2019
Journal - Research Article
Gaddam, R. R., Chambers, S., Fraser, R., Cogger, V. C., Le Couteur, D. G., Ishii, I., & Bhatia, M. (2019). Cystathionine-gamma-lyase-derived hydrogen sulfide-regulated substance P modulates liver sieve fenestrations in caecal ligation and puncture-induced sepsis. International Journal of Molecular Sciences, 20(13), 3191. doi: 10.3390/ijms20133191
2017
Journal - Research Article
Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755
2016
Journal - Research Article
Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521
Mohamad, M., Mitchell, S. J., Wu, L. E., White, M. Y., Cordwell, S. J., Mach, J., … Fraser, R., … Cogger, V. C. (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15(4), 706-715. doi: 10.1111/acel.124819
Cogger, V. C., Mohamad, M., Solon-Biet, S., Senior, A. M., Warren, A., O'Reilly, J. N., … Fraser, R., … Le Couteur, D. G. (2016). Dietary macronutrients and the aging liver sinusoidal endothelial cell. American Journal of Physiology: Heart & Circulatory Physiology, 310, H1064-H1070. doi: 10.1152/ajpheart.00949.2015
Badiei, A., Chambers, S. T., Gaddam, R. R., Fraser, R., & Bhatia, M. (2016). Cystathionine-gamma-lyase gene silencing with siRNA in monocytes/macrophages protects mice against acute pancreatitis. Applied Microbiology & Biotechnology, 100(1), 337-346. doi: 10.1007/s00253-015-6989-z
Conference Contribution - Published proceedings: Abstract
Gaddam, R. R., Fraser, R., Badiei, A., Cogger, V., Le Couteur, D., Ishii, I., & Bhatia, M. (2016). The effect of hydrogen sulfide synthesized by cystathionine-gamma-lyase on inflammation and liver sinusoidal endothelial cells in polymicrobial sepsis in mice. New Zealand Medical Journal, 129(1439), (pp. 88). Retrieved from http://www.nzma.org.nz/journal
2015
Conference Contribution - Published proceedings: Abstract
Bhatia, M., Badiei, A., Gaddam, R., Fraser, R., & Chambers, S. (2015). Inhibition of hydrogen sulfide synthesis by gene silencing protects mice against caerulein-induced acute pancreatitis. Pancreatology, 15(3, Suppl.), (pp. S2). doi: 10.1016/j.pan.2015.05.048
2014
Conference Contribution - Published proceedings: Abstract
Fraser, R., Bhatia, M., Gaddam, R. R., Jamieson, H. A., Dobbs, B. R., Wade, R. T., … Le Couteur, D. G. (2014). Arsenic containing water from Bangladeshi wells relates to local heart disease and stroke. Internationally, mining and exploratory fracking may lead to arsenical contamination of aquifers. Arsenical drinking-water, by closing the "liver sieve" causes dyslipidaemia and atherosclerosis? Proceedings of the 7th Annual Otago International Health Research Network (OIHRN) Conference. (pp. 9-10). Retrieved from http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/conference/index.html
2013
Journal - Research Article
Cogger, V. C., Roessner, U., Warren, A., Fraser, R., & Le Couteur, D. G. (2013). A sieve-raft hypothesis for the regulation of endothelial fenestrations. Computational & Structural Biotechnology Journal, 8(11), e201308003. doi: 10.5936/csbj.201308003
2012
Journal - Research Article
Fraser, R., Cogger, V. C., Dobbs, B., Jamieson, H., Warren, A., …, & Le Couteur, D. G. (2012). The liver sieve and atherosclerosis. Pathology, 44(3), 181-186. doi: 10.1097/PAT.0b013e328351bcc8
2011
Chapter in Book - Research
Svistunenko, D., Zykova, S. N., Cogger, V. C., Warren, A., Fraser, R., Smedsrød, B., … Le Couteur, D. G. (2011). Pseudocapillarization and the aging liver. In L. D. DeLeve & G. Garcia-Tsao (Eds.), Vascular liver disease: Mechanisms and management. (pp. 41-50). New York: Springer. doi: 10.1007/978-1-4419-8327-5_3
