Professor Antony Braithwaite
Position | Research Professor |
---|---|
Department | Department of Pathology (Dunedin) |
Qualifications | MSc(Auck) PhD(ANU) |
Research summary | Molecular mechanisms of cancer; tumour suppressors; p53 |
Research
- Apoptosis
- Cancer biology
- DNA tumour viruses
- Tumour suppressors
- Viral oncoproteins
Publications
Wiles, A. K., Mehta, S., Millier, M., Woolley, A. G., Li, K., Parker, K., Kazantseva, M., Wilson, M., Young, K., Bowie, S., Ray, S., Slatter, T. L., Stamp, L. K., Hessian, P. A., & Braithwaite, A. W. (2023). Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis. Arthritis Research & Therapy, 25, 62. doi: 10.1186/s13075-023-03040-8
Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267
Reinhardt, L. S., Zhang, X., Groen, K., Morten, B. C., De Iuliis, G. N., Braithwaite, A. W., … Avery-Kiejda, K. A. (2022). Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage. Cell Death & Disease, 13, 907. doi: 10.1038/s41419-022-05349-9
Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394
Zhang, X., Groen, K., Morten, B. C., Reinhardt, L. S., Campbell, H. G., Braithwaite, A. W., … Avery-Kiejda, K. A. (2022). The effect of p53 and its N-terminally truncated isoform, Δ40p53, on breast cancer migration and invasion. Molecular Oncology, 16, 447-465. doi: 10.1002/1878-0261.13118
Russell, A., Royds, J. A., & Braithwaite, A. W. (2004). Exploitation of cell cycle and cell death controls by Adenoviruses: The road to a productive infection. In C. Alonso (Ed.), Progress in molecular and subcellular biology: Viruses and apoptosis. (pp. 207-243). Berlin: Springer.
Chapter in Book - Research
Braithwaite, A. W., & Edwards, S. J. (2003). The p53 pathway, cancer and aging. In S. C. Kaul & R. Wadhwa (Eds.), Aging of cells in and outside the body. (pp. 121-149). UK: Kluwer Academic.
Chapter in Book - Research
Boix De Jesus, A. N., Taha, A., Wang, D., Mehta, P. M., Mehta, S., Reily-Bell, A., Polwatta Lekamlage, S., Machado Saraiva, A., Tahmeedzaman, T., … Royds, J., Braithwaite, A., Hung, N., & Slatter, T. L. (2023). Increased expression of the Δ133p53ß isoform enhances brain metastasis. International Journal of Molecular Sciences, 24, 1267. doi: 10.3390/ijms24021267
Journal - Research Article
Wiles, A. K., Mehta, S., Millier, M., Woolley, A. G., Li, K., Parker, K., Kazantseva, M., Wilson, M., Young, K., Bowie, S., Ray, S., Slatter, T. L., Stamp, L. K., Hessian, P. A., & Braithwaite, A. W. (2023). Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis. Arthritis Research & Therapy, 25, 62. doi: 10.1186/s13075-023-03040-8
Journal - Research Article
Reinhardt, L. S., Zhang, X., Groen, K., Morten, B. C., De Iuliis, G. N., Braithwaite, A. W., … Avery-Kiejda, K. A. (2022). Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damage. Cell Death & Disease, 13, 907. doi: 10.1038/s41419-022-05349-9
Journal - Research Article
Zhang, X., Groen, K., Morten, B. C., Reinhardt, L. S., Campbell, H. G., Braithwaite, A. W., … Avery-Kiejda, K. A. (2022). The effect of p53 and its N-terminally truncated isoform, Δ40p53, on breast cancer migration and invasion. Molecular Oncology, 16, 447-465. doi: 10.1002/1878-0261.13118
Journal - Research Article
Arsic, N., Slatter, T., Gadea, G., Villain, E., Fournet, A., Kazantseva, M., … Mehta, S., … Braithwaite, A., & Roux, P. (2021). Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nature Communications, 12, 5463. doi: 10.1038/s41467-021-25550-2
Journal - Research Article
