Associate Professor Jaydee Cabral

Contact Details

Phone: +64 3 479 7738
Email: jaydee.cabral@otago.ac.nz

University Links

Position

Research Associate Professor

Department

Department of Microbiology and Immunology

Qualifications

PhD

Research summary

Biomedical science, biomaterial, regenerative medicines and tissue engineering

Teaching

Postgraduate Bioengineering papers

Memberships

American Chemical Society
NZ Institute of Chemistry
Society for Biomaterials
Tissue and Regenerative Medicine Society
International Society of Biofabrication
Royal Society of NZ
Associate Investigator Maurice Wilkins Centre
Editorial Board member Frontiers in Bioengineering & Biotechnology and Journal of Biomaterial Applications
Reviewer Board member Marine Drugs

Clinical

Wound healing, regenerative medicine

Research

Dr Cabral's research applies an interdisciplinary approach to the development and characterization of medical devices, biomaterials, and bioengineered scaffolds.

She played a key role in the development of an FDA-approved, commercialised chitosan / dextran-based hydrogel, Chitogel. It is a post-operative surgical aid in the prevention of adhesion formation in ENT surgeries.

She utilizes polymer synthesis, chemical and physical characterization techniques, microbiological analysis, as well as in vitro mammalian tissue culture and in vivo mouse models.

Her laboratory possesses the latest in 3D bioprinting technology, the GeSIM 3.1 Bioscaffolder, the only one of its kind in NZ. She was awarded a Health Research Council Explorer and Lottery Health funded grants to develop 3D bioprinted vascularized, regenerative 'living dressings' for the treatment of chronic wounds.

She is interested in increasing biomaterial / bioink multifunctionality for the delivery of adult stem cells, among other cell types; using a variety of 3D printing techniques in order to make more in vivo-like 3D constructs for regenerative medicine and tissue engineering purposes.

Her current MBIE funded Smart Ideas project is to develop a novel medical device for drug delivery to the inner ear to treat hearing loss.

Publications

Thorsnes, Q. S., Turner, P. R., Ali, M. A., & Cabral, J. D. (2023). Integrating fused deposition modeling and melt electrowriting for engineering branched vasculature. Biomedicines, 11, 3139. doi: 10.3390/biomedicines11123139 Journal - Research Article

Kok, J. M. L., Dowd, G. C., Cabral, J. D., & Wise, L. M. (2023). Macrocystis pyrifera lipids reduce cytokine-induced pro-inflammatory signalling and barrier dysfunction in human keratinocyte models. International Journal of Molecular Sciences, 24, 1638. doi: 10.3390/ijms242216383 Journal - Research Article

Kok, J. M. L., Dowd, G. C., Cabral, J. D., & Wise, L. (2023). Investigating the effects of an omega-3 rich brown seaweed extract on atopic dermatitis in a keratinocytes raft model. Journal of Investigative Dermatology, 143, (pp. S334). doi: 10.1016/j.jid.2023.09.016 Conference Contribution - Published proceedings: Abstract

Rajabi, M., Cabral, J. D., Saunderson, S., Gould, M., & Ali, M. A. (2023). Development and optimisation of hydroxyapatite-polyethylene glycol diacrylate hydrogel inks for 3D printing of bone tissue engineered scaffolds. Biomedical Materials, 18, 065009. doi: 10.1088/1748-605X/acf90a Journal - Research Article

Thorsnes, Q., Ali, A., & Cabral, J. (2023, July). Novel additive manufacturing techniques for vascular bioscaffolds. Verbal presentation at the Faculty of Dentistry Clinical and Research Excellence Symposium, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

2023

Journal - Research Article

Rajabi, M., Cabral, J. D., Saunderson, S., & Ali, M. A. (2023). 3D printing of chitooligosaccharide-polyethylene glycol diacrylate hydrogel inks for bone tissue regeneration. Journal of Biomedical Materials Research Part A, 111, 1468-1481. doi: 10.1002/jbm.a.37548

Fahma, F., Firmanda, A., Cabral, J., Pletzer, D., Fisher, J., Mahadik, B., … Wulandari, A. (2023). Three-dimensional printed cellulose for wound dressing applications. 3D Printing & Additive Manufacturing, 10(5), 1015-1035. doi: 10.1089/3dp.2021.0327

Journal - Research Other

Yoshida, M., Turner, P. R., & Cabral, J. D. (2023). Intervertebral disc tissue engineering using additive manufacturing. Gels, 9, 25. doi: 10.3390/gels9010025

Conference Contribution - Published proceedings: Abstract

Conference Contribution - Verbal presentation and other Conference outputs

2022

Journal - Research Article

Firmanda, A., Fahma, F., Syamsu, K., Cabral, J., Pletzer, D., & Gustiananda, M. (2022). Cellulose composites containing active constituents of coffee and tea: A prospective novel wound dressing [Review]. Materials Advances, 3, 7463-7483. doi: 10.1039/D2MA00642A

