Dr Matthew McNeil

2024

Journal - Research Article

Jowsey, W. J., Cook, G. M., & McNeil, M. B. (2024). Antibiotic resistance in Mycobacterium tuberculosis alters tolerance to cell wall-targeting inhibitors. JAC: Antimicrobial Resistance, 6(3), dlae086. doi: 10.1093/jacamr/dlae086

Adolph, C., Cheung, C.-Y., McNeil, M. B., Jowsey, W. J., Williams, Z. C., Hards, K., Harold, L. K., … Tyndall, J. D. A., … Cook, G. M. (2024). A dual-targeting succinate dehydrogenase and F₁F_o-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chemical Biology, 31(4), 683-698. doi: 10.1016/j.chembiol.2023.12.002

Journal - Research Other

McNeil, M. B., Cook, G. M., & Krause, K. L. (2024). Dual transcriptional inhibition of glutamate and alanine racemase is synergistic in Mycobacterium tuberculosis. Microbiology, 170(8), 001484. doi: 10.1099/mic.0.001484

Other Research Output

McNeil, M. (2024, March). Combating Mycobacterium tuberculosis with high-throughput genetics. UOC Biomedical Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].

2023

Journal - Research Article

Waller, N. J. E., Cheung, C.-Y., Cook, G. M., & McNeil, M. B. (2023). The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis. Nature Communications, 14, 1517. doi: 10.1038/s41467-023-37184-7

2022

Journal - Research Article

Adolph, C., McNeil, M. B., & Cook, G. M. (2022). Impaired succinate oxidation prevents growth and influences drug susceptibility in Mycobacterium tuberculosis. mBio, 13(4). doi: 10.1128/mbio.01672-22

Harold, L. K., Jinich, A., Hards, K., Cordeiro, A., Keighley, L. M., Cross, A., McNeil, M. B., … Cook, G. M. (2022). Deciphering functional redundancy and energetics of malate oxidation in mycobacteria. Journal of Biological Chemistry, 298(5), 101859. doi: 10.1016/j.jbc.2022.101859

Cheung, C.-Y., McNeil, M. B., & Cook, G. M. (2022). Utilization of CRISPR interference to investigate the contribution of genes to pathogenesis in a macrophage model of Mycobacterium tuberculosis infection. Journal of Antimicrobial Chemotherapy, 77, 615-619. doi: 10.1093/jac/dkab437

Hards, K., Cheung, C.-Y., Waller, N., Adolph, C., Keighley, L., Tee, Z. S., Harold, L. K., Menorca, A., … Tyndall, J. D. A., McNeil, M. B., … Opel-Reading, H. K., Krause, K. L., … Berney, M., … Cook, G. M. (2022). An amiloride derivative is active against the F₁F_o-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis. Communications Biology, 5, 166. doi: 10.1038/s42003-022-03110-8

McNeil, M. B., Ryburn, H. W., Tirados, J., Cheung, C.-Y., & Cook, G. M. (2022). Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexes. iScience, 25(1), 103573. doi: 10.1016/j.isci.2021.103573

Journal - Research Other

McNeil, M. B., Cheung, C.-Y., Waller, N. J. E., Adolph, C., Chapman, C. L., Seeto, N. E. J., Jowsey, W., … Cook, G. M. (2022). Uncovering interactions between mycobacterial respiratory complexes to target drug-resistant Mycobacterium tuberculosis. Frontiers in Cellular & Infection Microbiology, 12, 980844. doi: 10.3389/fcimb.2022.980844

Conference Contribution - Poster Presentation (not in published proceedings)

Jowsey, W. J., McNeil, M. B., & Cook, G. M. (2022, August). Exploiting metabolic dysregulation to potentiate antibiotic killing of resistant Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Chapman, C. L., McNeil, M. B., & Cook, G. M. (2022, August). Multiplex transcriptional repression to investigate genetic interactions between bioenergetic complexes in Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Adolph, C. R., Cheung, C.-Y., McNeil, M. B., & Cook, G. M. (2022, August). Exploiting synergistic interactions in energy metabolism to combat drug resistant Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Waller, N., Cheung, C., McNeil, M., & Cook, G. (2022, August). Drug resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Journal - Research Article

McNeil, M. B., Keighley, L. M., Cook, J. R., Cheung, C.-Y., & Cook, G. M. (2021). CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis. Molecular Microbiology, 116, 1033-1043. doi: 10.1111/mmi.14790

Shelton, C. D., McNeil, M. B., Early, J. V., Ioerger, T. R., & Parish, T. (2021). Deletion of Rv2571c confers resistance to arylamide compounds in Mycobacterium tuberculosis. Antimicrobial Agents & Chemotherapy, 65, e02334-20. doi: 10.1128/aac.02334-20