Lasham, A., Knowlton, N., Mehta, S. Y., Braithwaite, A. W., & Print, C. G. (2021). Breast cancer patient prognosis is determined by the interplay between TP53 mutation and alternative transcript expression: Insights from TP53 long amplicon digital PCR assays. Cancers, 13(7), 1531. doi: 10.3390/cancers13071531
Journal - Research Article
Chin, C. V., Antony, J., Ketharnathan, S., Labudina, A., Gimenez, G., Parsons, K. M., … Braithwaite, A., Guilford, P., … Horsfield, J. A. (2020). Cohesin mutations are synthetic lethal with stimulation of WNT signaling. eLIFE, 9, e61405. doi: 10.7554/eLife.61405
Journal - Research Article
Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472
Journal - Research Article
Lasham, A., Tsai, P., Fitzgerald, S. J., Mehta, S. Y., Knowlton, N. S., Braithwaite, A. W., & Print, C. G. (2020). Accessing a new dimension in TP53 biology: Multiplex long amplicon digital PCR to specifically detect and quantitate individual TP53 transcripts. Cancers, 12(3), 769. doi: 10.3390/cancers12030769
Journal - Research Article
Mehta, S., Algie, M., Al-Jabry, T., McKinney, C., Kannan, S., Verma, C. S., … Parker, K., Henderson, L., Gould, M. L., Bhatia, P., Harfoot, R., … Kleffmann, T., … Woolley, A. G., … Braithwaite, A. (2020). Critical role for cold shock protein YB-1 in cytokinesis. Cancers, 12, 2473. doi: 10.3390/cancers12092473
Journal - Research Article
Mehta, S., McKinney, C., Algie, M., Verma, C. S., Kannan, S., Harfoot, R., … Gould, M. L., Parker, K., … Cunliffe, H. E., … Kleffmann, T., Braithwaite, A. W., & Woolley, A. G. (2020). Dephosphorylation of YB-1 is required for nuclear localisation during G2 phase of the cell cycle. Cancers, 12(2), 315. doi: 10.3390/cancers12020315
Journal - Research Article
Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3
Journal - Research Article
Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1
Journal - Research Article
Trevarton, A. J., Zhou, Y., Yang, D., Rewcastle, G. W., Flanagan, J. U., Braithwaite, A., … Lasham, A. (2019). Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1. Acta Pharmaceutica Sinica B, 9(5), 997-1007. doi: 10.1016/j.apsb.2018.12.011
Journal - Research Article
Vennin, C., Mélénec, P., Rouet, R., Nobis, M., Cazet, A. S., Murphy, K. J., … Braithwaite, A. W., … Timpson, P. (2019). CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature Communications, 10, 3637. doi: 10.1038/s41467-019-10968-6
Journal - Research Article
Campbell, H., Fleming, N., Roth, I., Mehta, S., Wiles, A., Williams, G., … Munro, F., McNoe, L., Black, M., McCall, J., Slatter, T. L., … Braithwaite, A. W. (2018). Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. Nature Communications, 9(1), 254. doi: 10.1038/s41467-017-02408-0
Journal - Research Article
Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111
Journal - Research Article
Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3
Journal - Research Article
Mehta, S. Y., Morten, B. C., Antony, J., Henderson, L., Lasham, A., Campbell, H., Cunliffe, H., Horsfield, J. A., … Braithwaite, A. W. (2018). Regulation of the interferon-gamma (IFN-γ) pathway by p63 and Δ133p53 isoform in different breast cancer subtypes. Oncotarget, 9(49), 29146-29161. doi: 10.18632/oncotarget.25635
Journal - Research Article
Zhang, J., Burn, C., Young, K., Wilson, M., Ly, K., Budhwani, M., Tschirley, A., Braithwaite, A., Baird, M., & Hibma, M. (2018). Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports, 8, 2373. doi: 10.1038/s41598-018-20779-2