Rajabi, M., Cabral, J., Saunderson, S., & Ali, M. A. (2022). Green synthesis of chitooligosaccharide-PEGDA derivatives through aza-Michael reaction for biomedical applications. Carbohydrate Polymers, 295, 119884. doi: 10.1016/j.carbpol.2022.119884

Turner, P. R., McConnell, M., Young, S. L., & Cabral, J. D. (2022). 3D living dressing improves healing and modulates immune response in a thermal injury model. Tissue Engineering Part C: Methods, 28(8), 431-439. doi: 10.1089/ten.TEC.2022.0088

Kok, J. M. L., Dowd, G., Cabral, J., & Wise, L. (2022). Time-dependent anti-inflammatory effects of a lipid extract from Macrocystis pyrifera on toll-like receptor 2 signaling in human THP-1 monocytes. Planta Medica International Open, 9, e80-e89. doi: 10.1055/a-1729-3654

Yoshida, M., Turner, P. R., McAdam, C. J., Ali, M. A., & Cabral, J. D. (2022). A comparison between β-tricalcium phosphate verse chitosan poly-caprolactone-based 3D melt extruded composite scaffolds. Biopolymers, 113, e23482. doi: 10.1002/bip.23482

Journal - Research Other

Firmanda, A., Syamsu, K., Sari, Y. W., Cabral, J., Pletzer, D., Mahadik, B., … Fahma, F. (2022). 3D printed cellulose based product applications. Materials Chemistry Frontiers, 6, 254-279. doi: 10.1039/d1qm00390a

Conference Contribution - Published proceedings: Abstract

Berry-Kilgour, C. R. H., Oey, I., Cabral, J. D., Dowd, G. C., & Wise, L. M. (2022). Decellularised seaweed as a novel biomaterial for treatment of skin wounds. In L. Wilson, H. Harcombe, P. Jayakaran, L. Burga, J. Antony, K. Morgaine, M. Garelja, A. Middleton, M. Anwar & T. Milne (Eds.), Proceedings of the 263rd Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839

Conference Contribution - Poster Presentation (not in published proceedings)

Rajabi, M., Ali, A., Cabral, J., & Saunderson, S. (2022, August). Chitooligosaccharide-based inks for 3D printing of hard tissue scaffolds. Poster session presented at the Advances in Microscopy Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Cabral, J. (2022, September). Development of peptide-functionalized hydrogel biolinks to create 3D living wound dressings. Verbal presentation at the Postgraduate & Early Career Researchers Committee (PERC) & Division of Health Sciences Early & Mid-Career Researcher (EMCR) Joint Research Symposium, Dunedin, New Zealand.

2021

Journal - Research Article

Rajabi, M., McConnell, M., Cabral, J., & Ali, A. (2021). Chitosan hydrogels in 3D printing for biomedical applications. Carbohydrate Polymers, 250, 117768. doi: 10.1016/j.carbpol.2021.117768

Yoshida, M., Turner, P. R., Ali, A., & Cabral, J. D. (2021). Three-dimensional melt-electrowritten polycaprolactone/chitosan scaffolds enhance mesenchymal stem cell behavior. ACS Applied Bio Materials, 4, 1319-1329. doi: 10.1021/acsabm.0c01213

Journal - Research Other

Berry-Kilgour, C., Cabral, J., & Wise, L. (2021). Advancements in the delivery of growth factors and cytokines for the treatment of cutaneous wound indications [Invited]. Advances in Wound Care, 10(11), 596-622. doi: 10.1089/wound.2020.1183

2020

Journal - Research Article

Turner, P. R., Yoshida, M., Ali, M. A., & Cabral, J. D. (2020). Melt electrowitten sandwich scaffold technique using Sulforhodamine B to monitor stem cell behavior. Tissue Engineering Part C: Methods, 26(10), 519-527. doi: 10.1089/ten.TEC.2020.0240

Turner, P. R., Murray, E., McAdam, C. J., McConnell, M. A., & Cabral, J. D. (2020). Peptide chitosan/dextran core/shell vascularized 3D constructs for wound healing. ACS Applied Materials & Interfaces, 12, 32328-32339. doi: 10.1021/acsami.0c07212

Journal - Research Other

Rajabi, M., Ali, A., McConnell, M., & Cabral, J. (2020). Keratinous materials: Structures and functions in biomedical applications. Materials Science & Engineering: C, 110, 110612. doi: 10.1016/j.msec.2019.110612

2019

Journal - Research Article

Hewitt, E., Mros, S., McConnell, M., Cabral, J. D., & Ali, A. (2019). Melt-electrowriting with novel milk protein/PCL biomaterials for skin regeneration. Biomedical Materials, 14, 055013. doi: 10.1088/1748-605X/ab3344

