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david_larsenPhD, MSc(Auck)

Tel: 03 479 7816
Location: Science II, 2n11

Research Interests

My research interests are primarily in the development of methodology the syntheses of natural products and also in the area of the synthesis of carbohydrates, glycolipids and their analogues.

On-going research projects are:

  • Structure, synthesis and biological activity of phosphatidylinositol mannosides from mycobacterium tuberculosis
  • Glycolipids as adjuvants for cancer vaccines
  • Total synthesis of the angucycline antibiotics
  • Carbon monoxide releasing molecules for organ transplant solutions
  • Mannosylation of Virus Like Particles
  • Bacterial cell wall skeletons as transporters of small molecules to APCs


Payne, F. M., Nie, S., Diffee, G. M., Larsen, D. S., Harrison, J. C., Baldi, J. C., & Sammut, I. A. (2023). Carbon monoxide release by oCOm-21 enhances calcium sensitivity of the cardiac myofilament. In T. Milne, M. Anwar, L. Burga, H. Harcombe, M. Garelja, A. Middleton, D. C. Ribeiro, N. Fleming, K. Ogbuehi & A. Bahn (Eds.), Proceedings of the 267th Otago Medical School Research Society (OMSRS) Meeting: PhD Student Speaker Awards. Dunedin, New Zealand: OMSRS. Retrieved from

Thwaite, S. H., Read, M. I., Larsen, D. S., Harrison, J. C., & Sammut, I. A. (2022, August-September). Prophylactic organic carbon monoxide donors protect hypertrophic hearts against ischaemia-reperfusion injury. Verbal presentation at the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists (ASCEPT) NZ Annual Scientific Meeting, Queenstown, New Zealand.

Bell, N. T., Payne, C. M., Sammut, I. A., & Larsen, D. S. (2022). Mechanistic studies of carbon monoxide release from norborn-2-en-7-one CORMs. Asian Journal of Organic Chemistry. Advance online publication. doi: 10.1002/ajoc.202200350

Johnston, H. M., Kueh, J. T. B., Hartley, R. H., Bland, A. R., Payne, F. M., Harrison, J. C., Sammut, I. A., & Larsen, D. S. (2022). Utilising fluorescent reporters to probe the mode of action of norbornen-7-one CO releasing molecules. Organic & Biomolecular Chemistry, 20, 5812-5819. doi: 10.1039/d2ob01076c

Sammut, I. A., Harrison, J. C., Hewitt, R. J., Read, M. I., Stanley, N. J., Woods, L. M., Kueh, J. T. B., … Smith, R. A. J., Giles, G., … Larsen, D. S. (2021). Carbon monoxide releasing norbornenone compounds. (11072584). United States.

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