Journal - Research Article
Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6
Journal - Research Article
Leroy, B., Ballinger, M. L., Baran-Marszak, F., Bond, G. L., Braithwaite, A., Concin, N., … Soussi, T. (2017). Recommended guidelines for validation, quality control, and reporting of TP53 variants in clinical practice. Cancer Research, 77(6), 1250-1260. doi: 10.1158/0008-5472.can-16-2179
Journal - Research Article
Dasgupta, T., Antony, J., Braithwaite, A. W., & Horsfield, J. A. (2016). HDAC8 inhibition blocks SMC3 deacetylation and delays cell cycle progression without affecting cohesin-dependent transcription in MCF7 cancer cells. Journal of Biological Chemistry, 291(24), 12761-12770. doi: 10.1074/jbc.M115.704627
Journal - Research Article
Lasham, A., Mehta, S. Y., Fitzgerald, S. J., Woolley, A. G., Hearn, J. I., Hurley, D. G., Ruza, I., Algie, M., … Braithwaite, A. W., & Print, C. G. (2016). A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line. International Journal of Cancer, 139(5), 1157-1170. doi: 10.1002/ijc.30137
Journal - Research Article
Mehta, S., Tsai, P., Lasham, A., Campbell, H., Reddel, R., Braithwaite, A., & Print, C. (2016). A study of TP53 RNA splicing illustrates pitfalls of RNA-seq methodology. Cancer Research, 76(24), 7151-7159. doi: 10.1158/0008-5472.can-16-1624
Journal - Research Article
Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., Woolley, A., … Fleming, N., Baird, M., & Braithwaite, A. W. (2016). The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene, 35, 4981-4989. doi: 10.1038/onc.2016.45
Journal - Research Article
Slatter, T. L., Wilson, M., Tang, C., Campbell, H. G., Ward, V. K., Young, V. L., … Fleming, N. I., Braithwaite, A. W., & Baird, M. A. (2016). Antitumor cytotoxicity induced by bone-marrow-derived antigen-presenting cells is facilitated by the tumor suppressor protein p53 via regulation of IL-12. OncoImmunology, 5(3), e1112941. doi: 10.1080/2162402X.2015.1112941
Journal - Research Article
Thomson, W. M., Zeng, J., Broadbent, J. M., Foster Page, L. A., Shalev, I., Moffitt, T. E., … Williams, S. M., Braithwaite, A. W., Robertson, S. P., & Poulton, R. (2016). Telomere length and periodontal attachment loss: A prospective cohort study. Journal of Clinical Periodontology, 43(2), 121-127. doi: 10.1111/jcpe.12499
Journal - Research Article
Sawhney, S., Hood, K., Shaw, A., Braithwaite, A. W., Stubbs, R., Hung, N. A., Royds, J. A., & Slatter, T. L. (2015). Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a Δ133p53α mimic. PLoS ONE, 10(2), e0116270. doi: 10.1371/journal.pone.0116270
Journal - Research Article
Slatter, T. L., Hung, N., Bowie, S., Campbell, H., Rubio, C., Speidel, D., Wilson, M., Baird, M., Royds, J. A., & Braithwaite, A. W. (2015). Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant. Cell Death & Disease, 6, e1783. doi: 10.1038/cddis.2015.149
Journal - Research Article
Sun, Y., Bell, J. L., Carter, D., Gherardi, S., Poulos, R. C., Milazzo, G., … Braithwaite, A., & Liu, T. (2015). WDR5 supports an N-Myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma. Cancer Research, 75(23), 5143-5154. doi: 10.1158/0008-5472.CAN-15-0423
Journal - Research Article
Hung, N., Chen, Y.-J., Taha, A., Olivecrona, M., Boet, R., Wiles, A., … Shaw, A., Eiholzer, R., Baguley, B. C., Eccles, M. R., Braithwaite, A. W., MacFarlane, M., Royds, J. A., & Slatter, T. (2014). Increased paired box transcription factor 8 has a survival function in Glioma. BMC Cancer, 14, 159. doi: 10.1186/1471-2407-14-159
