Tel: 03 479 7816 Location: Science II, 2n11 Email: dlarsen@chemistry.otago.ac.nz
Research Interests
My research interests are primarily in the development of methodology the syntheses of natural products and also in the area of the synthesis of carbohydrates, glycolipids and their analogues.
On-going research projects are:
Structure, synthesis and biological activity of phosphatidylinositol mannosides from mycobacterium tuberculosis
Glycolipids as adjuvants for cancer vaccines
Total synthesis of the angucycline antibiotics
Carbon monoxide releasing molecules for organ transplant solutions
Mannosylation of Virus Like Particles
Bacterial cell wall skeletons as transporters of small molecules to APCs
Publications
Payne, F. M., Nie, S., Diffee, G. M., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2023). Carbon monoxide release by oCOm-21 enhances calcium sensitivity of the cardiac myofilament. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from https://ourarchive.otago.ac.nz/handle/10523/12839
Conference Contribution - Published proceedings: Abstract
Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2022, August-September). Prophylactic organic carbon monoxide donors protect hypertrophic hearts against ischaemia-reperfusion injury. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Bell, N. T., Payne, C. M., Sammut, I. A., & Larsen, D. S. (2022). Mechanistic studies of carbon monoxide release from norborn-2-en-7-one CORMs. Asian Journal of Organic Chemistry. Advance online publication. doi: 10.1002/ajoc.202200350
Journal - Research Article
Johnston, H. M., Kueh, J. T. B., Hartley, R. H., Bland, A. R., Payne, F. M., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2022). Utilising fluorescent reporters to probe the mode of action of norbornen-7-one CO releasing molecules. Organic & Biomolecular Chemistry, 20, 5812-5819. doi: 10.1039/d2ob01076c
Journal - Research Article
Sammut, I. A., Harrison, J. C., Hewitt, R. J., Read, M. I., Stanley, N. J., Woods, L. M., Kueh, J. T. B., … Smith, R. A. J., Giles, G., … Larsen, D. S. (2021). Carbon monoxide releasing norbornenone compounds. (11072584). United States.
Intellectual Property
McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. (2021). Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology, 11, 709540. doi: 10.3389/fonc.2021.709540
Journal - Research Article
Richardson, A. T., McGhie, T. K., Cordiner, S. B., Stephens, T. T. H., Larsen, D. S., Laing, W. A., & Perry, N. B. (2021). 2-O-β-d-Glucopyranosyl L-ascorbic acid, a stable form of vitamin C, is widespread in crop plants. Journal of Agricultural & Food Chemistry, 69, 966-973. doi: 10.1021/acs.jafc.0c06330
Journal - Research Article
Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2021). Can carbon monoxide protect hypertrophic hearts against ischaemia-reperfusion injury. New Zealand Medical Journal, 134(1535), (pp. 98). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Kueh, J. T. B., Seifert-Simpson, J. M., Thwaite, S. H., Rodgers, G. D., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2020). Studies towards non-toxic, water soluble, vasoactive norbornene organic carbon monoxide releasing molecules. Asian Journal of Organic Chemistry, 9, 1-10. doi: 10.1002/ajoc.202000546
Journal - Research Article
Richardson, A. T., Cho, J., McGhie, T. K., Larsen, D. S., Schaffer, R. J., Espley, R. V., & Perry, N. B. (2020). Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris). Phytochemistry, 173, 112297. doi: 10.1016/j.phytochem.2020.112297
Journal - Research Article
Robinson, S. A., Yau, J., Terabe, M., Berzofsky, J. A., Painter, G. F., Compton, B. J., & Larsen, D. S. (2020). Synthetic preparation and immunological evaluation of β-mannosylceramide and related N-acyl analogues. Organic & Biomolecular Chemistry, 18, 2739-2746. doi: 10.1039/d0ob00223b
