Contact Details
- Phone
- +64 3 479 7536
- ping.liu@otago.ac.nz
University Links
- Position
- Professor
- Department
- Department of Anatomy
- Qualifications
- MB(Anhui) PhD(Otago)
- Research summary
- Ageing, neurodegenerative and psychiatric disorders
Research
Professor Liu's main research interests are:
- Neurobiological basis and intervention of age-related cognitive decline, and neurodegenerative and psychiatric disorders
- Biological basis of learning and memory
A combination of behavioural, in vivo microdialysis, neurochemical, molecular biological, immunohistochemical, and electrophysiological approaches are being used.
A growing body of evidence suggests the implications of altered arginine metabolism in the aging and neurodegenerative processes and psychiatric disorders. Professor Liu's research group has been focusing on how central and/or peripheral arginine metabolism is altered, aiming to better understand the neurobiological basis of aging and neurodegenerative (Alzheimer's disease in particular) and psychiatric (e.g., schizophrenia) disorders, to identify biomarkers and to explore the therapeutic target(s). Moreover, her research group has also been investigating the functional role of agmatine, a putative novel neurotransmitter, in learning and memory, and exploring its therapeutic potential for cognitive decline.
Publications
Highet, B., Wiseman, J. A., Mein, H., Parker, R., Ryan, B., Turner, C. P., Jing, Y., … Liu, P., … Faull, R. L. M., … Curtis, M. A. (2023). PSA-NCAM regulatory gene expression changes in the Alzheimer's disease entorhinal cortex revealed with multiplexed in situ hybridization. Journal of Alzheimer's Disease. Advance online publication. doi: 10.3233/jad-220986 Journal - Research Article
Deane, A. R., Jing, Y., Shoorangiz, R., Liu, P., & Ward, R. D. (2023). Cognitive and arginine metabolic correlates of temporal dysfunction in the MIA rat model of schizophrenia risk. Behavioral Neuroscience, 137(1), 67-77. doi: 10.1037/bne0000540 Journal - Research Article
Mein, H., Jing, Y., Ahmad, F., Zhang, H., & Liu, P. (2022). Altered polyamine system in the P301S (PS19) tauopathy model. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 49). Retrieved from https://www.queenstownresearchweek.org Conference Contribution - Published proceedings: Abstract
Ahmed, S., Jing, Y., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2022). Partial endothelial nitric oxide synthase deficiency exacerbates cognitive deficit and amyloid pathology in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease. International Journal of Molecular Sciences, 23(13), 7316. doi: 10.3390/ijms23137316 Journal - Research Article
Li, Z., Zhang, T., Xu, L., Wei, Y., Cui, H., Tang, Y., … Zhang, H., Liu, P., … Wang, J. (2022). Plasma metabolic alterations and potential biomarkers in individuals at clinical high risk for psychosis. Schizophrenia Research, 239, 19-28. doi: 10.1016/j.schres.2021.11.011 Journal - Research Article
2023
Journal - Research Article
Highet, B., Wiseman, J. A., Mein, H., Parker, R., Ryan, B., Turner, C. P., Jing, Y., … Liu, P., … Faull, R. L. M., … Curtis, M. A. (2023). PSA-NCAM regulatory gene expression changes in the Alzheimer's disease entorhinal cortex revealed with multiplexed in situ hybridization. Journal of Alzheimer's Disease. Advance online publication. doi: 10.3233/jad-220986
Deane, A. R., Jing, Y., Shoorangiz, R., Liu, P., & Ward, R. D. (2023). Cognitive and arginine metabolic correlates of temporal dysfunction in the MIA rat model of schizophrenia risk. Behavioral Neuroscience, 137(1), 67-77. doi: 10.1037/bne0000540
2022
Journal - Research Article
Ahmed, S., Jing, Y., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2022). Partial endothelial nitric oxide synthase deficiency exacerbates cognitive deficit and amyloid pathology in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease. International Journal of Molecular Sciences, 23(13), 7316. doi: 10.3390/ijms23137316
Li, Z., Zhang, T., Xu, L., Wei, Y., Cui, H., Tang, Y., … Zhang, H., Liu, P., … Wang, J. (2022). Plasma metabolic alterations and potential biomarkers in individuals at clinical high risk for psychosis. Schizophrenia Research, 239, 19-28. doi: 10.1016/j.schres.2021.11.011
Conference Contribution - Published proceedings: Abstract
Mein, H., Jing, Y., Ahmad, F., Zhang, H., & Liu, P. (2022). Altered polyamine system in the P301S (PS19) tauopathy model. In K. Horne (Ed.), Proceedings of the 38th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 49). Retrieved from https://www.queenstownresearchweek.org
2021
Journal - Research Article
Ahmad, F., Mein, H., Jing, Y., Zhang, H., & Liu, P. (2021). Behavioural functions and cerebral blood flow in a P301S tauopathy mouse model: A time-course study. International Journal of Molecular Sciences, 22, 9727. doi: 10.3390/ijms22189727
Zhang, J., Jing, Y., Zhang, H., & Liu, P. (2021). Effects of sex and estrous cycle on the brain and plasma arginine metabolic profile in rats. Amino Acids, 53, 1441-1454. doi: 10.1007/s00726-021-03040-5
Ahmad, F., & Liu, P. (2021). A time-efficient fluorescence spectroscopy-based assay for evaluating actin polymerization status in rodent and human brain tissues. Journal of Visualized Experiments, 172, e62268. doi: 10.3791/62268
Ahmad, F., Jing, Y., Lladó, A., & Liu, P. (2021). Chemical stimulation of rodent and human cortical synaptosomes: Implications in neurodegeneration. Cells, 10(5), 1174. doi: 10.3390/cells10051174
Conference Contribution - Published proceedings: Abstract
Thompson, K., Ahmad, F., Jing, Y., & Liu, P. (2021). Agmatine attenuates actin dynamic alteration and synaptic dysfunction in aged rats. New Zealand Medical Journal, 134(1547), (pp. 143). Retrieved from https://www.nzma.org.nz/journal
Mein, H. C., Ahmed, S., Jing, Y., Mockett, B. G., Abraham, W. C., & Liu, P. (2021). Partial endothelial nitric oxide synthase deficiency exacerbates Alzheimer's pathology in a murine model. New Zealand Medical Journal, 134(1535), (pp. 96). Retrieved from https://www.nzma.org.nz/journal
Other Research Output
Liu, P. (2021, May). Arginine metabolism: Implications for normal and pathological brain aging. University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].
