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Contact Details

Email
nils.birkholz@otago.ac.nz
Position
Postdoctoral Fellow
Department
Department of Microbiology and Immunology
Research summary
Bacterial defence systems and mobile genetic elements

Publications

Mayo-Muñoz, D., Pinilla-Redondo, R., Camara-Wilpert, S., Birkholz, N., & Fineran, P. C. (2024). Inhibitors of bacterial immune systems: Discovery, mechanisms and applications. Nature Reviews Genetics. Advance online publication. doi: 10.1038/s41576-023-00676-9

Mayo-Muñoz, D., Pinilla-Redondo, R., Birkholz, N., & Fineran, P. C. (2023). A host of armor: Prokaryotic immune strategies against mobile genetic elements. Cell Reports, 42(7), 112672. doi: 10.1016/j.celrep.2023.112672

Kim, G. E., Lee, S. Y., Birkholz, N., Kamata, K., Jeong, J.-H., Kim, Y.-G., Fineran, P. C., & Park, H. H. (2022). Molecular basis of dual anti-CRISPR and auto-regulatory functions of AcrIF24. Nucleic Acids Research, 50(19), 11344-11358. doi: 10.1093/nar/gkac880

Shehreen, S., Birkholz, N., Fineran, P. C., & Brown, C. M. (2022). Widespread repression of anti-CRISPR production by anti-CRISPR-associated proteins. Nucleic Acids Research, 50(15), 8615-8625. doi: 10.1093/nar/gkac674

Lee, S. Y., Birkholz, N., Fineran, P. C., & Park, H. H. (2022). Molecular basis of anti-CRISPR operon repression by Aca10. Nucleic Acids Research, 50(15), 8919-8928. doi: 10.1093/nar/gkac656

Mayo-Muñoz, D., Pinilla-Redondo, R., Camara-Wilpert, S., Birkholz, N., & Fineran, P. C. (2024). Inhibitors of bacterial immune systems: Discovery, mechanisms and applications. Nature Reviews Genetics. Advance online publication. doi: 10.1038/s41576-023-00676-9

Journal - Research Article

Birkholz, N., Jackson, S. A., Fagerlund, R. D., & Fineran, P. C. (2022). A mobile restriction-modification system provides phage defence and resolves an epigenetic conflict with an antagonistic endonuclease. Nucleic Acids Research, 50(6), 3348-3361. doi: 10.1093/nar/gkac147

Journal - Research Article

Kim, G. E., Lee, S. Y., Birkholz, N., Kamata, K., Jeong, J.-H., Kim, Y.-G., Fineran, P. C., & Park, H. H. (2022). Molecular basis of dual anti-CRISPR and auto-regulatory functions of AcrIF24. Nucleic Acids Research, 50(19), 11344-11358. doi: 10.1093/nar/gkac880

Journal - Research Article

Lee, S. Y., Birkholz, N., Fineran, P. C., & Park, H. H. (2022). Molecular basis of anti-CRISPR operon repression by Aca10. Nucleic Acids Research, 50(15), 8919-8928. doi: 10.1093/nar/gkac656

Journal - Research Article

Shehreen, S., Birkholz, N., Fineran, P. C., & Brown, C. M. (2022). Widespread repression of anti-CRISPR production by anti-CRISPR-associated proteins. Nucleic Acids Research, 50(15), 8615-8625. doi: 10.1093/nar/gkac674

Journal - Research Article

Usher, B., Birkholz, N., Beck, I. N., Fagerlund, R. D., Jackson, S. A., Fineran, P. C., & Blower, T. R. (2021). Crystal structure of the anti-CRISPR repressor Aca2. Journal of Structural Biology, 213, 107752. doi: 10.1016/j.jsb.2021.107752

Journal - Research Article

Birkholz, N., Fagerlund, R. D., Smith, L. M., Jackson, S. A., & Fineran, P. C. (2019). The autoregulator Aca2 mediates anti-CRISPR repression. Nucleic Acids Research, 47(18), 9658-9665. doi: 10.1093/nar/gkz721

Journal - Research Article

Jackson, S. A., Birkholz, N., Malone, L. M., & Fineran, P. C. (2019). Imprecise spacer acquisition generates CRISPR-Cas immune diversity through primed adaptation. Cell Host & Microbe, 25, 250-260. doi: 10.1016/j.chom.2018.12.014

Journal - Research Article

Mayo-Muñoz, D., Pinilla-Redondo, R., Birkholz, N., & Fineran, P. C. (2023). A host of armor: Prokaryotic immune strategies against mobile genetic elements. Cell Reports, 42(7), 112672. doi: 10.1016/j.celrep.2023.112672

Journal - Research Other

Birkholz, N., & Fineran, P. C. (2022). Turning down the (C)BASS: Phage-encoded inhibitors jam bacterial immune signaling. Molecular Cell, 82(12), 2185-2187. doi: 10.1016/j.molcel.2022.05.030

Journal - Research Other

Malone, L. M., Birkholz, N., & Fineran, P. C. (2021). Conquering CRISPR: How phages overcome bacterial adaptive immunity. Current Opinion in Biotechnology, 68, 30-36. doi: 10.1016/j.copbio.2020.09.008

Journal - Research Other

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