Dr Rachael Augustine

Contact Details
- Position
- Research Fellow
- Department
- Department of Physiology
- Qualifications
- BSc PGDipSci MSc PhD
- Research summary
- The regulation of sympathetic nerve activity by the hypothalamic neurons that synthesise oxytocin
Publications
Kumar, S. S., Bouwer, G. T., Jackson, M. K., Perkinson, M. R., McDonald, F. J., Brown, C. H., & Augustine, R. A. (2023). Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse. Brain Structure & Function, 228, 1535-1548. doi: 10.1007/s00429-023-02670-7
Abbasi, M., Augustine, R. A., Iremonger, K. J., & Brown, C. H. (2022). Central kisspeptin does not affect ERK1/2 or p38 phosphorylation in oxytocin neurons of late-pregnant rats. International Journal of Molecular Sciences, 23(14), 7729. doi: 10.3390/ijms23147729
Perkinson, M. R., Kirchner, M. K., Zhang, M., Augustine, R. A., Stern, J. E., & Brown, C. H. (2022). α-Melanocyte-stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation. Physiological Reports, 10, e15226. doi: 10.14814/phy2.15226
Sethi, S., Augustine, R. A., Bouwer, G. T., Perkinson, M. R., Cheong, I., Bussey, C. T., Schwenke, D. O., Brown, C. H., & Lamberts, R. R. (2021). Increased neuronal activation in sympathoregulatory regions of the brain and spinal cord in type 2 diabetic rats. Journal of Neuroendocrinology, 33, e13016. doi: 10.1111/jne.13016
Perkinson, M., Augustine, R. A., Bouwer, G. T., Brown, E. F., Cheong, I., Seymour, A. J., Fronius, M., & Brown, C. H. (2021). Plasticity in intrinsic excitability of hypothalamic magnocellular neurosecretory neurons in late-pregnant and lactating rats. International Journal of Molecular Sciences, 22(13), 7140. doi: 10.3390/ijms22137140
Woodside, B., Augustine, R. A., Ladyman, S. R., Naef, L., & Grattan, D. R. (2008). Role of prolactin in the metabolic adaptations to pregnancy and lactation. In R. S. Bridges (Ed.), Neurobiology of the parental brain. (pp. 249-267). London: Academic Press.
Chapter in Book - Research
Kumar, S. S., Bouwer, G. T., Jackson, M. K., Perkinson, M. R., McDonald, F. J., Brown, C. H., & Augustine, R. A. (2023). Kisspeptin neuron projections to oxytocin neurons are not necessary for parturition in the mouse. Brain Structure & Function, 228, 1535-1548. doi: 10.1007/s00429-023-02670-7
Journal - Research Article
Abbasi, M., Augustine, R. A., Iremonger, K. J., & Brown, C. H. (2022). Central kisspeptin does not affect ERK1/2 or p38 phosphorylation in oxytocin neurons of late-pregnant rats. International Journal of Molecular Sciences, 23(14), 7729. doi: 10.3390/ijms23147729
Journal - Research Article
Perkinson, M. R., Kirchner, M. K., Zhang, M., Augustine, R. A., Stern, J. E., & Brown, C. H. (2022). α-Melanocyte-stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation. Physiological Reports, 10, e15226. doi: 10.14814/phy2.15226
Journal - Research Article
Nair, B. B., Khant Aung, Z., Porteous, R., Prescott, M., Glendining, K. A., Jenkins, D. E., Augustine, R. A., Silva, M. S. B., Yip, S. H., Bouwer, G. T., Brown, C. H., Jasoni, C. L., Campbell, R. E., Bunn, S. J., Anderson, G. M., Grattan, D. R., Herbison, A. E., & Iremonger, K. J. (2021). Impact of chronic variable stress on neuroendocrine hypothalamus and pituitary in male and female C57BL/6J mice. Journal of Neuroendocrinology, 33, e12972. doi: 10.1111/jne.12972
Journal - Research Article
Perkinson, M., Augustine, R. A., Bouwer, G. T., Brown, E. F., Cheong, I., Seymour, A. J., Fronius, M., & Brown, C. H. (2021). Plasticity in intrinsic excitability of hypothalamic magnocellular neurosecretory neurons in late-pregnant and lactating rats. International Journal of Molecular Sciences, 22(13), 7140. doi: 10.3390/ijms22137140
Journal - Research Article
Sethi, S., Augustine, R. A., Bouwer, G. T., Perkinson, M. R., Cheong, I., Bussey, C. T., Schwenke, D. O., Brown, C. H., & Lamberts, R. R. (2021). Increased neuronal activation in sympathoregulatory regions of the brain and spinal cord in type 2 diabetic rats. Journal of Neuroendocrinology, 33, e13016. doi: 10.1111/jne.13016
Journal - Research Article
Augustine, R. A., Knowles, P. J., Khant Aung, Z., Grattan, D. R., & Ladyman, S. R. (2019). Impaired hypothalamic leptin sensitivity in pseudopregnant rats treated with chronic prolactin to mimic pregnancy. Journal of Neuroendocrinology, 31, e12702. doi: 10.1111/jne.12702
Journal - Research Article
Roy, R. K., Augustine, R. A., Brown, C. H., & Schwenke, D. O. (2019). Acute myocardial infarction activates magnocellular vasopressin and oxytocin neurons. Journal of Neuroendocrinology, 31, e12808. doi: 10.1111/jne.12808
Journal - Research Article
