Emeritus Professor Warren Tate, Our People, Brain Health Research Centre, University of Otago, New Zealand

Early in his research career, Emeritus Professor Warren Tate discovered translational frameshifting as a new mechanism of gene regulation which led to a study of the mechanism as a potential drug target for HIV-1.

Emeritus Professor Tate’s laboratory has had a long-term interest in protein synthesis and in particular, the decoding and recoding mechanisms on the ribosome at stop signals. Thirty years ago, a chance discovery of recoding called frameshifting (a cellular mechanism for regulating gene expression during protein synthesis) spurred an interest in the frameshift mechanism of HIV-1 as a potential site of vulnerability in the virus. Now they have focused on the only gene in the animal kingdom known to use this mechanism, human gene PEG10. Significantly, PEG10 uses the same frameshifting expression strategy as HIV-1 to produce two proteins.

In addition to his fundamental molecular biology research, Emeritus Professor Tate has been involved in a completely different research area: molecular neurobiology. With his Otago colleagues Professor Cliff Abraham and Dr Joanna Williams, he is looking at the mechanisms of neurological diseases. His research into the molecular basis of memory has progressed to the development of a brain protein fragment that can restore memory and has potential as a therapeutic agent for Alzheimer's disease. They believe this external secreted protein is a signalling molecule that can switch on a signalling pathway and activate a range of gene responses to protect and enhance memory; an activity that may be critical as a counterbalance in the development of Alzheimer’s disease. They have developed a simple recombinant production and purification process for this brain protein, secreted amyloid precursor protein-alpha, a neuroprotective protein that shows a lower concentration in Alzheimer’s patients. Remarkably, their recombinant protein alone can restore memory to rats impaired by drug treatment, not only in their electrophysiological responses but also in trials to determine memory of learned spatial tasks.

In 2010, Emeritus Professor Warren Tate was awarded New Zealand’s premier science and technology honour, the 2010 Rutherford Medal. He is a Fellow of the Royal Society of New Zealand and of the New Zealand Institute of Chemistry. He has been a Fellow of the Alexander von Humboldt Foundation of Germany, and an International Research Scholar of the Howard Hughes Medical Institute of the United States.

Listen to Emeritus Professor Warren Tate's seminar on Alzheimer's disease from Brain Day 2013: Alzheimer's under the microscope

Watch Emeritus Professor Warren Tate's 2020 BHRC Lecture on ME/CFS

Find out more about Emeritus Professor Warren Tate’s research

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Publications

Lam, P., Vinnakota, C., Calvo-Flores Guzmán, B., Newland, J., Peppercorn, K., Tate, W. P., … Kwakowsky, A. (2022). Beta-amyloid (Aβ_1-42) increases the expression of NKCC1 in the mouse hippocampus. Molecules, 27, 2440. doi: 10.3390/molecules27082440

Guévremont, D., Tsui, H., Knight, R. G., Fowler, C. J., Masters, C. L., Martins, R. N., Abraham, W. C., Tate, W. P., Cutfield, N. J., & Williams, J. M. (2022). Plasma microRNA vary in association with the progression of Alzheimer's disease. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 14, e12251. doi: 10.1002/dad2.12251

Ohline, S. M., Chan, C., Schoderboeck, L., Wicky, H. E., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2022). Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer's disease. Molecular Brain, 15, 5. doi: 10.1186/s13041-021-00889-1

Tate, W. (2021). The three macromolecules in the Central Dogma brought alive by over 60 years of biochemical and molecular studies assisted by visualisation and 'omic' technologies. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 160). Retrieved from https://www.faobmb2021.org

Bernhardt, H. S., & Tate, W. P. (2021). A new perspective on the Maillard reaction and the origin of life. Journal of Molecular Evolution. Advance online publication. doi: 10.1007/s00239-021-10030-4

Poole, E. S., Major, L. L., Cridge, A. G., & Tate, W. P. (2004). The mechanism of recoding in pro- and eukaryotes. In K. H. Nierhaus & D. N. Wilson (Eds.), Protein synthesis and ribosome structure: Translating the genome. (pp. 397-428). Weinheim, Germany: Wiley-VCH.

