. S402). doi: 10.1002/mds.116

Elder, M. K., Tate, W. P., Abraham, W. C., Schman, E., & Williams, J. (2018). Secreted amyloid precursor protein alpha regulates AMPA receptor synthesis and trafficking. Proceedings of the 38th Australasian Neuroscience Society (ANS) Annual Scientific Meeting. 9274. Retrieved from https://www.ans.org.au

Williams, J. M., Elder, M. K., & Tate, W. P. (2018). Cell surface expression of GluA1-containing AMPA receptors is enhanced by secreted amyloid precursor protein-alpha; visualized by BioPLAy. Proceedings of the Society for Neuroscience 48th Annual Meeting. 285.15/E44. SfN. Retrieved from https://www.sfn.org

Ryan, M. M., Guévremont, D., Mockett, B., Abraham, W. C., & Williams, J. M. (2018). Circulating plasma microRNA are altered with amyloidosis in a mouse model of Alzheimer's disease. Proceedings of the Society for Neuroscience 48th Annual Meeting. 132.17/S12. SfN. Retrieved from https://www.sfn.org

Livingstone, R. W., Elder, M. K., Barrett, M., Westlake, C., Tate, W., Abraham, W., & Williams, J. M. (2018). Arc protein expression in response to secreted amyloid precursor protein-α in primary hippocampal cultures. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 60). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr

Potemkin, N., Tate, W. P., & Williams, J. M. (2018). Amyloid-β increases SH-SY5y neuroblastoma cell viability. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 57). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr

Roy, J., Garvey, A., Guévremont, D., Cutfield, N. J., & Williams, J. M. (2018). MicroRNA expression in the diagnosis of Parkinson's disease. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 53). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr

2017

Journal - Research Article

Ryan, B., Logan, B. J., Abraham, W. C., & Williams, J. M. (2017). MicroRNAs, miR-23a-3p and miR-151-3p, are regulated in dentate gyrus neuropil following induction of long-term potentiation in vivo. PLoS ONE, 12(1), e0170407. doi: 10.1371/journal.pone.0170407

Conference Contribution - Published proceedings: Abstract

Mockett, B. G., Guévremont, D., Parfitt, K., Elder, M., Peppercorn, K., Kochen, L., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2017). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Proceedings of the Australasian Neuroscience Society 37th Annual Scientific Meeting. Retrieved from http://ans2017.aomevents.com.au

Elder, M., Peppercorn, K., Schuman, E. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2017). Secreted amyloid precursor protein alpha regulated AMPA receptor synthesis and trafficking. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 58). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Ryan, B., Ilse, C., Brickell, K., Baker, A., Addis, D. R., Williams, J., … Curtis, M. (2017). Identifying early markers of frontotemporal dementia. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 30). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Ryan, M. M., Guévremont, D., Mockett, B. G., Abraham, W. C., & Williams, J. M. (2017). Changes in circulating microRNA during disease progession in a mouse model of Alzheimer's disease. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 26). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html

Conference Contribution - Verbal presentation and other Conference outputs

Loehfelm, A., Elder, M., Williams, J., & Tups, A. (2017, September). Effects of fatty acids on neuronal morphology and function: Implications for Alzheimer’s disease. Verbal presentation at the Medical Sciences Congress (MedSci), Queenstown, New Zealand.

Kyrke-Smith, M., Abraham, W. C., & Williams, J. M. (2017, September). Histone deacetylase activity is regulated following induction of long-term potentiation in vivo. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Conference Contribution - Published proceedings: Abstract

Parfitt, K. D., Mockett, B., Hintz, T. J., Bourne, K., Williams, J. M., Tate, W. P., & Abraham, W. C. (2016). Secreted amyloid precursor protein-alpha enhances long-term potentiation via protein synthesis- and protein trafficking-dependent mechanisms. Alzheimer's & Dementia, 12(7, Suppl.), (pp. P1040). doi: 10.1016/j.jalz.2016.06.2159

Williams, J. M., Guevremont, D., Mockett, B., Peppercorn, K., Tate, W. P., & Abraham, W. C. (2016). Secreted amyloid precursor protein-alpha regulates glutamate receptor trafficking in the hippocampus. Alzheimer's & Dementia, 12(7, Suppl.), (pp. P1040-P1041). doi: 10.1016/j.jalz.2016.06.2160

