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Dr Mike Garratt

PositionSenior Lecturer
DepartmentDepartment of Anatomy
Research summaryLife history evolution, biology of ageing

Research

Our research is interested in how reproduction influences life-history, health and ageing. This includes physiological effects of gonadal-derived hormones, consequences of mating, and even impacts of social pheromone perception on life-history trajectory. A related research theme explores how sex-specific aspects of reproduction cause sexual-dimorphism in lifespan, and influence the effectiveness of interventions developed to improve healthy ageing.

Most experimental work is conducted in mice, which provides access to molecular-genetic techniques to directly manipulate physiology controlling development, reproduction and ageing. We also use comparative approaches to identify evolutionary and mechanistic drivers of diversification in life history on an interspecies scale, and have several collaborative projects that probe links between reproduction and ageing in wild animals.

Publications

Debarba, L. K., Jayarathne, H. S. M., Miller, R. A., Garratt, M., & Sadagurski, M. (2021). 17-a-estradiol has sex-specific effects on neuroinflammation that are partly reversed by gonadectomy. Journals of Gerontology Series A. doi: 10.1093/gerona/glab216

Sugrue, V. J., Zoller, J. A., Narayan, P., Lu, A. T., Ortega-Recalde, O. J., Grant, M. J., … Bond, D. M., … Garratt, M., … Hore, T. A., & Horvath, S. (2021). Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci. eLIFE, 10, e64932. doi: 10.7554/eLife.64932

Garratt, M., Try, H., & Brooks, R. C. (2021). Access to females and early life castration individually extend maximal but not median lifespan in male mice. GeroScience. Advance online publication. doi: 10.1007/s11357-020-00308-8

Herrera, J. J., Louzon, S., Pifer, K., Leander, D., Merrihew, G. E., Park, J. H., … Garratt, M. (2020). Acarbose has sex-dependent and -independent effects on age-related physical function, cardiac health, and lipid biology. JCI Insight, 5(21), e137474. doi: 10.1172/jci.insight.137474

Garratt, M., Try, H., Smiley, K. O., Grattan, D. R., & Brooks, R. C. (2020). Mating in the absence of fertilization promotes a growth-reproduction versus lifespan trade-off in female mice. PNAS, 117(27), 15748-15754. doi: 10.1073/pnas.2003159117

Gaillard, J.-M., Garratt, M., & Lemaître, J.-F. (2017). Senescence in mammalian life history traits. In R. P. Shefferson, O. R. Jones & R. Salguero-Gómez (Eds.), The evolution of senescence in the tree of life. (pp. 126-155). Cambridge, UK: Cambridge University Press. doi: 10.1017/9781139939867.007

Chapter in Book - Research

Debarba, L. K., Jayarathne, H. S. M., Miller, R. A., Garratt, M., & Sadagurski, M. (2021). 17-a-estradiol has sex-specific effects on neuroinflammation that are partly reversed by gonadectomy. Journals of Gerontology Series A. doi: 10.1093/gerona/glab216

Journal - Research Article

Garratt, M., Try, H., & Brooks, R. C. (2021). Access to females and early life castration individually extend maximal but not median lifespan in male mice. GeroScience. Advance online publication. doi: 10.1007/s11357-020-00308-8

Journal - Research Article

Sugrue, V. J., Zoller, J. A., Narayan, P., Lu, A. T., Ortega-Recalde, O. J., Grant, M. J., … Bond, D. M., … Garratt, M., … Hore, T. A., & Horvath, S. (2021). Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci. eLIFE, 10, e64932. doi: 10.7554/eLife.64932

Journal - Research Article

Garratt, M., Try, H., Smiley, K. O., Grattan, D. R., & Brooks, R. C. (2020). Mating in the absence of fertilization promotes a growth-reproduction versus lifespan trade-off in female mice. PNAS, 117(27), 15748-15754. doi: 10.1073/pnas.2003159117

Journal - Research Article

Herrera, J. J., Louzon, S., Pifer, K., Leander, D., Merrihew, G. E., Park, J. H., … Garratt, M. (2020). Acarbose has sex-dependent and -independent effects on age-related physical function, cardiac health, and lipid biology. JCI Insight, 5(21), e137474. doi: 10.1172/jci.insight.137474

Journal - Research Article

Lemaître, J.-F., Ronget, V., Tidière, N., Allainé, D., Berger, V., Cohas, A., … Garratt, M., … Gaillard, J.-M. (2020). Sex differences in adult lifespan and aging rates of mortality across wild mammals. PNAS, 117(15), 8546-8553. doi: 10.1073/pnas.1911999117

Journal - Research Article

Gale, T. J., Garratt, M., & Brooks, R. C. (2019). Female mice seek refuge from castrated males, but not intact or vasectomized males, mitigating a socially-induced glucocorticoid response. Physiology & Behavior, 211, 112678. doi: 10.1016/j.physbeh.2019.112678