Chapter in Book - Research

Tate, W. P., Dalphin, M. E., Pel, H. J., & Mannering, S. A. (1996). Decoding efficiencies of translational stop signals: a new facet of cellular regulation. In J. K. Setlow (Ed.), Genetic Engineering, Principles and Methods, Volume 18. (pp. 157-182). New York: Plenum Press.

Chapter in Book - Research

Tate, W. P., & Marshall, C. J. (2018). Post-dormancy transcription and translation in the brine shrimp. In R. A. Browne, P. Sorgeloos & C. N. A. Trotman (Eds.), Artemia biology. (pp. 21-36). Boca Raton, FL: Taylor & Francis. doi: 10.1201/9781351069892

Chapter in Book - Other

Journal - Research Article

Livingstone, R. W., Elder, M. K., Singh, A., Westlake, C. M., Tate, W. P., Abraham, W. C., & Williams, J. M. (2021). Secreted amyloid precursor protein-alpha enhances LTP through the synthesis and trafficking of Ca²⁺-permeable AMPA receptors. Frontiers in Molecular Neuroscience, 14, 660208. doi: 10.3389/fnmol.2021.660208

Journal - Research Article

Ryan, M., Tan, V. T. Y., Thompson, N., Guévremont, D., Mockett, B. G., Tate, W. P., Abraham, W. C., Hughes, S. M., & Williams, J. (2021). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha promotes long-term induction of neuroprotective genes and pathways in a mouse model of Alzheimer’s disease. Journal of Alzheimer's Disease, 79, 1075-1090. doi: 10.3233/JAD-200757

Journal - Research Article

Calvo-Flores Guzmán, B., Chaffey, T. E., Palpagama, T. H., Waters, S., Boix, J., Tate, W. P., Peppercorn, K., … Kwakowsky, A. (2020). The interplay between beta-amyloid 1-42 (Aβ_1-42)-induced hippocampal inflammatory response, p-tau, vascular pathology, and their synergistic contributions to neuronal death and behavioral deficits. Frontiers in Molecular Neuroscience, 13, 522073. doi: 10.3389/fnmol.2020.552073

Journal - Research Article

Helliwell, A. M., Sweetman, E. C., Stockwell, P. A., Edgar, C. D., Chatterjee, A., & Tate, W. P. (2020). Changes in DNA methylation profiles of myalgic encephalomyelitis/chronic fatigue syndrome patients reflect systemic dysfunctions. Clinical Epigenetics, 12(1), 167. doi: 10.1186/s13148-020-00960-z

Journal - Research Article

Sweetman, E., Kleffmann, T., Edgar, C., de Lange, M., Vallings, R., & Tate, W. (2020). A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction. Journal of Translational Medicine, 18, 365. doi: 10.1186/s12967-020-02533-3

Journal - Research Article

Vinnakota, C., Govindpani, K., Tate, W. P., Peppercorn, K., Anekal, P. V., Waldvogel, H. J., … Kwakowsky, A. (2020). An α5 GABAA receptor inverse agonist, α5IA, attenuates amyloid beta-induced neuronal death in mouse hippocampal cultures. International Journal of Molecular Sciences, 21(9), 3284. doi: 10.3390/ijms21093284

Journal - Research Article

Yeung, J. H. Y., Calvo-Flores Guzmán, B., Palpagama, H. T., Ethiraj, J., Zhai, Y., Tate, W. P., Peppercorn, K., … Kwakowsky, A. (2020). Amyloid-beta_1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus. Journal of Neurochemistry, 155, 62-80. doi: 10.1111/jnc.15099

Journal - Research Article

Yeung, J. H. Y., Palpagama, T. H., Tate, W. P., Peppercorn, K., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2020). The acute effects of amyloid-Beta_1–42 on glutamatergic receptor and transporter expression in the mouse hippocampus. Frontiers in Neuroscience, 13, 1427. doi: 10.3389/fnins.2019.01427