Elder, M. K., Peppercorn, K., tom Dieck, S., Kochen, L., Schuman, E., Tate, W., Abraham, C., & Williams, J. (2016). Secreted amyloid precursor protein-alpha regulates synthesis of the AMPA receptor subunit GluA1. Proceedings of the Society for Neuroscience 46th Annual Meeting. 397.08/E29. SfN. Retrieved from https://www.sfn.org/

Tippett, L., Melzer, T., Ilse, C., & Williams, J. (2016). Introduction to Brain Research New Zealand - Dementia Prevention Research Clinics. Neuroepidemiology, 47(3-4), (pp. 129-130). doi: 10.1159/000453097

Kyrke-Smith, M., Abraham, W. C., & Williams, J. M. (2016). Inhibition of histone deacetylase activity, after LTP induction, does not promote the persistence of LTP in vivo. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 27). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

2015

Journal - Research Article

Nido, G. S., Ryan, M. M., Benuskova, L., & Williams, J. M. (2015). Dynamical properties of gene regulatory networks involved in long-term potentiation. Frontiers in Molecular Neuroscience, 8, 42. doi: 10.3389/fnmol.2015.00042

Ryan, B., Joilin, G., & Williams, J. M. (2015). Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation. Frontiers in Molecular Neuroscience, 8, 4. doi: 10.3389/fnmol.2015.00004

Smith, C. C., Guévremont, D., Williams, J. M., & Napper, R. M. A. (2015). Apoptotic cell death and temporal expression of apoptotic proteins Bcl-2 and Bax in the hippocampus, following binge ethanol in the neonatal rat model. Alcoholism, 39(1), 36-44. doi: 10.1111/acer.12606

Ryan, M. M., Guévremont, D., Luxmanan, C., Abraham, W. C., & Williams, J. M. (2015). Aging alters long-term potentiation—related gene networks and impairs synaptic protein synthesis in the rat hippocampus. Neurobiology of Aging, 36(5), 1868-1880. doi: 10.1016/j.neurobiolaging.2015.01.012

Conference Contribution - Published proceedings: Abstract

Kyrke-Smith, M., Abraham, W. C., & Williams, J. M. (2015). Regulation of HDAC1 and HDAC2 following long-term potentiation. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 62). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

Ryan, B., Logan, B., Abraham, W. C., & Williams, J. M. (2015). Regulation of MicroRNAs at denate gyrus synapses after long-term potentiation induction in vivo. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 50). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

Elder, M., Peppercorn, K., Schuman, E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2015). Secreted amyloid precursor protein alpha regulates protein synthesis in primary hippocampal neuronal cultures. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 28). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

Ryan, M., Mockett, B., Guevremont, D., Abraham, W. C., & Williams, J. (2015). Distinct microma expression in a transgenic mouse model of Alzheimer's disease. Journal of Neurochemistry, 134(Suppl. 1), (pp. 328). doi: 10.1111/jnc.13189

Kyrke-Smith, M., Abraham, W. C., & Williams, J. (2015). Regulation of HDAC1 and HDAC2 following long-term potentiation. Journal of Neurochemistry, 134(Suppl. 1), (pp. 305). doi: 10.1111/jnc.13189

Elder, M., Peppercorn, K., Schuman, E., Tate, W., Abraham, C., & Williams, J. (2015). Secreted amyloid precursor protein alpha regulates protein synthesis in primary hippocampal neuronal cultures. Journal of Neurochemistry, 134(Suppl. 1), (pp. 302). doi: 10.1111/jnc.13189

2014

Journal - Research Article

Joilin, G., Guévremont, D., Ryan, B., Claudianos, C., Cristino, A. S., Abraham, W. C., & Williams, J. M. (2014). Rapid regulation of microRNA following induction of long-term potentiation in vivo. Frontiers in Molecular Neuroscience, 7, 98. doi: 10.3389/fnmol.2014.00098

Dickerson, D. D., Overeem, K. A., Wolff, A. R., Williams, J. M., Abraham, W. C., & Bilkey, D. K. (2014). Association of aberrant neural synchrony and altered GAD67 expression following exposure to maternal immune activation, a risk factor for schizophrenia. Translational Psychiatry, 4, e418. doi: 10.1038/tp.2014.64

Kennard, J. T. T., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2014). Redistribution of ionotropic glutamate receptors detected by laser microdissection of the rat dentate gyrus 48 h following LTP induction in vivo. PLoS ONE, 9(3), e92972. doi: 10.1371/journal.pone.0092972

