Associate Professor Daniel Pletzer

2025

Journal - Research Article

Xu, C., Feng, J., Zhou, Y., Ren, H., Pan, X., Chen, S., … Lamont, I. L., Pletzer, D., & Wu, W. (2025). Azithromycin represses evolution of ceftazidime/avibactam resistance by translational repression of rpoS in Pseudomonas aeruginosa. Journal of Bacteriology. Advance online publication. doi: 10.1128/jb.00552-24

Wardell, S. J. T., Yung, D. B. Y., Nielsen, J. E., Lamichhane, R., Sørensen, K., Molchanova, N., … Wise, L. M., … Pletzer, D. (2025). A biofilm-targeting lipo-peptoid to treat Pseudomonas aeruginosa and Staphylococcus aureus co-infections. Biofilm. Advance online publication. doi: 10.1016/j.bioflm.2025.100272

Wardell, S. J. T., Yung, D. B. Y., Gupta, A., Bostina, M., Overhage, J., Hancock, R. E. W., & Pletzer, D. (2025). DJK-5, an anti-biofilm peptide, increases Staphylococcus aureus sensitivity to colistin killing in co-biofilms with Pseudomonas aeruginosa. npj Biofilms & Microbiomes, 11, 8. doi: 10.1038/s41522-024-00637-y

Journal - Research Other

Cloeckaert, A., Pletzer, D., & Khaiboullina, S. (2025). Reviews in microbial pathogenesis. Frontiers in Microbiology, 16, 1568840. doi: 10.3389/fmicb.2025.1568840

Kabir, F., Yung, D. B. Y., da Cruz Nizer, W. S., Allison, K. N., Zigic, S., Russell, E., … Pletzer, D., & Overhage, J. (2025). Pressure injuries and biofilms: Microbiome, model systems and therapies. Wound Repair & Regeneration, 33(1), e70005. doi: 10.1111/wrr.70005

Conference Contribution - Published proceedings: Abstract

Hardie Boys, M. T., Taylor-Wardell, S., & Pletzer, D. (2025). Loss of aminoarabinose lipid modification leads to cephalosporin antibiotic resistance in Pseudomonas aeruginosa. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

2024

Journal - Research Article

Saseendran Nair, S., Kleffmann, T., Smith, B., Morris, V., Göbl, C., Pletzer, D., & Fellner, M. (2024). Comparative lipidomics profiles of planktonic and biofilms of methicillin-resistant and -susceptible Staphylococcus aureus. Analytical Biochemistry, 698, 115746. doi: 10.1016/j.ab.2024.115746

Shein, A. M. S., Wannigama, D. L., Hurst, C., Monk, P. N., Amarasiri, M., Wongsurawat, T., … Hosseini Rad, S. M. A., … Pletzer, D., … Abe, S. (2024). Phage cocktail amikacin combination as a potential therapy for bacteremia associated with carbapenemase producing colistin resistant Klebsiella pneumoniae. Scientific Reports, 14, 28992. doi: 10.1038/s41598-024-79924-9

Shein, A. M. S., Hongsing, P., Smith, O. K., Phattharapornjaroen, P., Miyanaga, K., Cui, L., … Pletzer, D., … Wannigama, D. L. (2024). Current and novel therapies for management of Acinetobacter baumannii-associated pneumonia [Review]. Critical Reviews in Microbiology. Advance online publication. doi: 10.1080/1040841x.2024.2369948

Na, T. U., Sander, V., Davidson, A. J., Lin, R., Hermant, Y. O., Hardie Boys, M. T., Pletzer, D., Campbell, G., Ferguson, S. A., Cook, G. M., … Cameron, A. J. (2024). Allenamides as a powerful tool to incorporate diversity: Thia-Michael lipidation of semisynthetic peptides and access to β-ketoamides. Angewandte Chemie International Edition. Advance online publication. doi: 10.1002/anie.202407764

Ross, C. L., Lawer, A., Sircombe, K. J., Pletzer, D., Gamble, A. B., & Hook, S. (2024). Site-specific antimicrobial activity of a dual-responsive ciprofloxacin prodrug. Journal of Medicinal Chemistry. Advance online publication. doi: 10.1021/acs.jmedchem.4c00724

Esposito, T. V. F., Blackadar, C., Wu, L., Rodríguez-Rodríguez, C., Haney, E. F., Pletzer, D., … Häfeli, U. O. (2024). Biodistribution of native and nanoformulated innate defense regulator peptide 1002. Molecular Pharmaceutics. Advance online publication. doi: 10.1021/acs.molpharmaceut.3c01169