Journal - Research Article
Warren, A., Cogger, V. C., Fraser, R., DeLeve, L. D., McCuskey, R. S., & Le Couteur, D. G. (2011). The effects of old age on hepatic stellate cells. Current Gerontology & Geriatrics Research, 2011, 439835. doi: 10.1155/2011/439835
Conference Contribution - Verbal presentation and other Conference outputs
Fraser, R., Dobbs, B. R., Cogger, V. C., & Le Couteur, D. G. (2011, September). Liver–sieve porosity influences cholesterolaemia, so affecting both lifestyle and familial atherosclerosis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2010
Journal - Research Article
O'Reilly, J. N., Cogger, V. C., Fraser, R., & Le Couteur, D. G. (2010). The effect of feeding and fasting on fenestrations in the liver sinusoidal endothelial cell. Pathology, 42(3), 255-258. doi: 10.3109/00313021003636469
Journal - Research Other
Fraser, R. (2010). Why teach human anatomy at Otago School of Medical Sciences? [Editorial]. New Zealand Medical Journal, 123(1312). Retrieved from http://journal.nzma.org.nz/journal/123-1312/4049/content.pdf
2009
Film/Video/CD Rom
Fraser, R., MacAskill, M., Gearry, R., Roberts, R., Sellman, D., & Wright, S. (2009). The Body, the Research, the Professor: Irritable Bowel Disease, Parkinson's & Brain Research, Mental Health [Episode 6] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1
Fraser, R., Anderson, T., Jones, R., Innes, C., Huckabee, M.-L., & Leech, R. (2009). The Body, the Research, the Professor: Brain Research [Episode 1] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1
Fraser, R., Beaven, D., Scott, R., Willis, J., Shaw, G., & Chase, G. (2009). The Body, the Research, the Professor: Diabetes [Episode 2] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1
Fraser, R., Richards, M., Pilbrow, A., & Troughton, R. (2009). The Body, the Research, the Professor: Cardiac Research [Episode 3] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1
Fraser, R., Joyce, P., Sellman, D., & Kennedy, M. (2009). The Body, the Research, the Professor: Mental Health [Episode 4] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1
Fraser, R., Chambers, S., Fellows, A., Brennan, S., Vissers, M., Fu, R., & Scott-Thomas, A. (2009). The Body, the Research, the Professor: Respiratory Research and Cystic Fibrosis [Episode 5] [Film]. Christchurch, New Zealand: Canterbury Medical Research Foundation. Retrieved from http://www.cmrf.org.nz/Home/Videos/#vid1
2008
Journal - Research Article
Le Couteur, D. G., Warren, A., Cogger, V. C., Smedsrød, B., Sørensen, K. K., de Cabo, R., Fraser, R., & McCuskey, R. S. (2008). Old age and the hepatic sinusoid. Anatomical Record, 291, 672-683. doi: 10.1002/ar.20661
Warren, A., Chaberek, S., Ostrowski, K., Cogger, V. C., Hilmer, S. N., McCuskey, R. S., Fraser, R., & Le Couteur, D. G. (2008). Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation, 15(3), 191-202. doi: 10.1080/10739680701600856
Conference Contribution - Published proceedings: Abstract
Dale, G., Cogger, V., Fraser, R., & Le Couteur, D. (2008). The effect of block co-polymer on hepatotoxicity following paracetamol overdose. New Zealand Medical Journal, 121(1271). Retrieved from http://journal.nzma.org.nz/journal/121-1271/2990/content.pdf
2007
Journal - Research Article
Jamieson, H. A., Hilmer, S. N., Cogger, V. C., Warren, A., Cheluvappa, R., Abernethy, D. R., … Fraser, R., … Le Couteur, D. G. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378.
Warren, A., Bertolino, P., Benseler, V., Fraser, R., McCaughan, G. W., & Le Couteur, D. G. (2007). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246.