Journal - Research Article

Garratt, M., Leander, D., Pifer, K., Bower, B., Herrera, J. J., Day, S. M., … Miller, R. A. (2019). 17-α estradiol ameliorates age-associated sarcopenia and improves late-life physical function in male mice but not in females or castrated males. Aging Cell, 18(2), e12920. doi: 10.1111/acel.12920

Journal - Research Article

Harrison, D. E., Strong, R., Alavez, S., Astle, C. M., DiGiovanni, J., Fernandez, E., … Garratt, M., … Miller, R. A. (2019). Acarbose improves health and lifespan in aging HET3 mice. Aging Cell, 18(2), e12898. doi: 10.1111/acel.12898

Journal - Research Article

Tyshkovskiy, A., Bozaykut, P., Borodinova, A. A., Gerashchenko, M. V., Ables, G. P., Garratt, M., … Gladyshev, V. N. (2019). Identification and application of gene expression signatures associated with lifespan extension. Cell Metabolism, 30(3), 573-593. doi: 10.1016/j.cmet.2019.06.018

Journal - Research Article

Gale, T., Garratt, M., & Brooks, R. C. (2018). Perceived threats of infanticide reduce maternal allocation during lactation and lead to elevated oxidative damage in offspring. Functional Ecology, 32(9), 2158-2169. doi: 10.1111/1365-2435.13146

Journal - Research Article

Garratt, M., Lagerborg, K. A., Tsai, Y.-M., Galecki, A., Jain, M., & Miller, R. A. (2018). Male lifespan extension with 17‐α estradiol is linked to a sex‐specific metabolomic response modulated by gonadal hormones in mice. Aging Cell, 17(4), e12786. doi: 10.1111/acel.12786

Journal - Research Article

Ronget, V., Gaillard, J.-M., Coulson, T., Garratt, M., Gueyffier, F., Lega, J.-C., & Lemaître, J.-F. (2018). Causes and consequences of variation in offspring body mass: Meta-analyses in birds and mammals. Biological Reviews, 93(1), 1-27. doi: 10.1111/brv.12329

Journal - Research Article

Brooks, R. C., & Garratt, M. G. (2017). Life history evolution, reproduction, and the origins of sex-dependent aging and longevity. Annals of the New York Academy of Sciences, 1389(1), 92-107. doi: 10.1111/nyas.13302

Journal - Research Article

Cady, G., Landeryou, T., Garratt, M., Kopchick, J. J., Qi, N., Garcia-Galiano, D., … Sadagurski, M. (2017). Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons. Molecular Metabolism, 6(5), 393-405. doi: 10.1016/j.molmet.2017.03.001

Journal - Research Article

Garratt, M., Bower, B., Garcia, G. G., & Miller, R. A. (2017). Sex differences in lifespan extension with acarbose and 17-α estradiol: Gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling. Aging Cell, 16(6), 1256-1266. doi: 10.1111/acel.12656

Journal - Research Article

Garratt, M., Nakagawa, S., & Simons, M. J. P. (2017). Life-span extension with reduced somatotrophic signaling: Moderation of aging effect by signal type, sex, and experimental cohort. Journals of Gerontology Series A, 72(12), 1620-1626. doi: 10.1093/gerona/glx010

Journal - Research Article

Ronget, V., Garratt, M., Lemaître, J.-F., & Gaillard, J.-M. (2017). The ‘evo-demo’ implications of condition-dependent mortality. Trends in Ecology & Evolution, 32(12), 909-921. doi: 10.1016/j.tree.2017.09.003

Journal - Research Article

Garratt, M., Kee, A. J., Palme, R., & Brooks, R. C. (2016). Male presence can increase body mass and induce a stress-response in female mice independent of costs of offspring production. Scientific Reports, 6(23538). doi: 10.1038/srep23538

Journal - Research Article

Garratt, M., Nakagawa, S., & Simons, M. J. P. (2016). Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction. Aging Cell, 15(4), 737-743. doi: 10.1111/acel.12489

Journal - Research Article

Garratt, M., & Brooks, R. C. (2015). A genetic reduction in antioxidant function causes elevated aggression in mice. Journal of Experimental Biology, 218(2), 223-227. doi: 10.1242/jeb.112011

Journal - Research Article

Garratt, M., Lemaître, J.-F., Douhard, M., Bonenfant, C., Capron, G., Warnant, C., … Gaillard, J.-M. (2015). High juvenile mortality is associated with sex-specific adult survival and lifespan in wild roe deer. Current Biology, 25(6), 759-763. doi: 10.1016/j.cub.2014.11.071

Journal - Research Article

Gibson, A. B., Garratt, M., & Brooks, R. C. (2015). Experimental evidence that litter size imposes an oxidative challenge to offspring. Journal of Experimental Biology, 218(24), 3911-3918. doi: 10.1242/jeb.116327