Journal - Research Article

Livingstone, R. W., Elder, M. K., Barrett, M. C., Westlake, C. M., Peppercorn, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2019). Secreted amyloid precursor protein-alpha promotes arc protein synthesis in hippocampal neurons. Frontiers in Molecular Neuroscience, 12, 198. doi: 10.3389/fnmol.2019.00198

Journal - Research Article

Mockett, B. G., Guévremont, D., Elder, M. K., Parfitt, K. D., Peppercorn, K., Morrissey, J., Singh, A., Hintz, T. J., … Tate, W. P., Williams, J. M., & Abraham, W. C. (2019). Glutamate receptor trafficking and protein synthesis mediate the facilitation of LTP by secreted amyloid precursor protein-alpha. Journal of Neuroscience, 39(17), 3188-3203. doi: 10.1523/jneurosci.1826-18.2019

Journal - Research Article

Morrissey, J. A., Bigus, E., Necarsulmer, J. C., Srinivasan, V., Peppercorn, K., O'Leary, D. J., Mockett, B. G., Tate, W. P., Hughes, S. M., … Abraham, W. C. (2019). The tripeptide RER mimics secreted amyloid precursor protein-alpha in upregulating LTP. Frontiers in Cellular Neuroscience, 13, 459. doi: 10.3389/fncel.2019.00459

Journal - Research Article

Morrissey, J. A., Mockett, B. G., Singh, A., Kweon, D., Ohline, S. M., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2019). A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease. Neuropharmacology, 157, 107670. doi: 10.1016/j.neuropharm.2019.107670

Journal - Research Article

Sweetman, E., Ryan, M., Edgar, C., MacKay, A., Vallings, R., & Tate, W. (2019). Changes in the transcriptome of circulating immune cells of a New Zealand cohort with myalgic encephalomyelitis/chronic fatigue syndrome. International Journal of Immunopathology & Pharmacology, 33, 1-8. doi: 10.1177/2058738418820402

Journal - Research Article

Cridge, A. G., Crowe-McAuliffe, C., Mathew, S. F., & Tate, W. P. (2018). Eukaryotic translational termination efficiency is influenced by the 3' nucleotides within the ribosomal mRNA channel. Nucleic Acids Research, gkx1315. doi: 10.1093/nar/gkx1315

Journal - Research Article

Mackay, A., & Tate, W. P. (2018). A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS. International Journal of Immunopathology & Pharmacology, 32, 1-8. doi: 10.1177/2058738418812342

Journal - Research Article

Tan, V. T. Y., Mockett, B. G., Ohline, S. M., Parfitt, K. D., Wicky, H. E., Peppercorn, K., Schoderboeck, L., Yahaya, M. F. b., Tate, W. P., Hughes, S. M., & Abraham, W. C. (2018). Lentivirus-mediated expression of human secreted amyloid precursor protein-alpha prevents development of memory and plasticity deficits in a mouse model of Alzheimer's disease. Molecular Brain, 11, 7. doi: 10.1186/s13041-018-0348-9

Journal - Research Article

Xiong, M., Jones, O. D., Peppercorn, K., Ohline, S. M., Tate, W. P., & Abraham, W. C. (2017). Secreted amyloid precursor protein-alpha can restore novel object location memory and hippocampal LTP in aged rats. Neurobiology of Learning & Memory, 138, 291-299. doi: 10.1016/j.nlm.2016.08.002

Journal - Research Article

Kwakowsky, A., Potapov, K., Kim, S., Peppercorn, K., Tate, W. P., & Ábrahám, I. M. (2016). Treatment of beta amyloid 1-42 (Αβ_1-42)-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo. Scientific Reports, 6, 21101. doi: 10.1038/srep21101

