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Dr Shakila Rizwan

Dr Rizwan is interested in novel formulation strategies for delivering pharmaceuticals to the brain. She and her lab are interested in two different routes; firstly via the intranasal route, and secondly across the blood-brain barrier.

Her research focus is investigating the formulation and physicochemical characterisation of lipid and polymer-based nano- and microparticle drug carriers. She is also trying to gain a better understanding of the biological basis of nanoparticle-mediated drug delivery across the healthy and diseased blood-brain barrier, and the biological basis of nose-to-brain drug delivery.

Find out more about Dr Rizwan's research here

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Publications

Younus, M., Hawley, A., Boyd, B. J., & Rizwan, S. B. (2018). Bulk and dispersed aqueous behaviour of an endogenous lipid, selachyl alcohol: Effect of Tween 80 and Pluronic F127 on nanostructure. Colloids & Surfaces B, 169, 135-142. doi: 10.1016/j.colsurfb.2018.05.013

Yepuri, N. R., Clulow, A. J., Prentice, R. N., Gilbert, E. P., Hawley, A., Rizwan, S. B., … Darwish, T. A. (2018). Deuterated phytantriol: A versatile material for probing material distribution in liquid crystalline lipid phases using neutron scattering. Journal of Colloid & Interface Science. Advance online publication. doi: 10.1016/j.jcis.2018.09.022

Rizwan, S. B., & Vernall, A. J. (2017). To prohibit or regulate psychoactive substances: Has New Zealand got the right approach? BMJ, 356, j1195. doi: 10.1136/bmj.j1195

Yarragudi, S. B., Richter, R., Lee, H., Walker, G. F., Clarkson, A. N., Kumar, H., & Rizwan, S. B. (2017). Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs. Carbohydrate Polymers, 163, 216-226. doi: 10.1016/j.carbpol.2017.01.044

Yarragudi, S. B., Barzegar-Fallah, A., Prentice, R. N., & Rizwan, S. B. (2017). Olfactory targeted mucoadhesive microparticles for enhanced brain uptake of phenytoin. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 84). Retrieved from http://www.asceptasm.com/

Chapter in Book - Research

Rizwan, S. B., & Boyd, B. J. (2015). Cubosomes: Structure, preparation and use as an antigen delivery system. In C. Foged, T. Rades, Y. Perrie & S. Hook (Eds.), Subunit vaccine delivery. (pp. 125-140). New York: Springer. doi: 10.1007/978-1-4939-1417-3

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Journal - Research Article

Younus, M., Hawley, A., Boyd, B. J., & Rizwan, S. B. (2018). Bulk and dispersed aqueous behaviour of an endogenous lipid, selachyl alcohol: Effect of Tween 80 and Pluronic F127 on nanostructure. Colloids & Surfaces B, 169, 135-142. doi: 10.1016/j.colsurfb.2018.05.013

Yepuri, N. R., Clulow, A. J., Prentice, R. N., Gilbert, E. P., Hawley, A., Rizwan, S. B., … Darwish, T. A. (2018). Deuterated phytantriol: A versatile material for probing material distribution in liquid crystalline lipid phases using neutron scattering. Journal of Colloid & Interface Science. Advance online publication. doi: 10.1016/j.jcis.2018.09.022

Rizwan, S. B., & Vernall, A. J. (2017). To prohibit or regulate psychoactive substances: Has New Zealand got the right approach? BMJ, 356, j1195. doi: 10.1136/bmj.j1195

Yarragudi, S. B., Richter, R., Lee, H., Walker, G. F., Clarkson, A. N., Kumar, H., & Rizwan, S. B. (2017). Formulation of olfactory-targeted microparticles with tamarind seed polysaccharide to improve nose-to-brain transport of drugs. Carbohydrate Polymers, 163, 216-226. doi: 10.1016/j.carbpol.2017.01.044

Azhari, H., Strauss, M., Hook, S., Boyd, B. J., & Rizwan, S. B. (2016). Stabilising cubosomes with Tween 80 as a step towards targeting lipid nanocarriers to the blood-brain barrier. European Journal of Pharmaceutics & Biopharmaceutics, 104, 148-155. doi: 10.1016/j.ejpb.2016.05.001