2020

Journal - Research Article

McNeil, M. B., O'Malley, T., Dennison, D., Shelton, C. D., Sunde, B., & Parish, T. (2020). Multiple mutations in Mycobacterium tuberculosis MmpL3 increase resistance to MmpL3 inhibitors. mSphere, 5(5), e00985-20. doi: 10.1128/mSphere.00985-20

McNeil, M. B., Ryburn, H. W. K., Harold, L. K., Tirados, J. F., & Cook, G. M. (2020). Transcriptional inhibition of the F₁F₀-type ATP synthase has bactericidal consequences on the viability of mycobacteria. Antimicrobial Agents & Chemotherapy, 64(8), e00492-20. doi: 10.1128/aac.00492-20

Shao, M., McNeil, M., Cook, G. M., & Lu, X. (2020). MmpL3 inhibitors as antituberculosis drugs. European Journal of Medicinal Chemistry, 200, 112390. doi: 10.1016/j.ejmech.2020.112390

Journal - Research Other

Hards, K., Adolph, C., Harold, L. K., McNeil, M. B., Cheung, C.-Y., Jinich, A., … Cook, G. M. (2020). Two for the price of one: Attacking the energetic-metabolic hub of mycobacteria to produce new chemotherapeutic agents. Progress in Biophysics & Molecular Biology, 152, 35-44. doi: 10.1016/j.pbiomolbio.2019.11.003

2019

Journal - Research Other

McNeil, M. B., & Cook, G. M. (2019). Utilization of CRISPR interference to validate MmpL3 as a drug target in Mycobacterium tuberculosis. Antimicrobial Agents & Chemotherapy, 63(8), e00629-19. doi: 10.1128/aac.00629-19

Conference Contribution - Verbal presentation and other Conference outputs

McNeil, M., Adolph, C., Cheung, C.-Y., Hards, K., Jinich, A., Rhee, K., & Cook, G. M. (2019, August-September). Essentiality of succinate metabolism in Mycobacterium tuberculosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Cheung, J., Adolph, C., Buckley, B. J., Majed, H., Aboelela, A., Bujaroski, R., … Hards, K., McNeil, M. B., … Cook, G. M. (2019, August-September). Next generation ATP synthase inhibitors to combat drug resistant tuberculosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Conference Contribution - Published proceedings: Abstract

McNeil, M. B., & Cook, G. M. (2018). Deciphering the functions and interactions of complex II respiratory enzymes in Mycobacterium tuberculosis. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 89). Retrieved from https://www.nzmsconference.org.nz

Adolph, C., Cheung, J., Buckley, B. J., Aboelela, A., Hards, K., McNeil, M., … Cook, G. M. (2018). Identification of novel antimicrobials targeting succinate dehydrogenase in Mycobacterium tuberculosis. Proceedings of the New Zealand Microbiological Society (NZMS) New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) Joint Annual Conference: Microbes & Molecules. (pp. 54-55). Retrieved from https://www.nzmsconference.org.nz

Conference Contribution - Verbal presentation and other Conference outputs

Saul, D., Rawle, C. B., Muralidhar, A., Rand, C. J., Mayall, K., Boykin, L., McNeil, M., Aung, H. L., & Stanton, J. L. (2018, December). Reliable sample preparation technology for point-of-need applications. Verbal presentation at the 4th One Health Aotearoa (OHA) Symposium, Wellington, New Zealand.

2017

Journal - Research Article

McNeil, M. B., Dennison, D. D., Shelton, C. D., & Parish, T. (2017). In vitro isolation and characterization of oxazolidinone-resistant Mycobacterium tuberculosis. Antimicrobial Agents & Chemotherapy, 61(10), e01296-17. doi: 10.1128/aac.01296-17

McNeil, M. B., Dennison, D., Shelton, C., Flint, L., Korkegian, A., & Parish, T. (2017). Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA. Tuberculosis, 107, 133-136. doi: 10.1016/j.tube.2017.09.003

Journal - Research Other

McNeil, M. B., Dennison, D., & Parish, T. (2017). Mutations in MmpL3 alter membrane potential, hydrophobicity and antibiotic susceptibility in Mycobacterium smegmatis [Short communication]. Microbiology, 163(7), 1065-1070. doi: 10.1099/mic.0.000498

2016

Journal - Research Article

Hampton, H. G., McNeil, M. B., Paterson, T. J., Ney, B., Williamson, N. R., Easingwood, R. A., Bostina, M., … Fineran, P. C. (2016). CRISPR-Cas gene-editing reveals RsmA and RsmC act through FlhDC to repress the SdhE flavinylation factor and control motility and prodigiosin production in Serratia. Microbiology, 162(6), 1047-1058. doi: 10.1099/mic.0.000283