Journal - Research Article
Hartley, R., Harrison, J. C., Johnston, H., Larsen, D. S., & Sammut, I. A. (2020). Examination of the cardiac mitochondrial-linked preconditioning mechanism of oCOm-58. New Zealand Medical Journal, 133(1518), (pp. 94-95). Retrieved from https://www.nzma.org.nz/journal
Conference Contribution - Published proceedings: Abstract
Kramer, K., Al-Barwani, F., Baird, M. A., Young, V. L., Larsen, D. S., Ward, V. K., & Young, S. L. (2019). Functionalisation of virus-like particles enhances antitumour immune responses. Journal of Immunology Research, 2019, 5364632. doi: 10.1155/2019/5364632
Journal - Research Article
Osman, H., Larsen, D. S., & Muralikrishna, A. (2019). A stereoselective approach to the angucyclinone antibiotics: A total synthesis of (±)-urdamycinone B. Arabian Journal of Chemistry, 12, 2501-2512. doi: 10.1016/j.arabjc.2015.04.022
Journal - Research Article
Payne, C. M., Cho, K., & Larsen, D. S. (2019). 5-Bromo-norborn-2-en-7-one derivatives as a carbon monoxide source for palladium catalyzed carbonylation reactions. RSC Advances, 9, 30736-30740. doi: 10.1039/c9ra06594f
Journal - Research Article
Sammut, I., Kueh, B., Adams, J., Read, M., Larsen, D., & Harrison, J. (2018). Prophylactic treatment of ischaemically stored organs with novel organic carbon monoxide donor molecules. Cryobiology, 81, (pp. 222). doi: 10.1016/j.cryobiol.2017.12.045
Conference Contribution - Published proceedings: Abstract
Hogue, R. W., Dhers, S., Hellyer, R. M., Luo, J., Hanan, G. S., Larsen, D. S., Garden, A. L., & Brooker, S. (2017). Self-assembly of cyclohelicate [M3L3] triangles over [M4L4] squares, despite near-linear bis-terdentate L and octahedral M. Chemistry: A European Journal, 23(57), 14193-14199. doi: 10.1002/chem.201702153
Journal - Research Article
Kueh, J. T. B., Stanley, N. J., Hewitt, R. J., Woods, L. M., Larsen, L., Harrison, J. C., … Sammut, I. A., & Larsen, D. S. (2017). Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs. Chemical Science, (8), 5454-5459. doi: 10.1039/c7sc01647f
Journal - Research Article
Malthus, S. J., Wilson, R. K., Aggarwal, A. V., Cameron, S. A., Larsen, D. S., & Brooker, S. (2017). Carbazole-based N4-donor Schiff base macrocycles: Obtained metal free and as Cu(II) and Ni(II) complexes. Dalton Transactions, 46(10), 3141-3149. doi: 10.1039/c6dt04598g
Journal - Research Article
Moodie, L. W. K., Trepos, R., Cervin, G., Larsen, L., Larsen, D. S., Pavia, H., … Svenson, J. (2017). Probing the structure-activity relationship of the natural antifouling agent polygodial against both micro- and macrofoulers by semisynthetic modification. Journal of Natural Products, 80(2), 515-525. doi: 10.1021/acs.jnatprod.6b01056
Journal - Research Article
Nhu, D., Larsen, L., Perry, N. B., Larsen, D. S., & Hawkins, B. C. (2017). Sweet poisons: Synthetic strategies towards tutin glycosides. Australian Journal of Chemistry, 70(3), 301-306. doi: 10.1071/CH16429
Journal - Research Article
Malthus, S. J., Wilson, R. K., Larsen, D. S., & Brooker, S. (2016). Acridine-based ligands from cobalt(II) mediated rearrangement of diphenylamine-based starting materials. Supramolecular Chemistry, 28(1-2), 98-107. doi: 10.1080/10610278.2015.1091458
Journal - Research Article
Compton, B. J., Anderson, R. J., Hayman, C. M., Tang, C.-w., Osmond, T. L., Larsen, D. S., … Painter, G. F. (2016). NKT cell-dependent glycolipid-peptide conjugates: Towards generating therapeutic vaccines for cancer. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Conference Contribution - Published proceedings: Abstract