Le Couteur, D. G., Cogger, V. C., McCuskey, R. S., de Cabo, R., Smedsrød, B., Sorensen, K. K., … Fraser, R. (2007). Age-related changes in the liver sinusoidal endothelium: A mechanism for dyslipidemia. Annals of the New York Academy of Sciences, 1114, 79-87.
Jamieson, H. A., Cogger, V. C., Twigg, S. M., McLennan, S. V., Warren, A., Cheluvappa, R., … Fraser, R., … Le Couteur, D. G. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia, 50, 1969-1976.
Slow, S., Vasudevamurthy, M., Fraser, R., McEntyre, C., Lever, M., Chambers, S., & George, P. (2007). Dimethylthetin treatment causes diffuse alveolar lung damage: A pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD). Experimental & Toxicologic Pathology, 58, 285-290.
2006
Chapter in Book - Research
Le Couteur, D. G., Cogger, V. C., Hilmer, S. N., Muller, M., Harris, M., Sullivan, D., … Fraser, R. (2006). Aging, atherosclerosis and the liver sieve. In L. V. Clark (Ed.), New research on atherosclerosis. (pp. 19-44). New York: Nova Science.
Journal - Research Article
Cogger, V. C., Hilmer, S. N., Sullivan, D., Muller, M., Fraser, R., & Le Couteur, D. (2006). Hyperlipidemia and surfactants: The liver sieve is a link. Atherosclerosis, 189, 273-281.
Warren, A., Le Couteur, D. G., Fraser, R., Bowen, D. G., McCaughan, G. W., & Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190.
Conference Contribution - Published proceedings: Abstract
Jamieson, H. A., Cogger, V. C., Hilmer, S., Le Couteur, D. G., & Fraser, R. (2006). Effects of aging on liver sinusoid caveolin-1 expression. New Zealand Medical Journal, 119(1231). Retrieved from http://journal.nzma.org.nz/journal/119-1231/1922/content.pdf
Conference Contribution - Verbal presentation and other Conference outputs
Fraser, R., Jamieson, H. A., Cogger, V. C., Hilmer, S. N., de Cabo, R., Warren, A., & Le Couteur, D. G. (2006, September). Longevity pseudocapillarization and caloric restriction. Verbal presentation at the 13th International Symposium on Cells of the Hepatic Sinusoid, Niigata, Japan.
2005
Journal - Research Article
Le Couteur, D. G., Fraser, R., Hilmer, S., Rivory, L. P., & McLean, A. J. (2005). The hepatic sinusoid in aging and cirrhosis [Major review]. Clinical Pharmacokinetics, 44(2), 187-200.
Warren, A., Bertolino, P., Cogger, V. C., McLean, A. J., Fraser, R., & Le Couteur, D. G. (2005). Hepatic pseudocapillarization in aged mice. Experimental Gerontology, 40, 807-812.
Hilmer, S. N., Cogger, V. C., Fraser, R., McLean, A. J., Sullivan, D., & Le Couteur, D. G. (2005). Age-related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat. Hepatology, 42, 1349-1354.
2004
Journal - Research Article
Keenan, J. I., Peterson, R. A., Fraser, R., Frampton, C. M., Walmsley, T. A., Allardyce, R. A., & Roake, J. A. (2004). The effect of Helicobacter pylori infection and dietary iron deficiency on host iron homeostasis: A study in mice. Helicobacter, 9(6), 643-650.
Cogger, V. C., Muller, M., Fraser, R., McLean, A. J., Khan, J., & Le Couteur, D. G. (2004). The effects of oxidative stress on the liver sieve. Journal of Hepatology, 41, 370-376.