Journal - Research Article

Garratt, M., Pichaud, N., Glaros, E. N., Kee, A. J., & Brooks, R. C. (2014). Superoxide dismutase deficiency impairs olfactory sexual signaling and alters bioenergetic function in mice. PNAS, 111(22), 8119-8124. doi: 10.1073/pnas.1322282111

Journal - Research Article

Aloise King, E. D., Garratt, M., & Brooks, R. (2013). Manipulating reproductive effort leads to changes in female reproductive scheduling but not oxidative stress. Ecology & Evolution, 3(12), 4161-4171. doi: 10.1002/ece3.786

Journal - Research Article

Garratt, M., Bathgate, R., de Graaf, S. P., & Brooks, R. C. (2013). Copper-zinc superoxide dismutase deficiency impairs sperm motility and in vivo fertility. Reproduction, 146(4), 297-304. doi: 10.1530/REP-13-0229

Journal - Research Article

Garratt, M., Gaillard, J.-M., Brooks, R. C., & Lemaître, J.-F. (2013). Diversification of the eutherian placenta is associated with changes in the pace of life. PNAS, 110(19), 7760-7765. doi: 10.1073/pnas.1305018110

Journal - Research Article

Garratt, M., Pichaud, N., Aloise King, E. D., & Brooks, R. C. (2013). Physiological adaptations to reproduction. I. Experimentally increasing litter size enhances aspects of antioxidant defence but does not cause oxidative damage in mice. Journal of Experimental Biology, 216(15), 2879-2888. doi: 10.1242/jeb.082669

Journal - Research Article

Pichaud, N., Garratt, M., Ballard, J. W. O., & Brooks, R. C. (2013). Physiological adaptations to reproduction. II. Mitochondrial adjustments in livers of lactating mice. Journal of Experimental Biology, 216(15), 2889-2895. doi: 10.1242/jeb.082685

Journal - Research Article

Garratt, M., McArdle, F., Stockley, P., Vasilaki, A., Beynon, R. J., Jackson, M. J., & Hurst, J. L. (2012). Tissue-dependent changes in oxidative damage with male reproductive effort in house mice. Functional Ecology, 26(2), 423-433. doi: 10.1111/j.1365-2435.2011.01952.x

Journal - Research Article

Garratt, M., Stockley, P., Armstrong, S. D., Beynon, R. J., & Hurst, J. L. (2011). The scent of senescence: Sexual signalling and female preference in house mice. Journal of Evolutionary Biology, 24(11), 2398-2409. doi: 10.1111/j.1420-9101.2011.02367.x

Journal - Research Article

Garratt, M., Vasilaki, A., Stockley, P., McArdle, F., Jackson, M., & Hurst, J. L. (2011). Is oxidative stress a physiological cost of reproduction? An experimental test in house mice. Proceedings of the Royal Society B, 278(1708), 1098-1106. doi: 10.1098/rspb.2010.1818

Journal - Research Article

Garratt, M. (2020). Why do sexes differ in lifespan extension? Sex-specific pathways of aging and underlying mechanisms for dimorphic responses. Nutrition & Healthy Aging, 5, 247-259. doi: 10.3233/NHA-190067

Journal - Research Other

Lemaître, J.-F., Garratt, M., & Gaillard, J.-M. (2020). Going beyond lifespan in comparative biology of aging. Advances in Geriatric Medicine & Research, 2(2), e200011. doi: 10.20900/agmr20200011

Journal - Research Other

Garratt, M., & Stout, M. B. (2018). Hormone actions controlling sex-specific life-extension. Aging, 10(3), 293-294. doi: 10.18632/aging.101396

Journal - Research Other

Dantzer, B., & Garratt, M. (2017). Sex differences in telomeres and lifespan in Soay sheep: From the beginning to the end. Molecular Ecology, 26(12), 3090-3092. doi: 10.1111/mec.14129

Journal - Research Other

Garratt, M., Brooks, R. C., Lemaître, J.-F., & Gaillard, J.-M. (2014). Female promiscuity and maternally dependent offspring growth rates in mammals [Brief communication]. Evolution, 68(4), 1207-1215. doi: 10.1111/evo.12333

Journal - Research Other

Speakman, J. R., & Garratt, M. G. (2014). Oxidative stress as a cost of reproduction: Beyond the simplistic trade-off model. BioEssays, 36(1), 93-106. doi: 10.1002/bies.201300108

Journal - Research Other

Gale, T., Gibson, A. B., Brooks, R. C., & Garratt, M. (2013). Exposure to a novel male during late pregnancy influences subsequent growth of offspring during lactation [Short communication]. Journal of Evolutionary Biology, 26(9), 2057-2062. doi: 10.1111/jeb.12192

Journal - Research Other

Garratt, M., & Brooks, R. C. (2012). Oxidative stress and condition-dependent sexual signals: More than just seeing red. Proceedings of the Royal Society B, 279(1741), 3121-3130. doi: 10.1098/rspb.2012.0568

Journal - Research Other

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