Hall, E. A., Young, S. L., Ward, V. K., & Larsen, D. S. (2016). Synthesis of mannoside-VLP conjugates for antigen delivery. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Conference Contribution - Published proceedings: Abstract
Larsen, D. S., Compton, B. J., Tang, C.-W., Johnston, K. A., Osmond, T., Hayman, C. M., … Painter, G. F. (2016). Synthesis and activity of 6"-deoxy-6"-thio-α-GalCer and peptide conjugates. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Conference Contribution - Published proceedings: Abstract
Robinson, S. A., Painter, G. F., Compton, B. J., & Larsen, D. S. (2016). A synthetic methodology for accessing ceramide based iNKT cell agonists. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Retrieved from http://www.nzic16.org/
Conference Contribution - Published proceedings: Abstract
Sammut, I. A., Harrison, J. C., Read, M. I., Kueh, J. T. B., & Larsen, D. S. (2016). Novel organic carbon monoxide donor molecules provide organ protection during ischaemic events. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html
Conference Contribution - Published proceedings: Abstract
Anderson, R. J., Compton, B. J., Tang, C.-W., Authier-Hall, A., Hayman, C. M., Swinerd, G. W., … Larsen, D. S., … Weinkove, R., Hermans, I. F., & Painter, G. F. (2015). NKT cell-dependent glycolipid—peptide vaccines with potent anti-tumour activity. Chemical Science, 6(9), 5095-5312. doi: 10.1039/c4sc03599b
Journal - Research Article
Compton, B. J., Tang, C.-W., Johnston, K. A., Osmond, T. O., Hayman, C. M., Larsen, D. S., Hermans, I. F., & Painter, G. F. (2015). Synthesis and activity of 6''-Deoxy-6''-thio-α-GalCer and peptide conjugates. Organic Letters, 17, 5954-5957. doi: 10.1021/acs.orglett.5b02836
Journal - Research Article
Finichiu, P. G., Larsen, D. S., Evans, C., Larsen, L., Bright, T. P., Robb, E. L., … Smith, R. A. J., & Murphy, M. P. (2015). A mitochondria-targeted derivative of ascorbate: MitoC. Free Radical Biology & Medicine, 89, 668-678. doi: 10.1016/j.freeradbiomed.2015.07.160
Journal - Research Article
Jiménez-Dalmaroni, M. J., Radcliffe, C. M., Harvey, D. J., Wormald, M. R., Verdino, P., Ainge, G. D., Larsen, D. S., … Wilson, I. A. (2015). Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids. Innate Immunity, 21(2), 175-193. doi: 10.1177/1753425914524077
Journal - Research Article
Kueh, J. T. B., Moodie, L. W. K., Lucas, N. T., & Larsen, D. S. (2015). Synthesis of acyloxy-semicyclic dienes using an enyne metathesis/ring closing metathesis approach. European Journal of Organic Chemistry, 2015(7), 1485-1490. doi: 10.1002/ejoc.201403482
Journal - Research Article
Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. (2015). Bridging small molecules to modified bacterial microparticles using a disulphide linkage: MIS416 as a cargo delivery system. PLoS ONE, 10(12), e0145403. doi: 10.1371/journal.pone.0145403
Journal - Research Article
Zheng, T., Luo, D., Compton, B. J., Painter, G. F., Alley, M. R., Larsen, D. S., … Heiser, A. (2015). Adjuvanticity of a synthetic phosphatidylinositol dimannoside to a subvirion influenza vaccine in an influenza mouse model. Journal of Vaccines & Vaccination, 6(2), 1000277. doi: 10.4172/2157-7560.1000277
Journal - Research Article
Harrison, J. C., Diwan, V., Read, M. I., Larsen, L., Kueh, B., Hewitt, R. J., Stanley, N., Larsen, D., & Sammut, I. A. (2015). Novel carbon monoxide releasing molecules improve renal outcomes in a model of transplant reperfusion. Proceedings of the World Congress of Nephrology. Retrieved from http://www.wcn2015.org/
Conference Contribution - Published proceedings: Abstract
