PhD(W'gong), BMedCHem(Hons)Tel: 03 471 6217
Location: Science II 2n8
Email: bhawkins@chemistry.otago.ac.nz
Bill completed his PhD at the University of Wollongong, followed by postdoctoral positions at the University of Melbourne and Ecole Polytechnique (France). After a short stay at the Walter and Eliza Hall institute for medical research, he joined the Department of Chemistry at the University of Otago as a lecturer (2012) and was promoted to senior lecturer in 2016. His research interests include the synthesis of bioactive natural products and their use as chemical probes to understand biological processes and inform drug design, as well as the development of new synthetic methodologies.
For more information about the Hawkins Research Group: https://blogs.otago.ac.nz/hawkinsgroup/
Publications
Henneveld, J. S., Shiri, F., Ariafard, A., Lucas, N. T., Bissember, A. C., & Hawkins, B. C. (2023). Dipole-transmissive 1,3-dipolar cycloadditions for the rapid construction of polycyclic N-heterocycles: Synthetic and mechanistic investigations. Chemistry: A European Journal. Advance online publication. doi: 10.1002/chem.202301254
Journal - Research Article
Lewin, H., Gamble, A., & Hawkins, B. (2022, November). Investigation into self immolative linkers for cancer prodrugs leading to in situ bioactive synthesis. Verbal presentation at the School of Pharmacy Research Day, Dunedin, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Olivier, W. J., Henneveld, J. S., Smith, J. A., Hawkins, B. C., & Bissember, A. C. (2022). Strategies for the synthesis of Stemona alkaloids: An update. Natural Product Reports, 39, 2308-2335. doi: 10.1039/d2np00058j
Journal - Research Other
Watts, B. A., Berry, M., Bland, A. R., Hawkins, B. C., & Ashton, J. C. (2022, August-September). Tumour cell suppression by Spiroleucettadine through dual regulation of cell cycle and apoptosis. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Bissember, A. C., Hyland, C. J. T., Wales, S. M., Hawkins, B. C., Chen, J. L.-Y., Fleming, C. L., Cording, A. P., Henneveld, J. S., … Zarfos, S. D. (2021). Seven-membered rings. In G. W. Gribble & J. A. Joule (Eds.), Progress in heterocyclic chemistry (Vol. 33). (pp. 533-581). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-323-98410-2.00016-3
Chapter in Book - Research
Bissember, A. C., Hyland, C. J. T., Wales, S. M., Hawkins, B. C., Chen, J. L.-Y., Fleming, C. L., Cording, A. P., Henneveld, J. S., … Zarfos, S. D. (2021). Seven-membered rings. In G. W. Gribble & J. A. Joule (Eds.), Progress in heterocyclic chemistry (Vol. 33). (pp. 533-581). Amsterdam, The Netherlands: Elsevier. doi: 10.1016/B978-0-323-98410-2.00016-3
Chapter in Book - Research
O'Donnell, M. J., Craig, A. J., & Hawkins, B. C. (2016). Ethyl N-(Diphenylmethylene)glycinate. In e-EROS: Encyclopedia of reagents for organic synthesis. (pp. 1-6). Wiley. doi: 10.1002/047084289X.re063m.pub2
Chapter in Book - Research
Henneveld, J. S., Shiri, F., Ariafard, A., Lucas, N. T., Bissember, A. C., & Hawkins, B. C. (2023). Dipole-transmissive 1,3-dipolar cycloadditions for the rapid construction of polycyclic N-heterocycles: Synthetic and mechanistic investigations. Chemistry: A European Journal. Advance online publication. doi: 10.1002/chem.202301254
Journal - Research Article
Badart, M. P., Barnes, E. M., Cording, A. P., Gilmer, S. C. L., Billinghurst, I. D., Edupuganti, V. V. S. R., … Bland, A. R., Bower, R. L., Rana, Z., Ferguson, S. A., Opel Reading, H. K., Cook, G. M., Rosengren, R. J., Krause, K. L., Gamble, A. B., Ashton, J. C., & Hawkins, B. C. (2021). Synthesis and biological evaluation of (-) and (+)-spiroleucettadine and analogues. ChemMedChem, 16, 1308-1315. doi: 10.1002/cmdc.202000954
Journal - Research Article
Gai, S., Henneveld, J. S., Cording, A. P., Badart, M. P., Lucas, N. T., & Hawkins, B. C. (2021). The synthesis of benzannulated spiroketals from 1,1-diacyl-2-phenylcyclopropanes. Tetrahedron Letters, 69, 152984. doi: 10.1016/j.tetlet.2021.152984
Journal - Research Article
Henneveld, J. S., Gilmer, S. C. L., Lucas, N. T., & Hawkins, B. C. (2021). Rapid generation of 2-acyl-4-phenyltetralones from 1,1-diacylphenylcyclopropanes. Asian Journal of Organic Chemistry, 10, 2553-2556. doi: 10.1002/ajoc.202100500
Journal - Research Article
Philem, P., Kleffmann, T., Gai, S., Hawkins, B. C., Wilbanks, S. M., & Lamont, I. L. (2021). Identification of active site residues of the siderophore synthesis enzyme PvdF and evidence for interaction of PvdF with a substrate-providing enzyme. International Journal of Molecular Sciences, 22(4), 2211. doi: 10.3390/ijms22042211
Journal - Research Article