Trotman, M., Barad, Z., Guévremont, D., Williams, J., & Leitch, B. (2014). Changes in the GRIP 1&2 scaffolding proteins in the cerebellum of the ataxic stargazer mouse. Brain Research, 1546, 53-62. doi: 10.1016/j.brainres.2013.12.027

Conference Contribution - Published proceedings: Abstract

Joilin, G., Guevremont, D., Abraham, W., Print, C., & Williams, J. M. (2014). Bioinformatic identification of genes targeted by microRNA regulated following induction of long-term potentiation in vivo. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts

Parfitt, K. D., Mockett, B. G., Guevremont, D., Bourne, K., Tate, W. P., Williams, J. M., & Abraham, W. C. (2014). Secreted amyloid precursor protein-alpha (sAPPα) modulates long-term potentiation, induces metaplasticity and regulates glutamate receptor localization in rat hippocampus. Proceedings of the Society for Neuroscience 44th Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2014/abstracts

Kyrke-Smith, M., Abraham, W. C., & Williams, J. M. (2014). Temporal analysis of HDAC1 and HDAC2 activity during long-term potentiation. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 67). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

Elder, M., Mockett, B. G., Blok, J., Peppercorn, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2014). Secreted amyloid precursor protein-α attenuates apoptosis following amyloid-β insult and ischemic injury. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 32nd International Australasian Winter Conference on Brain Research. 32, (pp. 62). AWCBR. Retrieved from https://web.psy.otago.ac.nz/awcbr/proceedings.html

2013

Journal - Research Article

Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013). Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics, 14, 376. doi: 10.1186/1471-2164-14-376

Eckert, M. J., Guévremont, D., Williams, J. M., & Abraham, W. C. (2013). Rapid visual stimulation increases extrasynaptic glutamate receptor expression but not visual-evoked potentials in the adult rat primary visual cortex. European Journal of Neuroscience, 37(3), 400-406. doi: 10.1111/ejn.12053

Conference Contribution - Published proceedings: Abstract

Nido, G., Benuskova, L., & Williams, J. (2013). Different stability of gene networks formed following induction of long-term potentiation identified using Boolean models. Proceedings of the 21st Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) & the 12th European Conference on Computational Biology (ECCB). Retrieved from http://www.iscb.org/cms_addon/conferences/ismbeccb2013/posterlist.php?cat=O

Overeem, K. A., Wolff, A. R., Bilkey, D. K., & Williams, J. M. (2013). Aberrant expression of microRNA in blood plasma and CA1 of adult animals exposed to maternal immune activation. Proceedings of the Society for Neuroscience 43rd Annual Meeting. SfN. Retrieved from http://www.sfn.org/annual-meeting/neuroscience-2013/abstracts-and-sessions

Elder, M., Blok, J., Mockett, B., & Williams, J. (2013). Secreted amyloid precursor protein-α attenuates cell death in organotypic hippocampal slices. New Zealand Medical Journal, 126(1386). Retrieved from http://www.nzma.org.nz/journal

Williams, J. M., Joilin, G., Guévremont, D., Logan, B., & Abraham, W. C. (2013). Regulation of microRNA following induction of long-term potentiation in vivo. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 73). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Williams, J. M., Guévremont, D., Tsui, H., Logan, B., Knight, R., Abraham, W. C., Tate, W. P., & Cutfield, N. (2013). Altered expression of plasma microRNA in sporadic Alzheimer's disease. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 70). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Ryan, B., Logan, B., Abraham, W. C., & Williams, J. M. (2013). MicroRNA, miR-28-5p, is down-regulated at dentate gyrus synapses after long-term potentiation induction in vivo. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 64). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html

Conference Contribution - Verbal presentation and other Conference outputs

Williams, J. M., Joilin, G., Guévremont, D., Logan, B., & Abraham, W. C. (2013, August). Regulation of microRNA following induction of long-term potentiation in vivo. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2012

Journal - Research Article

Ryan, M. M., Ryan, B., Kyrke-Smith, M., Logan, B., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS ONE, 7(7), e40538. doi: 10.1371/journal.pone.0040538

