Dr Zhang’s research is focused on preclinical studies of new anti-aging, antibiotics and central nervous system (CNS) agents using various animal models and the extrapolation of these results to humans. His research areas have included the following inter-related areas: biopharmaceutical analysis, pharmacokinetics, drug metabolism, toxicity, drug discovery and development.
Since 2005, he has collaborated with Dr Ping Liu (Anatomy) on the contribution of the arginine metabolic to age-associated cognitive decline, disease biomarker identification and its potential use for drug discovery and development. Knowledge gained from this work will contribute significantly to the basic understanding of the neurobiology of the ageing brain and may lead to a LC/MS based metabonomic biomarker discovery and the development of agmatine based therapeutics for cognitive decline in Alzheimer’s disease. They are currently funded by the New Zealand Neurological Foundation and the Health Research Council of New Zealand.
Find out more about Dr Zhang’s research https://www.otago.ac.nz/pharmacy/people/profile/index.html?id=281
Publications
Li, Z., Zhang, T., Xu, L., Wei, Y., Cui, H., Tang, Y., … Zhang, H., Liu, P., … Wang, J. (2022). Plasma metabolic alterations and potential biomarkers in individuals at clinical high risk for psychosis. Schizophrenia Research, 239, 19-28. doi: 10.1016/j.schres.2021.11.011
Ahmad, F., Mein, H., Jing, Y., Zhang, H., & Liu, P. (2021). Behavioural functions and cerebral blood flow in a P301S tauopathy mouse model: A time-course study. International Journal of Molecular Sciences, 22, 9727. doi: 10.3390/ijms22189727
Zhang, J., Jing, Y., Zhang, H., & Liu, P. (2021). Effects of sex and estrous cycle on the brain and plasma arginine metabolic profile in rats. Amino Acids. Advance online publication. doi: 10.1007/s00726-021-03040-5
Vemula, P. K., Jing, Y., Cicolini, J., Zhang, H., Mockett, B. G., Abraham, W. C., & Liu, P. (2020). Altered brain arginine metabolism with age in the APPswe/PSEN1dE9 mouse model of Alzheimer's disease. Neurochemistry International, 140, 104798. doi: 10.1016/j.neuint.2020.104798
Feng, F., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2020). Cell-based, animal and H1 receptor binding studies relative to the sedative effects of ketotifen and norketotifen atropisomers. Journal of Pharmacy & Pharmacology, 72, 507-518. doi: 10.1111/jphp.13220
Li, Z., Zhang, T., Xu, L., Wei, Y., Cui, H., Tang, Y., … Zhang, H., Liu, P., … Wang, J. (2022). Plasma metabolic alterations and potential biomarkers in individuals at clinical high risk for psychosis. Schizophrenia Research, 239, 19-28. doi: 10.1016/j.schres.2021.11.011
Journal - Research Article
Ahmad, F., Mein, H., Jing, Y., Zhang, H., & Liu, P. (2021). Behavioural functions and cerebral blood flow in a P301S tauopathy mouse model: A time-course study. International Journal of Molecular Sciences, 22, 9727. doi: 10.3390/ijms22189727
Journal - Research Article
Zhang, J., Jing, Y., Zhang, H., & Liu, P. (2021). Effects of sex and estrous cycle on the brain and plasma arginine metabolic profile in rats. Amino Acids. Advance online publication. doi: 10.1007/s00726-021-03040-5
Journal - Research Article
Feng, F., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2020). Cell-based, animal and H1 receptor binding studies relative to the sedative effects of ketotifen and norketotifen atropisomers. Journal of Pharmacy & Pharmacology, 72, 507-518. doi: 10.1111/jphp.13220
Journal - Research Article
Vemula, P. K., Jing, Y., Cicolini, J., Zhang, H., Mockett, B. G., Abraham, W. C., & Liu, P. (2020). Altered brain arginine metabolism with age in the APPswe/PSEN1dE9 mouse model of Alzheimer's disease. Neurochemistry International, 140, 104798. doi: 10.1016/j.neuint.2020.104798
Journal - Research Article
Bergin, D. H., Jing, Y., Williams, G., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2019). Safety and neurochemical profiles of acute and sub-chronic oral treatment with agmatine sulfate. Scientific Reports, 9, 12669. doi: 10.1038/s41598-019-49078-0