Lyons, N., Wu, W., Jin, Y., Lamont, I. L., & Pletzer, D. (2024). Using host-mimicking conditions and a murine cutaneous abscess model to identify synergistic antibiotic combinations effective against Pseudomonas aeruginosa. Frontiers in Cellular & Infection Microbiology, 14, 1352339. doi: 10.3389/fcimb.2024.1352339

Rajchakit, U., Lamba, S., Wang, K., Lyons, N., Lu, J., Swift, S., Pletzer, D., & Sarojini, V. (2024). Size-controlled synthesis of gold nanoparticles tethering antimicrobial peptides with potent broad-spectrum antimicrobial and antibiofilm activities. Molecular Pharmaceutics. Advance online publication. doi: 10.1021/acs.molpharmaceut.3c00734

Saha, T., Lyons, N., Yung, D. B. Y., Quiñones‑Mateu, M. E., Pletzer, D., & Das, S. C. (2024). Repurposing ebselen as an inhalable dry powder to treat respiratory tract infections. European Journal of Pharmaceutics & Biopharmaceutics, 195, 114170. doi: 10.1016/j.ejpb.2023.12.010

Journal - Research Other

Choudhury, M., Brunton, P., Dias, G., Schwass, D., Meledandri, C., Ratnayake, J., Pletzer, D., & Tompkins, G. (2024). Gold nanoparticles as innovative therapeutics for oral mucositis: A review of current evidence. Drug Delivery & Translational Research. Advance online publication. doi: 10.1007/s13346-024-01748-x

Pérez de la Lastra, J. M., Wardell, S. J. T., Pal, T., de la Fuente-Nunez, C., & Pletzer, D. (2024). From data to decisions: Leveraging artificial intelligence and machine learning in combating antimicrobial resistance: A comprehensive review. Journal of Medical Systems, 48, 71. doi: 10.1007/s10916-024-02089-5

Wei, X., Gao, J., Zhou, D., Xu, C., Chen, P., Chen, S., … Lamont, I. L., Pletzer, D., … Wu, W. (2024). Murepavadin promotes the killing efficacies of aminoglycoside antibiotics against Pseudomonas aeruginosa by enhancing membrane potential. Antimicrobial Agents & Chemotherapy, 68(4), e01539-23. doi: 10.1128/aac.01539-23

Choudhury, M., Brunton, P., Schwass, D., Pletzer, D., Ratnayake, J., Dias, G., & Tompkins, G. (2024). Effectiveness of gold nanoparticles in prevention and treatment of oral mucositis in animal models: A systematic review. Systematic Reviews, 13(1), 39. doi: 10.1186/s13643-023-02425-9

Conference Contribution - Published proceedings: Abstract

Lamont, B., Suwanarusk, R., Yung, D., Barron, A. E., Pletzer, D., Russell, B., & Muhsin-Sharafaldine, M.-R. (2024). Antiparasitic activity of novel peptoids against Cryptosporidium parvum. Proceedings of the Australian and New Zealand Societies for Parasitology and the 7th International Conference on Anaerobic Protists: Parasites in the Pacific. (pp. 57). Retrieved from https://www.parasite.org.au/aspconference/

Conference Contribution - Poster Presentation (not in published proceedings)

Hardie Boys, M. T., Taylor-Wardell, S., & Pletzer, D. (2024, September). Loss of aminoarabinose lipid modification leads to cephalosporin antibiotic resistance in Pseudomonas aeruginosa. Poster session presented at the Queenstown Research Week (QRW) Pathogen Genomics Meeting, Queenstown, New Zealand.

Smith, O. K., Babiychuk, E., & Pletzer, D. (2024, September). Cell membrane-mimicking liposomes as an anti-virulence therapy for Acinetobacter baumannii and Staphylococcus aureus. Poster session presented at the Queenstown Research Week (QRW) Biomolecular Interactions Meeting, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Sircombe, K. J., Gamble, A., Pletzer, D., & Hook, S. (2024, November). Development and evaluation of controlled release responsive antibiotic delivery systems. Verbal presentation at the School of Pharmacy Research Symposium, Dunedin, New Zealand.

2023

Journal - Research Article

Shein, A. M. S., Wannigama, D. L., Hurst, C., Monk, P. N., Amarasiri, M., Badavath, V. N., … Pletzer, D., … Hosseini Rad, S. M. A., … Abe, S. (2023). Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection. Biomedicine & Pharmacotherapy, 168, 115793. doi: 10.1016/j.biopha.2023.115793

Wei, X., Gao, J., Xu, C., Pan, X., Jin, Y., Bai, F., … Lamont, I. L., Pletzer, D., & Wu, W. (2023). Murepavadin induces envelope stress response and enhances the killing efficacies of β-lactam antibiotics by impairing the outer membrane integrity of Pseudomonas aeruginosa. Microbiology Spectrum, 11(5). doi: 10.1128/spectrum.01257-23