Journal - Research Article

Cardno, T. S., Shimaki, Y., Sleebs, B. E., Lackovic, K., Parisot, J. P., Moss, R. M., Crowe-McAuliffe, C., Mathew, S. F., Edgar, C. D., Kleffmann, T., & Tate, W. P. (2015). HIV-1 and human PEG10 frameshift elements are functionally distinct and distinguished by novel small molecule modulators. PLoS ONE, 10(10), e0139036. doi: 10.1371/journal.pone.0139036

Journal - Research Article

Mathew, S. F., Crowe-McAuliffe, C., Graves, R., Cardno, T. S., McKinney, C., Poole, E. S., & Tate, W. P. (2015). The highly conserved codon following the Slippery Sequence Supports -1 frameshift efficiency at the HIV-1 frameshift site. PLoS ONE, 10(3), e0122176. doi: 10.1371/journal.pone.0122176

Journal - Research Article

Ramsay, J. P., Tester, L. G. L., Major, A. S., Sullivan, J. T., Edgar, C. D., Kleffmann, T., … Tate, W. P., … Ronson, C. W. (2015). Ribosomal frameshifting and dual-target antiactivation restrict quorum-sensing–activated transfer of a mobile genetic element. PNAS, 112(3), 4104-4109. doi: 10.1073/pnas.1501574112

Journal - Research Article

Imhoff, F. M., Yang, D., Mathew, S. F., Clarkson, A. N., Kawagishi, Y., Tate, W. P., Koishi, K., & McLennan, I. S. (2013). The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors. FEBS Letters, 587(12), 1749-1753. doi: 10.1016/j.febslet.2013.04.014

Journal - Research Article

Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013). Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus. BMC Genomics, 14, 376. doi: 10.1186/1471-2164-14-376

Journal - Research Article

Baratchi, S., Evans, J., Tate, W. P., Abraham, W. C., & Connor, B. (2012). Secreted amyloid precursor proteins promote proliferation and glial differentiation of adult hippocampal neural progenitor cells. Hippocampus, 22(7), 1517-1527. doi: 10.1002/hipo.20988

Journal - Research Article

Bernhardt, H. S., & Tate, W. P. (2012). Primordial soup or vinaigrette: Did the RNA world evolve at acidic pH? Biology Direct, 7(4). doi: 10.1186/1745-6150-7-4

Journal - Research Article

Ryan, M. M., Ryan, B., Kyrke-Smith, M., Logan, B., Tate, W. P., Abraham, W. C., & Williams, J. M. (2012). Temporal profiling of gene networks associated with the late phase of long-term potentiation in vivo. PLoS ONE, 7(7), e40538. doi: 10.1371/journal.pone.0040538

Journal - Research Article

Morgan, N. V., Goddard, S., Cardno, T. S., McDonald, D., Rahman, F., Barge, D., Ciupek, A., … Tate, W. P., … Maher, E. R. (2011). Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ⁺ T cells. Journal of Clinical Investigation, 121(2), 695-702. doi: 10.1172/JCI41931

Journal - Research Article

Ryan, M. M., Mason-Parker, S. E., Tate, W. P., Abraham, W. C., & Williams, J. M. (2011). Rapidly induced gene networks following induction of long-term potentiation at perforant path synapses in vivo. Hippocampus, 21(5), 541-553. doi: 10.1002/hipo.20770

Journal - Research Article

Bernhardt, H. S., & Tate, W. P. (2010). The transition from noncoded to coded protein synthesis: Did coding mRNAs arise from stability-enhancing binding partners to tRNA? Biology Direct, 5, 16. doi: 10.1186/1745-6150-5-16

Journal - Research Article

Young, D. J., Edgar, C. D., Murphy, J., Fredebohm, J., Poole, E. S., & Tate, W. P. (2010). Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria. RNA, 16(6), 1146-1155. doi: 10.1261/rna.1970310

Journal - Research Article

Young, D. J., Edgar, C. D., Poole, E. S., & Tate, W. P. (2010). The codon specificity of eubacterial release factors is determined by the sequence and size of the recognition loop. RNA, 16, 1623-1633. doi: 10.1261/rna.2117010