2020
Journal - Research Article
Neale, J. P. H., Pearson, J. T., Thomas, K. N., Tsuchimochi, H., Hosoda, H., Kojima, M., … Jones, G. T., Denny, A. P., Daniels, L. J., Chandrasekera, D., Liu, P., van Rij, A. M., Katare, R., & Schwenke, D. O. (2020). Dysregulation of ghrelin in diabetes impairs the vascular reparative response to hindlimb ischemia in a mouse model; Clinical relevance to peripheral artery disease. Scientific Reports, 10, 13651. doi: 10.1038/s41598-020-70391-6
Vemula, P. K., Jing, Y., Cicolini, J., Zhang, H., Mockett, B. G., Abraham, W. C., & Liu, P. (2020). Altered brain arginine metabolism with age in the APPswe/PSEN1dE9 mouse model of Alzheimer's disease. Neurochemistry International, 140, 104798. doi: 10.1016/j.neuint.2020.104798
Du, Z.-P., Feng, S., Li, Y.-L., Li, R., Lv, J., Ren, W.-Q., … Liu, P., & Wang, Q.-N. (2020). Di-(2-ethylhexyl) phthalate inhibits expression and internalization of transthyretin in human placental trophoblastic cells. Toxicology & Applied Pharmacology, 394, 114960. doi: 10.1016/j.taap.2020.114960
Zhu, Y.-d., Liang, C.-m., Hu, Y.-b., Li, Z.-j., Wang, S.-f., Xiang, H.-Y., … Liu, P., & Tao, F.-B. (2020). Repeated measures of prenatal thallium exposure and placental inflammatory cytokine mRNA expression: The Ma'anshan birth cohort (MABC) study. Chemosphere, 246, 125721. doi: 10.1016/j.chemosphere.2019.125721
Journal - Research Other
Ahmad, F., & Liu, P. (2020). (Ascorb)ing Pb neurotoxicity in the developing brain. Antioxidants, 9, 1311. doi: 10.3390/antiox9121311
Ahmad, F., & Liu, P. (2020). Synaptosome as a tool in Alzheimer’s disease research. Brain Research, 1746, 147009. doi: 10.1016/j.brainres.2020.147009
2019
Journal - Research Article
Bergin, D. H., Jing, Y., Williams, G., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2019). Safety and neurochemical profiles of acute and sub-chronic oral treatment with agmatine sulfate. Scientific Reports, 9, 12669. doi: 10.1038/s41598-019-49078-0
Hariharan, A., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2019). Altered neurovascular coupling and brain arginine metabolism in endothelial nitric oxide synthase deficient mice. Nitric Oxide, 87, 60-72. doi: 10.1016/j.niox.2019.03.006
Vemula, P., Jing, Y., Zhang, H., Hunt, Jr, J. B., Sandusky-Beltran, L. A., Lee, D. C., & Liu, P. (2019). Altered brain arginine metabolism in a mouse model of tauopathy. Amino Acids, 51, 513-528. doi: 10.1007/s00726-018-02687-x
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2019). Maternal immune activation altered microglial immunoreactivity in the brain of postnatal day 2 rat offspring. Synapse, 73, e22072. doi: 10.1002/syn.22072
Conference Contribution - Published proceedings: Abstract
Ahmed, S., Jing, Y., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2019). Partial eNOS deficiency promotes cognitive impairment in a murine model of Alzheimer's disease. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 51). Retrieved from http://www.otago.ac.nz/awcbr
Zhu, Y. D., Xie, Y., Huang, K., Liu, P., & Tao, F. B. (2019). Behavioural deficits and hippocampal apoptosis in offspring with prenatal Di-(2-ethylhexyl) phthalate exposure. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 48). Retrieved from http://www.otago.ac.nz/awcbr
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2019). Maternal immune activation alters pre-pulse inhibition and hippocampal nitric oxide synthase in postnatal day 35 and 60 rat offspring. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 47). Retrieved from http://www.otago.ac.nz/awcbr
Vemula, P., Jing, Y., Zhang, H., Cicolini, J., Mockett, B., Abraham, W. C., & Liu, P. (2019). Altered brain arginine metabolism with age in the APPswe/PSEN1dE9 mouse model of Alzheimer's disease. In K. Hillman (Ed.), Proceedings of the 37th International Australasian Winter Conference on Brain Research (AWCBR). (pp. 40). Retrieved from http://www.otago.ac.nz/awcbr
2018
Journal - Research Article
Bergin, D. H., Jing, Y., Mockett, B. G., Zhang, H., Abraham, W. C., & Liu, P. (2018). Altered plasma arginine metabolome precedes behavioural and brain arginine metabolomic profile changes in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease. Translational Psychiatry, 8, 108. doi: 10.1038/s41398-018-0149-z
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2018). Maternal immune activation leads to increased nNOS immunoreactivity in the brain of postnatal day 2 rat offspring. Synapse, 72(1), e22011. doi: 10.1002/syn.22011
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2018). Effects of maternal immune activation on brain arginine metabolism of postnatal day 2 rat offspring. Schizophrenia Research, 192, 431-441. doi: 10.1016/j.schres.2017.05.016
Conference Contribution - Published proceedings: Abstract
Hariharan, A., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2018). Increased urea levels in the brain of endothelial nitric oxide synthase deficient mice. Alzheimer's & Dementia, 14(Suppl. 7), (pp. 1456). doi: 10.1016/j.jalz.2018.06.2464
Hariharan, A., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2018). Endothelial nitric oxide synthase deficiency alters neurovascular coupling and brain glutamine metabolism. Alzheimer's & Dementia, 14(Suppl. 7), (pp. 1146). doi: 10.1016/j.jalz.2018.06.1563
Liu, P., Jing, Y., Collie, N. D., Dean, B., & Zhang, H. (2018). Altered arginine metabolism in the frontal cortex of patients with major depression. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 68). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2018). Maternal immune activation affects hippocampal nNOS immunoreactivity and microglia in postnatal day 35 rat offspring. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 52). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
Hariharan, A., Collie, N. D., Jing, Y., Zhang, H., & Liu, P. (2018). Endothelial nitric oxide synthase deficiency leads to increased urea levels in the brain. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. (pp. 43). AWCBR. Retrieved from https://www.otago.ac.nz/awcbr
2017
Journal - Research Article
Mazlan, M., Hamizah, H. S., Taridi, N. M., Jing, Y., Liu, P., Zhang, H., … Damanhuri, H. A. (2017). Effects of aging and tocotrienol-rich fraction supplementation on brain arginine metabolism in rats. Oxidative Medicine & Cellular Longevity, 2017, 6019796. doi: 10.1155/2017/6019796
Liu, P., Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Smith, P. F. (2017). Further studies of the effects of aging on arginine metabolites in the rat vestibular nucleus and cerebellum. Neuroscience, 348, 273-287. doi: 10.1016/j.neuroscience.2017.02.033
Knox, L. T., Jing, Y., Bawazier-Edgecombe, J., Collie, N. D., Zhang, H., & Liu, P. (2017). Effects of withdrawal from repeated phencyclidine administration on behavioural function and brain arginine metabolism in rats. Pharmacology Biochemistry & Behavior, 153, 45-59. doi: 10.1016/j.pbb.2016.12.006
Conference Contribution - Published proceedings: Abstract