Craig, A. J., Cording, A. P., Garden, A. L., & Hawkins, B. C. (2020). Does the reaction of cyclopropyl acid chlorides and imines to form 1, 3-oxazin-4-enone heterocycles proceed via a ketene or an N-acyl-Iminium mechanism? Journal of Organic Chemistry, 85, 5486-5492. doi: 10.1021/acs.joc.0c00229
Journal - Research Article
Swaney, B., Luxenburger, A., Lucas, N. T., Hawkins, B. C., & Hinkley, S. F. R. (2020). The synthesis of 3-azabicyclo[4.3.0]nonane scaffolds from Brefeldin A. Tetrahedron Letters, 61, 152006. doi: 10.1016/j.tetlet.2020.152006
Journal - Research Article
Bland, A. R., Bower, R. L., Nimick, M., Hawkins, B. C., Rosengren, R. J., & Ashton, J. C. (2019). Cytotoxicity of curcumin derivatives in ALK positive non-small cell lung cancer. European Journal of Pharmacology, 865, 172749. doi: 10.1016/j.ejphar.2019.172749
Journal - Research Article
Hamiaux, C., Larsen, L., Lee, H. W., Luo, Z., Sharma, P., Hawkins, B. C., Perry, N. B., & Snowden, K. C. (2019). Chemical synthesis and characterization of a new quinazolinedione competitive antagonist for strigolactone receptors with an unexpected binding mode. Biochemical Journal, 476, 1843-1856. doi: 10.1042/bcj20190288
Journal - Research Article
Smith, R. J., & Hawkins, B. C. (2019). Synthetic strategies towards the synthesis of oxyisocyclointegrin. European Journal of Organic Chemistry, 40, 6847-6854. doi: 10.1002/ejoc.201901294
Journal - Research Article
Smith, R. J., Bower, R. L., Ferguson, S. A., Rosengren, R. J., Cook, G. M., & Hawkins, B. C. (2019). The synthesis of (±)-oxyisocyclointegrin. European Journal of Organic Chemistry, (7), 1571-1573. doi: 10.1002/ejoc.201801751
Journal - Research Article
Chen, S., Nimick, M., Cridge, A. G., Hawkins, B. C., & Rosengren, R. J. (2018). Anticancer potential of novel curcumin analogs towards castrate-resistant prostate cancer. International Journal of Oncology, 52(2), 579-588. doi: 10.3892/ijo.2017.4207
Journal - Research Article
French, S. A., Clark, M. R., Smith, R. J., Brind, T., & Hawkins, B. C. (2018). Expedient synthesis of xanthones and multi-functionalized chromones from 1,1-diacyl cyclopropanes. Tetrahedron, 74(38), 5340-5350. doi: 10.1016/j.tet.2018.04.003
Journal - Research Article
Lamb, R. A., Lucas, N. T., Lessene, G., & Hawkins, B. C. (2018). Strategies, setbacks, and successes in the synthesis of (-)-spiroleucettadine. Journal of Organic Chemistry, 83(17), 10120-10133. doi: 10.1021/acs.joc.8b01404
Journal - Research Article
Craig, A. J., & Hawkins, B. C. (2017). Metal-free synthesis of oxazinones and their reductive ring opening to provide cyclopropyl carbinols. Synthesis, 49(9), 1955-1968. doi: 10.1055/s-0036-1588748
Journal - Research Article
Lamb, R. A., Aberle, N. S., Lucas, N. T., Lessene, G., & Hawkins, B. C. (2017). Total synthesis of (—)-Spiroleucettadine [Brief communication]. Angewandte Chemie International Edition, 56(46), 14663-14666. doi: 10.1002/anie.201708110
Journal - Research Article
Nhu, D., Larsen, L., Perry, N. B., Larsen, D. S., & Hawkins, B. C. (2017). Sweet poisons: Synthetic strategies towards tutin glycosides. Australian Journal of Chemistry, 70(3), 301-306. doi: 10.1071/CH16429
Journal - Research Article
Revalde, J. L., Li, Y., Wijeratne, T. S., Budge, P., Hawkins, B. C., Rosengren, R. J., & Paxton, J. W. (2017). Curcumin and its cyclohexanone analogue inhibited human Equilibrative nucleoside transporter 1 (ENT1) in pancreatic cancer cells. European Journal of Pharmacology, 803, 167-173. doi: 10.1016/j.ejphar.2017.03.055
Journal - Research Article
Smith, R. J., Nhu, D., Clark, M. R., Gai, S., Lucas, N. T., & Hawkins, B. C. (2017). Synthesis of chromones from 1,1-diacylcyclopropanes: Toward the synthesis of bromophycoic acid E. Journal of Organic Chemistry, 82(10), 5317-5327. doi: 10.1021/acs.joc.7b00648
Journal - Research Article
Badart, M. P., Squires, C. M. L., Baird, S. K., & Hawkins, B. C. (2016). The synthesis of clavatadine C. Tetrahedron Letters, 57(46), 5108-5111. doi: 10.1016/j.tetlet.2016.10.019
Journal - Research Article
Chiluka, R., Gamble, A. B., Lucas, N. T., Hawkins, B. C., Bhumkar, A., Achanta, P. S., & Bobbala, R. K. (2016). Flavone C-glycosides from Trichuriella monsoniae (L.f.) Bennet. Natural Product Research. doi: 10.1080/14786419.2016.1149707
Journal - Research Article
Smith, R. J., Mills, D. A., Nhu, D., Tan, E. W., Lucas, N. T., & Hawkins, B. C. (2016). The synthesis of multifunctionalized 1,3-oxazin-4-ones from donor-acceptor cyclopropanes. Journal of Organic Chemistry, 81(5), 2099-2105. doi: 10.1021/acs.joc.6b00112
Journal - Research Article
Craig, A. J., van der Salm, L., Stevens-Cullinane, L., Lucas, N. T., Tan, E. W., & Hawkins, B. C. (2015). Expedient metal-free synthesis of 1,3-oxazinen-4-ones. Organic Letters, 17(2), 234-237. doi: 10.1021/ol503350h
Journal - Research Article