Larsen, D. S., Sammut, I., Harrison, J., Anderson, R., Compton, B. J., Harper, J. L., … Painter, G. F. (2015). Development of immuno-regulatory molecules for cancer and atopic disorders. Proceedings of the Diagnostic Drug Device Discovery (D4) Conference. Retrieved from https://www.regonline.com.au/builder/site/Default.aspx?EventID=1758070
Conference Contribution - Published proceedings: Abstract
Painter, G., Tang, C., Anderson, R., Compton, B., Authier-Hall, A., Hayman, C., … Farrand, K., … Larsen, D., Weinkove, R., & Hermans, I. (2015). Bioorthagonal synthesis and biological activity of CD1d dependent glycolipid-peptide vaccines. Proceedings of the 250th National American Chemical Society (ACS) Fall Meeting. Retrieved from https://www.acs.org
Conference Contribution - Published proceedings: Abstract
Al-Barwani, F., Young, S. L., Baird, M. A., Larsen, D. S., & Ward, V. K. (2014). Mannosylation of virus-like particles enhances internalization by antigen presenting cells. PLoS ONE, 9(8), e104523. doi: 10.1371/journal.pone.0104523
Journal - Research Article
Anderson, R. J., Tang, C.-w., Daniels, N. J., Compton, B. J., Hayman, C. M., Johnston, K. A., … Larsen, D. S., … Hermans, I. F. (2014). A self-adjuvanting vaccine induces cytotoxic T lymphocytes that suppress allergy. Nature Chemical Biology, 10, 943-949. doi: 10.1038/nchembio.1640
Journal - Research Article
Hubert, M., Larsen, D. S., Hayman, C. M., Rades, T., & Hook, S. (2014). Physical characterization of synthetic phosphatidylinositol dimannosides and analogues in binary systems with phosphatidylcholine. Molecular Pharmaceutics, 11(3), 913-921. doi: 10.1021/mp400588y
Journal - Research Article
Lee, A. M. M., Painter, G. F., Compton, B. J., & Larsen, D. S. (2014). Resolution of orthogonally protected myo-inositols with Novozym 435 providing an enantioconvergent Pathway to Ac2PIM1. Journal of Organic Chemistry, 79(22), 10916-10931. doi: 10.1021/jo5019188
Journal - Research Article
Moodie, L. W. K., & Larsen, D. S. (2014). A ring-closing enyne metathesis approach to functionalized semicyclic dienes: The total synthesis of (–)-tetrangomycin. European Journal of Organic Chemistry, 2014(8), 1684-1694. doi: 10.1002/ejoc.201301627
Journal - Research Article
Nakatani, Y., Larsen, D. S., Cutfield, S. M., & Cutfield, J. F. (2014). Major change in regiospecificity for the exo-1,3-β-glucanase from Candida albicans following its conversion to a glycosynthase. Biochemistry, 53(20), 3318-3326. doi: 10.1021/bi500239m
Journal - Research Article
Pun, P. B. L., Logan, A., Darley-Usmar, V., Chacko, B., Johnson, M. S., Huang, G. W., … Larsen, L., Larsen, D. S., … Smith, R. A. J., & Murphy, M. P. (2014). A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetes. Free Radical Biology & Medicine, 67, 437-450. doi: 10.1016/j.freeradbiomed.2013.11.025
Journal - Research Article
Hubert, M., Compton, B. J., Hayman, C. M., Larsen, D. S., Painter, G. F., Rades, T., & Hook, S. (2013). Physicochemical and biological characterization of synthetic phosphatidylinositol dimannosides and analogues. Molecular Pharmaceutics, 10(5), 1928-1939. doi: 10.1021/mp300707a
Journal - Research Article
Logan, A., Cochemé, H. M., Li Pun, P. B., Apostolova, N., Smith, R. A. J., Larsen, L., Larsen, D. S., … Murphy, M. P. (2013). Using exomarkers to assess mitochondrial reactive species in vivo. Biochimica et Biophysica Acta: General Subjects, 1840(2), 923-930. doi: 10.1016/j.bbagen.2013.05.026
Journal - Research Article
Rankin, G. M., Maxwell-Cameron, I., Painter, G. F., & Larsen, D. S. (2013). The Dimethoxyphenylbenzyl Protecting Group: An alternative to the p-methoxybenzyl group for protection of carbohydrates. Journal of Organic Chemistry, 5264-5272. doi: 10.1021/jo4004184
Journal - Research Article