Seo, S., Kohe, S. E., Gowing, E., Zheng, Y., Kokay, I., Grattan, D. R., Liu, P., & Oorschot, D. E. (2017). Effect of extreme prematurity on brain monoamine metabolism. Proceedings of the Society for Neuroscience 47th Annual Meeting. 035.06/C44. SfN. Retrieved from https://www.sfn.org/
Hariharan, A., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2017). Altered neurovascular coupling and glutamine metabolism in endothelial nitric oxide synthase deficient mice. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 66). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
Vemula, P., Jing, Y., Zhang, H., Hunt, Jr, J. B., Sandusky, L. A., Lee, D. C., & Liu, P. (2017). Early and long-lasting increases in brain arginase product in a mouse model of tauopathy. Alzheimer's & Dementia, 13(7, Suppl.), (pp. P1298). doi: 10.1016/j.jalz.2017.06.1973
Vemula, P., Jing, Y., Zhang, H., Hunt, J. B., Sandusky, L. A., Lee, D. C., & Liu, P. (2017). Hippocampal arginine metabolism shifted to favour the polyamine pathway in a mouse model of tauopathy. In B. Leitch (Ed.), Proceedings of the 35th International Australasian Winter Conference on Brain Research. (pp. 52). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr/index.html
2016
Journal - Research Article
Liu, P., Jing, Y., Collie, N. D., Dean, B., Bilkey, D. K., & Zhang, H. (2016). Altered brain arginine metabolism in schizophrenia. Translational Psychiatry, 6, e871. doi: 10.1038/tp.2016.144
Jing, Y., Liu, P., & Leitch, B. (2016). Region-specific changes in presynaptic agmatine and glutamate levels in the aged rat brain. Neuroscience, 312, 10-18. doi: 10.1016/j.neuroscience.2015.11.002
Conference Contribution - Published proceedings: Abstract
Cicolini, J., Jing, Y., Waldvogel, H. J., Faull, R. L. M., & Liu, P. (2016). Urea cycle enzymes and peptidylarginine deiminase in Alzheimer's superior frontal gyrus. Alzheimer's & Dementia, 12(7, Suppl.), (pp. P460). doi: 10.1016/j.jalz.2016.06.897
Liu, P., Jing, Y., Collie, N. D., Dean, B., Bilkey, D. K., & Zhang, H. (2016). Brain arginine metabolism is altered in patients with schizophrenia. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 69). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Zhang, J., Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2016). Maternal immune activation alters immunoreactive profiles of nNOS-containing neurons and microglia in postnatal day 2 rat brains. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 43). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Jing, Y., Zhang, H., Bilkey, D. K., & Liu, P. (2016). Effects of maternal immune activation on brain arginine metabolism of juvenile rat offspring. In B. Leitch (Ed.), Proceedings of the 34th International Australasian Winter Conference on Brain Research. (pp. 31). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
2015
Journal - Research Article
Bergin, D. H., Jing, Y., Zhang, H., & Liu, P. (2015). A single intracerebroventricular Aβ25-35 infusion leads to prolonged alterations in arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience, 298, 367-379. doi: 10.1016/j.neuroscience.2015.04.034
Conference Contribution - Published proceedings: Abstract
Jing, Y. R., Knox, L. T., Zhang, H., & Liu, P. (2015). Prolonged impact of perinatal exposure to phencyclidine on brain arginine metabolism in rats. Proceedings of the Society for Neuroscience 45th Annual Meeting. 48.22/E44. SfN. Retrieved from https://www.sfn.org
Jing, Y., Zhang, H., & Liu, P. (2015). Blood arginine metabolic profile is altered in male Sprague-Dawley rats. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 70). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
Cicolini, J., Jing, Y., Waldvogel, H. J., Faull, R. L. M., & Liu, P. (2015). The urea cycle is induced in Alzheimer's brains. In B. Leitch (Ed.), Proceedings of the 33rd International Australasian Winter Conference on Brain Research. (pp. 64). AWCBR. Retrieved from http://www.otago.ac.nz/awcbr
2014
Journal - Research Article
Liu, P., Fleete, M. S., Jing, Y., Collie, N. D., Curtis, M. A., Waldvogel, H. J., … Abraham, W. C., & Zhang, H. (2014). Altered arginine metabolism in Alzheimer’s disease brains. Neurobiology of Aging, 35(9), 1992-2003. doi: 10.1016/j.neurobiolaging.2014.03.013
Knox, L. T., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2014). Effects of acute phencyclidine administration on arginine metabolism in the hippocampus and prefrontal cortex in rats. Neuropharmacology, 81, 195-205. doi: 10.1016/j.neuropharm.2014.02.004
Conference Contribution - Published proceedings: Abstract
Liu, P., Bergin, D., Jing, Y., Mockett, B., Abraham, W. C., & Zhang, H. (2014). Age-related plasma L-arginine metabolic profile changes in APP/PS1 mice. Alzheimer's & Dementia, 10(4, Suppl.), (pp. P490). doi: 10.1016/j.jalz.2014.05.729
Cinco, P., & Liu, P. (2014). Behavioural effects of phencyclidine treatment in rats. New Zealand Medical Journal, 127(1395). Retrieved from http://www.nzma.org.nz/journal
2013
Journal - Research Article
Smith, P. F., Ganesh, S., & Liu, P. (2013). A comparison of random forest regression and multiple linear regression for prediction in neuroscience. Journal of Neuroscience Methods, 220(1). doi: 10.1016/j.jneumeth.2013.08.024
Jing, Y., Fleete, M. S., Collie, N. D., Zhang, H., & Liu, P. (2013). Regional variations and age-related changes in arginine metabolism in the rat brain stem and spinal cord. Neuroscience, 252, 98-108. doi: 10.1016/j.neuroscience.2013.08.002
Jing, Y., Zhang, H., Wolff, A. R., Bilkey, D. K., & Liu, P. (2013). Altered arginine metabolism in the hippocampus and prefrontal cortex of maternal immune activation rat offspring. Schizophrenia Research, 148(1-3), 151-156. doi: 10.1016/j.schres.2013.06.001
Rushaidhi, M., Zhang, H., & Liu, P. (2013). Effects of prolonged agmatine treatment in aged male Sprague-Dawley rats. Neuroscience, 234, 116-124. doi: 10.1016/j.neuroscience.2013.01.004
Rushaidhi, M., Jing, Y., Zhang, H., & Liu, P. (2013). Participation of hippocampal agmatine in spatial learning: An in vivo microdialysis study. Neuropharmacology, 65, 200-205. doi: 10.1016/j.neuropharm.2012.10.007
Journal - Research Other
Piletz, J. E., Aricioglu, F., Cheng, J.-T., Fairbanks, C. A., Gilad, V. H., Haenisch, B., … Liu, P., … Gilad, G. M. (2013). Agmatine: Clinical applications after 100 years in translation. Drug Discovery Today, 18(17-18), 880-893. doi: 10.1016/j.drudis.2013.05.017
Conference Contribution - Published proceedings: Abstract