Conference Contribution - Published proceedings: Abstract

Cabral, J. D., Murray, E., McAdam, C. J., & Turner, P. R. (2019). Chitosan/dextran-based 3D bioprinted core/shell regenerative constructs. Proceedings of the Tissue Engineering and Regenerative Medicine International Society Americas Chapter Meeting (TERMIS AM). 154. Retrieved from https://termis.org/index.php?q=chapters-americas

Conference Contribution - Verbal presentation and other Conference outputs

Cabral, J. D., Murray, E., Turner, P., & Wise, L. (2019, August-September). Wound healing biomaterials as cell and drug delivery vehicles. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Yoshida, M., Ali, A., & Cabral, J. (2019, August-September). Development and in vitro biocompatibility of 3D printed scaffolds for intervertebral disc tissue engineering. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Journal - Research Article

Intini, C., Elviri, L., Cabral, J., Mros, S., Bergonzi, C., Bianchera, A., … McConnell, M. (2018). 3D-printed chitosan-based scaffolds: An in vitro study of human skin cell growth and an in-vivo wound healing evaluation in experimental diabetes in rats. Carbohydrate Polymers, 199, 593-602. doi: 10.1016/j.carbpol.2018.07.057

Conference Contribution - Verbal presentation and other Conference outputs

Cabral, J. (2018, April). Biomaterials for cell therapy. Verbal presentation at the University of Otago Centre for Bioengineering & Nanomedicine Symposium: Biomaterials and Regenerative Medicine, Dunedin, New Zealand.

Other Research Output

Cabral, J. (2018, September). Wound healing biomaterials as post-surgical aides: 3D bioinks and drug release delivery vehicles. Department of Microbiology & Immunology, University of Otago, Dunedin, New Zealand. [Department Seminar].

2017

Chapter in Book - Research

Moratti, S. C., & Cabral, J. D. (2017). Antibacterial properties of chitosan. In J. A. Jennings & J. D. Bumgardner (Eds.), Chitosan based biomaterials (Vol. 1: Fundamentals). (pp. 31-44). Elsevier. doi: 10.1016/B978-0-08-100230-8.00002-9

Journal - Research Article

Nelson, V. J., Dinnunhan, M. F. K., Turner, P. R., Faed, J. M., & Cabral, J. D. (2017). A chitosan/dextran-based hydrogel as a delivery vehicle of human bone-marrow derived mesenchymal stem cells. Biomedical Materials, 12(3), 035012. doi: 10.1088/1748-605X/aa70f2

2016

Chapter in Book - Research

Cabral, J. D. (2016). Antimicrobial polymeric hydrogels. In S. Kalia (Ed.), Polymeric hydrogels as smart biomaterials. (pp. 153-170). Cham, Switzerland: Springer. doi: 10.1007/978-3-319-25322-0_6

Journal - Research Article

Jalalvandi, E., Cabral, J., Hanton, L. R., & Moratti, S. C. (2016). Cyclodextrin-polyhydrazine degradable gels for hydrophobic drug delivery. Materials Science & Engineering: C, 69, 144-153. doi: 10.1016/j.msec.2016.06.058

Ghosh, S., Cabral, J. D., Hanton, L. R., & Moratti, S. C. (2016). Strong poly(ethylene oxide) based gel adhesives via oxime cross-linking. Acta Biomaterialia, 29, 206-214. doi: 10.1016/j.actbio.2015.10.018

Conference Contribution - Verbal presentation and other Conference outputs

Cabral, J. D., Nelson, V., Faed, J., Hanton, L., & Moratti, S. (2016, August-September). Development and characterization of chitosan/dextran-based hydrogels for adult stem cell delivery. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Chan, M., Brooks, H. J. L., Moratti, S. C., Hanton, L. R., & Cabral, J. D. (2015). Reducing the oxidation level of dextran aldehyde in a chitosan/dextran-based surgical hydrogel increases biocompatibility and decreases antimicrobial efficacy. International Journal of Molecular Sciences, 16(6), 13798-13814. doi: 10.3390/ijms160613798

Cabral, J. D., McConnell, M. A., Fitzpatrick, C., Mros, S., Williams, G., Wormald, P. J., Moratti, S. C., & Hanton, L. R. (2015). Characterization of the in vivo host response to a bi-labeled chitosan-dextran based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part A, 103(8), 2611-2620. doi: 10.1002/jbm.a.35395

Aziz, M. A., Cabral, J. D., Brooks, H. J. L., McConnell, M. A., Fitzpatrick, C., Hanton, L. R., & Moratti, S. C. (2015). In vitro biocompatibility and cellular interactions of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Biomedical Materials Research Part B, 103(2), 332-341. doi: 10.1002/jbm.b.33206