Wiesmann, C. L., Zhang, Y., Alford, M., Hamilton, C. D., Dosanjh, M., Thoms, D., … Pletzer, D., … Haney, C. H. (2023). The ColR/S two-component system is a conserved determinant of host association across Pseudomonas species. ISME Journal, 17, 286-296. doi: 10.1038/s41396-022-01343-3

Fahma, F., Firmanda, A., Cabral, J., Pletzer, D., Fisher, J., Mahadik, B., … Wulandari, A. (2023). Three-dimensional printed cellulose for wound dressing applications. 3D Printing & Additive Manufacturing, 10(5), 1015-1035. doi: 10.1089/3dp.2021.0327

Conference Contribution - Published proceedings: Abstract

Wardell, S., & Pletzer, D. (2023). Polymicrobial skin infections promote unique host transcriptional responses leading to increased morbidity. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Yung, D., Wardell, S. J. T., Hancock, R. E. W., Bostina, M., & Pletzer, D. (2023). Anti-biofilm peptide DJK-5 potentiates activity of colistin against Pseudomonas aeruginosa and Staphylococcus aureus co-biofilms. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Hardie Boys, M., & Pletzer, D. (2023). Loss of aminoarabinose lipid modification leads to cephalosporin antibiotic resistance in Pseudomonas aeruginosa. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Smith-Beech, A., Fellner, M., & Pletzer, D. (2023). A biochemical description of UspN and its function in the anaerobic metabolism of Pseudomonas aeruginosa. Proceedings of the New Zealand Society for Biochemistry and Molecular Biology (NZSBMB) 50th Anniversary Conference. Retrieved from https://www.nzsbmb.org/conference

Su, S., Hook, S., Pletzer, D., & Gamble, A. (2023). Overcoming efflux-mediated multidrug resistance in Pseudomonas aeruginosa. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home

Sircombe, K. J., Gamble, A., Pletzer, D., & Hook, S. (2023). Development and evaluation of controlled release responsive antibiotic delivery systems. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home

Ross, C., Lawer, A., Sircombe, K., Pletzer, D., Gamble, A., & Hook, S. (2023). Development of controlled release antibiotic prodrugs. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home

Hardie Boys, M. T., & Pletzer, D. (2023). Cross-resistance to cephalosporin antibiotics occurs in Pseudomonas aeruginosa lacking the aminoarabinosylation system. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 268th Otago Medical School Research Society (OMSRS) Meeting: Masters/Honours/Postgraduate Diploma Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Saha, T., Lyons, N., Yung, D., Pletzer, D., Quiñones Mateu, M. E., & Das, S. (2023). Inhalable ebselen dry powder for respiratory tract infections. Pharmacy Education, 23(6), (pp. 147). doi: 10.46542/pe.2023.236.129157

Conference Contribution - Verbal presentation and other Conference outputs

Pletzer, D. (2023, February). Developing new approaches to fight infectious diseases. Verbal presentation at the Maurice Wilkins Centre (MWC) for Molecular Biodiversity Symposium, Dunedin, New Zealand.

Pletzer, D. (2023, August). Peptides and peptidomimetics as a potential treatment for hard-to-treat polymicrobial infections. Verbal presentation at the 33rd Queenstown Molecular Biology Meeting (QMB), Queenstown, New Zealand.

2022

Journal - Research Article

Belanger, C. R., Dostert, M., Blimkie, T. M., Lee, A. H.-Y., Dhillon, B. K., Wu, B. C., … Pletzer, D., … Hancock, R. E. W. (2022). Surviving the host: Microbial metabolic genes required for growth of Pseudomonas aeruginosa in physiologically-relevant conditions. Frontiers in Microbiology, 13, 1055512. doi: 10.3389/fmicb.2022.1055512

Adhikari, B. R., Sinha, S., Lyons, N., Pletzer, D., Lamont, I., Gordon, K. C., & Das, S. C. (2022). Inhalable ceftazidime-roflumilast powder targeting infection and inflammation: Influence of incorporating roflumilast into ceftazidime-leucine co-amorphous formulation. European Journal of Pharmaceutics & Biopharmaceutics, 180, 260-268. doi: 10.1016/j.ejpb.2022.10.005

Firmanda, A., Fahma, F., Syamsu, K., Cabral, J., Pletzer, D., & Gustiananda, M. (2022). Cellulose composites containing active constituents of coffee and tea: A prospective novel wound dressing [Review]. Materials Advances, 3, 7463-7483. doi: 10.1039/D2MA00642A