Al Barwani, F., Baird, M., Young, S., Larsen, D., & Ward, V. (2013). Mannosylated VLP: Potent antigen delivery vehicles. Proceedings of the Australasian Virology Society (AVS) Meeting. Retrieved from http://www.avs.org.au/scientific-program/
Conference Contribution - Published proceedings: Abstract
Al Barwani, F., Young, S., Baird, M., Kirman, J., Larsen, D., & Ward, V. (2013). The sweetening of VLP. Proceedings of 15th Conference on Formulation and Delivery of Bioactives: Found in Translation. Retrieved from http://bioactives.otago.ac.nz/
Conference Contribution - Published proceedings: Abstract
Al-Barwani, F., Young, S., Baird, M., Larsen, D., & Ward, V. (2013). Enhancement of VLP functionality though mannosylation. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 69). Retrieved from http://www.asi2013.org/
Conference Contribution - Published proceedings: Abstract
Larsen, D. S., & Moodie, L. W. K. (2013). A ring-closing enyne metathesis approach to functionalised semi-cyclic dienes: The total synthesis of (-)-tetrangomycin. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]
Conference Contribution - Published proceedings: Abstract
Lee, A. M. M., Larsen, D. S., & Compton, B. J. (2013). Chemoenzymatic approaches to phosphatidylinositol mannosides and other phospholipids. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]
Conference Contribution - Published proceedings: Abstract
Painter, G. F., Tang, C., Anderson, R. J., Compton, B. J., Hayman, C. M., Johnston, K. A., Young, K., Hook, S., Larsen, D. S., & Hermans, I. F. (2013). Synthetic self-adjuvanting peptide vaccines. Proceedings of the New Zealand Institute of Chemistry (NZIC) Conference. Christchurch, New Zealand: NZIC. [Abstract]
Conference Contribution - Published proceedings: Abstract
Zheng, T., Luo, D., Compton, B., Painter, G., Larsen, D., Buddle, B., & Heiser, A. (2013). Phosphatidylinositol di-mannosides and aluminium hydroxide enhance protection of a subvirion influenza vaccine in a mouse influenza challenge model. Proceedings of the 43rd Australasian Society for Immunology (ASI) Annual Scientific Meeting. (pp. 162). Retrieved from http://www.asi2013.org/
Conference Contribution - Published proceedings: Abstract
Rankin, G. M., Compton, B. J., Johnston, K. A., Hayman, C. M., Painter, G. F., & Larsen, D. S. (2012). Synthesis and mass spectral characterization of mycobacterial phosphatidylinositol and its dimannosides. Journal of Organic Chemistry, 77(16), 6743-6759. doi: 10.1021/jo301189y
Journal - Research Article
Al Barwani, F., Young, S., Baird, M., Larsen, D., & Ward, V. (2012). The sweetening of VLP. Proceedings of the Virus-Like Particle & Nano-Particle Vaccines (VLPNPV) International Conference. [CD-ROM] [Abstract]
Conference Contribution - Published proceedings: Abstract
Ainge, G. D., Compton, B. J., Hayman, C. M., Martin, W. J., Toms, S. M., Larsen, D. S., Harper, J. L., & Painter, G. F. (2011). Chemical synthesis and immunosuppressive activity of dipalmitoyl phosphatidylinositol hexamannoside. Journal of Organic Chemistry, 76(12), 4941-4951. doi: 10.1021/jo200588u
Journal - Research Article
Ainge, G. D., Martin, W. J., Compton, B. J., Hayman, C. M., Larsen, D. S., Yoon, S.-I., … Painter, G. F. (2011). Synthesis and toll-like receptor 4 (TLR4) activity of phosphatidylinositol dimannoside analogues. Journal of Medicinal Chemistry, 54(20), 7268-7279. doi: 10.1021/jm2008419
Journal - Research Article
Feltham, H. L. C., Klöwer, F., Cameron, S. A., Larsen, D. S., Lan, Y., Tropiano, M., … Powell, A. K., & Brooker, S. (2011). A family of 13 tetranuclear zinc(II)-lanthanide(III) complexes of a [3 + 3] Schiff-base macrocycle derived from 1‚4-diformyl-2‚3-dihydroxybenzene. Dalton Transactions, 40, 11425-11432. doi: 10.1039/c1dt11038a
Journal - Research Article