2014

Journal - Research Article

Richter, C., Dy, R. L., McKenzie, R. E., Watson, B. N. J., Taylor, C., Chang, J. T., McNeil, M. B., Staals, R. H. J., & Fineran, P. C. (2014). Priming in the Type I-F CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer. Nucleic Acids Research, 42(13), 8516-8526. doi: 10.1093/nar/gku527

McNeil, M. B., Hampton, H. G., Hards, K. J., Watson, B. N. J., Cook, G. M., & Fineran, P. C. (2014). The succinate dehydrogenase assembly factor, SdhE, is required for the flavinylation and activation of fumarate reductase in bacteria. FEBS Letters, 588(3), 414-421. doi: 10.1016/j.febslet.2013.12.019

2013

Journal - Research Article

Fineran, P. C., Iglesias Cans, M. C., Ramsay, J. P., Wilf, N. M., Cossyleon, D., McNeil, M. B., … Stanton, J.-A. L., … Salmond, G. P. C. (2013). Draft genome sequence of Serratia sp. strain ATCC 39006, a model bacterium for analysis of the biosynthesis and regulation of prodigiosin, a carbapenem, and gas vesicles. Genome Announcements, 1(6), e01039-13. doi: 10.1128/genomeA.01039-13

McNeil, M. B., & Fineran, P. C. (2013). The conserved RGxxE motif of the bacterial FAD assembly factor SdhE is required for succinate dehydrogenase flavinylation and activity. Biochemistry, 52, 7628-7640. doi: 10.1021/bi401006a

McNeil, M. B., Iglesias Cans, M. C., Clulow, J. S., & Fineran, P. C. (2013). YgfX (CptA) is a multimeric membrane protein that interacts with the succinate dehydrogenase assembly factor SdhE (YgfY). Microbiology, 159, 1352-1365. doi: 10.1099/mic.0.068510-0

McNeil, M. B., & Fineran, P. C. (2013). Prokaryotic assembly factors for the attachment of flavin to complex II. Biochimica et Biophysica Acta: Bioenergetics, 1827, 637-647. doi: 10.1016/j.bbabio.2012.09.003

2012

Journal - Research Article

McNeil, M. B., Clulow, J. S., Wilf, N. M., Salmond, G. P. C., & Fineran, P. C. (2012). SdhE is a conserved protein required for the flavinylation of succinate dehydrogenase in bacteria. Journal of Biological Chemistry, 287(22), 18418-18428. doi: 10.1074/jbc.M111.293803

Conference Contribution - Verbal presentation and other Conference outputs

McNeil, M., & Fineran, P. (2012, November). Functional characterisation of the FAD cofactor chaperone SdhE. Verbal presentation at the 57th New Zealand Microbiological Society (NZMS) Annual Scientific Meeting, Dunedin, New Zealand.

Awarded Doctoral Degree

McNeil, M. B. (2012). Characterisation of the conserved hypothetical proteins SdhE and YgfX in Serratia 39006 (PhD). University of Otago. Retrieved from http://hdl.handle.net/10523/2373

2011

Journal - Research Article

Gristwood, T., McNeil, M. B., Clulow, J. S., Salmond, G. P. C., & Fineran, P. C. (2011). PigS and PigP regulate prodigiosin biosynthesis in Serratia via differential control of divergent operons, which include predicted transporters of sulfur-containing molecules. Journal of Bacteriology, 193(5), 1076-1085. doi: 10.1128/JB.00352-10

2010

Conference Contribution - Verbal presentation and other Conference outputs

McNeil, M. (2010, November). Characterisation of conserved hypothetical ygfYX genes in Serratia. Verbal presentation at the Genetics Otago Symposium, Dunedin, New Zealand.

2009

Conference Contribution - Published proceedings: Abstract

McNeil, M. B., Iglesias Cans, M., Richter, C., Gristwood, T., Salmond, G. P. C., & Fineran, P. C. (2009). A putative signal transduction system that is widely conserved in enteric bacteria. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Xu, X., Edgar, R. J., McNeil, M., Cutfield, S. M., & Lamont, I. L. (2009). A genetic and biochemical approach to investigate anti-sigma: Sigma factor interactions. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

McNeil, M., & Lamont, I. (2009). Interaction of the Pseudomonas aeruginosa sigma factor, PvdS, with the anti-sigma factor, FpvR. New Zealand Medical Journal, 122(1293). Retrieved from http://journal.nzma.org.nz/journal/122-1293/3572/content.pdf

2008

Conference Contribution - Published proceedings: Abstract

McNeil, M., & Lamont, I. (2008). Pyoverdine production by Pseudomonas aeruginosa isolates from patients with cystic fibrosis. New Zealand Medical Journal, 121(1274). Retrieved from http://journal.nzma.org.nz/journal/121-1274/3078/content.pdf