Rushaidhi, M., Jing, Y., Kennard, J. T., Collie, N. D., Williams, J. M., Zhang, H., & Liu, P. (2012). Aging affects L-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels. Neuroscience, 209, 21-31. doi: 10.1016/j.neuroscience.2012.02.021

Conference Contribution - Published proceedings: Full paper

Nido, G. S., Williams, J. M., & Benuskova, L. (2012). Bistable properties of a memory-related gene regulatory network. Proceedings of the Annual International Joint Conference on Neural Networks (IJCNN). (pp. 1602-1607). IEEE. doi: 10.1109/IJCNN.2012.6252588

Conference Contribution - Published proceedings: Abstract

Leitch, B., Trotman, M., Barad, Z., Guevremont, D., & Williams, J. (2012). Changes in GRIP expression at cerebellar synapses in the ataxic Stargazer mutant mouse. FENS Abstracts. 7, 011.06. Retrieved from http://fens2012.meetingxpert.net/FENS_331/poster_31521/program.aspx/anchor385

Overeem, K. A., Guévremont, D., Bilkey, D. K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Comparison of methods for the isolation of microRNA from rat and human plasma: Beginning the search for biomarkers of neurological disorders. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 124). Retrieved from http://www.ans.org.au/ans-annual-conference/

Williams, J., Joilin, G., Ryan, B., Guevremont, D., Ryan, M., Logan, B., & Abraham, W. (2012). Rapid down-regulation of microRNA following induction of long-term potentiation in vivo. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 49). Retrieved from http://www.ans.org.au/ans-annual-conference/

Overeem, K., Wolff, A., Bilkey, D., & Williams, J. (2012). Aberrant expression of plasma microRNAs in the maternal immune activation model of schizophrenia. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 65). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html

Joilin, G., Guévremont, D., Ryan, B., Logan, B., Abraham, W. C., & Williams, J. M. (2012). N-methyl-D-aspartic acid receptor-specific down-regulation of mature microRNA, miR-34a, following indcution of long-term potentiation in vivo. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 44). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html

Conference Contribution - Verbal presentation and other Conference outputs

Joilin, G., Guévremont, D., Ryan, B., Logan, B., Abraham, W. C., & Williams, J. M. (2012, August). N-methyl-D-aspartic acid receptor-specific down-regulation of mature microRNA, miR-34a, following induction of long-term potentiation in vivo. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2011

Journal - Research Article

Mockett, B. G., Guévremont, D., Wutte, M., Hulme, S. R., Williams, J. M., & Abraham, W. C. (2011). Calcium/calmodulin-dependent protein kinase II mediates Group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus. Journal of Neuroscience, 31(20), 7380-7391. doi: 10.1523/JNEUROSCI.6656-10.2011

Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2011). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo. Hippocampus, 21(5), 541-553. doi: 10.1002/hipo.20770

Conference Contribution - Published proceedings: Abstract

Ryan, M. M., Morris, G., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2011). Secreted amyloid precursor protein-alpha regulates hippocampal gene expression. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 163). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf

Claasen, A. M., Guévremont, D., Abraham, W. C., Tate, W. P., & Williams, J. M. (2011). Secreted amyloid precursor protein-alpha activates MAP kinase and CaM kinase signalling pathways at rat cortical synapses. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 91). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf

Mockett, B. G., Guevremont, D., Williams, J. M., & Abraham, W. C. (2011). Novel role for CaMKII in regulating group I mGluR-mediated LTD in rat hippocampus. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 79). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Oral%20Abstracts.pdf

Nido, G. S., Benuskova, L., & Williams, J. (2011). Bistability in LTP-related gene regulatory networks. Proceedings of the 5th Australian Workshop on Computational Neuroscience. (pp. 49). Australia: University of Western Sydney. Retrieved from http://marcs.uws.edu.au/rescom//resources/AWCN%20Abstract%20Booklet_FINAL%20for%20website.pdf

Joilin, G., Ryan, B., Guévremont, D., Logan, B., Ryan, M. M., Abraham, W. C., & Williams, J. M. (2011). Rapid down-regulation of a microRNA controller of gene expression, microRNA-132, following induction of long-term potentiation in vivo. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.28. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html

Joilin, G., Guévremont, D., Logan, B., Ryan, M., Abraham, W., & Williams, J. (2011). Rapid down-regulation of microRNA following induction of long-term potentiation in vivo. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf

Overeem, K., Wolff, A., Bilkey, D., Williams, J., & Abraham, W. (2011). Maternal immune activation reduces inhibitory drive in CA1 of the dorsal hippocampus: A potential characteristic of increased risk for schizophrenia development. New Zealand Medical Journal, 124(1342). Retrieved from http://journal.nzma.org.nz/journal/124-1342/4875/content.pdf

Ryan, B., Guévremont, D., Ryan, M., Logan, B., Abraham, W., & Williams, J. (2011). Plasticity-related down-regulation of microRNA regulators of gene expression. New Zealand Medical Journal. 124(1335). Retrieved from http://www.nzma.org.nz/journal/124-1335/4693/content.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Abraham, C., Ryan, M., Logan, B., & Williams, J. (2011, May). LTP-associated gene expression: NFkappaB as a potential hub of activity. Verbal presentation at the Spring Hippocampal Research Conference, Verona, Italy.

2010

Journal - Research Article

Tenorio, G., Connor, S. A., Guévremont, D., Abraham, W. C., Williams, J., O'Dell, T. J., & Nguyen, P. V. (2010). 'Silent' priming of translation-dependent LTP by β-adrenergic receptors involves phosphorylation and recruitment of AMPA receptors. Learning & Memory, 17(12), 627-638. doi: 10.1101/lm.1974510

Conference Contribution - Published proceedings: Abstract

Rushaidhi, M., Chary, S., Jing, Y., Kennard, J. T., Collie, N. D., Williams, J. M., Zhang, H., & Liu, P. (2010). Effects of aging on agmatine levels in the rat hippocampus and prefrontal cortex. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 48). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm

Mockett, B. G., Hulme, S. R., Guévremont, D., Williams, J. M., & Abraham, W. C. (2010). Both synaptically- and chemically-induced group 1 mGluR-mediated LTD are regulated by CaMKII in rat hippocampus. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 24). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm

Eckert, M. J., Guevremont, D., Williams, J. M., & Abraham, W. C. (2010). Rapid visual stimulation increases cell-surface glutamate receptor expression in rat primary visual cortex. Proceedings of the Society for Neuroscience 40th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/Plan/SSResults.aspx

2009

Journal - Research Article

Kennard, J. T. T., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2009). Increased expression, but not postsynaptic localisation, of ionotropic glutamate receptors during the late-phase of long-term potentiation in the dentate gyrus in vivo. Neuropharmacology, 56(1), 66-72. doi: 10.1016/j.neuropharm.2008.07.044

Claasen, A. M., Guévremont, D., Mason-Parker, S. E., Bourne, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2009). Secreted amyloid precursor protein-α upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. Neuroscience Letters, 460, 92-96. doi: 10.1016/j.neulet.2009.05.040

Leitch, B., Shevtsova, O., Guévremont, D., & Williams, J. (2009). Loss of calcium channels in the cerebellum of the ataxic and epileptic stargazer mutant mouse. Brain Research, 1279, 156-167. doi: 10.1016/j.brainres.2009.04.051

Conference Contribution - Published proceedings: Abstract

Shevtsova, O., Guévremont, D., Williams, J. M., & Leitch, B. (2009). Alteration in calcium channel expression at cerebellar synapses in the ataxic and epileptic stargazer mutant mouse. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 36). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm

McKearney, J. S., Guévremont, D., Mockett, B., Abraham, W. C., & Williams, J. (2009). Activation of Group I metabotropic receptors reduces intracellular pools of the AMPA receptor subunit, GluA1. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 37). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm

Reynolds, J. N. J., Williams, J. M., & Schulz, J. M. (2009). Induction of pause responses in striatal cholinergic interneurons by sensory stimuli: An in vivo intracellular study. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Ryan, M. M., Morris, G., Bourne, K., Mockett, B. G., Abraham, W. C., Tate, W. P., & Williams, J. M. (2009). Regulation of gene expression by sAPPα and RER derivative in differentiated neuroblastoma cells. Alzheimer's & Dementia, 5(4, Suppl. 1), (pp. P421). doi: 10.1016/j.jalz.2009.04.938

Conference Contribution - Verbal presentation and other Conference outputs

Overeem, K., Gill, H., Geuvremont, D., Williams, J., Bilkey, D., & Abraham, C. (2009, September). Does the maternal immune activation model of schizophrenia alter hippocampal levels of the GABA-synthesizing enzymes GAD65 and GAD67 or the NMDA receptor subunit NR1? Verbal presentation at the 16th New Zealand Schizophrenia Research Group Annual Research Conference, Dunedin, New Zealand.