Journal - Research Article
Hariharan, A., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2019). Altered neurovascular coupling and brain arginine metabolism in endothelial nitric oxide synthase deficient mice. Nitric Oxide, 87, 60-72. doi: 10.1016/j.niox.2019.03.006
Journal - Research Article
Vemula, P., Jing, Y., Zhang, H., Hunt, Jr, J. B., Sandusky-Beltran, L. A., Lee, D. C., & Liu, P. (2019). Altered brain arginine metabolism in a mouse model of tauopathy. Amino Acids, 51, 513-528. doi: 10.1007/s00726-018-02687-x
Journal - Research Article
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2019). Maternal immune activation altered microglial immunoreactivity in the brain of postnatal day 2 rat offspring. Synapse, 73, e22072. doi: 10.1002/syn.22072
Journal - Research Article
Bergin, D. H., Jing, Y., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2018). Altered plasma arginine metabolome precedes behavioural and brain arginine metabolomic profile changes in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease. Translational Psychiatry, 8, 108. doi: 10.1038/s41398-018-0149-z
Journal - Research Article
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2018). Effects of maternal immune activation on brain arginine metabolism of postnatal day 2 rat offspring. Schizophrenia Research, 192, 431-441. doi: 10.1016/j.schres.2017.05.016
Journal - Research Article
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2018). Maternal immune activation leads to increased nNOS immunoreactivity in the brain of postnatal day 2 rat offspring. Synapse, 72(1), e22011. doi: 10.1002/syn.22011
Journal - Research Article
Knox, L. T., Jing, Y., Bawazier-Edgecombe, J., Collie, N. D., Zhang, H., & Liu, P. (2017). Effects of withdrawal from repeated phencyclidine administration on behavioural function and brain arginine metabolism in rats. Pharmacology Biochemistry & Behavior, 153, 45-59. doi: 10.1016/j.pbb.2016.12.006
Journal - Research Article
Liu, P., Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Smith, P. F. (2017). Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum. Neuroscience, 348, 273-287. doi: 10.1016/j.neuroscience.2017.02.033
Journal - Research Article
Mazlan, M., Hamizah, H. S., Taridi, N. M., Jing, Y., Liu, P., Zhang, H., … Damanhuri, H. A. (2017). Effects of aging and tocotrienol-rich fraction supplementation on brain arginine metabolism in rats. Oxidative Medicine & Cellular Longevity, 2017, 6019796. doi: 10.1155/2017/6019796
Journal - Research Article
Liu, P., Jing, Y., Collie, N. D., Dean, B., Bilkey, D. K., & Zhang, H. (2016). Altered brain arginine metabolism in schizophrenia. Translational Psychiatry, 6, e871. doi: 10.1038/tp.2016.144
Journal - Research Article
Bergin, D. H., Jing, Y., Zhang, H., & Liu, P. (2015). A single intracerebroventricular Aβ25-35 infusion leads to prolonged alterations in arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience, 298, 367-379. doi: 10.1016/j.neuroscience.2015.04.034
Journal - Research Article
Knox, L. T., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2014). Effects of acute phencyclidine administration on arginine metabolism in the hippocampus and prefrontal cortex in rats. Neuropharmacology, 81, 195-205. doi: 10.1016/j.neuropharm.2014.02.004
Journal - Research Article
Liu, P., Fleete, M. S., Jing, Y., Collie, N. D., Curtis, M. A., Waldvogel, H. J., … Abraham, W. C., & Zhang, H. (2014). Altered arginine metabolism in Alzheimer’s disease brains. Neurobiology of Aging, 35(9), 1992-2003. doi: 10.1016/j.neurobiolaging.2014.03.013
Journal - Research Article
Jing, Y., Fleete, M. S., Collie, N. D., Zhang, H., & Liu, P. (2013). Regional variations and age-related changes in arginine metabolism in the rat brain stem and spinal cord. Neuroscience, 252, 98-108. doi: 10.1016/j.neuroscience.2013.08.002
Journal - Research Article