Younus, M., Prentice, R. N., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2016). Incorporation of an endogenous neuromodulatory lipid, oleoylethanolamide, into cubosomes: Nanostructural characterization. Langmuir, 32(35), 8942-8950. doi: 10.1021/acs.langmuir.6b02395

Rizwan, S. B., McBurney, W. T., Young, K., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2013). Cubosomes containing the adjuvants imiquimod and monophosphoryl lipid A stimulate robust cellular and humoral immune responses. Journal of Controlled Release, 165(1), 16-21. doi: 10.1016/j.jconrel.2012.10.020

Gordon, S., Young, K., Wilson, R., Rizwan, S., Kemp, R., Rades, T., & Hook, S. (2012). Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems. Journal of Liposome Research, 22(3), 193-204. doi: 10.3109/08982104.2011.637502

Rizwan, S. B., Assmus, D., Boehnke, A., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2011). Preparation of phytantriol cubosomes by solvent precursor dilution for the delivery of protein vaccines. European Journal of Pharmaceutics & Biopharmaceutics, 79(1), 15-22. doi: 10.1016/j.ejpb.2010.12.034

Kojarunchitt, T., Hook, S., Rizwan, S., Rades, T., & Baldursdottir, S. (2011). Development and characterisation of modified poloxamer 407 thermoresponsive depot systems containing cubosomes. International Journal of Pharmaceutics, 408(1-2), 20-26. doi: 10.1016/j.ijpharm.2011.01.037

Rizwan, S. B., Boyd, B. J., Rades, T., & Hook, S. (2010). Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion on Drug Delivery, 7(10), 1133-1144. doi: 10.1517/17425247.2010.515584

Rizwan, S. B., Hanley, T., Boyd, B. J., Rades, T., & Hook, S. (2009). Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: Characterisation, swelling and release kinetics. Journal of Pharmaceutical Sciences, 98(11), 4191-4204. doi: 10.1002/jps.21724

Rizwan, S. B., Dong, Y.-D., Boyd, B. J., Rades, T., & Hook, S. (2007). Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy (cryo FESEM). Micron, 38, 478-485. doi: 10.1016/j.micron.2006.08.003

Boyd, B. J., Rizwan, S. B., Dong, Y.-D., Hook, S., & Rades, T. (2007). Self-assembled geometric liquid-crystalline nanoparticles imaged in three dimensions: Hexosomes are not necessarily flat hexagonal prisms. Langmuir, 23(25), 12461-12464. doi: 10.1021/la7029714

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Conference Contribution - Published proceedings: Full paper

Rizwan, S. B., McBurney, W., Boyd, B. J., Rades, T., & Hook, S. (2008). In vitro activity of phytantriol cubosomes containing the adjuvants imiquimod or monophosphoryl lipid A in bone marrow derived dendritic cells. Proceedings of the 35th Annual Meeting & Exposition of the Controlled Release Society. [CD-ROM] St Paul, MN: CRS. [Full Paper]

Rizwan, S. B., Boyd, B. J., Rades, T., & Hook, S. (2008). Characterisation, swelling and release from liquid crystalline systems of phytantriol and glycerylmonooleate as platforms for controlled release of bioactives. Proceedings of the 35th Annual Meeting & Exposition of the Controlled Release Society. [CD-ROM] St Paul, MN: CRS. [Full Paper]

Hook, S., Rizwan, S., Gordon, S., Saupe, A., & Rades, T. (2007). Towards the development of controlled release cancer vaccines. Proceedings of the 34th Annual Meeting & Exposition of the Controlled Release Society. [CD-ROM] Minnesota, USA: CRS. [Full Paper]

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Conference Contribution - Published proceedings: Abstract

Yarragudi, S. B., Barzegar-Fallah, A., Prentice, R. N., & Rizwan, S. B. (2017). Olfactory targeted mucoadhesive microparticles for enhanced brain uptake of phenytoin. Proceedings of the Australasian Pharmaceutical Science Association and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (APSA-ASCEPT) Joint Scientific Meeting. (pp. 84). Retrieved from http://www.asceptasm.com/

Yarragudi, S. B., Lee, H., Richter, R., Kumar, H., & Rizwan, S. B. (2016). Formulation of olfactory-targeted microparticles of tamarind seed polysaccharide for nose-to-brain delivery of drug. Proceedings of the Drug Delivery Australia Conference. (pp. 77). Retrieved from http://www.crsaustralia.org/