Liu, P., Fleete, M. S., Jing, Y., Collie, N. D., Curtis, M. A., Faull, R. L. M., Abraham, W. C., & Zhang, H. (2013). Altered arginine metabolism in Alzheimer's brains. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 71). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Bergin, D. H., Jing, Y., Zhang, H., & Liu, P. (2013). A single amyloid beta25-35 brain infusion induces long-term changes in L-arginine metabolism in the rat hippocampus and prefrontal cortex. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 53). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Knox, L. T., Jing, Y., Zhang, H., & Liu, P. (2013). Effects of acute phencyclidine administration on behavioural function and brain arginine metabolism in rats. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 44). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Jing, Y., Knox, L. T., Zhang, H., & Liu, P. (2013). Repeated phencyclidine treatment alters arginine metabolism in rat hippocampus and prefrontal cortex. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 31st International Australasian Winter Conference on Brain Research. 31, (pp. 35). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2013copy.html
Bergin, D., Jing, Y., Zhang, H., Mockett, B., Abraham, W., & Liu, P. (2013). Time-course of behavioral and L-arginine metabolic profile changes in the APP SWE PS1 ΔE9 mouse model of Alzheimer's disease. Alzheimer's & Dementia, 9(4 (Suppl.)), (pp. P181). doi: 10.1016/j.jalz.2013.05.301
Liu, P., Fleete, M., Jing, Y., Collie, N., Curtis, M., Faull, R., Abraham, W., & Zhang, H. (2013). Altered arginine metabolism in the Alzheimer's hippocampus. Alzheimer's & Dementia, 9(4, Suppl.), (pp. P346). doi: 10.1016/j.jalz.2013.05.644
2012
Journal - Research Article
Gupta, N., Jing, Y., Collie, N. D., Zhang, H., & Liu, P. (2012). Ageing alters behavioural function and brain arginine metabolism in male Sprague-Dawley rats. Neuroscience, 226, 178-196. doi: 10.1016/j.neuroscience.2012.09.013
Rushaidhi, M., Jing, Y., Kennard, J. T., Collie, N. D., Williams, J. M., Zhang, H., & Liu, P. (2012). Aging affects L-arginine and its metabolites in memory-associated brain structures at the tissue and synaptoneurosome levels. Neuroscience, 209, 21-31. doi: 10.1016/j.neuroscience.2012.02.021
Rushaidhi, M., Collie, N. D., Zhang, H., & Liu, P. (2012). Agmatine selectively improves behavioural function in aged male Sprague-Dawley rats. Neuroscience, 218(30), 206-215. doi: 10.1016/j.neuroscience.2012.05.015
Gupta, N., Zhang, H., & Liu, P. (2012). Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats. Pharmacology Biochemistry & Behavior, 100(3), 464-473. doi: 10.1016/j.pbb.2011.10.011
Conference Contribution - Published proceedings: Abstract
Jing, Y., Bergin, D. H., Zhang, H., & Liu, P. (2012). Pre-aggregated amyloid beta25-35 leads to prolonged alteration of arginine metabolism in the rat hippocampus and prefrontal cortex. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 74). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Bergin, D. H., Mockett, B. G., Abraham, W. C., & Liu, P. (2012). Age-dependent spatial learning and memory impairments in the APP/PS1 transgenic mouse model of Alzheimer's disease. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 58). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
Rushaidhi, M., Jing, Y., Zhang, H., & Liu, P. (2012). Direct participation of agmatine in spatial learning: An in vivo microdialysis study. In B. Leitch & J. Shemmell (Eds.), Proceedings of the 30th International Australasian Winter Conference on Brain Research. 30, (pp. 55). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2012.html
2011
Journal - Research Article
Knox, L. T., Jing, Y., Fleete, M. S., Collie, N. D., Zhang, H., & Liu, P. (2011). Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus. Neuropharmacology, 61(8), 1452-1462. doi: 10.1016/j.neuropharm.2011.08.042
Liu, P., Jing, Y., Collie, N. D., Campbell, S. A., & Zhang, H. (2011). Pre-aggregated Aβ25-35 alters arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience, 193, 269-282. doi: 10.1016/j.neuroscience.2011.07.054
Seo, S., Liu, P., & Leitch, B. (2011). Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals. Neuroscience, 129, 28-36. doi: 10.1016/j.neuroscience.2011.07.007
Leitch, B., Shevtsova, O., Reusck, K., Bergin, D. H., & Liu, P. (2011). Spatial learning-induced increase in agmatine levels at hippocampal CA1 synapses. Synapse, 65(2), 146-153. doi: 10.1002/syn.20828
Conference Contribution - Published proceedings: Abstract
Knox, L. T., Collie, N. D., & Liu, P. (2011). Effects of agmatine pre-treatment on scopolamine-induced behavioural deficits in the rat. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 114). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Poster%20Abstracts.pdf
Liu, P., Campbell, S. A., & Collie, N. D. (2011). Time course of Aβ25-35- and Aβ35-25-induced behavioural changes in rats. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 39). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Oral%20Abstracts.pdf
Liu, P., Knox, L. T., Jing, Y., Fleete, M. S., Collie, N. D., & Zhang, H. (2011). Scopolamine alters behaviour and arginine metabolism in the rat hippocampus. Proceedings of the Society for Neuroscience 41st Annual Meeting. SfN. Retrieved from http://www.sfn.org/am2011/index.aspx?pagename=abstracts_main
Bergin, D. H., & Liu, P. (2011). Learning and memory deficits following a single intracerebroventricular infusion of pre-aggregated Aβ25-35 in rats. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.7. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Fleete, M., Collie, N. D., Jing, Y., Curtis, M. A., Faull, R. L. M., Abraham, W. C., Zhang, H., & Liu, P. (2011). Altered nitric oxide synthase and arginase activity and expression in Alzheimer's disease brain. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.5. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Liu, P., Campbell, S. A., Jing, Y., Collie, N. D., & Zhang, H. (2011). Pre-aggregated Aβ25-35 alters arginine metabolism in the rat hippocampus and prefrontal cortex. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 2.7. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Jing, Y., Liu, P., & Leitch, B. (2011). Regional specific changes of agmatine level in the presynaptic terminals in the aged rat brain. In B. Leitch (Ed.), Proceedings of the 29th International Australasian Winter Conference on Brain Research. 29, 5.8. AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/abstracts/abstracts2011.html
Seo, S., Liu, P., & Leitch, B. (2011). Learning-induced changes at glutamatergic and agmatinergic synapses in the hippocampal CA1 region. Proceedings of the Australian Neuroscience Society (ANS) Annual Scientific Meeting. (pp. 43). Retrieved from http://www.ans.org.au/uploads/documents/2011%20Docs/conference%20abstracts/ANS%202011%20Oral%20Abstracts.pdf
Fleete, M., & Liu, P. (2011). Altered nitric oxide synthase and arginase activity and expression in the Alzheimer’s diseased brain. New Zealand Medical Journal, 124(1346). Retrieved from http://journal.nzma.org.nz/journal/124-1346/4980/content.pdf
Fleete, M., & Liu, P. (2011). Effects of aging on arginine metabolism in the striatum and spinal cord in rats. New Zealand Medical Journal, 124(1335). Retrieved from http://www.nzma.org.nz/journal/124-1335/4693/content.pdf
2010
Journal - Research Article
