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Robin FraserEmeritus Professor

ONZM, BSc, MB BS(Syd), PhD(ANU), MD(Otago), FRCPA

Email robin.fraser@otago.ac.nz

Background and research interests

After graduating in Medicine at the University of Sydney and three years at the Royal Prince Alfred Hospital Professor Robin Fraser began his medical career as a country doctor in Australia.

Professor Fraser's interest in medical research led him to gain his PhD in the field of lipoprotein metabolism from the Australian National University. He took a post-doc at the University of Chicago before becoming a Senior Lecturer at the University of Sydney.

He took an appointment as an Associate Professor at the Christchurch School of Medicine and Health Sciences in 1974.

He is now Emeritus Professor but keeps his interest in the liver sieve as visiting professor to the University of Sydney. This work is directed by Professor David Le Couteur (Centre for Education and Research on Ageing at Concord Hospital and the ANZAC Institute of Medical Research). Professor Fraser is a collaborator and an advisor to this exciting work.

Publications

Gaddam, R. R., Chambers, S., Fraser, R., Cogger, V. C., Le Couteur, D. G., Ishii, I., & Bhatia, M. (2019). Cystathionine-gamma-lyase-derived hydrogen sulfide-regulated substance P modulates liver sieve fenestrations in caecal ligation and puncture-induced sepsis. International Journal of Molecular Sciences, 20(13), 3191. doi: 10.3390/ijms20133191

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., & Bhatia, M. (2017). Differential effects of Kupffer cell inactivation on inflammation and the liver sieve following caecal-ligation and puncture-induced sepsis in mice. Shock, 47(4), 480-490. doi: 10.1097/shk.0000000000000755

Gaddam, R. R., Fraser, R., Badiei, A., Chambers, S., Cogger, V. C., Le Couteur, D. G., … Bhatia, M. (2016). Cystathionine-gamma-lyase gene deletion protects mice against inflammation and liver sieve injury following polymicrobial sepsis. PLoS ONE, 11(8), e0160521. doi: 10.1371/journal.pone.0160521

Gaddam, R. R., Fraser, R., Badiei, A., Cogger, V., Le Couteur, D., Ishii, I., & Bhatia, M. (2016). The effect of hydrogen sulfide synthesized by cystathionine-gamma-lyase on inflammation and liver sinusoidal endothelial cells in polymicrobial sepsis in mice. New Zealand Medical Journal, 129(1439), (pp. 88). Retrieved from http://www.nzma.org.nz/journal

Mohamad, M., Mitchell, S. J., Wu, L. E., White, M. Y., Cordwell, S. J., Mach, J., … Fraser, R., … Cogger, V. C. (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15(4), 706-715. doi: 10.1111/acel.124819

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