Esposito, T. V. F., Rodríguez-Rodríguez, C., Blackadar, C., Haney, E. F., Pletzer, D., Hancock, R. E. W., … Häfeli, U. O. (2022). Biodistribution and Toxicity of Innate Defense Regulator 1018 (IDR-1018). European Journal of Pharmaceutics & Biopharmaceutics, 179, 11-25. doi: 10.1016/j.ejpb.2022.08.004

Wolfmeier, H., Wardell, S. J. T., Liu, L. T., Falsafi, R., Draeger, A., Babiychuk, E. B., Pletzer, D., & Hancock, R. E. W. (2022). Targeting the Pseudomonas aeruginosa virulence factor phospholipase C with engineered liposomes. Frontiers in Microbiology, 13, 867449. doi: 10.3389/fmicb.2022.867449

Neilsen, J. E., Alford, M. A., Yung, D. B. Y., Molchanova, N., Fortkort, J. A., Lin, J. S., … Pletzer, D., … Barron, A. E. (2022). Self-assembly of antimicrobial peptoids impacts their biological effects on ESKAPE bacterial pathogens. ACS Infectious Diseases, 8, 533-545. doi: 10.1021/acsinfecdis.1c00536

Sousa, M. G. d. C., de Almeida, G. C., Mota, D. C. M., da Costa, R. A., Dias, S. C., Limberger, S. N., … Pletzer, D., … Rezende, T. M. B. (2022). Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures. Bioactive Materials, 16, 173-186. doi: 10.1016/j.bioactmat.2022.01.027

Harfoot, R., Yung, D. B. Y., Anderson, W. A., Wild, C. E. K., Coetzee, N., Hernández, L. C., Lawley, B., Pletzer, D., Derraik, J. G. B., … Quiñones‑Mateu, M. E. (2022). Ultraviolet-C irradiation, heat, and storage as potential methods of inactivating SARS-CoV-2 and bacterial pathogens on filtering facepiece respirators. Pathogens, 11(1), 83. doi: 10.3390/pathogens11010083

Journal - Research Other

Firmanda, A., Syamsu, K., Sari, Y. W., Cabral, J., Pletzer, D., Mahadik, B., … Fahma, F. (2022). 3D printed cellulose based product applications. Materials Chemistry Frontiers, 6, 254-279. doi: 10.1039/d1qm00390a

Conference Contribution - Published proceedings: Abstract

Lamont, B., Pletzer, D., Russell, B., & Muhsin, R. (2022). Novel peptoids as treatment for Cryptosporidiosis. Proceedings of the New Zealand Society for Parasitology (NZSP) 49th Conference & Annual Meeting. (pp. 15). Retrieved from https://nzs4p.org.nz

Choudhury, M., Tompkins, G., Brunton, P., Dias, G., Pletzer, D., & Ratnayake, J. (2022). Gold nanoparticles against oropharyngeal pathogens in cancer therapy. New Zealand Dental Journal, 118(4), (pp. 168). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Lyons, N. M. A., Wu, W., Jin, Y., Lamont, I. L., & Pletzer, D. (2022, August). Using antibiotic combinations to suppress development of resistance. Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Sircombe, K. J., Kirman, J. R., & Pletzer, D. (2022, August). Can BCG vaccination train innate immune cells to protect against skin and soft tissue infections? Poster session presented at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Su, S., Hook, S., Pletzer, D., & Gamble, A. (2022, November). Overcoming efflux-mediated multidrug resistance in Pseudomonas aeruginosa. Verbal presentation at the School of Pharmacy Research Day, Dunedin, New Zealand.

Ross, C. L., Lawer, A., Sircombe, K. J., Mros, S., McConnell, M., Pletzer, D., Gamble, A. B., & Hook, S. (2022, November). Development of a dual prodrug for triggered antibiotic activation. Verbal presentation at the School of Pharmacy Research Day, Dunedin, New Zealand.

Pletzer, D. (2022, September). Peptides and peptidomimetics to combat adaptive multidrug resistant high-density infections. Plenary presentation at the Australasian Wound & Tissue Repair Society (AWTRS) Meeting, Sydney, Australia.

