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Contact Details

Phone
64 3 479 5091
Email
htin.aung@otago.ac.nz
Position
Senior Research Fellow
Department
Department of Microbiology and Immunology
Qualifications
PhD
Research summary
Next-generation sequencing, diagnostic microbiology, molecular microbiology, structural biology

Research

Antimicrobial Resistance (AMR) is a global public health emergency. Drug-resistant tuberculosis including multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) is the main cause of deaths related to AMR.

Our research goal is to tackle AMR with a multidisciplinary, integrative approach using cutting-edge technologies such as next- and third generation whole-genome sequencing (Illumina and Oxford Nanopore).

Our research focuses on:

  • Identification of novel molecular signatures associated with antimicrobial resistance particularly drug-resistant Mycobacterium tuberculosis.
  • Identification of the genetic basis for resistance in Mycobacterium tuberculosis for the development of diagnostics and anti-TB drugs
  • Insights into the transmission of drug-resistant tuberculosis at community and national level for effective and targeted interventions

Publications

Christensen, P., Cinzah, R., Suwanarusk, R., Chua, A. C. Y., Kaneko, O., Kyle, D. E., Aung, H. L., Matheson, J., … Cook, G. M., … Russell, B. (2024). Extended blood stage sensitivity profiles of Plasmodium cynomolgi to doxycycline and tafenoquine, as a model for Plasmodium vivax. Antimicrobial Agents & Chemotherapy. Advance online publication. doi: 10.1128/aac.00280-24 Journal - Research Other

Tun, T., Baleivanualala, S. C., Erdmann, M. B., Gimenez, G., & Aung, H. L. (2024). An extensively drug-resistant Pseudomonas aeruginosa isolate from Myanmar [Genome note]. Journal of Global Antimicrobial Resistance, 36, 1-3. doi: 10.1016/j.jgar.2023.11.004 Journal - Research Other

van Os, M., Cross, H., Kardailsky, O., Jeunen, G.-J., Collins, C., McDonald, K., Kinaston, R., Vlok, M., Walter, R., Cook, G., Aung, H. L., Matisoo-Smith, L., Buckley, H., & Knapp, M. (2023). The conundrum of related taxa: Detection and authentication of pathogen DNA in bioarchaeological samples from the Pacific. Proceedings of the 1st Australian & New Zealand Environmental DNA (eDNA) Conference: Innovation & Application. Retrieved from https://ednaconference.com.au Conference Contribution - Published proceedings: Abstract

Phyu, A. N., Aung, S. T., Palittapongarnpim, P., Htet, K. K. K., Mahasirimongkol, S., Ruangchai, W., … Aung, H. L., … Chongsuvivatwong, V. (2023). Genomic sequencing profiles of Mycobacterium tuberculosis in Mandalay region, Myanmar. Tropical Medicine & Infectious Disease, 8, 239. doi: 10.3390/tropicalmed8040239 Journal - Research Article

Aung, S. T., Nyunt, W. W., Moe, M. M., Aung, H. L., & Lwin, T. (2022). The fourth national tuberculosis prevalence survey in Myanmar. PLOS Global Public Health, 2(6), e0000588. doi: 10.1371/journal.pgph.0000588 Journal - Research Article

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