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Professor Brian Hyland

Brian HylandProfessor Brian Hyland is interested in systems neuroscience, in particular the neurophysiology of midbrain dopamine systems and other brain structures which modulate dopamine neuron activity. He is also investigating the activity of these systems in reward-mediated learning, as well as the functions of circuits concerned with control of movement. His research extends from normal to abnormal functioning of these circuits in disease states such as Parkinson’s disease and attention deficit-hyperactivity disorder.

Professor Hyland has ongoing collaborations with Professors Jeff Wickens and Gordon Arbuthnott, Okinawa Institute of Science & Technology, Japan, Associate Professor J. Greg Anson, University of Auckland, Dr Alessandro Villa, Lausanne Switzerland, Professor Jason Chen, Tainan, Taiwan and members of the University of Otago Basal Ganglia Research Group.

His funding is, or has recently been, provided by the Health Research Council of New Zealand, the Marsden Fund, Boehringer Ingelheim Pharma GmbH, and the Neurological Foundation of New Zealand.


Find out more about Professor Hyland’s research.

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Publications

Reynolds, J. N. J., Hyland, B. I., & Wickens, J. (2001). A cellular mechanism of reward-related learning. Nature, 413, 67-70.

Hyland, B. I., Reynolds, J. N. J., Hay, J., Perk, C. G., & Miller, R. (2002). Firing modes of midbrain dopamine cells in the freely moving rat. Neuroscience, 114(2), 475-492.

Pan, W.-X., Schmidt, R., Wickens, J. R., & Hyland, B. I. (2005). Dopamine cells respond to predicted events during classical conditioning: Evidence for eligibility traces in the reward-learning network. Journal of Neuroscience, 25(26), 6235-6242.

Dejean, C., Arbuthnott, G., Wickens, J. R., Le Moine, C., Boraud, T., & Hyland, B. I. (2011). Power fluctuations in beta and gamma frequencies in rat globus pallidus: Association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors. Journal of Neuroscience, 31(16), 6098-6107. doi: 10.1523/JNEUROSCI.3311-09.2011

Li, Y., Dalphin, N., & Hyland, B. I. (2013). Association with reward negatively modulates short latency phasic conditioned responses of dorsal raphe nucleus neurons in freely moving rats. Journal of Neuroscience, 33(11), 5065-5078. doi: 10.1523/jneurosci.5679-12.2013

Chapter in Book - Research

Wickens, J. R., Hyland, B. I., & Tripp, G. (2006). Frontostriatal mechanisms in reinforcement: Implications for ADHD. In E. Bezard (Ed.), Recent breakthroughs in basal ganglia research. (pp. 65-80). New York: Nova Science.

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Journal - Research Article

Li, Y., Lindemann, C., Goddard, M. J., & Hyland, B. I. (2016). Complex multiplexing of reward-cue- and licking-movement-related activity in single midline thalamus neurons. Journal of Neuroscience, 36(12), 3567-3578. doi: 10.1523/jneurosci.1107-15.2016

Moaddab, M., Hyland, B. I., & Brown, C. H. (2015). Oxytocin excites nucleus accumbens shell neurons in vivo. Molecular & Cellular Neuroscience, 68, 323-330. doi: 10.1016/j.mcn.2015.08.013

Seeger-Armbruster, S., Bosch-Bouju, C., Little, S. T. C., Smither, R. A., Hughes, S. M., Hyland, B. I., & Parr-Brownlie, L. C. (2015). Patterned, but not tonic, optogenetic stimulation in motor thalamus improves reaching in acute drug-induced Parkinsonian rats. Journal of Neuroscience, 35(3), 1211-1216. doi: 10.1523/jneurosci.3277-14.2015

Perk, C. G., Wickens, J. R., & Hyland, B. I. (2015). Differing properties of putative fast-spiking interneurons in the striatum of two rat strains. Neuroscience, 294, 215-226. doi: 10.1016/j.neuroscience.2015.02.051

Blakemore, R. L., Hyland, B. I., Hammond-Tooke, G. D., & Anson, J. G. (2015). Deficit in late-stage contingent negative variation provides evidence for disrupted movement preparation in patients conversion paresis. Biological Psychology, 109, 73-85. doi: 10.1016/j.biopsycho.2015.04.009

Moaddab, M., Hyland, B. I., & Brown, C. H. (2015). Oxytocin enhances the expression of morphine-induced conditioned place preference in rats. Psychoneuroendocrinology, 53, 159-169. doi: 10.1016/j.psyneuen.2015.01.003

Bosch-Bouju, C., Smither, R. A., Hyland, B. I., & Parr-Brownlie, L. C. (2014). Reduced reach-related modulation of motor thalamus neural activity in a rat model of Parkinson's disease. Journal of Neuroscience, 34(48), 15836-15850. doi: 10.1523/jneurosci.0893-14.2014

Li, Y., Dalphin, N., & Hyland, B. I. (2013). Association with reward negatively modulates short latency phasic conditioned responses of dorsal raphe nucleus neurons in freely moving rats. Journal of Neuroscience, 33(11), 5065-5078. doi: 10.1523/jneurosci.5679-12.2013

Bosch-Bouju, C., Hyland, B. I., & Parr-Brownlie, L. C. (2013). Motor thalamus integration of cortical, cerebellar and basal ganglia information: Implications for normal and Parkinsonian conditions. Frontiers in Computational Neuroscience, 7, 163. doi: 10.3389/fncom.2013.00163

Blakemore, R. L., Hyland, B. I., Hammond-Tooke, G. D., & Anson, J. G. (2013). Distinct modulation of event-related potentials during motor preparation in patients with motor conversion disorder. PLoS ONE, 8(4), e62539. doi: 10.1371/journal.pone.0062539