Jing, Y., Zhang, H., Wolff, A. R., Bilkey, D. K., & Liu, P. (2013). Altered arginine metabolism in the hippocampus and prefrontal cortex of maternal immune activation rat offspring. Schizophrenia Research, 148(1-3), 151-156. doi: 10.1016/j.schres.2013.06.001
Journal - Research Article
Nayak, P. K., Zhang, H., & Kerr, D. S. (2013). Determination of 1-(4’-aminophenyl)-4-methyl-7,8-methylene-dioxy-2,3-benzodiazepine by high-performance liquid chromatography—diode array detection in plasma and brain in healthy and hypoxic–ischaemic rats. Neuroscience, 232, 139-150. doi: 10.1016/j.neuroscience.2012.12.001
Journal - Research Article
Rushaidhi, M., Jing, Y., Zhang, H., & Liu, P. (2013). Participation of hippocampal agmatine in spatial learning: An in vivo microdialysis study. Neuropharmacology, 65, 200-205. doi: 10.1016/j.neuropharm.2012.10.007
Journal - Research Article
Rushaidhi, M., Zhang, H., & Liu, P. (2013). Effects of prolonged agmatine treatment in aged male Sprague-Dawley rats. Neuroscience, 234, 116-124. doi: 10.1016/j.neuroscience.2013.01.004
Journal - Research Article
Yang, L., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2013). Effect of 12-oxochenodeoxycholate on the pharmacokinetics and pharmacodynamics of morphine 6-glucuronide in Wistar rats. Journal of Pharmacy & Pharmacology, 65(4), 561-566. doi: 10.1111/jphp.12020
Journal - Research Article
Chen, G., Yang, L., Zhang, H., Tucker, I. G., & Fawcett, J. P. (2012). Effect of ketocholate derivatives on methotrexate uptake in Caco-2 cell monolayers. International Journal of Pharmaceutics, 433, 89-93. doi: 10.1016/j.ijpharm.2012.04.077
Journal - Research Article
Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2012). Ageing alters behavioural function and brain arginine metabolism in male Sprague-Dawley rats. Neuroscience, 226, 178-196. doi: 10.1016/j.neuroscience.2012.09.013
Journal - Research Article
Gupta, N., Zhang, H., & Liu, P. (2012). Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats. Pharmacology Biochemistry & Behavior, 100(3), 464-473. doi: 10.1016/j.pbb.2011.10.011
Journal - Research Article
Lee, H. J., Zhang, H., Orlovich, D. A., & Fawcett, J. P. (2012). The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica, 42(8), 791-797. doi: 10.3109/00498254.2012.660508
Journal - Research Article
Rushaidhi, M., Collie, N. D., Zhang, H., & Liu, P. (2012). Agmatine selectively improves behavioural function in aged male Sprague-Dawley rats. Neuroscience, 218(30), 206-215. doi: 10.1016/j.neuroscience.2012.05.015
Journal - Research Article
Rushaidhi, M., Jing, Y., Kennard, J. T., Collie, N. D., Williams, J. M., Zhang, H., & Liu, P. (2012). Aging affects L-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels. Neuroscience, 209, 21-31. doi: 10.1016/j.neuroscience.2012.02.021
Journal - Research Article
Yang, L., Fawcett, J. P., Østergaard, J., Zhang, H., & Tucker, I. G. (2012). Mechanistic studies of the effect of bile salts on rhodamine 123 uptake into RBE4 cells. Molecular Pharmaceutics, 9(1), 29-36. doi: 10.1021/mp200201y
Journal - Research Article
Knox, L. T., Jing, Y., Fleete, M. S., Collie, N. D., Zhang, H., & Liu, P. (2011). Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus. Neuropharmacology, 61(8), 1452-1462. doi: 10.1016/j.neuropharm.2011.08.042
Journal - Research Article
Liu, P., Jing, Y., Collie, N. D., Campbell, S. A., & Zhang, H. (2011). Pre-aggregated Aβ25-35 alters arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience, 193, 269-282. doi: 10.1016/j.neuroscience.2011.07.054
Journal - Research Article
Yang, L., Zhang, H., Fawcett, J. P., Mikov, M., & Tucker, I. G. (2011). Effect of bile salts on the transport of morphine-6-glucuronide in rat brain endothelial cells. Journal of Pharmaceutical Sciences, 100(4), 1516-1524. doi: 10.1002/jps.22390
Journal - Research Article
Li, Y., Zhang, H., Fawcett, J. P., & Tucker, I. G. (2010). Effect of cyclosporin A on the pharmacokinetics of mitoquinone (MitoQ10), a mitochondria-targeted antioxidant, in rat. Asian Journal of Pharmaceutical Sciences, 5(3), 106-113.