Yung, D. B. Y., Esposito, T. V. F., Hafeli, U. O., Barron, A., Hancock, R. E. W., & Pletzer, D. (2022, August). Peptides and peptidomimetics to combat adaptive multidrug resistant high-density infections. Verbal presentation at the Webster Centre for Infectious Diseases Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

2021

Chapter in Book - Research

Haney, E. F., Pletzer, D., & Hancock, R. E. W. (2021). Impact of host defense peptides on chronic wounds and infections. In M. A. Shiffman & M. Low (Eds.), Chronic wounds, wound dressings and wound healing. (pp. 3-19). Cham, Switzerland: Springer. doi: 10.1007/15695_2017_88

Journal - Research Article

Drayton, M., Alford, M. A., Pletzer, D., Haney, E. F., Machado, Y., Luo, H. D., … Straus, S. K. (2021). Enzymatically releasable polyethylene glycol: Host defense peptide conjugates with improved activity and biocompatibility. Journal of Controlled Release, 339, 220-231. doi: 10.1016/j.jconrel.2021.09.035

Ren, H., Zhang, J., Zhou, J., Xu, C., Fang, Z., Pan, X., … Pletzer, D., & Wu, W. (2021). Synergistic bactericidal activities of tobramycin with ciprofloxacin and azithromycin against Klebsiella pneumoniae. Journal of Antibiotics, 74, 528-537. doi: 10.1038/s41429-021-00427-0

Wilkinson, L. V., Alford, M. A., Coleman, S. R., Wu, B. C., Lee, A. H. Y., Blimkie, T. M., … Pletzer, D., & Hancock, R. E. W. (2021). Peptide 1018 inhibits swarming and influences Anr-regulated gene expression downstream of the stringent stress response in Pseudomonas aeruginosa. PLoS ONE, 16(4), e0250977. doi: 10.1371/journal.pone.0250977

Khomtchouk, K. M., Joseph, L. I., Khomtchouk, B. B., Kouhi, A., Massa, S., Xia, A., … Pletzer, D., … Santa Maria, P. L. (2021). Treatment with a neutrophil elastase inhibitor and ofloxacin reduces P. aeruginosa burden in a mouse model of chronic suppurative otitis media. npj Biofilms & Microbiomes, 7, 31. doi: 10.1038/s41522-021-00200-z

Alford, M. A., Choi, K.-Y. G., Trimble, M. J., Masoudi, H., Kalsi, P., Pletzer, D., & Hancock, R. E. W. (2021). Murine model of sinusitis infection for screening antimicrobial and immunomodulatory therapies. Frontiers in Cellular & Infection Microbiology, 11, 621081. doi: 10.3389/fcimb.2021.621081

Pletzer, D., Asnis, J., Slavin, Y. N., Hancock, R. E. W., Bach, H., Saatchi, K., & Häfeli, H. O. (2021). Rapid microwave-based method for the preparation of antimicrobial lignin-capped silver nanoparticles active against multidrug-resistant bacteria. International Journal of Pharmaceutics, 596, 120299. doi: 10.1016/j.ijpharm.2021.120299

Wu, B., Haney, E. F., Akhoundsadegh, N., Pletzer, D., Trimble, M. J., Adriaans, A. E., … Hancock, R. E. W. (2021). Human organoid biofilm model for assessing antibiofilm activity of novel agents. npj Biofilms & Microbiomes, 7(1), 8. doi: 10.1038/s41522-020-00182-4

Coleman, S. R., Pletzer, D., & Hancock, R. E. W. (2021). Contribution of swarming motility to dissemination in a Pseudomonas aeruginosa murine skin abscess infection model. Journal of Infectious Diseases, 224, 726-733. doi: 10.1093/infdis/jiaa778

Journal - Research Other

Yung, D. B. Y., Sircombe, K. J., & Pletzer, D. (2021). Friends or enemies? The complicated relationship between Pseudomonas aeruginosa and Staphylococcus aureus. Molecular Microbiology, 116, 1-15. doi: 10.1111/mmi.14699

Conference Contribution - Published proceedings: Abstract

Ross, C. L., Lawer, A., Sircombe, K., McConnell, M., Pletzer, D., Gamble, A., & Hook, S. (2021). Developing a dual prodrug for triggered antibiotic activation. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 244). Retrieved from https://www.faobmb2021.org

Yung, D. B. Y., Barron, A. E., & Pletzer, D. (2021). Anti-biofilm and anti-abscess activity of novel peptoids against Pseudomonas-Staphylococcus polymicrobial infections. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 273). Retrieved from https://www.faobmb2021.org

Yung, D., Alford, M., Barron, A., Hancock, R. E. W., & Pletzer, D. (2021). Synthetic peptides and peptidomimetics to treat infections caused by multidrug resistant ESKAPE pathogens. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 185). Retrieved from https://www.faobmb2021.org

2020

Journal - Research Article

Belanger, C. R., Lee, A. H.-Y., Pletzer, D., Dhillon, B. K., Falsafi, R., & Hancock, R. E. W. (2020). Identification of novel targets of azithromycin activity against Pseudomonas aeruginosa grown in physiologically relevant media. PNAS, 117(2), 33519-33529. doi: 10.1073/pnas.2007626117