2008

Journal - Research Article

Abraham, W. C., & Williams, J. M. (2008). LTP maintenance and its protein synthesis-dependence. Neurobiology of Learning & Memory, 89(3), 260-268. doi: 10.1016/j.nlm.2007.10.001

Conference Contribution - Published proceedings: Abstract

Renshaw, J. A., Ryan, M., Williams, J., & Tate, W. (2008). Recombinant sAPPα causes specific changes in gene expression in neuroblastoma cells and rat hippocampal cell slices. New Zealand Medical Journal, 121(1274). Retrieved from http://journal.nzma.org.nz/journal/121-1274/3078/content.pdf

Claasen, A. M., Guévremont, D., Mason-Parker, S. E., Bourne, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2008). Secreted amyloid precursor protein alpha-dependent upregulation of synaptic protein synthesis is dose and protein kinase G-dependent. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 46). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Leitch, B., Shevtsova, O., Guévremont, D., & Williams, J. M. (2008). Synaptic changes in cerebellar neurons of an ataxic mouse. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 29). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Luxmanan, C., Ryan, M., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2008). Age-related changes in LTP-associated gene expression profiles in the dentate gyrus. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 21). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Kennard, J. T. T., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2008). Dentate gyrus subregional analysis of glutamate receptor expression following perforant path LTP in vivo. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 22). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Tate, W., Bourne, K., Turner, P. R., Claasen, A., Ryan, M., Taylor, C., Ireland, D., Ballagh, I., Marechal, N., Bilkey, D., Williams, J., & Abraham, W. (2008, November-December). Secreted amyloid precursor protein alpha: A mammalian memory molecule. Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

2007

Journal - Research Article

Mockett, B. G., Guévremont, D., Williams, J. M., & Abraham, W. C. (2007). Dopamine D₁/D₅ receptor activation reverses NMDA receptor-dependent long-term depression in rat hippocampus. Journal of Neuroscience, 27(11), 2918-2926. doi: 10.1523/JNEUROSCI.0838-06.2007

Williams, J. M., Guévremont, D., Mason-Parker, S. E., Luxmanan, C., Tate, W. P., & Abraham, W. C. (2007). Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. Journal of Neuroscience, 27(51), 14171-14178.

Conference Contribution - Published proceedings: Abstract

Young, G., Bourne, K., Tate, W. P., & Williams, J. M. (2007). Regulation of N-methyl-D-asparate receptor subunits NR1 and NR2A expression in vitro. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 43). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf

Ryan, M. M., Luxmanan, C., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2007). Profiling early gene expression changes during LTP in-vivo. Proceedings of the Society for Neuroscience 37th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/viewer/SearchResults.asp

Conference Contribution - Poster Presentation (not in published proceedings)

Luxmanan, C., Ryan, M. M., Gill, A., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2007, November). Evidence for ageing-related attenuation of LTP-inducible transcription-related gene expression in rats. Poster session presented at the Society for Neuroscience 37th Annual Meeting, San Diego, California.

Ryan, M. M., Luxmanan, C., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2007, July). Profiling early gene expression changes in an LTP-model of learning. Poster session presented at the 7th International Brain Research Organization World Congress of Neuroscience, Melbourne, Australia.

2006

Conference Contribution - Published proceedings: Abstract

Ballagh, I., Ireland, D., Mockett, B., Bourne, K., Tate, W., Williams, J., & Abraham, W. (2006). The effect of secreted-amyloid precursor protein on NMDA receptors in cultured rat hippocampal slices. New Zealand Medical Journal, 119(1234). Retrieved from http://journal.nzma.org.nz/journal/119-1234/1991/content.pdf

Abraham, W. C., Guévremont, D., Williams, J. M., & Kerr, D. S. (2006). Aging-related decrease in synaptic protein synthesis in rat hippocampus. In J. G. Anson (Ed.), Proceedings of the 24th International Australasian Winter Conference on Brain Research. 24, (pp. 58). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2006Abstracts.pdf

Bisky, S., Mason-Parker, S., Abraham, W., & Williams, J. (2006). Bioinformatically informed analysis of the gene transcription cascade following induction of long-term potentiation in the rat dentate gyrus. New Zealand Medical Journal, 119(1234). Retrieved from http://journal.nzma.org.nz/journal/119-1234/1991/content.pdf