Harper, J. L., Hayman, C. M., Larsen, D. S., Painter, G. F., & Singh-Gill, G. (2011). A PIM2 analogue suppresses allergic airway disease. Bioorganic & Medicinal Chemistry, 19, 2, 917-925. doi: 10.1016/j.bmc.2010.11.058
Journal - Research Article
Kitchen, J. A., Larsen, D. S., & Brooker, S. (2010). Alkylations of N4-(4-Pyridyl)-3,5-di(2-pyridyl)-1,2,4-triazole: First observation of room-temperature rearrangement of an N4-substituted triazole to the N1 analogue. Chemistry: An Asian Journal, 5(4), 910-918. doi: 10.1002/asia.200900485
Journal - Research Article
Denis, M., Ainge, G. D., Larsen, D. S., Severn, W. B., & Painter, G. F. (2009). A synthetic analogue of phosphatidylinositol mannoside is an efficient adjuvant. Immunopharmacology & Immunotoxicology, 31(4), 577-582. doi: 10.3109/08923970902824862
Journal - Research Article
Driessen, N. N., Ummels, R., Maaskant, J. J., Gurcha, S. S., Besra, G. S., Ainge, G. D., Larsen, D. S., … Appelmelk, B. J. (2009). Role of phosphatidylinositol mannosides in the interaction between mycobacteria and DC-SIGN. Infection & Immunity, 77(10), 4538-4547. doi: 10.1128/iai.01256-08
Journal - Research Article
Feltham, H. L. C., Larsen, D. S., & Brooker, S. (2009). A hexanuclear iron(III) complex of a hexadentate fully conjugated diimine ligand derived from 1,4-diformyl-2,3-dihydroxybenzene. New Journal of Chemistry, 33, 2001-2003. doi: 10.1039/b9nj00347a
Journal - Research Article
Hellyer, R. M., Larsen, D. S., & Brooker, S. (2009). Cobalt and silver complexes of terdentate pyrazine-based amide ligands and assembly of monocobalt building blocks through a silver connector. European Journal of Inorganic Chemistry, (9), 1162-1171. doi: 10.1002/ejic.200801187
Journal - Research Article
Jimenez-Dalmaroni, M. J., Xiao, N., Corper, A. L., Verdino, P., Ainge, G. D., & Larsen, D. S. (2009). Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS ONE, 4(10), e7411. doi: 10.1371/journal.pone.0007411
Journal - Research Article
Osman, H., Larsen, D. S., & Simpson, J. (2009). Synthesis of orthogonally protected D-olivoside, 1,3-di-O-acetyl-4-O-benzyl-2,6-dideoxy-D-arabinopyranose, as a C-glycosyl donor. Tetrahedron, 65(21), 4092-4098. doi: 10.1016/j.tet.2009.03.092
Journal - Research Article
Compton, B. J., Larsen, D. S., Larsen, L., & Weavers, R. T. (2008). Reactive diene for synthesis of substituted catechols. Tetrahedron Letters, 49(2), 219-221. doi: 10.1016/j.tetlet.2007.11.085
Journal - Research Article
Osman, H., Larsen, D. S., Hanton, L. R., & Simpson, J. (2008). Phenyl 2,3-O-isopropylidene-1-thio-α-D-rhamnopyranoside. Acta Crystallographica Section E, E64, o24-o25. doi: 10.1107/S1600536807061004
Journal - Research Article
Parlane, N. A., Denis, M., Severn, W. B., Skinner, M. A., Painter, G. F., La Flamme, A. C., Ainge, G. D., Larsen, D. S., & Buddle, B. M. (2008). Phosphatidylinositol mannosides are efficient mucosal adjuvants. Immunological Investigations, 37(2), 129-142. doi: 10.1080/08820130701690782
Journal - Research Article
Ainge, G. D., Parlane, N. A., Denis, M., Dyer, B. S., Härer, A., Hayman, C. M., Larsen, D. S., & Painter, G. F. (2007). Phosphatidylinositol mannoside ether analogues: Syntheses and interleukin-12-inducing properties. Journal of Organic Chemistry, 72(14), 5291-5296. doi: 10.1021/jo070639m
Journal - Research Article
de Geest, D. J., Noble, A., Moubaraki, B., Murray, K. S., Larsen, D. S., & Brooker, S. (2007). Dicopper(II) complexes of a new pyrazolate-containing Schiff-base macrocycle and related acyclic ligand. Dalton Transactions, 467-475.
Journal - Research Article
Dyer, B. S., Jones, J. D., Ainge, G. D., Denis, M., Larsen, D. S., & Painter, G. F. (2007). Synthesis and structure of phosphatidylinositol dimannoside. Journal of Organic Chemistry, 72, 3282-3288.