Liu, P., Zhang, H., Devaraj, R., Ganesalingam, G., & Smith, P. F. (2010). A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hearing Research, 269(1-2), 122-133. doi: 10.1016/j.heares.2010.06.019
Bergin, D. H., & Liu, P. (2010). Agmatine protects against β-amyloid25-35-induced memory impairments in the rat. Neuroscience, 169, 794-811. doi: 10.1016/j.neuroscience.2010.05.004
Conference Contribution - Published proceedings: Abstract
Leitch, B., Shevtsova, O., Reusck, K., Bergin, D. H., & Liu, P. (2010). Spatial learning-induced increase in agmatine levels at hippocampal CA1 synapses. Proceedings of the 30th Annual Meeting of the Australian Neuroscience Society, in conjunction with the 50th Anniversary Meeting of the Australian Physiological Society (ANS/AuPS). (pp. 175). Retrieved from http://www.sallyjayconferences.com.au/sydney2010/abstracts.html
Bergin, D. H., & Liu, P. (2010). Agmatine prevents against beta-amyloid (25-35)-induced spatial and object recognition memory deficits in the rat. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 49). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Rushaidhi, M., Chary, S., Jing, Y., Kennard, J. T., Collie, N. D., Williams, J. M., Zhang, H., & Liu, P. (2010). Effects of aging on agmatine levels in the rat hippocampus and prefrontal cortex. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 48). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Seo, S., Shevtsova, O., Liu, P., & Leitch, B. (2010). Co-localization of L-glutamate and agmatine in the hippocampal CA1 synaptic terminals in rats. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 37). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Jing, Y., Zhang, H., Wolff, A., Bilkey, D. K., & Liu, P. (2010). Altered arginine metabolism in the hippocampus and prefrontal cortex in maternal immune activation rat offspring. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 29). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Campbell, S. A., Collie, N. D., & Liu, P. (2010). Behavioural effects of a single bilateral intracerebroventrocular infusion of preaggregated Aβ25-35 in rats. In B. Leitch (Ed.), Proceedings of the 28th International Australasian Winter Conference on Brain Research. 28, (pp. 36). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2010.htm
Rushaidhi, M., Zhang, H., & Liu, P. (2010). Agmatine supplementation attenuates age-related learning and memory deficits. Proceedings of the Society for Neuroscience 40th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/Plan/SSResults.aspx
Liu, P., Campbell, S. A., Jing, Y., Collie, N. D., & Zhang, H. (2010). Single intracerebroventricular infusion of Aβ25-35 results in behavioural and neurochemical changes. Proceedings of the Society for Neuroscience 40th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/Plan/SSResults.aspx
Conference Contribution - Verbal presentation and other Conference outputs
Liu, P., & Zhang, H. (2010, June). Arginine metabolic pathways and cognitive decline during aging. Verbal presentation at the 1st Annual World Congress of NeuroTalk: From Nervous Functions to Treatment, Singapore.
Rushaidhi, M., Zhang, H., Jing, Y., & Liu, P. (2010, February). Agmatine readily and rapidly crosses blood brain barrier: An in vivo brain microdialysis study in freely moving rats. Verbal presentation at the New Zealand Chapter of the Controlled Release Society 12th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.
2009
Journal - Research Article
Liu, P., Jing, Y., & Zhang, H. (2009). Age-related changes in arginine and its metabolites in memory-associated brain structures. Neuroscience, 164(2), 611-628. doi: 10.1016/j.neuroscience.2009.08.029
Liu, P., & Collie, N. D. (2009). Behavioral effects of agmatine in naive rats are task- and delay-dependent. Neuroscience, 163(1), 82-96. doi: 10.1016/j.neuroscience.2009.05.061
Nerad, L., Liu, P., & Bilkey, D. K. (2009). Bilateral NMDA lesions centered on the postrhinal cortex have minimal effects on hippocampal place cell firing. Hippocampus, 19(3), 221-227. doi: 10.1002/hipo.20517
Liu, P., Jing, Y., Collie, N. D., Chary, S., & Zhang, H. (2009). Memory-related changes in L-citrulline and agmatine in the rat brain. Hippocampus, 19(7), 597-602. doi: 10.1002/hipo.20561
Liu, P., & Bergin, D. H. (2009). Differential effects of i.c.v. mcroinfusion of agmatine on spatial working and reference memory in the rat. Neuroscience, 159(3), 951-961. doi: 10.1016/j.neuroscience.2009.01.039
Gupta, N., Zhang, H., & Liu, P. (2009). Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. Neuroscience, 161(3), 691-706. doi: 10.1016/j.nueroscience.2009.03.075
Conference Contribution - Published proceedings: Abstract
Bergin, D., & Liu, P. (2009). Differential effects of agmatine treatment on spatial working and reference memory. New Zealand Medical Journal, 122(1306). Retrieved from http://journal.nzma.org.nz/journal/122-1306/3899/content.pdf
Gupta, N., Zhang, H., & Liu, P. (2009). Chronic putrescine depletion results in spatial learning and memory impairment in rats. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 69). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm
Rushaidhi, M., Zhang, H., Jing, Y., & Liu, P. (2009). A microdialysis study of agmatine: Extracellular pharmacokinetics in rat brain. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 41). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm
Liu, P., Jing, Y., Collie, N. D., Chary, S., & Zhang, H. (2009). Direct involvement of agmatine in learning and memory processing. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 68). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm
Bergin, D. H., & Liu, P. (2009). Behavioural effects of agmatine in the rat are dose- and task-dependent. In R. Napper (Ed.), Proceedings of the 27th International Australasian Winter Conference on Brain Research. 27, (pp. 68). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/Abstracts2009.htm
Gupta, N., Zhang, H., & Liu, P. (2009). Potential involvement of polyamines in age-associated behavioural deficits. Proceedings of the Society for Neuroscience 39th Annual Meeting. SfN. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx
Zhang, H., Gupta, N., Chary, S., Jing, Y., Tucker, I., & Liu, P. (2009). Regional variations of agmatine and putrescine levels in memory-associated brain structures. Journal of Neurochemistry. 109(Suppl. 1), (pp. 304). [Abstract]
Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2009). Aging alters agmatine levels in memory-associated brain structures. Journal of Neurochemistry. 109(Suppl. 1), (pp. 304). doi: 10.1111/j.1471-4159.2009.05927.x
Conference Contribution - Verbal presentation and other Conference outputs
Smith, P. F., Devaraj, R., Zhang, H., Ganesalingham, G., & Liu, P. (2009, September). Multivariate analysis of neurochemical changes in the aging rat brain. Verbal presentation at the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists New Zealand Annual Scientific Meeting, Dunedin, New Zealand.
