PSCI204 Formulation Principles II

Overview

Physicochemical principles and formulation of solid dosage forms; principles of drug release, manufacture, quality control and stability.

PSCI204 brings together aspects of the chemical, physical and biological sciences, with an emphasis on physical chemistry, to provide the basis for pharmaceutical formulation.

About this paper

Prerequisite

BIOC 192

Restriction

PHCY 255

Contact

Associate Professor Greg Walker

More information link

View more information about the Bachelor of Pharmaceutical Science

Teaching staff

Paper Co-ordinator: Associate Professor Greg Walker

 Professor Shyamal Das

Dr Shakila Rizwan

Textbooks

Available on reserve in Health Sciences library:

• Allen, L., Popovich, N., Ansel, H., (2011) Ansel's pharmaceutical dosage forms and drug delivery systems 9th Ed, Lippincott, Williams & Wilkins.
• Aulton, M. E. (2013) Aulton’s Pharmaceutics: The Design and Manufacture of Medicines, 4th Ed, Edinburgh, Churchill Livingston.
• Barber, J., Rostron, C., (2013) Pharmaceutical Chemistry, Oxford University Press.
• Florence, A.T. and Attwood, D. (2011) Physicochemical Principles of Pharmacy, 5th Ed, Pharmaceutical Press.
• Patrick, G. L. (2013) An Introduction to Medicinal Chemistry, 5th Ed, Oxford University Press.
• Perrie, Y. and Rades, T. (2012) FASTtrack: Pharmaceutics - Drug delivery and targeting. Pharmaceutical Press.
• Ritter, J., Flower, R., Henderson, G., Rang, H. (2015) Rang and Dale’s Pharmacology, 8th Ed, Elsevier Churchill Livingston.

Graduate Attributes Emphasised

Lifelong learning, Scholarship, Communication, Critical thinking, Research, Self-motivation, Teamwork.
View more information about Otago's graduate attributes.

Learning Outcomes

Students who successfully complete the paper will be able to:

1. Understanding of key physicochemical principles relevant to drug formulation and preformulation.
2. Explain the importance of stability and hence the need for appropriate storage of medicines and importance of expiry date.
3. Outline common mechanisms of chemical and physical degradation of drugs.
4. Describe what formulation and storage factors can be controlled to maximise the stability of medicines.
5. State the methods used to determine shelf-life and storage conditions of medicines and estimate shelf-life.
6. Describe how physical properties and processes influence the production and efficacy of oral solid dosage forms.
7. Describe the process of formulating and assessing the quality of oral solid dosage forms (tablets and capsules).
8. Describe the principles of drug release such as disintegration, dissolution, absorption.

Overview

Physicochemical principles and formulation of solid dosage forms; principles of drug release, manufacture, quality control and stability.

PSCI 204 brings together aspects of the chemical, physical and biological sciences, with an emphasis on physical chemistry, to provide the basis for pharmaceutical formulation.

About this paper

Prerequisite

BIOC 192

Restriction

PHCY 255

Contact

Associate Professor Greg Walker

More information link

View more information about the Bachelor of Pharmaceutical Science.

Teaching staff

Paper Co-ordinator: Associate Professor Greg Walker

 Professor Shyamal Das

Dr Shakila Rizwan

Paper Structure

PSCI 204 will be taught through lectures, laboratories and workshops/tutorials covering:

1. Semi-solid dosage forms
2. Solid dosage forms 
3. Principles of drug release such as disintegration, dissolution, absorption.
4. Quality control of dosage forms
5. Stability of medicines 

Textbooks

Available on reserve in Health Sciences library:

• Allen, L. V., Popovich, N. G., & Ansel, H. C. (2011). Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems (9th ed.). Lippincott, Williams & Wilkins.
• Aulton, M. E. (2013). Aulton’s Pharmaceutics: The Design and Manufacture of Medicines (4th ed.). Churchill Livingston.
• Barber, J., & Rostron, C. (Eds). (2013). Pharmaceutical Chemistry. Oxford University Press.
• Florence, A. T., & Attwood, D. (2011). Physicochemical Principles of Pharmacy (5th ed.). Pharmaceutical Press.
• Patrick, G. L. (2013). An Introduction to Medicinal Chemistry (5th ed.). Oxford University Press.
• Perrie, Y., & Rades, T. (2012). FASTtrack: Pharmaceutics - Drug Delivery and Targeting (2nd ed.). Pharmaceutical Press.
• Rang, H. P., Ritter, J. M., Flower, R. J., & Henderson, G. (2015). Rang and Dale’s Pharmacology (8th ed.). Elsevier Churchill Livingston.

Graduate Attributes Emphasised

Lifelong learning, Scholarship, Communication, Critical thinking, Research, Self-motivation, Teamwork.
View more information about Otago's graduate attributes.

Learning Outcomes

Students who successfully complete the paper will be able to:

• Understand key physicochemical principles relevant to drug formulation and preformulation.
• Explain the importance of stability and hence the need for appropriate storage of medicines and importance of expiry date.
• Outline common mechanisms of chemical and physical degradation of drugs.
• Describe what formulation and storage factors can be controlled to maximise the stability of medicines.
• State the methods used to determine shelf-life and storage conditions of medicines and estimate shelf-life.
• Describe how physical properties and processes influence the production and efficacy of oral solid dosage forms.
• Describe the process of formulating and assessing the quality of oral solid dosage forms (tablets and capsules).
• Describe the principles of drug release such as disintegration, dissolution, absorption.