Overview
Drug targets, drug lead design and discovery including computer-aided molecular modelling, key functional groups necessary for drug action, metabolism, stereochemistry and selected drug classes in medicinal chemistry.
PSCI 302 builds on pharmaceutical chemistry with a focus on medicinal chemistry topics. Students will investigate the concepts of drug targets of small molecule drugs, drug design and discovery including computer-aided modelling and design, key functional groups necessary for drug action, testing of drug leads, optimisation of drug leads, metabolism, stereochemistry and selected drug classes in medicinal chemistry.
About this paper
| Paper title | Medicinal Chemistry |
|---|---|
| Subject | Pharmaceutical Science |
| EFTS | 0.1500 |
| Points | 18 points |
| Teaching period | Semester 1 (On campus) |
| Domestic Tuition Fees ( NZD ) | $1,318.20 |
| International Tuition Fees | Tuition Fees for international students are elsewhere on this website. |
- Prerequisite
- PSCI 201 or CHEM 202
- Restriction
- PHCY 258, CHEM 305
- Eligibility
PSCI 302 builds on the principles of pharmaceutical chemistry (PSCI 201 or CHEM 202) with a focus on drug design and discovery. The paper provides a strong base for further study in medicinal chemistry and can complement BSc degrees with a chemistry, pharmacology, biochemistry or biology focus.
- Contact
- More information link
- Teaching staff
Paper Co-ordinator: Professor Joel Tyndall
- Paper Structure
PSCI302 will be taught through lectures, laboratories and tutorials covering the following general topics,
- Small molecule drug targets.
- Drug-protein interactions.
- Chemical principles of drug design and discovery.
- Assays and screening.
- Computational methods for drug design.
- Case studies.
- Textbooks
Recommended: Patrick, G. L. (2017) An Introduction to Medicinal Chemistry, 6th Ed, Oxford University Press.
- Graduate Attributes Emphasised
Global perspective, Interdisciplinary perspective, Lifelong learning, Scholarship, Communication, Critical thinking, Information literacy, Research, Self-motivation, Teamwork
View more information about Otago's graduate attributes.- Learning Outcomes
By completion of this paper students will be able to,
- Describe how small molecule drugs interact with different biological targets in the context of the human body.
- Demonstrate an understanding of the identification and development of drug leads.
- Operate and understand computational modelling techniques.
- Demonstrate laboratory skills relevant to medicinal pharmaceutical chemistry, including synthesis, characterisation and measurement and analysis of drug activity.
- Evaluates and applies scientific literature.
- Exhibit high level communication skills for a scientific audience.
Overview
Drug targets, drug lead design and discovery including computer-aided molecular modelling, key functional groups necessary for drug action, metabolism, stereochemistry and selected drug classes in medicinal chemistry.
PSCI 302 builds on pharmaceutical chemistry with a focus on medicinal chemistry topics. Students will investigate the concepts of drug targets of small molecule drugs, drug design and discovery including computer-aided modelling and design, key functional groups necessary for drug action, testing of drug leads, optimisation of drug leads, metabolism, stereochemistry and selected drug discovery case studies in medicinal chemistry.
About this paper
| Paper title | Medicinal Chemistry |
|---|---|
| Subject | Pharmaceutical Science |
| EFTS | 0.1500 |
| Points | 18 points |
| Teaching period | Semester 1 (On campus) |
| Domestic Tuition Fees | Tuition Fees for 2027 have not yet been set |
| International Tuition Fees | Tuition Fees for international students are elsewhere on this website. |
- Prerequisite
- PSCI 201 or CHEM 202
- Restriction
- PHCY 258, CHEM 305
- Eligibility
PSCI 302 builds on the principles of pharmaceutical chemistry (PSCI 201 or CHEM 202) with a focus on drug design and discovery. The paper provides a strong base for further study in medicinal chemistry and can complement BSc degrees with a chemistry, pharmacology, biochemistry or biology focus.
- Contact
- More information link
View more information on the Bachelor of Pharmaceutical Science (BPharmSc) website
- Teaching staff
Paper Co-ordinator: Professor Joel Tyndall
- Paper Structure
PSCI 302 will be taught through lectures, laboratories and tutorials covering the following general topics:
- Small molecule drug targets.
- Drug-protein interactions.
- Chemical principles of drug design and discovery.
- Assays and screening.
- Computational methods for drug design.
- Case studies.
- Textbooks
Recommended: Patrick, G. L. (2023) An Introduction to Medicinal Chemistry, 7th Ed, Oxford University Press.
- Graduate Attributes Emphasised
Global perspective, Interdisciplinary perspective, Lifelong learning, Scholarship, Communication, Critical thinking, Information literacy, Research, Self-motivation, Teamwork
View more information about Otago's graduate attributes.- Learning Outcomes
By completion of this paper students will be able to:
- Describe how small molecule drugs interact with different biological targets in the context of the human body.
- Demonstrate an understanding of the identification and development of drug leads.
- Operate and understand computational modelling techniques.
- Demonstrate laboratory skills relevant to medicinal pharmaceutical chemistry, including synthesis, characterisation and measurement and analysis of drug activity.
- Exhibit high level communication skills for a scientific audience.
- Assessment details
The assessments for this paper are two End-of-Module tests, a written assignment and a final exam.