Dianne Harker, Our people, University of Otago, Christchurch, University of Otago, New Zealand

Clinical Research Nurse/Study Coordinator

MA Nursing (Victoria), DipSocSci Nursing (Massey), RN (Gynaecology Research Nurse)

Dianne joined the department in July 2001.

She works with Associate Professor Peter Sykes and coordinates the gynaecology research projects.

Her interest in women's health research is focused on gynaecological oncology.

Dianne completed an MA (Nursing) titled "Nurses as patients: The stories of two women nurse educators as recipients of nursing care" which was based in the women's health field.

Dianne has an interest in and provides professional supervision for health professionals in private practice.

Research studies

PRINCess - The Prediction of regression in CIN2 - A prospective multicentre trial of conservative management of CIN2 in women under the age of 25.
A prospective audit of sentinel node biopsy for Vulval Carcinoma in Australia and New Zealand
PARAGON- Phase II study of aromatase inhibitors in women with potentially hormone responsive recurrent/metastatic gynaecological neoplasms: ANZGOG 0903
LACE - Laparoscopic Approach to Cancer of the Endometrium: An International Multicenter Randomised Phase 3 Clinical Trial
Cancer Society Tissue Bank
EXCISE – EXcisional treatment Comparison for In Situ Endocervical adenocarcinoma
IPOCC - A Randomized Trial of Intravenous Paclitaxel plus IV Carboplatin versus IV Paclitaxel plus IP Carboplatin in women with Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer
AOCS - Genomic mechanisms underlying long‐term response to treatment in serous ovarian cancer.
FEMME - A Phase II Randomised Clinical Trial of Mirena® ± Metformin ± Weight Loss Intervention in Patients with Early Stage Cancer of the Endometrium
CART-WHEEL - the Center for Analysis of Rare Tumors database
CINƎMA - A prospective multicentre trial of observational management of CIN3 in women under the age of 25

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Publications

Taghavi, K., Lamb, J., MacNab, H., Innes, C., Peddie, D., Harker, D., Williman, J., Sykes, P., & Simcock, B. (2022). Patient choice may improve adherence to follow-up in cervical screening: A randomised-control trial. New Zealand Medical Journal, 135(1550), 134-144. Retrieved from https://journal.nzma.org.nz/

Sykes, P. H., Simcock, B. J., Innes, C. R., Harker, D., Williman, J. A., Whitehead, M., van der Griend, R. A., … Hibma, M., … Petrich, S., … Sadler, L. (2022). Predicting regression of cervical intraepithelial neoplasia grade 2 in women under 25 years. American Journal of Obstetrics & Gynecology, 226, 222.e1-222.e13. doi: 10.1016/j.ajog.2021.09.009

Goyani, A. D., Innes, C. R., Simcock, B. J., Harker, D., Dudley, N. M., Eva, L., Bergzoll, C., MacNab, H., & Sykes, P. H. (2020). Trends in the diagnosis of high-grade cervical abnormalities in young women in the post-vaccination era. New Zealand Medical Journal, 133(1524), 50-63. Retrieved from https://www.nzma.org.nz/journal

Cohen, P. A., Leung, Y., Anderson, L., van der Griend, R., Chivers, P., Bilic, S., … Harker, D., … Simcock, B., … Sykes, P., … Wrede, C. D. H. (2020). Excisional treatment comparison for in situ endocervical adenocarcinoma (EXCISE): A phase 2 pilot randomized controlled trial to compare histopathological margin status, specimen size and fragmentation after loop electrosurgical excision procedure and cold knife cone biopsy. Gynecologic Oncology, 159, 623-629. doi: 10.1016/j.ygyno.2020.09.053

Chitcholtan, K., Harker, D., Simcock, B., & Sykes, P. (2020). Sensitivity of EGFR/HER-2 positive cells isolated from ascitic fluid of advanced ovarian cancer patients to EGFR/HER-2 inhibitors. Applied Sciences, 10(7), 2343. doi: 10.3390/app10072343