Journal - Research Article
Hellyer, R. M., Joule, J. A., Larsen, D. S., & Brooker, S. (2007). 4-(Pyrrol-1-yl)-1,2,4-triazole. Acta Crystallographica Section C, C63, o358-o360.
Journal - Research Article
Ainge, G. D., Hudson, J., Larsen, D. S., Painter, G. F., Gill, G. S., & Harper, J. L. (2006). Phosphatidylinositol mannosides: Synthesis and suppression of allergic airway disease. Bioorganic & Medicinal Chemistry, 14, 5632-5642.
Journal - Research Article
Ainge, G. D., Parlane, N. A., Denis, M., Hayman, C. M., Larsen, D. S., & Painter, G. F. (2006). Phosphatidylinositol mannosides: Synthesis and adjuvant properties of phosphatidylinositol di- and tetramannosides. Bioorganic & Medicinal Chemistry, 14, 7615-7624.
Journal - Research Article
Hayman, C. M., Larsen, D. S., Simpson, J., Bailey, K. B., & Gill, G. S. (2006). A stereoselective synthesis of 6,6,6-trifluoro-L-daunosamine and 6,6,6-trifluoro-L-acosamine. Organic & Biomolecular Chemistry, 4, 2794-2800.
Journal - Research Article
Larsen, D. S., Osman, H., Caygill, G. B., McFarlane, B. S., & McMorran, D. A. (2006). rac-Hatomarubigin C. Acta Crystallographica Section E, E62, o5748-o5750.
Journal - Research Article
Larsen, D. S., Lins, R. J., Stoodley, R. J., & Trotter, N. S. (2004). Studies related to carba-pyranoses: A radical decarboxylation approach to monocarba-disaccharides. Organic & Biomolecular Chemistry, 2, 1934-1942.
Journal - Research Article
Li, R., Evans, L. S., Larsen, D. S., Gale, P. A., & Brooker, S. (2004). Synthesis and anion binding behaviour of diamide derivatives of pyrrole-2,5-diacetic acid. New Journal of Chemistry, 28, 1340-1343.
Journal - Research Article
Landells, J. S., Larsen, D. S., & Simpson, J. (2003). Remote stereochemical control in asymmetric Diels-Alder reactions: Synthesis of the angucycline antibiotics, (-)-tetrangomycin and MM 47755. Tetrahedron Letters, 44, 5193-5196.
Journal - Research Article
Li, R., Larsen, D. S., & Brooker, S. (2003). Syntheses, structures and tautomers of 2,5-disubstituted pyrroles. New Journal of Chemistry, 27, 1353-1359.
Journal - Research Article
Dufour, J.-P., Wierda, R., Leus, M., Lissens, G., Delvaux, F., Derdelinckx, G., & Larsen, D. S. (2002). Quantitative analysis of beer aromatic alcohols using stable isotope dilution assay. Journal of the American Society of Brewing Chemists, 60(2), 88-96.
Journal - Research Article
Caygill, G. B., Larsen, D. S., & Brooker, S. (2001). Total synthesis of (+)-Hatomarubigin B. Journal of Organic Chemistry, 66, 7427-7431.
Journal - Research Article
Larsen, D. S., Lins, R. J., Stoodley, R. J., & Trotter, N. S. (2001). Studies related to carba-pyranoses: a strategy for the synthesis of β-1,3-glycosidically linked aminomonocarba-disaccharides. Journal of the Chemical Society, Perkin Transactions 1, 1(18), 2204-2212. doi: 10.1039/B105374B
Journal - Research Article
Andrews, F. L., Larsen, D. S., & Larsen, L. (2000). Synthetic approaches to the angucycline antibiotics. A route to C-Glycosidic Benz[a]anthraquinones. Australian Journal of Chemistry, 53, 15-24.
Journal - Research Article
Kerr, J. L., Landells, J. S., Larsen, D. S., Robinson, B. H., & Simpson, J. (2000). Synthesis and structure of N-ferrocenylglycosylamines; redox chemistry of O-ferrocenylglycosides and N-ferrocenylglycosylamines. Journal of the Chemical Society, Dalton Transactions, 9, 1411-1417.