Hilmer, S. N., Warren, A., Cogger, V. C., Fraser, R., McLean, A. J., Sullivan, D., & Le Couteur, D. G. (2004). The effect of aging on the immunohistochemistry of apolipoprotein E in the liver. Experimental Gerontology, 39(1), 53-57. doi: 10.1016/j.exger.2003.09.016
Conference Contribution - Published proceedings: Abstract
Hilmer, S., Fraser, R., & Le Couteur, D. (2004). The fenestrated sinusoidal endothelium and post-prandial hyperlipidaemia in old age. Internal Medicine Journal, 34(Suppl.), (pp. A57). doi: 10.1111/j.1444-0903.2004.abstract_1.x
Cogger, V. C., Hilmer, S. N., Fraser, R., & Le Couteur, D. G. (2004). Defenestration of the liver sieve in a hyperlipidemic mouse model. Proceedings of the XII International Symposium on Cells of the Hepatic Sinusoid. (pp. O7). [Abstract]
Warren, A., Bertolino, P., Fraser, R., Bowen, D., McCaughan, G. W., Board, P., & Le Couteur, D. G. (2004). Model of interaction between naïve T lymphocytes and hepatocytes. Proceedings of the XII International Symposium on Cells of the Hepatic Sinusoid. (pp. O23-O24). [Abstract]
2003
Journal - Research Article
Braet, F., Fraser, R., & McCuskey, R. S. (2003). Thirty-five years of liver sinusoidal cells: Eddie Wisse in retirement [A tribute]. Hepatology, 38, 156-158.
Munro, A. R., Beasley, S. W., Pattemore, P. K., & Fraser, R. (2003). Fatal late onset necrotising enterocolitis in a term infant: Atypical Kawasaki disease or polyarteritis nodosa of infancy? Journal of Paediatrics & Child Health, 39, 555-557.
Cogger, V. C., Warren, A., Fraser, R., Ngu, M., McLean, A., & Le Couteur, D. G. (2003). Hepatic sinusoidal pseudocapillarization with aging in the non-human primate. Experimental Gerontology, 38, 1101-1107.
Journal - Research Other
Fraser, R., Le Couteur, D., Warren, A., Cogger, V., Bertolino, P., & Smith, M. (2003). The liver sieve and gene therapy [Letter to the editor]. Blood, 101(8), 3338.
Cogger, V. C., Fraser, R., & Le Couteur, D. G. (2003). Liver dysfunction and heart failure. American Journal of Cardiology, 91(11), 1399.
2002
Journal - Research Article
Le Couteur, D., Fraser, R., Cogger, V., & McLean, A. J. (2002). Hepatic pseudocapillarisation and atherosclerosis in ageing. Lancet, 359, 1612-1615.
Fraser, R. (2002). The liver, in health and disease. New Zealand Pharmacy, 22, 36-40.
2001
Chapter in Book - Research
Jamieson, H. A., Dobbs, B. R., Day, W. A., Rogers, G. W. T., & Fraser, R. (2001). The liver sieve in diabetes: Are the ultrastructural changes similar to those seen in alcoholism? In E. Wisse, D. L. Knook, R. De Zanger & M. P. J. Arthur (Eds.), Cells of the hepatic sinusoid (vol. 8). (pp. 123-124). Netherlands: The Kupffer Cell Foundation.
Journal - Research Article
Fraser, R. (2001). Undergraduate medical education. New Zealand Medical Journal, 114, 554-555.
Conference Contribution - Published proceedings: Abstract
Keenan, J. I., Fraser, R., Allardyce, R. A., & Roake, J. A. (2001). H. pylori infection, iron deficiency and disease expression in mice. International Journal of Medical Microbiology. 291(Suppl.31), (pp. 134). [Abstract]
Fraser, R., Dobbs, B. R., Jamieson, H. A., Cogger, V. C., & Le Couteur, D. (2001). Ageing, Atherosclerosis, Defenestration of the Liver Sieve. Proceedings of the Royal Australian College of Pathologists, New Zealand Committee. [Abstract]
Jamieson, H. A., Dobbs, B. R., Day, W. A., Rogers, G. W. T., & Fraser, R. (2001). The liver sieve in diabetes: are the ultrastructural changes similar to those seen in alcoholism? Cells of the Hepatic Sinusoids, Proceedings of the Tenth International Symposium on Cells of the Hepatic Sinusoids. 8, (pp. 123-124). Leiden, the Netherlands: The Kupffer Cell Foundation. [Abstract]
2000
Conference Contribution - Published proceedings: Abstract
Fraser, R. (2000). Chylomicron size and structure depends on the amount and saturation of food fats, so affecting cholesterol metabolism and atherogenesis. Proceedings of the Royal Australian College of Pathologists, New Zealand Committee. [Abstract]
1999
Chapter in Book - Research
Jamieson, H. A., Day, W. A., Dobbs, B. R., Rogers, G. W. T., & Fraser, R. (1999). Is the fatty liver of diabetes like that of alcohol related to an increased porosity of the liver sieve? In E. Wisse, D. L. Knook, R. deZanger & R. Fraser (Eds.), Cells of Hepatic Sinusoid Volume 7. (pp. 96-98). Leiden: The Kupffer Cell Foundation.
