Professor Gregory Cook

Schulz, S., Iglesias-Cans, M., Krah, A., Yildiz, Ö., Leone, V., Matthies, D., Cook, G. M., … Meier, T. (2013). A new type of Na⁺-driven ATP synthase membrane rotor with a two-carboxylate ion-coupling motif. PLoS Biology, 11(6), e1001596. doi: 10.1371/journal.pbio.1001596 Journal - Research Article

McMillan, D. G. G., Keis, S., Dimroth, P., & Cook, G. M. (2007). A specific adaptation in the a subunit of thermoalkaliphilic F₁F_o-ATP synthase enables ATP synthesis at high pH but not at neutral pH values. Journal of Biological Chemistry, 282(24), 17395-17404. Journal - Research Article

Meier, T., Morgner, N., Matthies, D., Pogoryelov, D., Keis, S., Cook, G. M., … Brutschy, B. (2007). A tridecameric c ring of the adenosine triphosphate (ATP) synthase from the thermoalkaliphilic Bacillus sp. strain TA2.A1 facilitates ATP synthesis at low electrochemical proton potential. Molecular Microbiology, 65(5), 1181-1192. Journal - Research Article

Gauntlett, J. C., Gebhard, S., Keis, S., Manson, J. M., Pos, K. M., & Cook, G. M. (2008). Molecular analysis of BcrR, a membrane-bound bacitracin sensor and DNA-binding protein from Enterococcus faecalis. Journal of Biological Chemistry, 283(13), 8591-8600. doi: 10.1074/jbc.M709503200 Journal - Research Article

Berney, M., & Cook, G. M. (2010). Unique flexibility in energy metabolism allows mycobacteria to combat starvation and hypoxia. PLoS ONE, 5(1), e8614. doi: 10.1371/journal.pone.0008614 Journal - Research Article

Cook, G. M., Berney, M., Gebhard, S., Heinemann, M., Cox, R. A., Danilchanka, O., & Niederweis, M. (2009). Physiology of mycobacteria. In R. K. Poole (Ed.), Advances in microbial physiology (Vol. 55). (pp. 83-183). London: Elsevier. doi: 10.1016/s0065-2911(09)05502-7 Chapter in Book - Research

McMillan, D. G. G., Ferguson, S. A., Dey, D., Schröder, K., Aung, H. L., Carbone, V., … Cook, G. M. (2011). A₁A_o-ATP synthase of Methanobrevibacter ruminantium couples sodium ions for ATP synthesis under physiological conditions. Journal of Biological Chemistry, 286(46), 39882-39892. doi: 10.1074/jbc.M111.281675 Journal - Research Other

Yu, Z., Bekker, M., Tramonti, A., Cook, G. M., van Ulsen, P., Scheffers, D.-J., … Luirink, J. (2011). Activators of glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli. Journal of Bacteriology, 193(6), 1308-1316. doi: 10.1128/JB.01209-10 Journal - Research Article

Kalamorz, F., Keis, S., McMillan, D. G. G., Olsson, K., Stanton, J.-A., Stockwell, P., Black, M. A., … Cook, G. M. (2011). Draft genome sequence of the thermoalkaliphilic Caldalkalibacillus thermarum strain TA2.A1. Journal of Bacteriology, 193(16), 4290-4291. doi: 10.1128/jb.05035-11 Journal - Research Article

Tannock, G. W., Wilson, C. M., Loach, D., Cook, G. M., Eason, J., O'Toole, P. W., … Lawley, B. (2012). Resource partitioning in relation to cohabitation of Lactobacillus species in the mouse forestomach. ISME Journal, 6, 927-938. doi: 10.1038/ismej.2011.161 Journal - Research Article

Sims, I. M., Frese, S. A., Walter, J., Loach, D., Wilson, M., Appleyard, K., … Livingston, M., Baird, M., Cook, G., & Tannock, G. W. (2011). Structure and functions of exopolysaccharide produced by gut commensal Lactobacillus reuteri 100-23. ISME Journal, 5(7), 1115-1124. doi: 10.1038/ismej.2010.201 Journal - Research Article