Journal - Research Article
Landells, J. S., Kerr, J. L., Larsen, D. S., Robinson, B. H., & Simpson, J. (2000). Synthesis of water soluble O-glycosides of N-(hydroxyalkyl)-aminomethylferrocenes. Journal of the Chemical Society, Dalton Transactions, 1403-1409.
Journal - Research Article
Sum Idris, M., Larsen, D. S., Pritchard, R. G., Schofield, A., Stoodley, R. J., & Tiffin, P. D. (2000). Regio- and stereo-selective bromo(alkoxylation)s of (E)-α-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxymethylene) carbonyl compounds; A route to near-stereopure α-bromo α-dioxymethyl carbonyl compounds. Journal of the Chemical Society, Perkin Transactions 1, 1(14), 2195-2204. doi: 10.1039/B002749I
Journal - Research Article
Trotter, N. S., Larsen, D. S., Stoodley, R. J., & Brooker, S. (2000). A Diels-Alder strategy to 1,4-glycosidically linked monocarba-disaccharides. Tetrahedron Letters, 41, 8957-8962.
Journal - Research Article
Watt, D. K., Brasch, D. J., Larsen, D. S., Melton, L. D., & Simpson, J. (2000). Oligosaccharides related to xyloglucan: Synthesis and X-ray crystal structure of methyl α-L-fucopyranosyl-(1→2)-β-D-galactopyranosyl-(1→2)-α-D-xylopyranoside and the synthesis of methyl α-L-fucopyranosyl-(1→2)- β-D-galactopyranosy1]-(1→2)-β-D-xylopyranoside. Carbohydrate Research, 325, 300-312.
Journal - Research Article
Hayman, C. M., Hanton, L. R., Larsen, D. S., & Guthrie, J. M. (1999). A stereoselective synthesis of 2,6-dideoxy-6,6,6-trifluoro-arabino-hexoses via an asymmetric Diels-Alder strategy. Australian Journal of Chemistry, 52, 921-927.
Journal - Research Article
Watts, D. K., Brasch, D. J., Larsen, D. S., & Melton, L. D. (1999). Isolation, characterization, and NMR study of xyloglucan from enzymically depectinized and non-depectinized apple pomace. Carbohydrate Polymers, 39, 165-180.
Journal - Research Article
Hayman, C. M., Larsen, D. S., & Brooker, S. (1998). A facile synthesis of 2,6-dideoxy,6,6,6-trifluorinated carbohydrate analogues. Australian Journal of Chemistry, 51, 545-553.
Journal - Research Article
Caygill, G. B., Larsen, D. S., & McFarlane, B. S. (1997). Synthetic approaches to the angucycline antibiotics: a synthesis of (+/-) hatomarubigin B and C. Australian Journal of Chemistry, 50(4), 301-308.
Journal - Research Article
Larsen, D. S., Rutledge, P. S., & Woodgate, P. D. (1997). Iodination of thallium (I) salts of phenols. Australian Journal of Chemistry, 50(7), 767-769.
Journal - Research Article
Larsen, D. S., & O'Shea, M. D. (1996). Synthetic approaches to the angucycline antiobiotics: a concise entry to the ring system of PD 116740 and TAN 1085. Journal of Organic Chemistry, 61, 5681-5683.
Journal - Research Article
Larsen, D. S., O'Shea, M. D., & Brooker, S. (1996). Total syntheses of the angucyclinone antibiotics (+)-emycin A and (+)-ochromycinone. Chemical Communications, 203-204.
Journal - Research Article
Larsen, D. S., Schofield, A. E. M., Stoodley, R. J., & Tiffin, P. D. (1996). Diastereoselective hydrogenations of a-alkyl a-(2,3,4,6-tetra-O-acetyl-b-D-glucopyranosyloxy)methylene carbonyl compounds. New route to stereopure a-alkyl a-oxymethyl carbonyl compounds. Journal of the Chemical Society, Perkin Transactions 1, 2487-2493.
Journal - Research Article
Watt, D. W., Brasch, D. J. A., Larsen, D. S., Melton, L. D., & Simpson, J. (1996). Oligosaccharides related to xyloglucan: synthesis and x-ray crystal structure of methyl 2O(a-L-fucopyranosyl)-b-D-galactopyranoside. Carbohydrate Research, 285, 1-15.
Journal - Research Article