2005

Conference Contribution - Published proceedings: Abstract

Kennard, J. T. T., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2005). Alterations in glutamate receptor subunit expression in the rat dentate gyrus following induction of long-term potentiation. Proceedings of the Society for Neuroscience 35th Annual Meeting. Washington, DC: SfN. [Abstract]

Kennard, J. T. T., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2005). Alterations in glutamate receptor subunit expression in the rat dentate gyrus associated with long-term potentiation. Proceedings of the Australasian Winter Conference on Brain Research. 23, (pp. 24). Dunedin, New Zealand: University of Otago. Retrieved from http://psy.otago.ac.nz/awcbr/Proceedings.htm

2004

Journal - Research Article

Ireland, D. R., Guévremont, D., Williams, J. M., & Abraham, W. C. (2004). Metabotropic glutamate receptor-mediated depression of the slow afterhyperpolarization is gated by tyrosine phosphatases in hippocampal CA1 pyramidal neurons. Journal of Neurophysiology, 92, 2811-2819.

Conference Contribution - Published proceedings: Abstract

Kennard, J. T. T., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2004). Alterations in synaptic protein expression associated with the maintenance of long-term potentiation. Proceedings of the 22nd International Australasian Winter Conference on Brain Research. 22, (pp. 12-13). [Abstract]

2003

Journal - Research Article

Abraham, W. C., & Williams, J. M. (2003). Properties and mechanisms of LTP maintenance. Neuroscientist, 9(6), 463-474.

Williams, J. M., Guévremont, D., Kennard, J. T. T., Mason-Parker, S. E., Tate, W. P., & Abraham, W. C. (2003). Long-term regulation of N-methyl-_D-aspartate receptor subunits and associated synaptic proteins following hippocampal synaptic plasticity. Neuroscience, 118, 1003-1013.

Conference Contribution - Poster Presentation (not in published proceedings)

Williams, J. M., Guévremont, D., Mason-Parker, S. E., & Abraham, W. C. (2003, November). Rapid cell surface accumulation of GluR1 is followed by delayed up-regulation of protein levels after LTP induction at perforant path synapses in vivo. Poster session presented at the Poster presented at 13th Neuropharmacology conference: Post-translational modification of protein structure and synaptic function, New Orleans.

Conference Contribution - Verbal presentation and other Conference outputs

Luxmanan, C., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2003). Analysis of gene expression profiles using the DNA microarray in the LTP-model of memory. Verbal presentation at the Third Annual Australian Microarray Conference

2002

Conference Contribution - Published proceedings: Abstract

Kennard, J., Guévremont, D., Abraham, W. C., & Williams, J. M. (2002). Biochemical investigations into NMDA receptor numbers following LTP. New Zealand Medical Journal. 115(1159). Retrieved from http://www.nzma.org.nz/journal/115-1159/121

Kennard, J., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2002). Regulation of the NMDA receptor complex following LTP: A biochemical investigation. Proceedings of the 20th International Australasian Winter Conference on Brain Research. Queenstown: AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts2002.htm#Kennard

Kennard, J., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2002). Regulation of the NMDA receptor complex following LTP: A biochemical investigation. Proceedings of the International Australasian Winter Conference on Brain Research. 20(10), (pp. 2). awcbr.org>abstracts>2002. [Abstract]

Kennard, J., Guévremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2002). Biochemical investigations into NMDA receptor numbers following long-term potentiation. Proceedings of the NZJM. (115). http://www.nzma.org.nz/journal/115-1159/121/. [Abstract]

Kennard, J., Guevremont, D., Mason-Parker, S. E., Abraham, W. C., & Williams, J. M. (2002). Regualtion of the NMDA receptor complex following LPT: A biochemical investigation. Proceedings of International Australasian Winter Conference on Brain Research. 20(10). [Abstract]

2001

Conference Contribution - Published proceedings: Abstract

Williams, J. M., Guevremont, D., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (2001). Regulation of NMDA receptor subunit NR1 folloing synaptic activity. Molecular Mechanisms of Synaptic Function. 2(42). [Abstract]

Williams, J. M., Thompson, V. L., Guevremont, D., Abraham, W. C., Tate, W. P., & Nairn, A. C. (2001). Presynaptic protein synthesis in axon terminals isolated from adult rat cortex. Proceedings of International Australasian Winter Conference on Brain Research. 19. [Abstract]