Journal - Research Article

Cardno, T. S., Poole, E. S., Mathew, S. F., Graves, R., & Tate, W. P. (2009). A homogeneous cell-based bicistronic fluorescence assay for high-throughput identification of drugs that perturb viral gene recoding and read-through of nonsense stop codons. RNA, 15(8), 1614-1621. doi: 10.1261/rna.1586709

Journal - Research Article

Claasen, A. M., Guévremont, D., Mason-Parker, S. E., Bourne, K., Tate, W. P., Abraham, W. C., & Williams, J. M. (2009). Secreted amyloid precursor protein-α upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. Neuroscience Letters, 460, 92-96. doi: 10.1016/j.neulet.2009.05.040

Journal - Research Article

Jacobs, G. H., Chen, A., Stevens, S. G., Stockwell, P. A., Black, M. A., Tate, W. P., & Brown, C. M. (2009). Transterm: A database to aid the analysis of regulatory sequences in mRNAs. Nucleic Acids Research, 37(Database issue), D72-D76. doi: 10.1093/nar/gkn763

Journal - Research Article

Bernhardt, H. S., & Tate, W. P. (2008). Evidence from glycine transfer RNA of a frozen accident at the dawn of the genetic code. Biology Direct, 3, 53. doi: 10.1186/1745-6150-3-53

Journal - Research Article

Bernhardt, H. S., & Tate, W. P. (2008). Self-assembling transfer RNA has potential for nanoparticle arrays. Current Applied Physics, 8(3-4), 380-382. doi: 10.1016/j.cap.2007.10.035

Journal - Research Article

Taylor, C. J., Ireland, D. R., Ballagh, I., Bourne, K., Marechal, N. M., Turner, P. R., Bilkey, D. K., Tate, W. P., & Abraham, W. C. (2008). Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiology of Disease, 31(2), 250-260. doi: 10.1016/j.nbd.2008.04.011

Journal - Research Article

Clark, M. B., Jänicke, M., Gottesbühren, U., Kleffmann, T., Legge, M., Poole, E. S., & Tate, W. P. (2007). A mammalian gene PEG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. Journal of Biological Chemistry, 282(52), 37359-37369.

Journal - Research Article

Poole, E. S., Young, D. J., Askarian-Amiri, M. E., Scarlett, D.-J. G., & Tate, W. P. (2007). Accommodating the bacterial decoding release factor as an alien protein among the RNAs at the active site of the ribosome. Cell Research, 17, 591-607.

Journal - Research Article

Soleimanpour-Lichaei, H. R., Kühl, I., Gaisne, M., Passos, J. F., Wydro, M., Rorbach, J., … Tate, W., … Chrzanowska-Lightowlers, Z. (2007). mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. Molecular Cell, 27, 745-757.

Journal - Research Article

Turner, P. R., Bourne, K., Garama, D., Carne, A., Abraham, W. C., & Tate, W. P. (2007). Production, purification and functional validation of human secreted amyloid precursor proteins for use as neuropharmacological reagents. Journal of Neuroscience Methods, 164, 68-74.

Journal - Research Article

Williams, J. M., Guévremont, D., Mason-Parker, S. E., Luxmanan, C., Tate, W. P., & Abraham, W. C. (2007). Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. Journal of Neuroscience, 27(51), 14171-14178.

Journal - Research Article

Cridge, A. G., Major, L. L., Mahagaonkar, A. A., Poole, E. S., Isaksson, L. A., & Tate, W. P. (2006). Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms. Nucleic Acids Research, 34(7), 1959-1973. doi: 10.1093/nar/gkl074

Journal - Research Article

Jacobs, G. H., Stockwell, P. A., Tate, W. P., & Brown, C. M. (2006). Transterm: Extended search facilities and improved integration with other databases. Nucleic Acids Research, 34(Database), D37-D40.

Journal - Research Article

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