Roy, R. K., Augustine, R. A., Brown, C. H., & Schwenke, D. O. (2018). Activation of oxytocin neurons in the paraventricular nucleus drives cardiac sympathetic nerve activation following myocardial infarction in rats. Communications Biology, 1, 160. doi: 10.1038/s42003-018-0169-5
Journal - Research Article
Augustine, R. A., Ladyman, S. R., Bouwer, G. T., Alyousif, Y., Sapsford, T. J., Scott, V., Kokay, I. C., Grattan, D. R., & Brown, C. H. (2017). Prolactin regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Physiology, 595(11), 3591-3605. doi: 10.1113/jp273712
Journal - Research Article
Seymour, A. J., Scott, V., Augustine, R. A., Bouwer, G. T., Campbell, R. E., & Brown, C. H. (2017). Development of an excitatory kisspeptin projection to the oxytocin system in late pregnancy. Journal of Physiology, 595(3), 825-838. doi: 10.1113/jp273051
Journal - Research Article
Augustine, R. A., Bouwer, G. T., Seymour, A. J., Grattan, D. R., & Brown, C. H. (2016). Reproductive regulation of gene expression in the hypothalamic supraoptic and paraventricular nuclei. Journal of Neuroendocrinology, 28(4). doi: 10.1111/jne.12350
Journal - Research Article
Ladyman, S. R., Augustine, R. A., Scherf, E., Phillipps, H. R., Brown, C. H., & Grattan, D. R. (2016). Attenuated hypothalamic responses to α-melanocyte stimulating hormone during pregnancy in the rat. Journal of Physiology, 594(4), 1087-1101. doi: 10.1113/jp271605
Journal - Research Article
Rizwan, M. Z., Poling, M. C., Corr, M., Cornes, P. A., Augustine, R. A., Quennell, J. H., … Anderson, G. M. (2012). RFamide-related peptide-3 receptor gene expression in GnRH and kisspeptin neurons and GnRH-dependent mechanism of action. Endocrinology, 153(8), 3770-3779. doi: 10.1210/en.2012-1133
Journal - Research Article
Quennell, J. H., Howell, C. S., Roa, J., Augustine, R. A., Grattan, D. R., & Anderson, G. M. (2011). Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice. Endocrinology, 152(4), 1541-1550. doi: 10.1210/en.2010-1100
Journal - Research Article
Koch, C., Augustine, R. A., Steger, J., Ganjam, G. K., Benzler, J., Pracht, C., … Anderson, G. M., Grattan, D. R., & Tups, A. (2010). Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. Journal of Neuroscience, 30(48), 16180-16187. doi: 10.1523/JNEUROSCI.3202-10.2010
Journal - Research Article
Ladyman, S. R., Augustine, R. A., & Grattan, D. R. (2010). Hormone interactions regulating energy balance during pregnancy. Journal of Neuroendocrinology, 22, 805-817. doi: 10.1111/j.1365-2826.2010.02017.x
Journal - Research Article
Tups, A., Anderson, G. M., Rizwan, M., Augustine, R. A., Chaussade, C., Shepherd, P. R., & Grattan, D. R. (2010). Both p110α and p110β isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus. Journal of Neuroendocrinology, 22(6), 534-542. doi: 10.1111/j.1365-2826.2010.01975.x
Journal - Research Article
Ladyman, S. R., Tups, A., Augustine, R. A., Swahn-Azavedo, A., Kokay, I. C., & Grattan, D. R. (2009). Loss of hypothalamic response to leptin during pregnancy associated with development of melanocortin resistance. Journal of Neuroendocrinology, 21(5), 449-456. doi: 10.1111/j.1365-2826.2009.01862.x
Journal - Research Article
Augustine, R. A., & Grattan, D. R. (2008). Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology, 149(3), 1049-1055. doi: 10.1210/en.2007-1018
Journal - Research Article
Augustine, R. A., Ladyman, S. R., & Grattan, D. R. (2008). From feeding one to feeding many: Hormone-induced changes in bodyweight homeostasis during pregnancy (Symposium report). Journal of Physiology, 586(2), 387-397. doi: 10.1113/jphysiol.2007.146316
Journal - Research Article
Grattan, D. R., Ladyman, S. R., & Augustine, R. A. (2007). Hormonal induction of leptin resistance during pregnancy. Physiology & Behavior, 91, 366-374.
Journal - Research Article
Augustine, R. A., Kokay, I. C., Andrews, Z. B., Ladyman, S. R., & Grattan, D. R. (2003). Quantitation of prolactin receptor mRNA in the maternal rat brain during pregnancy and lactation. Journal of Molecular Endocrinology, 31, 221-232.
Journal - Research Article
Grattan, D. R., Pi, X. J., Andrews, Z. B., Augustine, R. A., Kokay, I. C., Summerfield, M. R., Todd, B., & Bunn, S. J. (2001). Prolactin receptors in the brain during pregnancy and lactation: Implications for behaviour. Hormones & Behavior, 40, 115-124.
Journal - Research Article
Augustine, R. A., Seymour, A. J., Campbell, R. E., Grattan, D. R., & Brown, C. H. (2018). Integrative neurohumoral regulation of oxytocin neurone activity in pregnancy and lactation. Journal of Neuroendocrinology, 30(8), e12569. doi: 10.1111/jne.12569
Journal - Research Other