Journal - Research Article
Shalev, I., Moffitt, T. E., Braithwaite, A. W., Danese, A., Fleming, N. I., Goldman-Mellor, S., … Poulton, R., Robertson, S. P., … Caspi, A. (2014). Internalizing disorders and leukocyte telomere erosion: A prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. Molecular Psychiatry, 19, 1163-1170. doi: 10.1038/mp.2013.183
Journal - Research Article
Bildsoe, H., Loebel, D. A. F., Jones, V. J., Hor, A. C. C., Braithwaite, A. W., Chen, Y.-T., … Tam, P. P. L. (2013). The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Developmental Biology, 374, 295-307. doi: 10.1016/j.ydbio.2012.12.004
Journal - Research Article
Campbell, H. G., Mehta, R., Neumann, A. A., Rubio, C., Baird, M., Slatter, T. L., & Braithwaite, A. W. (2013). Activation of p53 following ionizing radiation, but not other stressors, is dependent on the proline-rich domain (PRD). Oncogene, 32(7), 827-836. doi: 10.1038/onc.2012.102
Journal - Research Article
Lasham, A., Print, C. G., Woolley, A. G., Dunn, S. E., & Braithwaite, A. W. (2013). YB-1: Oncoprotein, prognostic marker and therapeutic target? Biochemical Journal, 449, 11-23. doi: 10.1042/bj20121323
Journal - Research Article
Campbell, H. G., Slatter, T. L., Jeffs, A., Mehta, R., Rubio, C., Baird, M., & Braithwaite, A. W. (2012). Does Δ133p53 isoform trigger inflammation and autoimmunity? Cell Cycle, 11(3), 446-450. doi: 10.4161/cc.11.3.19054
Journal - Research Article
Huschtscha, L. I., Napier, C. E., Noble, J. R., Bower, K., Au, A. Y. M., Campbell, H. G., Braithwaite, A. W., & Reddell, R. R. (2012). Enhanced isolation of fibroblasts from human skin explants. Biotechniques, 53(4), 239-244. doi: 10.2144/0000113939
Journal - Research Article
Lasham, A., Samuel, W., Cao, H., Patel, R., Mehta, R., Stern, J. L., … Woolley, A. G., … Black, M. A., Shelling, A. N., Print, C. G., & Braithwaite, A. W. (2012). YB-1, the E2F Pathway, and regulation of tumor cell growth. Journal of the National Cancer Institute, 104(2), 133-146. doi: 10.1093/jnci/djr512
Journal - Research Article
Joshi, S., Braithwaite, A. W., Robinson, P. J., & Chircop, M. (2011). Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression. Molecular Cancer, 10, 78. doi: 10.1186/1476-4598-10-78
Journal - Research Article
Li, C. G., Nyman, J. E., Braithwaite, A. W., & Eccles, M. R. (2011). PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene, 30, 4824-4834. doi: 10.1038/onc.2011.190
Journal - Research Article
Royds, J. A., Al Nadaf, S., Wiles, A. K., Chen, Y.-J., Ahn, A., Shaw, A., Bowie, S., … Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival. PLoS ONE, 6(10), e26737. doi: 10.1371/journal.pone.0026737
Journal - Research Article
Slatter, T. L., Hung, N., Campbell, H., Rubio, C., Mehta, R., Renshaw, P., Williams, G., Wilson, M., … Jeffs, A., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2011). Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform. Blood, 117(19), 5166-5177. doi: 10.1182/blood-2010-11-321851
Journal - Research Article
Woolley, A. G., Algie, M., Samuel, W., Harfoot, R., Wiles, A., Hung, N. A., … Royds, J. A., Perez, D., Yoon, H.-S., … Braithwaite, A. W. (2011). Prognostic association of YB-1 expression in breast cancers: A matter of antibody. PLoS ONE, 6(6), e20603. doi: 10.1371/journal.pone.0020603
Journal - Research Article
Cohen, S. B., Ma, W., Valova, V. A., Algie, M., Harfoot, R., Woolley, A. G., … Braithwaite, A. W. (2010). Genotoxic stress-induced nuclear localization of oncoprotein YB-1 in the absence of proteolytic processing. Oncogene, 29, 403-410. doi: 10.1038/onc.2009.321