Etayash, H., Qian, Y., Pletzer, D., Zhang, Q., Xie, J., Cui, R., … Hancock, R. E. W. (2020). Host defense peptide-mimicking amphiphilic β-peptide polymer (Bu:DM) exhibiting anti-biofilm, immunomodulatory, and in Vivo anti-infective activity. Journal of Medicinal Chemistry, 63, 12921-12928. doi: 10.1021/acs.jmedchem.0c01321

Copp, J. N., Pletzer, D., Brown, A. S., van der Heijden, J., Miton, C. M., Rich, M. H., … Ackerley, D. F. (2020). Mechanistic understanding enables the rational design of salicylanilide combination therapies for gram-negative infections. mBio, 11(5), e02068-20. doi: 10.1128/mBio.02068-20

Etayash, H., Pletzer, D., Kumar, P., Straus, S. K., & Hancock, R. E. W. (2020). Cyclic derivative of host-defense peptide IDR-1018 improves proteolytic stability, suppresses inflammation, and enhances in vivo activity. Journal of Medicinal Chemistry, 63(17), 9228-9236. doi: 10.1021/acs.jmedchem.0c00303

Khomtchouk, K. M., Kouhi, A., Xia, A., Bekale, L. A., Massa, S. M., Sweere, J. M., Pletzer, D., … Santa Maria, P. L. (2020). A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation. Science Advances, 6(33), eabc1828. doi: 10.1126/sciadv.abc1828

Pletzer, D., Blimkie, T. M., Wolfmeier, H., Li, Y., Baghela, A., Lee, A. H. Y., … Hancock, R. E. W. (2020). The stringent stress response controls proteases and global regulators under optimal growth conditions in Pseudomonas aeruginosa. mSystems, 5(4), e00495-20. doi: 10.1128/mSystems.00495-20

Alford, M. A., Baghela, A., Yeung, A. T. Y., Pletzer, D., & Hancock, R. E. W. (2020). NtrBC regulates invasiveness and virulence of Pseudomonas aeruginosa during high-density infection. Frontiers in Microbiology, 11. doi: 10.3389/fmicb.2020.00773

Moosavian, M., Emam, N., Pletzer, D., & Savari, M. (2020). Rough-type and loss of the LPS due to lpx genes deletions are associated with colistin resistance in multidrug-resistant clinical Escherichia coli isolates not harbouring mcr genes. PLoS ONE, 15(5), e0233518. doi: 10.1371/journal.pone.0233518

Pletzer, D., Sun, E., Ritchie, C., Wilkinson, L., Liu, L. T., Trimble, M. J., … Hancock, R. E. W. (2020). Surfing motility is a complex adaptation dependent on the stringent stress response in Pseudomonas aeruginosa LESB58. PLoS Pathogens, 16(3), e1008444. doi: 10.1371/journal.ppat.1008444

2019

Journal - Research Article

Kłodzińska, S. N., Pletzer, D., Rahanjam, N., Rades, T., Hancock, R. E. W., & Nielsen, H. M. (2019). Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5. Nanomedicine, 20, 102022. doi: 10.1016/j.nano.2019.102022

Woehlk, H., Trimble, M. J., Mansour, S. C., Pletzer, D., Trouillet, V., Welle, A., … Fairfull-Smith, K. E. (2019). Controlling biofilm formation with nitroxide functional surfaces. Polymer Chemistry, 10(31), 4252-4258. doi: 10.1039/c9py00690g

Kumar, P., Pletzer, D., Haney, E. F., Rahanjam, N., Cheng, J. T. J., Yue, M., … Straus, S. K. (2019). Aurein-derived antimicrobial peptides formulated with pegylated phospholipid micelles to target methicillin-resistant Staphylococcus aureus skin infections. ACS Infectious Diseases, 5, 443-453. doi: 10.1021/acsinfecdis.8b00319

Journal - Research Other

Alford, M. A., Pletzer, D., & Hancock, R. E. W. (2019). Dismantling the bacterial virulence program. Microbial Biotechnology, 12(3), 409-413. doi: 10.1111/1751-7915.13388

2018

Journal - Research Article

Pletzer, D., Mansour, S. C., & Hancock, R. E. W. (2018). Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens. PLoS Pathogens, 14(6), e1007084. doi: 10.1371/journal.ppat.1007084

Wolfmeier, H., Pletzer, D., Mansour, S. C., & Hancock, R. E. W. (2018). New perspectives in biofilm eradication. ACS Infectious Diseases, 4(2), 93-106. doi: 10.1021/acsinfecdis.7b00170

Wolfmeier, H., Mansour, S. C., Liu, L. T., Pletzer, D., & Draeger, A. (2018). Liposomal therapy attenuates dermonecrosis induced by community-associated methicillin-resistant Staphylococcus aureus by targeting α-type phenol-soluble modulins and α-hemolysin. EBioMedicine, 33, 211-217. doi: 10.1016/j.ebiom.2018.06.016