Journal - Research Article
Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019
Journal - Research Article
Gupta, N., Zhang, H., & Liu, P. (2009). Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. Neuroscience, 161(3), 691-706. doi: 10.1016/j.nueroscience.2009.03.075
Journal - Research Article
Liu, P., Jing, Y., & Zhang, H. (2009). Age-related changes in arginine and its metabolites in memory-associated brain structures. Neuroscience, 164(2), 611-628. doi: 10.1016/j.neuroscience.2009.08.029
Journal - Research Article
Liu, P., Jing, Y., Collie, N. D., Chary, S., & Zhang, H. (2009). Memory-related changes in L-citrulline and agmatine in the rat brain. Hippocampus, 19(7), 597-602. doi: 10.1002/hipo.20561
Journal - Research Article
Yang, L., Zhang, H., Mikov, M., & Tucker, I. G. (2009). Physicochemical and biological characterization of monoketocholic acid, a novel permeability enhancer. Molecular Pharmaceutics, 6(2), 448-456. doi: 10.1021/mp800143w
Journal - Research Article
Li, Y., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2008). Transport and metabolism of some cationic ubiquinone antioxidants (MitoQn) in Caco-2 cell monolayers. European Journal of Drug Metabolism & Pharmacokinetics, 33(4), 199-204.
Journal - Research Article
Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2008). Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus, 18, 853-856. doi: 10.1002/hipo.20448
Journal - Research Article
Liu, P., Collie, N. D., Chary, S., Jing, Y., & Zhang, H. (2008). Spatial learning results in elevated agmatine levels in the rat brain. Hippocampus, 18, 1094-1098. doi: 10.1002/hipo.20482
Journal - Research Article
Liu, P., Gupta, N., Jing, Y., & Zhang, H. (2008). Age-related changes in polyamines in memory-associated brain structures in rats. Neuroscience, 155, 789-796. doi: 10.1016/j.neuroscience.2008.06.033
Journal - Research Article
Liu, P., Rushaidhi, M., Collie, N. D., Leong, M.-T. T., & Zhang, H. (2008). Behavioral effects of intracerebroventricular microinfusion of agmatine in adult rats. Behavioral Neuroscience, 122(3), 557-569. doi: 10.1037/0735-7044.122.3.557
Journal - Research Article
Li, Y., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2007). Transport and metabolism of MitoQ10, a mitochondria-targeted antioxidant, in Caco-2 cell monolayers. Journal of Pharmacy & Pharmacology, 59, 503-511.
Journal - Research Article
Li, Y., Zhang, H., Fawcett, J. P., & Tucker, I. G. (2007). Quantitation and metabolism of mitoquinone, a mitochondria-targeted antioxidant, in rat by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 1958-1964.
Journal - Research Article
McLeod, B. J., Zhang, H., Huang, L., Thompson, E. G., Butt, A. G., & Tucker, I. G. (2005). An in situ single-pass perfusion model for assessing absorption across the intestinal mucosa of the brushtail possum. New Zealand Veterinary Journal, 53(4), 234-241.
Journal - Research Article
Pukrittayakamee, S., Pitisuttithum, P., Zhang, H., Jantra, A., Wanwimolruk, S., & White, N. J. (2002). Effects of cigarette smoking on quinine pharmacokinetics in malaria. European Journal of Clinical Pharmacology, 58, 315-319.
Journal - Research Article