Rushaidhi, M., Zhang, H., Jing, Y., Chary, S., & Liu, P. (2009, February). Studies on the disposition of agmatine, a novel neurotransmitter, in rat brain using in vivo microdialysis in freely moving rat. Verbal presentation at the New Zealand Chapter of the Controlled Release Society 11th Conference on Formulation and Delivery of Bioactives, Dunedin, New Zealand.
2008
Journal - Research Article
Liu, P., Smith, P. F., & Darlington, C. L. (2008). Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Synapse, 62, 834-841. doi: 10.1002/syn.20563
Liu, P., Collie, N. D., Chary, S., Jing, Y., & Zhang, H. (2008). Spatial learning results in elevated agmatine levels in the rat brain. Hippocampus, 18, 1094-1098. doi: 10.1002/hipo.20482
Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2008). Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus, 18, 853-856. doi: 10.1002/hipo.20448
Liu, P., Rushaidhi, M., Collie, N. D., Leong, M.-T. T., & Zhang, H. (2008). Behavioral effects of intracerebroventricular microinfusion of agmatine in adult rats. Behavioral Neuroscience, 122(3), 557-569. doi: 10.1037/0735-7044.122.3.557
Liu, P., Gupta, N., Jing, Y., & Zhang, H. (2008). Age-related changes in polyamines in memory-associated brain structures in rats. Neuroscience, 155, 789-796. doi: 10.1016/j.neuroscience.2008.06.033
Conference Contribution - Published proceedings: Abstract
Kerr, D. S., Guy, K., Liu, P., & Collie, N. (2008). Acute and preconditioning effects of domoic acid on spatial memory and LTP and LTD induction in rat hippocampus. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 52). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Guy, K., Liu, P., Collie, N., & Kerr, D. S. (2008). Low-dose domoic acid preconditioning enhances LTP and LTD induction in rat hippocampal CA1. Proceedings of the Australian Neuroscience Society 28th Annual Meeting. 18, (pp. 92). Kent Town, Australia: ANS. [Abstract]
Rushaidhi, M., Zhang, H., & Liu, P. (2008). Agmatine suppresses age-related increases in nitric oxide synthase activity in the rat hippocampus and prefrontal cortex. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 47). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Liu, P., Collie, N. D., Chary, S., Jing, Y., & Zhang, H. (2008). Spatial learning results in elevated agmatine levels in the rat brain. In J. G. Anson (Ed.), Proceedings of the 26th International Australasian Winter Conference on Brain Research. 26, (pp. 21). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2008Abstracts.pdf
Conference Contribution - Poster Presentation (not in published proceedings)
Zhang, H., Gupta, N., Chary, S., Jing, Y., Tucker, I., & Liu, P. (2008, June-July). Regional variations of agmatine and putrescine levels in memory-associated brain structures. Poster session presented at the Third International Society for Neurochemistry Special Neurochemistry Conference: 8th International Meeting on Brain Energy Metabolism, Beijing, China.
Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C. L., Smith, P. F., Tucker, I. G., & Zhang, H. (2008, June-July). Aging alters agmatine levels in memory-associated brain structures. Poster session presented at the Third International Society for Neurochemistry Special Neurochemistry Conference: 8th International Meeting on Brain Energy Metabolism, Beijing, China.
2007
Conference Contribution - Published proceedings: Abstract
Rushaidhi, M., & Liu, P. (2007). Effects of intracerebroventricular microinfusion of agmatine on spatial learning and memory. New Zealand Medical Journal, 120(1265). Retrieved from http://journal.nzma.org.nz/journal/120-1265/2822/content.pdf
Liu, P., Devaraj, R., Collie, N. D., Chary, S., Bilkey, D. K., Smith, P. F., Darlington, C. L., & Zhang, H. (2007). Effects of aging on agmatine levels in memory-associated brain structures. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 26). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
Gupta, N., Zhang, H., & Liu, P. (2007). Behavioural effects of intracerebroventricular microinfusion of difluoromethyl ornithine in rats. In J. G. Anson (Ed.), Proceedings of the 25th International Australasian Winter Conference on Brain Research. 25, (pp. 51). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2007Abstracts.pdf
Zhang, H., Sree, C., Devaraj, R., Tucker, I., & Liu, P. (2007). Determination of agmatine and putrescine in rat brain by LC/MS/MS. AAPS Journal, 9(S2). Retrieved from http://www.aapsj.org/abstracts/AM_2007/AAPS2007-002703.PDF
Conference Contribution - Poster Presentation (not in published proceedings)
Liu, P., Collie, N. D., Leong, M. T., & Zhang, H. (2007, July). Behavioural effects of intracerebroventricular microinfusion of agmatine in adult rats. Poster session presented at the 7th International Brain Research Organization Congress of Neuroscience, Melbourne, Australia.