Journal - Research Article

Dempster-Rivett, K., Innes, C. R., Simcock, B. J., Harker, D., Williman, J. A., Van Der Griend, R. A., Whitehead, M., Hibma, M., … Petrich, S., Faherty, J., … Sykes, P. H. (2020). Evaluation of guidelines for observational management of cervical intraepithelial neoplasia 2 in young women. American Journal of Obstetrics & Gynecology, 223, 408.e1-408.e11. doi: 10.1016/j.ajog.2020.02.029

Journal - Research Article

Sykes, P., Eva, L., van der Griend, R., McNally, O., Blomfield, P., Brand, A., … Petrich, S., Kenwright, D., … Innes, C., Harker, D., … Simcock, B. (2019). Pathological process has a crucial role in sentinel node biopsy for vulvar cancer. Gynecologic Oncology, 153, 292-296. doi: 10.1016/j.ygyno.2019.02.012

Journal - Research Article

Yeoh, S., Simcock, B., Innes, C., Mclachlan, J., Harker, D., & Sykes, P. (2019). Trends in the overall survival rates in women with advanced ovarian cancer in a single tertiary centre in New Zealand. Australian & New Zealand Journal of Obstetrics & Gynaecology, 59, 861-866. doi: 10.1111/ajo.13076

Journal - Research Article

Innes, C. R., Sykes, P. H., Harker, D., Williman, J. A., Van der Griend, R. A., Whitehead, M., Hibma, M., … Petrich, S., Faherty, J., … Simcock, B. J. (2018). Changes in human papillomavirus genotypes associated with cervical intraepithelial neoplasia grade 2 lesions in a cohort of young women (2013–2016). Papillomavirus Research, 6, 77-82. doi: 10.1016/j.pvr.2018.10.010

Journal - Research Article

Sykes, P. H., Harker, D. Y., Miller, A., Whitehead, M., Neal, H., Wells, J. E., & Peddie, D. (2008). A randomised comparison of SurePath liquid-based cytology and conventional smear cytology in a colposcopy clinic setting. BJOG, 115(11), 1375-1381. doi: 10.1111/j.1471-0528.2008.01865.x

Journal - Research Article

Sykes, P., Harker, D., & Peddie, D. (2005). Findings and outcome of teenage women referred for colposcopy at Christchurch Women's Hospital, New Zealand. New Zealand Medical Journal, 118(1211). Retrieved from http://journal.nzma.org.nz/journal/118-1211/1350/content.pdf

Journal - Research Article

Sykes, P., Jennings, L., Harker, D., & Beynon, K. (2005). Human papilloma virus is detectable by the Hybrid Capture 2 test in cervical smear samples from women over 40 years of age with high-grade squamous intraepithelial lesions. Australian & New Zealand Journal of Obstetrics & Gynaecology, 45, 457-459.

Journal - Research Article

Journal - Research Other

Sykes, P., Innes, C., Harker, D., Whitehead, M., van der Griend, R., Lawton, B., Hibma, M., … Petrich, S., Faherty, J., Bergzoll, C., … Parker, C., Sadler, L., & Simcock, B. (2016). Observational management of CIN 2 in young women: A prospective multicenter trial. Journal of Lower Genital Tract Disease, 20(4), 343-347. doi: 10.1097/lgt.0000000000000244

Journal - Research Other

Bowden, V., Cuddihy, S., Yeoh, S., Innes, C., van der Griend, R., Simcock, B., Sykes, P., & Harker, D. (2019). Audit of intraoperative ovarian frozen section accuracy in a single tertiary centre. Australian & New Zealand Journal of Obstetrics & Gynaecology, 59(Suppl. 1), (pp. 53-54). doi: 10.1111/ajo.13067

Conference Contribution - Published proceedings: Abstract

Simcock, B., Innes, C., Sykes, P., Harker, D., Williman, J., van der Griend, R., … Bergzoll, C., Petrich, S., & Lawton, B. (2017). Changing face of HPV in CIN2 in young New Zealand women. Australian & New Zealand Journal of Obstetrics & Gynaecology, 57(Suppl. 1), (pp. 62). doi: 10.1111/ajo.12725

Conference Contribution - Published proceedings: Abstract

Chitcholtan, K., Harker, D., Simcock, B., & Sykes, P. (2018, August). Inhibition of EGFR/HER-2 affects growth of ascitic ovarian cancer cells in vitro study. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Poster Presentation (not in published proceedings)

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