Conference Contribution - Published proceedings: Abstract
Fraser, R., Day, W. A., Dobbs, B. R., Jamieson, H. A., & Rogers, G. W. T. (1999). The simplest of recptors - the liver sieve. Progress in Microcirculation Research: Proceedings of the tenth Australian and New Zealand Microcirculation Society Conference. (pp. 4-6). Adelaide: Flinders Press. [Abstract]
1998
Edited Book - Research
Wisse, E., Knook, D. L., de Zander, R., & Fraser, R. (Eds.). (1998). Cells of the hepatic sinusoids. Volume 7. Leiden: The Kupffer Cell Foundation, 310p.
1997
Chapter in Book - Research
Dobbs, B. R., Fraser, R., & Rogers, G. W. T. (1997). Reduction of the hepatotoxicity of dimethyl-nitrosamine with gadolinium chloride. In E. Wisse, D. L. Knook & C. Balabaud (Eds.), Cells of the hepatic sinusoids. Volume 6. (pp. 308-309). Leiden: The Kupffer Cell FOundation.
Conference Contribution - Published proceedings: Abstract
Tournadre, J.-P., Barclay, M. L., Fraser, R., Young, R. J., Jury, P., Fergusson, L., … Dent, J. (1997). Motricité gastro-intestinale lors de la nutrition entérale précoce apres chirurgie abdominale. Annales Francaises d'Anesthesie et de Reanimation. 16, (pp. 686). [Abstract]
Barclay, M. L., Fraser, R., Tournadre, J.-P., Young, R., Jury, P., Ferguson, L., … Dent, J. (1997). Gastro-intestinal motility and early duodenal feeding after major abdominal surgery. Anesthesiology. 87, (pp. A223). [Abstract]
1996
Journal - Research Article
Johnson, S. J., Toole, K., Fraser, R., Rogers, G., Dobbs, B. R., & Burt, A. D. (1996). Methylprednisolone does not inhibit the nonparenchymal cell responses to dimethylnitrosamine-induced liver injury. International Hepatology Communications, 4, 201-206.
1995
Chapter in Book - Research
Dobbs, B. R., Rogers, G. R., & Fraser, R. (1995). Reduction of the hepatotoxicity of dimethylnitrosamine with gadolinium chloride. In E. Wisse, D. L. Knook & K. Wake (Eds.), Cells of the Hepatic Sinusoid, vol.5. (pp. 308-309). Leiden: Kupffer Cell Foundation.
Journal - Research Article
Fraser, R., Rogers, G. R., Sutton, L. E., & Dobbs, B. R. (1995). Single dose models of defenestration: tools to explore mechanisms, modulation and measurement of hepatic sinusoidal porosity. Cells of the Hepatic Sinusoid, 5, 263-266.
Crump, J. A., Beard, M. E. J., Angus, H. B., Fraser, R., Hart, D., & Nicholls, M. G. (1995). Acute adrenal insufficiency: A new presentation of Castleman's disease [Case report]. Journal of Internal Medicine, 238, 81-84. doi: 10.1111/j.1365-2796.1995.tb00903.x
Conference Contribution - Published proceedings: Full paper
Fraser, R., Rogers, G. W. T., Sutton, L. E., & Dobbs, B. R. (1995). Are liver functions tests affected by the hepatic microcirculation? Progress in Microcirculation Research. Proceedings of the Eighth Australian and New Zealand Symposium. (pp. 21-22). Auckland: Uniprint, University of Auckland. [Full Paper]