2006
Conference Contribution - Published proceedings: Abstract
Liu, P., Smith, P. F., & Darlington, C. L. (2006). Effects of aging on NMDA receptor subunits in memory-associated brain structures. In J. G. Anson (Ed.), Proceedings of the 24th International Australasian Winter Conference on Brain Research. 24, (pp. 57). AWCBR. Retrieved from http://psy.otago.ac.nz/awcbr/Abstracts/2006Abstracts.pdf
Liu, P., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2006). Effects of perirhinal nitric oxide synthase inhibition in the water maze task. Acta Pharmacologica Sinica. 27(Suppl.), (pp. 371). [Abstract]
2005
Journal - Research Article
Lindsay, L., Liu, P., Gliddon, C., Zheng, Y., Smith, P. F., & Darlington, C. L. (2005). Cytosolic glucocorticoid receptor expression in the rat vestibular nucleus and hippocampus following unilateral vestibular deafferentation. Experimental Brain Research, 162, 309-314. doi: 10.1007/s00221-004-2168-7
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2005). Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits. Hippocampus, 15, 642-655.
Smith, P. F., Horii, A., Russell, N., Bilkey, D. K., Zheng, Y., Liu, P., Kerr, D. S., & Darlington, C. L. (2005). The effects of vestibular lesions on hippocampal function in rats. Progress in Neurobiology, 75, 391-405.
Conference Contribution - Published proceedings: Abstract
Liu, P., Chen, G., Appleton, I., Smith, P. F., & Darlington, C. L. (2005). Regional variations and age-related changes in cyclooxygenase in memory-associated brain structures. Proceedings of the 23rd International Australasian Winter Conference on Brain Research. (pp. 55). [Abstract]
2004
Journal - Research Article
Liu, P., Gliddon, C. M., Lindsay, L., Darlington, C. L., & Smith, P. F. (2004). Nitric oxide synthase and arginase expression changes in the rat perirhinal and entorhinal cortices following unilateral vestibular damage: A link to deficits in object recognition? Journal of Vestibular Research, 14, 411-417.
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004). Potential involvement of NOS and arginase in age-related behavioural impairments. Experimental Gerontology, 39(8), 1207-1222.
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004). Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortex. Neurobiology of Aging, 25(4), 547-552.
Ashton, J. C., Zheng, Y., Liu, P., Darlington, C. L., & Smith, P. F. (2004). Immunohistochemical characterisation and localisation of cannabinoid CB1 receptor protein in the rat vestibular nucleus complex and the effects of unilateral vestibular deafferentation. Brain Research, 1021, 264-271.
Liu, P., Jarrard, L. E., & Bilkey, D. K. (2004). Excitotoxic lesions of the pre- and parasubiculum disrupt the place fields of hippocampal pyramidal cells. Hippocampus, 14(1), 107-116.
Conference Contribution - Verbal presentation and other Conference outputs
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2004, August). Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits. Verbal presentation at the 22nd International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
2003
Journal - Research Article
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2003). Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus. Neuroscience, 119(3), 679-687.
Liu, P., Bilkey, D. K., Darlington, C. L., & Smith, P. F. (2003). Cannabinoid CB1 receptor protein expression in the rat hippocampus and entorhinal, perirhinal, postrhinal and temporal cortices: Regional variations and age-related changes. Brain Research, 979(1-2), 235-239.
Liu, P., Smith, P. F., Appleton, I., Darlington, C. L., & Bilkey, D. K. (2003). Nitric oxide synthase and arginase in the rat hippocampus and the entorhinal, perirhinal, postrhinal, and temporal cortices: Regional variations and age-related changes. Hippocampus, 13, 859-867.
Liu, P., Zheng, Y., King, J., Darlington, C. L., & Smith, P. F. (2003). Long-term changes in hippocampal N-methyl-D-aspartate receptor subunits following unilateral vestibular damage in rat. Neuroscience, 117, 965-970.
Liu, P., Zheng, Y., King, J., Darlington, C. L., & Smith, P. F. (2003). Nitric oxide synthase and arginase expression in the vestibular nucleus and hippocampus following unilateral vestibular deafferentation in the rat. Brain Research, 966, 19-25.
Liu, P., Zheng, Y., Smith, P. F., & Bilkey, D. K. (2003). Changes in NOS protein expression and activity in the rat hippocampus, entorhinal and postrhinal cortices after unilateral electrolytic perirhinal cortex lesions. Hippocampus, 13, 561-571.
Conference Contribution - Published proceedings: Abstract
Liu, P., Bilkey, D. K., Darlington, C. L., & Smith, P. F. (2003). Age-related changes in glucocorticoid receptor protein expression in the rat hippocampus and parahippocampal region. In J. G. Anson & J. Wickens (Eds.), Proceedings of the 21st International Australasian Winter Conference on Brain Research. (pp. 53). Queenstown: AWCBR. [Abstract]
2002
Journal - Research Article
Liu, P., & Bilkey, D. (2002). The effects of NMDA lesions centered on the postrhinal cortex on spatial memory tasks in the rat. Behavioral Neuroscience, 116, 860-873.
King, J., Zheng, Y., Liu, P., Darlington, C. L., & Smith, P. F. (2002). NMDA and AMPA receptor subunit protein expression in the rat vestibular nucleus following unilateral labyrinthectomy. NeuroReport, 13(12), 1541-1545.
Conference Contribution - Published proceedings: Abstract
Darlington, C. L., King, J., Zheng, Y., Liu, P., & Smith, P. F. (2002). Nitric oxide synthase and arginase expression in the rat vestibular nucleus following unilateral vestibular deafferentation. 20th International Australasian Winter Conference on Brain Research. 20, (pp. 38). [Abstract]
King, J., Zheng, Y., Darlington, C. L., Smith, P. F., & Liu, P. (2002). NMDA and AMPA receptor subunit protein expression in the rat vestibular nucleus following unilateral labyrinthectomy. 20th International Australasian Conference on Brain Research. 20, (pp. 37). [Abstract]
Smith, P. F., King, J., Zheng, Y., Liu, P., & Darlington, C. L. (2002). Nitric Oxide Synthase and Arginase expression in the rat hippocampus following unilateral vestibular deafferentation. 20th International Australasian Winter Conference on Brain R. 20, (pp. 34). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Liu, P., Zheng, Y., King, J., Darlington, C., & Smith, P. (2002). NMDA and AMPA receptor subunit protein expression in the rat hippocampus following unilateral labyrinthectomy. Verbal presentation at the Twentieth International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
2001
Journal - Research Article
Liu, P., & Bilkey, D. (2001). The effect of excitotoxic lesions centered on the hippocampus or perirhinal cortex in object recognition and spatial memory tasks. Behavioral Neuroscience, 115(1), 94-111.
Zironi, I., Iacovelli, P., Aicardi, G., Liu, P., & Bilkey, D. K. (2001). Prefrontal cortex lesions augment the location-related firing properties of area TE/perirhinal cortex neurons in a working memory task. Cerebral Cortex, 11, 1093-1100.