Azhari, H., Hook, S., Boyd, B., & Rizwan, S. (2016). Formulation and uptake of cationic cubosomes in the zebrafish brain. Proceedings of the Drug Delivery Australia Conference. (pp. 70). Retrieved from http://www.crsaustralia.org/

Rizwan, S., & Alsop, T.-A. (2016). Contemplating strategies for teaching applied mathematics to diverse student cohort. Proceedings of the Tertiary Education Research in New Zealand (TERNZ) Conference. Retrieved from http://herdsa.org.nz/ternz/2016

Prentice, R., Burroughs, W., Mohammad, Y., & Rizwan, S. (2016). From SAXS to FACS: Investigating cellular interactions of phytantriol-oleoylethanolamide cubosomes. Proceedings of the Drug Delivery Australia Conference. (pp. 67). Retrieved from http://www.crsaustralia.org/

Rizwan, S. (2016). Delivery of therapeutic molecules to the brain using particulate carriers. Proceedings of the Drug Delivery Australia Conference. (pp. 31). Retrieved from http://www.crsaustralia.org/

Rizwan, S., & Alsop, T.-A. (2016). Applied teaching verses foundation knowledge: How can we balance prior learning and applied teaching to ensure mathematically competent students in the health sciences? Proceedings of the First Year Biology Educators' Colloquium (FYBC). (pp. 7). Retrieved from http://www.otago.ac.nz/fybec/programme-and-speakers/index.html

Younus, M., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2016). Investigating the effects of Tween 80 on sterically stabilising non-lamellar liquid crystalline nanoparticles of selachyl alcohol. Proceedings of the Drug Delivery Australia Conference. (pp. 57). Retrieved from http://www.crsaustralia.org/

Rizwan, S. B., Yarragudi, S. B., Richter, R., Walker, G. F., & Clarkson, A. N. (2016). Olfactory-targeted microparticles: A novel approach to bypass the blood-brain barrier. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 60). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

Azhari, H., Tey, W. K., Hook, S., Boyd, B. J., & Rizwan, S. (2015). Interaction of cationic cubosomes with immortalized human brain endothelial cells. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Younus, M., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2015). Structural stability of oleoylethanolamide, an endogenous neuromodulatory lipid is conserved when incorporated into cubosomes. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Azhari, H., Rizwan, S., Hook, S., Boyd, B. J., & Strauss, M. (2015). Modifying the surface of cubosomes with blood-brain barrier targeting ligands strongly influences its nanostructure. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html

Yarragudi, S. B., Ritcher, R., Walker, G. F., Clarkson, A. N., & Rizwan, S. B. (2015). Formulation of monodispursed mucoadhesive microparticles for nose-to-brain delivery. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070

Azhari, H., Boyd, B., Hook, S., & Rizwan, S. (2015). Enhanced uptake of drug into the brain when delivered in BBB-targeted cubosomes. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 46). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr

Yarragudi, S. B., Walker, G. F., Clarkson, A. N., & Rizwan, S. B. (2015). Scanning electron microscopy as a tool to understand the effects of process variables on microparticle formation. Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html

Mohammad, Y., Clarkson, A. N., Boyd, B. J., & Rizwan, S. B. (2015). Aqueous mixtures of phytantriol-oleoylethanolamide and pluronic F127 result in an intriguing variety of self-assembled lipid nanoparticles as revealed by Cryogenic Transmission Electron Microscopy (cryo-TEM). Proceedings of the 27th National Conference on Microscopy. Retrieved from http://microscopy2015.otago.ac.nz/index.html

Azhari, H., Boyd, B. J., & Rizwan, S. B. (2014). Influence of the surfactant Tween 80 on aqueous self-assembly of phytantriol. Proceedings of the 5th Pharmaceutical Sciences World Congress (PSWC). Retrieved from http://www.fip.org/pswc2014/Melbourne/2041/Programme/

Azhari, H., Boyd, B. J., & Rizwan, S. B. (2013). Phytantriol cubosomes sterically stabilised with the surfactants Tween 80 and Myrj 100: Formulation, characterisation and permeability studies in an in vitro model of the blood-brain barrier. Proceedings of the Australasian Pharmaceutical Science Association (APSA) Conference. Retrieved from http://apsa-online.org/home.html