Aggarwal, M., Hyland, B. I., & Wickens, J. R. (2012). Neural control of dopamine neurotransmission: Implications for reinforcement learning. European Journal of Neuroscience, 35(7), 1115-1123. doi: 10.1111/j.1460-9568.2012.08055.x

Dejean, C., Arbuthnott, G., Wickens, J. R., Le Moine, C., Boraud, T., & Hyland, B. I. (2011). Power fluctuations in beta and gamma frequencies in rat globus pallidus: Association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors. Journal of Neuroscience, 31(16), 6098-6107. doi: 10.1523/JNEUROSCI.3311-09.2011

Wickens, J. R., Hyland, B. I., & Tripp, G. (2011). Animal models to guide clinical drug development in ADHD: Lost in translation? British Journal of Pharmacology, 164, 1107-1128. doi: 10.1111/j.1476-5381.2011.01412.x

Igelstrom, K. M., Herbison, A. E., & Hyland, B. I. (2010). Enhanced c-Fos expression in superior colliculus, paraventricular thalamus and septum during learning of cue-reward association. Neuroscience, 168(3), 706-714. doi: 10.1016/j.neuroscience.2010.04.018

Wu, Y.-N., Chen, J.-J. J., Zhang, L.-Q., & Hyland, B. I. (2009). Regulation of hind-limb tone by adenosine A2A receptor in rats. Neuroscience, 159(4), 1408-1413. doi: 10.1016/j.neuroscience.2009.01.068

Dejean, C., Hyland, B., & Arbuthnott, G. (2009). Cortical effects of subthalamic stimulation correlate with behavioral recovery from dopamine antagonist induced akinesia. Cerebral Cortex, 19(5), 1055-1063. doi: 10.1093/cercor/bhn149

Sutherland, K. R., Alsop, B., McNaughton, N., Hyland, B. I., Tripp, G., & Wickens, J. R. (2009). Sensitivity to delay of reinforcement in two animal models of attention deficit hyperactivity disorder (ADHD). Behavioural Brain Research, 205(2), 372-376. doi: 10.1016/j.bbr.2009.07.011

Pan, W.-X., Schmidt, R., Wickens, J. R., & Hyland, B. I. (2008). Tripartite mechanism of extinction suggested by dopamine neuron activity and temporal difference model. Journal of Neuroscience, 28(39), 9619-9631. doi: 10.1523/JNEUROSCI.0255-08.2008

Wu, Y.-N., Hyland, B. I., & Chen, J.-J. J. (2007). Biomechanical and electromyogram characterization of neuroleptic-induced rigidity in the rat. Neuroscience, 147, 183-196.

Pan, W.-X., Schmidt, R., Wickens, J. R., & Hyland, B. I. (2005). Dopamine cells respond to predicted events during classical conditioning: Evidence for eligibility traces in the reward-learning network. Journal of Neuroscience, 25(26), 6235-6242.

Parr-Brownlie, L. C., & Hyland, B. I. (2005). Bradykinesia induced by dopamine D2 receptor blockade is associated with reduced motor cortex activity in the rat. Journal of Neuroscience, 25(24), 5700-5709.

Pan, W.-X., & Hyland, B. I. (2005). Pedunculopontine tegmental nucleus controls conditioned responses of midbrain dopamine neurons in behaving rats. Journal of Neuroscience, 25(19), 4725-4732.

Reynolds, J. N. J., Hyland, B. I., & Wickens, J. R. (2004). Modulation of an afterhyperpolarization by the substantia nigra induces pauses in the tonic firing of striatal cholinergic interneurons. Journal of Neuroscience, 24(44), 9870-9877.

Wickens, J., Reynolds, J. N. J., & Hyland, B. I. (2003). Neural mechanisms of reward-related motor learning. Current Opinion in Neurobiology, 13, 685-690.

Hyland, B. I., Reynolds, J. N. J., Hay, J., Perk, C. G., & Miller, R. (2002). Firing modes of midbrain dopamine cells in the freely moving rat. Neuroscience, 114(2), 475-492.

Reynolds, J. N. J., Hyland, B. I., & Wickens, J. (2001). A cellular mechanism of reward-related learning. Nature, 413, 67-70.

Hajos, M., Hoffmann, W. E., Tetko, I. V., Hyland, B. I., Sharp, T., & Villa, A. E. (2001). Different tonic regulation of neuronal activity in the rat dorsal raphe and medial prefrontal cortex via 5-HT 1A receptors. Neuroscience Letters, 304, 129-132.

Jarratt, H. L., & Hyland, B. I. (1999). Neuronal activity in rat red nucleus during forelimb reach-to-grasp movements. Neuroscience, 88(2), 629-642.

Kazennikov, O., Hyland, B. I., Corboz, M., Babalian, A., Rouiller, E. M., & Wiesendanger, M. (1999). Neural activity of supplementary and primary motor areas in monkeys and its relation to bimanual and unimanual movement sequences. Neuroscience, 89(3), 661-674.

Villa, A. E., Tetko, I. V., Hyland, B. I., & Najem, A. (1999). Spatiotemporal activity patterns of rat cortical neurons predict responses in a conditioned task. PNAS, 96, 1106-1111.

Hyland, B. I. (1998). Neural activity related to reaching and grasping in rostral and caudal regions of rat motor cortex. Behavioural Brain Research, 94, 255-269.

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Journal - Research Other

Wickens, J. R., Budd, C. S., Hyland, B. I., & Arbuthnott, G. W. (2007). Striatal contributions to reward and decision making: Making sense of regional variations in a reiterated processing matrix. Annals of the New York Academy of Sciences, 1104, 192-212.

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