Windham, I. H., Servetas, S. L., Whitmire, J. M., Pletzer, D., Hancock, R. E. W., & Merrell, D. S. (2018). Helicobacter pylori biofilm formation is differentially affected by common culture conditions, and proteins play a central role in the biofilm matrix. Applied & Environmental Microbiology, 84(14), e00391-18. doi: 10.1128/AEM.00391-18

Luscher, A., Moynié, L., Auguste, P. S., Bumann, D., Mazza, L., Pletzer, D., … Köhler, T. (2018). TonB-dependent receptor repertoire of Pseudomonas aeruginosa for uptake of siderophore-drug conjugates. Antimicrobial Agents & Chemotherapy, 62(6), e00097-18. doi: 10.1128/AAC.00097-18

Journal - Research Other

Pletzer, D., & Hancock, R. E. W. (2018). Is synergy the key to treating high-density infections? Future Microbiology, 13(15), 1629-1632. doi: 10.2217/fmb-2018-0216

2017

Journal - Research Article

Pletzer, D., Wolfmeier, H., Bains, M., & Hancock, R. E. W. (2017). Synthetic peptides to target stringent response-controlled virulence in a Pseudomonas aeruginosa murine cutaneous infection model. Frontiers in Microbiology, 8, 1867. doi: 10.3389/fmicb.2017.01867

Moynié, L., Luscher, A., Rolo, D., Pletzer, D., Tortajada, A., Weingart, H., … Köhler, T. (2017). Structure and function of the PiuA and PirA siderophore-drug receptors from Pseudomonas aeruginosa and Acinetobacter baumannii. Antimicrobial Agents & Chemotherapy, 61, e02531-16. doi: 10.1128/AAC.02531-16

Pothula, K. R., Dhanasekar, N. N., Lamichhane, U., Younas, F., Pletzer, D., Benz, R., … Kleinekathöfer, U. (2017). Single residue acts as gate in OccK channels. Journal of Physical Chemistry B, 121, 2614-2621. doi: 10.1021/acs.jpcb.7b01787

Pletzer, D., Mansour, S. C., Wuerth, K., Rahanjam, N., & Hancock, R. E. W. (2017). New mouse model for chronic infections by gram-negative bacteria enabling the study of anti-infective efficacy and host-microbe interactions. mBio, 8(1), e00140-17. doi: 10.1128/mBio.00140-17

Chalhoub, H., Pletzer, D., Weingart, H., Braun, Y., Tunney, M. M., Elborn, J. S., … Van Bambeke, F. (2017). Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic. Scientific Reports, 7, 40208. doi: 10.1038/srep40208

Journal - Research Other

Belanger, C. R., Mansour, S. C., Pletzer, D., & Hancock, R. E. W. (2017). Alternative strategies for the study and treatment of clinical bacterial biofilms. Emerging Topics in Life Sciences, 1, 41-53. doi: 10.1042/ETLS20160020

2016

Journal - Research Article

Pletzer, D., Braun, Y., & Weingart, H. (2016). Swarming motility is modulated by expression of the putative xenosiderophore transporter SppR-SppABCD in Pseudomonas aeruginosa PA14. Antonie van Leeuwenhoek, 109, 737-753. doi: 10.1007/s10482-016-0675-8

Ganguly, S., Jimenez-Galisteo, G., Pletzer, D., Winterhalter, M., Benz, R., & Viñas, M. (2016). Draft genome sequence of Dietzia maris DSM 43672, a Gram-positive bacterium of the mycolata group. Genome Announcements, 4(3), e00542-16. doi: 10.1128/genomeA.00542-16

Abdallah, K., Hartman, K., Pletzer, D., Zhurina, D., & Ullrich, M. S. (2016). The bacteriophage-derived transcriptional regulator, LscR, activates the expression of levansucrase genes in Pseudomonas syringae. Molecular Microbiology, 102(6), 1062-1074. doi: 10.1111/mmi.13536

Mansour, S. C., Pletzer, D., de la Fuente-Núñez, C., Kim, P., Cheung, G. Y. C., Joo, H.-S., … Hancock, R. E. W. (2016). Bacterial abscess formation is controlled by the stringent stress response and can be targeted therapeutically. EBioMedicine, 12, 219-226. doi: 10.1016/j.ebiom.2016.09.015

Pletzer, D., Coleman, S. R., & Hancock, R. E. W. (2016). Anti-biofilm peptides as a new weapon in antimicrobial warfare. Current Opinion in Microbiology, 33, 35-40. doi: 10.1016/j.mib.2016.05.016