Arcus, V. L., McKenzie, J. L., Robson, J., & Cook, G. M. (2011). The PIN-domain ribonucleases and the prokaryotic VapBC toxin—antitoxin array. Protein Engineering, Design & Selection, 24(1-2), 33-40. doi: 10.1093/protein/gzq081 Journal - Research Article

Cook, G. M., & Heikal, A. (2012). Bridging the gap between a TB drug and its target. Science Translational Medicine, 4(150), 150fs33. doi: 10.1126/scitranslmed.3004816 Journal - Research Other

Taniguchi, N., Suzuki, T., Berney, M., Yoshida, M., & Cook, G. M. (2011). The regulatory C-terminal domain of subunit ε of F_oF₁ ATP synthase is dispensable for growth and survival of Escherichia coli. Journal of Bacteriology, 193(8), 2046-2052. doi: 10.1128/JB.01422-10 Journal - Research Article

Frampton, R., Aggio, R. B. M., Villas-Bôas, S. G., Arcus, V. L., & Cook, G. M. (2012). Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival. Journal of Biological Chemistry, 287(8), 5340-5356. doi: 10.1074/jbc.M111.286856 Journal - Research Article

McMillan, D. G. G., Velasquez, I., Nunn, B. L., Goodlett, D. R., Hunter, K. A., Lamont, I., Sander, S. G., & Cook, G. M. (2010). Acquisition of iron by alkaliphilic Bacillus species. Applied & Environmental Microbiology, 76(20), 6955-6961. doi: 10.1128/AEM.01393-10 Journal - Research Article

Shepherd, M., Sanguinetti, G., Cook, G. M., & Poole, R. K. (2010). Compensations for diminished terminal oxidase activity in Escherichia coli: Cytochrome bd-II-mediated respiration and glutamate metabolism. Journal of Biological Chemistry, 285(24), 18464-18472. doi: 10.1074/jbc.M110.118448 Journal - Research Article

Swe, P. M., Heng, N. C. K., Cook, G. M., Tagg, J. R., & Jack, R. W. (2010). Identification of Dysl, the immunity factor of the streptococcal bacteriocin dysgalacticin. Applied & Environmental Microbiology, 76(23), 7885-7889. doi: 10.1128/AEM.01707-10 Journal - Research Article

Hümpel, A., Gebhard, S., Cook, G. M., & Berney, M. (2010). The SigF regulon in Mycobacterium smegmatis reveals roles in adaptation to stationary phase, heat and oxidative stress. Journal of Bacteriology, 192(10), 2491-2502. doi: 10.1128/JB.00035-10 Journal - Research Article

Gebhard, S., Gaballa, A., Helmann, J. D., & Cook, G. M. (2009). Direct stimulus perception and transcription activation by a membrane-bound DNA binding protein. Molecular Microbiology, 73(3), 482-491. doi: 10.1111/j.1365-2958.2009.06787.x Journal - Research Article

Swe, P. M., Cook, G. M., Tagg, J. R., & Jack, R. W. (2009). Mode of action of dysgalacticin: A large heat-labile bacteriocin. Journal of Antimicrobial Chemotherapy, 63(4), 679-686. doi: 10.1093/jac/dkn552 Journal - Research Article

McMillan, D. G. G., Keis, S., Berney, M., & Cook, G. M. (2009). Nonfermentative thermoalkaliphilic growth is restricted to alkaline environments. Applied & Environmental Microbiology, 75(24), 7649-7654. doi: 10.1128/AEM.01639-09 Journal - Research Article

Robson, J., McKenzie, J. L., Cursons, R., Cook, G. M., & Arcus, V. L. (2009). The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. Journal of Molecular Biology, 390, 353-367. doi: 10.1016/j.jmb.2009.05.006 Journal - Research Article

Hartman, T., Weinrick, B., Vilchèze, C., Berney, M., Tufariello, J., Cook, G. M., & Jacobs, Jr, W. R. (2014). Succinate dehydrogenase is the regulator of respiration in Mycobacterium tuberculosis. PLoS Pathogens, 10(11), e1004510. doi: 10.1371/journal.ppat.1004510 Journal - Research Article