2014

Journal - Research Article

Cabral, J. D., Roxburgh, M., Shi, Z., Liu, L., McConnell, M., Williams, G., … Hanton, L. R., Simpson, J., Moratti, S. C., Robinson, B. H., … Robinson, S. (2014). Synthesis, physiochemical characterization, and biocompatibility of a chitosan/dextran-based hydrogel for postsurgical adhesion prevention. Journal of Materials Science: Materials in Medicine, 25(12), 2743-2756. doi: 10.1007/s10856-014-5292-3

Conference Contribution - Verbal presentation and other Conference outputs

Cabral, J., Hanton, L., Moratti, S., McConnell, M., Fitzpatrick, C., & Mros, S. (2014, November). In vivo biodistribution, biodegradation, and inflammatory response of a NIR/[3H]-chitosan/dextran-based hydrogel for post-surgical adhesion prevention. Verbal presentation at the Devices for Diagnostics and Drug Delivery (D4) Conference, Dunedin, New Zealand.

2013

Conference Contribution - Verbal presentation and other Conference outputs

Cabral, J. (2013, October). In vitro and in vivo biocompatibility of a chitosan/dextran-based surgical hydrogel. Verbal presentation at the Polymers in Medicine and Biology Conference, Santa Rosa, CA.

McConnell, M. A., Brooks, H. J., Moratti, S. C., Hanton, L. R., & Cabral, J. D. (2013, July). In vitro and in vivo biocompatibility of a chitosan/dextan-based surgical hydrogel. Plenary presentation at the ChemEd Conference, Dunedin, New Zealand.

Cabral, J. (2013, December). In vitro and in vivo biocompatibility of a chitosan/dextran-based surgical hydrogel. Verbal presentation at the 12th International Conference on Frontiers of Polymers and Advanced Materials (ICFPAM), Auckland, New Zealand.

2012

Journal - Research Article

Cabral, J. D., & Moratti, S. C. (2012). Advances in biomedical hydrogels. Chemistry in New Zealand, 76(2), 44-48.

Aziz, M. A., Cabral, J. D., Brooks, H. J. L., Moratti, S. C., & Hanton, L. R. (2012). Antimicrobial properties of a chitosan dextran-based hydrogel for surgical use. Antimicrobial Agents & Chemotherapy, 56(1), 280-287. doi: 10.1128/aac.05463-11

Conference Contribution - Published proceedings: Abstract

Cabral, J. D., Aziz, M. A., Moratti, S. C., Brooks, H., Hanton, L. R., & Boissezon, R. (2012). Physical characterization and biocompatibility of a chitosan/dextran-based hydrogel for surgical use. Proceedings of the 243rd American Chemical Society (ACS) National Meeting & Exposition. Retrieved from http://www.acs.org/content/acs/en/meetings/nationalmeetings/programarchive.html

Conference Contribution - Verbal presentation and other Conference outputs

Cabral, J. D., Aziz, M. A., McConnell, M. A., Brooks, H. J., Williams, G., Hanton, L. R., & Moratti, S. C. (2012, October). Characterization of chitosan/dextran-based surgical hydrogel. Verbal presentation at the International Union of Pure and Applied Chemistry (IUPAC) 8th International Conference on Novel Materials and their Synthesis (NMS-VIII) & 22nd International Symposium on Fine Chemistry and Functional Polymers (FCFP-XXII), Xi'an, China.

2011

Journal - Research Article

Valentine, R., Boase, S., Jervis-Bardy, J., Cabral, J.-D. D., Robinson, S., & Wormald, P.-J. (2011). The efficacy of hemostatic techniques in the sheep model of carotid artery injury. International Forum of Allergy & Rhinology, 1(2), 118-122. doi: 10.1002/alr.20033

Cabral, J., & Moratti, S. C. (2011). Hydrogels for biomedical applications. Future Medicinal Chemistry, 3(15), 1877-1888. doi: 10.4155/fmc.11.134

Conference Contribution - Verbal presentation and other Conference outputs

Aziz, M., Moratti, S., Brooks, H., Hanton, L., & Cabral, J. (2011, November). Antimicrobial properties of chitosan/dextran based hydrogels for surgical use. Verbal presentation at the 3rd Biohydrogels International Congress, Florence, Italy.

2010

Conference Contribution - Published proceedings: Abstract

Cabral, J., Moratti, S., Hanton, L., Aziz, M., Kirchhoefer, C., Bork, O., & Brooks, H. (2010). Drug release studies and biological properties of chitosan/dextran-based hydrogels for surgical use. Proceedings of the International Chemical Congress of Pacific Basin Societies (Pacifichem). Retrieved from http://pacifichem.abstractcentral.com/planner