Journal - Research Other

Pletzer, D., & Hancock, R. E. W. (2016). Antibiofilm peptides: Potential as broadspectrum agents. Journal of Bacteriology, 198(19), 2572-2578. doi: 10.1128/JB.00017-16

2015

Journal - Research Article

Pletzer, D., Stahl, A., Oja, A. E., & Weingart, H. (2015). Role of the cell envelope stress regulators BaeR and CpxR in control of RND-type multidrug efflux pumps and transcriptional cross talk with exopolysaccharide synthesis in Erwinia amylovora. Archives of Microbiology, 197, 761-772. doi: 10.1007/s00203-015-1109-0

Pletzer, D., Braun, Y., Dubiley, S., Lafon, C., Köhler, T., Page, M. G. P., … Weingart, H. (2015). The Pseudomonas aeruginosa PA14 ABC transporter NppA1A2BCD is required for uptake of peptidyl nucleoside antibiotics. Journal of Bacteriology, 197(13), 2217-2228. doi: 10.1128/JB.00234-15

Stahl, A., Pletzer, D., Mehmood, A., & Ullrich, M. S. (2015). Marinobacter adhaerens HP15 harbors two CzcCBA efflux pumps involved in zinc detoxification. Antonie van Leeuwenhoek, 108, 649-658. doi: 10.1007/s10482-015-0520-5

Mehmood, A., Abdallah, K., Khandekar, S., Zhurina, D., Srivastava, A., Al-Karablieh, N., … Pletzer, D., & Ullrich, M. S. (2015). Expression of extra-cellular levansucrase in Pseudomonas syringae is controlled by the in planta fitness-promoting metabolic repressor HexR. BMC Microbiology, 15, 48. doi: 10.1186/s12866-015-0349-0

2014

Journal - Research Article

Karar, M. G. E., Pletzer, D., Jaiswal, R., Weingart, H., & Kuhnert, N. (2014). Identification, characterization, isolation and activity against Escherichia coli of quince (Cydonia oblonga) fruit polyphenols. Food Research International, 65(A), 121-129. doi: 10.1016/j.foodres.2013.10.040

Pletzer, D., Lafon, C., Braun, Y., Köhler, T., Page, M. G. P., Mourez, M., & Weingart, H. (2014). High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in pseudomonas aeruginosa. PLoS ONE, 9(10), e111311. doi: 10.1371/journal.pone.0111311

Johnston, C. D., Bannantine, J. P., Govender, R., Endersen, L., Pletzer, D., Weingart, H., … Sleator, R. D. (2014). Enhanced expression of codon optimized Mycobacterium avium subsp. paratuberculosis antigens in Lactobacillus salivarius. Frontiers in Cellular & Infection Microbiology, 4, 120. doi: 10.3389/fcimb.2014.00120

Khandekar, S., Srivastava, A., Pletzer, D., Stahl, A., & Ullrich, M. S. (2014). The conserved upstream region of lscB/C determines expression of different levansucrase genes in plant pathogen Pseudomonas syringae. BMC Microbiology, 14, 79. doi: 10.1186/1471-2180-14-79

Pletzer, D., & Weingart, H. (2014). Characterization of AcrD, a Resistance-Nodulation-Cell Division-type multidrug efflux pump from the fire blight pathogen Erwinia amylovora. BMC Microbiology, 14, 13. doi: 10.1186/1471-2180-14-13

Pletzer, D., & Weingart, H. (2014). Characterization and regulation of the Resistance-Nodulation-Cell Division-type multidrug efflux pumps MdtABC and MdtUVW from the fire blight pathogen Erwinia amylovora. BMC Microbiology, 14, 185. doi: 10.1186/1471-2180-14-185

Pletzer, D., Schweizer, G., & Weingart, H. (2014). AraC/XylS family stress response regulators Rob, SoxS, PliA, and OpiA in the fire blight pathogen Erwinia amylovora. Journal of Bacteriology, 196(17), 3098-3110. doi: 10.1128/JB.01838-14

2013

Journal - Research Article

Johnston, C., Douarre, P. E., Soulimane, T., Pletzer, D., Weingart, H., MacSharry, J., … O'Mahony, J. (2013). Codon optimisation to improve expression of a Mycobacterium avium ssp. paratuberculosis-specific membrane-associated antigen by Lactobacillus salivarius. Pathogens & Disease, 68, 27-38. doi: 10.1111/2049-632X.12040

2009

Journal - Research Article

Veyrier, F., Pletzer, D., Turenne, C., & Behr, M. A. (2009). Phylogenetic detection of horizontal gene transfer during the step-wise genesis of Mycobacterium tuberculosis. BMC Evolutionary Biology, 9, 196. doi: 10.1186/1471-2148-9-196