Matthies, D., Preiss, L., Klyszejko, A. L., Muller, D. J., Cook, G. M., Vonck, J., & Meier, T. (2009). The C₁₃ ring from a thermoalkaliphilic ATP synthase reveals an extended diameter due to a special structural region. Journal of Molecular Biology, 388(3), 611-618. doi: 10.1016/j.jmb.2009.03.052 Journal - Research Article

Mesbah, N. M., Cook, G. M., & Wiegel, J. (2009). The halophilic alkalithermophile Natranaerobius thermophilus adapts to multiple environmental extremes using a large repertoire of Na⁺(K⁺)/H⁺ antiporters. Molecular Microbiology, 74(2), 270-281. doi: 10.1111/j.1365-2958.2009.06845.x Journal - Research Article

Wilson, J. L., Jesse, H. E., Hughes, B., Lund, V., Naylor, K., Davidge, K. S., Cook, G. M., … Poole, R. K. (2013). Ru(CO)₃Cl(glycinate) (CORM-3): A carbon monoxide–releasing molecule with broad-spectrum antimicrobial and photosensitive activities against respiration and cation transport in Escherichia coli. Antioxidants & Redox Signaling, 19(5), 497-509. doi: 10.1089/ars.2012.4784 Journal - Research Article

Kingston, A. W., Zhao, H., Cook, G. M., & Helmann, J. D. (2014). Accumulation of heptaprenyl diphosphate sensitizes Bacillus subtilis to bacitracin: Implications for the mechanism of resistance mediated by the BceAB transporter. Molecular Microbiology, 93(1), 37-49. doi: 10.1111/mmi.12637 Journal - Research Article

Lagautriere, T., Bashiri, G., Paterson, N. G., Berney, M., Cook, G. M., & Baker, E. N. (2014). Characterization of the proline-utilization pathway in Mycobacterium tuberculosis through structural and functional studies. Acta Crystallographica Section D, 70(Pt 4), 968-980. doi: 10.1107/s1399004713034391 Journal - Research Article

Cook, G. M., Hards, K., Vilchèze, C., Hartman, T., & Berney, M. (2014). Energetics of respiration and oxidative phosphorylation in mycobacteria. Microbiology Spectrum, 2(3), MGM2-0015-2013. doi: 10.1128/microbiolspec.MGM2-0015-2013 Journal - Research Article

Berney, M., Weimar, M. R., Heikal, A., & Cook, G. M. (2012). Regulation of proline metabolism in mycobacteria and its role in carbon metabolism under hypoxia. Molecular Microbiology, 84(4), 664-681. doi: 10.1111/j.1365-2958.2012.08053.x Journal - Research Article

Cook, G. M., Greening, C., Hards, K., & Berney, M. (2014). Energetics of pathogenic bacteria and opportunities for drug development. In Advances in microbial physiology. Elsevier. doi: 10.1016/bs.ampbs.2014.08.001 Chapter in Book - Research

Pecsi, I., Hards, K., Ekanayaka, N., Berney, M., Hartman, T., Jacobs, Jr, W. R., & Cook, G. M. (2014). Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia. mBio, 5(4), e01093-14. doi: 10.1128/mBio.01093-14 Journal - Research Article

Kalia, N. P., Hasenoehrl, E. J., Ab Rahman, N. B., Koh, V. H., Ang, M. L. T., Sajorda, D. R., Hards, K., … Cook, G. M., … Pethe, K. (2017). Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection. PNAS, 114(28), 7426-7431. doi: 10.1073/pnas.1706139114 Journal - Research Article

Cook, G. M., & Poole, R. K. (2016). A bacterial oxidase like no other? Science, 352(6285), 518-519. doi: 10.1126/science.aaf5514 Journal - Professional & Other Non-Research Articles

Greening, C., Biswas, A., Carere, C. R., Jackson, C. J., Taylor, M. C., Stott, M. B., Cook, G. M., & Morales, S. E. (2016). Genomic and metagenomic surveys of hydrogenase distribution indicate H₂ is a widely utilised energy source for microbial growth and survival. ISME Journal, 10, 761-777. doi: 10.1038/ismej.2015.153 Journal - Research Article