Liu, P., Jarrard, L. E., & Bilkey, D. (2001). Excitotoxic lesions of the pre- and parasubiculum disrupt object recognition and spatial memory processes. Behavioral Neuroscience, 115(1), 112-124.
Conference Contribution - Published proceedings: Abstract
Richmond, J., Liu, P., Bilkey, D., & Smith, P. F. (2001). Changes in NOS activity and protein expression in the rat hippocampus and entorhinal and postrhinal cortoces following unilateral perirhinal lesions. Society for Neuroscience Abstracts. 27. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Liu, P., & Bilkey, D. K. (2001). The effects of NMDA lesions centred on the postrhinal cortex on spatial memory tasks in the rat. Verbal presentation at the 19th International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
Lu, X., Liu, P., & Bilkey, D. K. (2001). Perirhinal lesions affect firing properties of hippocampal place cells. Verbal presentation at the 19th International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
Russell, N. A., Liu, P., Darlington, C. L., Bilkey, D. K., Horii, A., & Smith, P. F. (2001). Hippocampal neuron firing rate correlations with angular velocity and angular acceleration in rats with vestibular lesions. Verbal presentation at the 19th International Australasian Winter Conference on Brain Research, Queenstown, New Zealand.
2000
Journal - Research Article
Bilkey, D., & Liu, P. (2000). The effects of separate and combined perirhinal and prefrontal cortex lesions on spatial memory tasks in the rat. Psychobiology, 28(1), 12-20.
Conference Contribution - Published proceedings: Abstract
Bilkey, D. K., Liu, P., & Jarrard, L. E. (2000). Lesions of pre/parasubiculum produce a delay-dependent deficit in a delayed non-match to position procedure. European Journal of Neuroscience. 12(Suppl. 11), (pp. 80). [Abstract]
Liu, P., Jarrard, L. E., & Bilkey, D. K. (2000). Excitotoxic lesions of the pre- and parasubiculum disrupt spatial memory and degrade the place fields of hippocampal pyramidal cells. Society for Neuroscience Abstracts. 26, (pp. 471). [Abstract]
Russell, N. A., Horii, A., Liu, P., Smith, P. F., Darlington, C. L., & Bilkey, D. K. (2000). Hippocampal place fields have decreased stability in rats with bilateral vestibular labyrinthectomies. Proceedings of the Society for Neuroscience. 26, (pp. 471). [Abstract]
Zironi, I., Iacovelli, P., Aicardi, G., Liu, P., & Bilkey, D. K. (2000). Lesions of prefrontal cortex alter the location-related firing properties of perirhinal cortex neurons in a working memory task. Society for Neuroscience Abstracts. 26, (pp. 473). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Bilkey, D. K., Liu, P., & Jarrard, L. E. (2000). Lesions of pre/para subiculum produce a delay-dependent deficit in a delayed non-match to Position procedure. Verbal presentation at the Forum of European Neuroscience, Brighton, UK.
Liu, P., & Bilkey, D. K. (2000). Local inhibition of rat perirhinal cortex muscarinic receptors and nitric oxide synthase disrupt performance in the Morris water maze task. Verbal presentation at the Eighteenth International Australasian Winter Conference on Brain Research, Queenstown.
Russell, N., Horii, A., Liu, P., Smith, P., Darlington, C., & Bilkey, D. K. (2000). Hippocampal theta rhythm has decreased power in rats with bilateral vestibular labyrinthectomies. Verbal presentation at the Eighteenth International Australasian Winter Conference on Brain Research, Queenstown.
1999
Journal - Research Article
Liu, P., & Bilkey, D. (1999). The effects of excitotoxic lesions centered on the perirhinal cortex in two versions of the radial arm maze task. Behavioral Neuroscience, 113(4), 672-682.
Journal - Professional & Other Non-Research Articles
Liu, P., & Bilkey, D. (1999). Current source density analysis does not reveal a direct projection from the perirhinal cortex to septal part of hippocampal CA1 or dentate gyrus - A Reply. Hippocampus, 9, 601-602.
1998
Journal - Research Article
Liu, P., & Bilkey, D. (1998). Excitotoxic lesions centered on perirhinal cortex produce delay-dependent deficits in a test of spatial memory. Behavioral Neuroscience, 112(2), 512-524.
Liu, P., & Bilkey, D. (1998). Perirhinal cortex contributions to performance in the water maze. Behavioral Neuroscience, 112(2), 304-315.
Liu, P., & Bilkey, D. (1998). Lesions of perirhinal cortex produce spatial memory deficits in the radial maze. Hippocampus, 8(2), 114-121.
Conference Contribution - Published proceedings: Abstract
Liu, P., & Bilkey, D. (1998). The contribution of perirhinal cortex to spatial memory. Proceedings of the University of Otago Medical School. 76, (pp. 8). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Liu, P., & Bilkey, D. K. (1998). Excitotoxic lesions centred on perirhinal cortex disrupt performance in the morris water maze. Verbal presentation at the Proceedings of the 16th International Australasian Winter Conference on Brain Research
1997
Journal - Research Article
Liu, P., & Bilkey, D. K. (1997). Current source density analysis of the potential evoked in hippocampus by perirhinal cortex stimulation. Hippocampus, 7(4), 389-396.
Liu, P., & Bilkey, D. K. (1997). Parallel involvement of perirhinal and lateral entorhinal cortex in the polysynaptic activation of hippocampus by olfactory inputs. Hippocampus, 7(3), 296-306.
Journal - Professional & Other Non-Research Articles
Bilkey, D., & Liu, P. (1997). Origin of the lateral perforant path: reply. Hippocampus, 7(3), 351.
Conference Contribution - Published proceedings: Abstract
Liu, P., Abraham, W. C., & Bilkey, D. K. (1997). The effects of separate and combined prefrontal and perirhinal cortical lesions in spatial reference and working memory tasks. Society for Neuroscience Abstracts. 23, (pp. 1599). [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Liu, P., & Bilkey, D. K. (1997). Spatial reference and working memory deficits in rats with electrolyte perirhinal cortex lesions. Verbal presentation at the 15th International Australasian Winter Conference on Brain Research, Queenstown.
1996
Journal - Research Article
Liu, P., & Bilkey, D. (1996). Long-term potentration the perirhinal-hippocampus pathway is NMDA dependent. NeuroReport, 7, 1241-1244.
Liu, P., & Bilkey, D. (1996). The direct connection between perirhinal cortex and hippocampus is a major constituent of the lateral perforant path. Hippocampus, 6, 125-134.