Williams, J. M., Thompson, V. L., Guévremont, D., Abraham, W. C., Tate, W. P., & Nairn, A. C. (2001). Presynaptic protein synthesis in axon terminals isolated from adult rat cortex. Society for Neuroscience Abstract. 27, (pp. 275.9). San Diego, USA: Society for Neuroscience. [Abstract]

Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (2001). Regulation of NMDA receptor subunit NR1 following synaptic activity. 11th Neuropharmacology Conference Molecular Mechanisms of Synaptic Function. (pp. 2.42). United Kingdom: Elzevier Science. [Abstract]

Williams, J. M., Thompson, V. L., Guevremont, D., Abraham, W. C., Tate, W. P., & Nairn, A. C. (2001). Protein synthesis in axon terminals isolated from adult rat cortex. 19th International Australasian Winter Conference on Brain and Research. 19, (pp. 40). Queenstown, New Zealand: Australasian Winter Conference on Brain and Research. [Abstract]

Thompson, V. L., Williams, J. M., & Tate, W. P. (2001). Synaptoneurosomes as a model for studying glutamate regulation of synaptic protein synthesis. International Journal of Neuroscience. 109, (pp. 201). [Abstract]

2000

Journal - Research Article

Williams, J. M., Beckmann, A. M., Mason-Parker, S. E., Abraham, W. C., Wilce, P. A., & Tate, W. P. (2000). Sequential increase in Egr-1 and AP-1 DNA binding activity in the dentate gyrus following the induction of long-term potentiation. Molecular Brain Research, 77, 258-266.

Coussens, C. M., Williams, J. M., Ireland, D. R., & Abraham, W. C. (2000). Tyrosine phosphorylation-dependent inhibition of hippocampal synaptic plasticity. Neuropharmacology, 39, 2267-2277.

Conference Contribution - Published proceedings: Abstract

Webb, S. C., Williams, J. M., Tate, W. P., & Abraham, W. C. (2000). Involvement of the cAMP cascade in the printing of hippocampal LTP by metabotropic glutamate receptors. Society for Neuroscience Abstract. 26, (pp. 361). USA: Society fo Neuroscience. [Abstract]

1999

Conference Contribution - Published proceedings: Abstract

Coussens, C. M., Williams, J. M., & Abraham, W. C. (1999). Tyrosine phosphorylation regulates the induction of synaptic plasticity via regulation of the NMDA receptor. International Journal of Neuroscience. 97, (pp. 266). [Abstract]

1998

Journal - Research Article

Williams, J. M., Thompson, V. L., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1998). Synaptic activity-dependent modulation of mitochondrial gene expression in the rat hippocampus. Molecular Brain Research, 60, 50-56.

Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1998). Biphasic changes in the levels of N-methyl-D-aspartate receptor-2 subunits correlate with the induction and persistence of long-term potentiation. Molecular Brain Research, 60, 21-27.

Conference Contribution - Published proceedings: Abstract

Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1998). Rapid increase in N-methyl-D-aspartate receptor subunit NR2B following long-term potentiation. International Journal of Neuroscience. 94, (pp. 108). [Abstract]

1997

Journal - Research Article

Abraham, W. C., Logan, B., Thompson, V. L., Williams, J. M., & Tate, W. P. (1997). Sequence-independent effects of phosphorothioated oligonucleotides on synaptic transmission and excitability in the hippocampus in vivo. Neuropharmacology, 36, 345-352.

Conference Contribution - Published proceedings: Abstract

Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1997). Rapid and persistent elevation in N-methyl-D-aspartate receptor subunit NR2B following long-term potentiation. Society for Neuroscience Abstract. 23, (pp. 1175). San Diego, USA: Society for Neuroscience. [Abstract]

Williams, J. M., Mason-Parker, S. E., Abraham, W. C., & Tate, W. P. (1997). NMDA receptor subunit composition and phosphorylation following long-term potentiation. International Journal of Neuroscience. 89, (pp. 91). [Abstract]

Webb, S. C., Williams, J. M., Tate, W. P., Mason-Parker, S. E., & Abraham, W. C. (1997). Expression of elongation factor-2 during the maintenance of long-term potentiation. International Journal of Neuroscience. 89, (pp. 92). [Abstract]