Rizwan, S. (2013). Zebrafish as a vertebrate model: Opportunities in pharmaceutical research. Proceedings of the Australasian Pharmaceutical Science Association (APSA) Conference. Retrieved from http://apsa-online.org/home.html

Kojarunchitt, T., Hook, S., Rizwan, S., Rades, T., & Baldursdottir, S. (2010). Development of sustained release vaccine delivery system containing modified poloxamer 407 loaded with cubosomes. Proceedings of the Globalization of Pharmaceutics Education Network (GPEN) 8th Biennial Meeting. (pp. 139). Retrieved from http://www.pharmacy.unc.edu/news/events/globalization-of-pharmaceutics-education-network-eighth-meeting-2010/program/GPEN2010_Program.pdf

Hook, S., Myschik, J., Gordon, S., Rizwan, S., McBurney, W., & Rades, T. (2009). Designing sustained release, particulate, sub-unit vaccines. Proceedings of the Webster Centre for Infectious Diseases Symposium. WCID. Retrieved from http://www.webstercentre.otago.ac.nz/WCIDSymposiumProgramme.pdf

Rizwan, S., McBurney, W., Boyd, B., Rades, T., & Hook, S. (2008). Enhanced type-1 immune response from a novel particulate vaccine delivery system comprised of phytantriol cubosomes containing toll-like receptor agonists imiquimod and or monophosphoryl lipid A. AAPS Journal, 10(S2). Retrieved from http://www.aapsj.org/abstracts/AM_2008/AAPS2008-001145.PDF

Rizwan, S., Boyd, B., Hook, S., & Rades, T. (2006). Characterisation of bicontinuous cubic liquid crystalline phases by cryo FESEM. In P. Munroe (Ed.), Proceedings of the Australian Conference on Microscopy and Microanalysis. Melbourne, Australia: Australian Microscopy and Microanalysis Society Inc. Retrieved from www.acmm19.org.au

Rizwan, S. (2005). Lyotropic liquid crystalline nanoparticles for delivery of cancer vaccines. Proceedings of the ChemEd Conference. (pp. 14). [Abstract]

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Conference Contribution - Poster Presentation (not in published proceedings)

Azhari, H., Hook, S., Boyd, B. J., & Rizwan, S. B. (2015, July). Zebrafish can be used to determine permeability of nanoparticles across the blood-brain barrier in vivo. Poster session presented at the 11th International Conference on Cerebral Vascular Biology, Paris, France.

Azhari, H., Boyd, B. J., Strauss, M., & Rizwan, S. (2014, September). Influence of the surfactant Tween 80 on aqueous self-assembly of phytantriol. Poster session presented at the Division of Health Sciences Research Forum: Learning Different Research Languages, Dunedin, New Zealand.

Mohammad, Y., Clarkson, A., Boyd, B., & Rizwan, S. (2014, November). Formulation and characterisation of phytantriol-oleoylethanolamide cubosomes. Poster session presented at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand.

Rizwan, S., Azhari, H., Tey, W. K., & Boyd, B. (2014, November). Formulation and characterisation of catatonic cubosomes of phytantrial with cetrimonium bromide (CTAB) or N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride (DOTAP). Poster session presented at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand.

Yarragudi, S., Walker, G., Clarkson, A., & Rizwan, S. (2014, November). Formulation and characterisation of a novel microparticle system for nose-to-brain drug delivery. Poster session presented at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand.

Rizwan, S., Assmus, D., Boyd, B. J., Rades, T., & Hook, S. (2007, February). Development and characterisation of phytantriol based lyotropic liquid crystalline nanoparticles produced via low viscosity precursors. Poster session presented at the 9th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.

Rizwan, S., Dong, C., Boyd, B. J., Rades, T., & Hook, S. (2007, February). Characterising bicontinuous cubic nanoparticles by cryo field emission scanning electron microscopy. Poster session presented at the 9th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.

Rizwan, S., Assmus, D., Boyd, B., Rades, T., & Hook, S. (2007, November). Spontaneous formation of phytantriol based lyotropic liquid crystalline nanoparticles produced from liquid precursors. Poster session presented at the American Association of Pharmaceutical Scientists Annual Meeting and Exposition, San Diego, CA.

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