Journal - Research Article
Heinlein, C., Deppert, W., Braithwaite, A. W., & Speidel, D. (2010). A rapid and optimization-free procedure allows the in vivo detection of subtle cell cycle and ploidy alterations in tissues by flow cytometry. Cell Cycle, 9(17), 3584-3590. doi: 10.4161/cc.9.17.12831
Journal - Research Article
Joshi, S., Perera, S., Gilbert, J., Smith, C. M., Mariana, A., Gordon, C. P., … Braithwaite, A. W., & Chircop, M. (2010). The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Molecular Cancer Therapeutics, 9(7), 1995-2006. doi: 10.1158/1535-7163.MCT-10-0161
Journal - Research Article
Slatter, T. L., Ganesan, P., Holzhauer, C., Mehta, R., Rubio, C., Williams, G., Wilson, M., Royds, J. A., Baird, M. A., & Braithwaite, A. W. (2010). p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors. Cell Death & Differentiation, 17, 540-550. doi: 10.1038/cdd.2009.136
Journal - Research Article
Hancox, R. J., Poulton, R., Welch, D., Olova, N., McLachlan, C. R., Greene, J. M., … Moffitt, T. E., Robertson, S. P., & Braithwaite, A. W. (2009). Accelerated decline in lung function in cigarette smokers is associated with TP53/MDM2 polymorphisms. Human Genetics, 126(4), 559-565. doi: 10.1007/s00439-009-0704-z
Journal - Research Article
Hibma, M. H., Real, N. C., Wiles, A., Dobson-Le, D., Dix, B. R., Wynford-Thomas, D., Braithwaite, A. W., & Royds, J. A. (2009). Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells. Virus Research, 145(1), 112-120. doi: 10.1016/j.virusres.2009.06.016
Journal - Research Article
Huschtscha, L., Moore, J. D., Noble, J. R., Campbell, H. G., Royds, J. A., Braithwaite, A. W., & Reddel, R. R. (2009). Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21WAF1/CIP1. Journal of Cell Science, 122(16), 2989-2995. doi: 10.1242/jcs.044107
Journal - Research Article
Jiang, W.-Q., Zhong, Z.-H., Nguyen, A., Henson, J. D., Toouli, C. D., Braithwaite, A. W., & Reddel, R. (2009). Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins. Journal of Cell Biology, 185(5), 797-810. doi: 10.1083/jcb.200810084
Journal - Research Article
Chen, Y.-J., Campbell, H. G., Wiles, A. K., Eccles, M. R., Reddel, R. R., Braithwaite, A. W., & Royds, J. A. (2008). PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Research, 68(14), 5724-5732. doi: 10.1158/0008-5472.CAN-08-0058
Journal - Research Article
Humar, B., McNoe, L., Dunbier, A., Heathcott, R., Braithwaite, A. W., & Reeve, A. E. (2008). Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition. Biologics, 2(2), 329-337.
Journal - Research Article
Braithwaite, A. W., & Prives, C. L. (2006). p53: More research and more questions. Cell Death & Differentiation, 13, 877-880.
Journal - Research Article
Braithwaite, A. W., Del Sal, G., & Lu, X. (2006). Some p53-binding proteins that can function as arbiters of life and death. Cell Death & Differentiation, 13, 984-993.
Journal - Research Article
Chen, Y.-J., Hakin-Smith, V., Teo, M., Xinarianos, G. E., Jellinek, D. A., Carroll, T., … Braithwaite, A. W., … Royds, J. A. (2006). Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. Cancer Research, 66(13), 6473-6476.
Journal - Research Article
Royds, J. A., Hibma, M., Dix, B. R., Hananeia, L., Russell, I. A., Wiles, A., … Braithwaite, A. W. (2006). p53 promotes adenoviral replication and increases late viral gene expression. Oncogene, 25, 1509-1520.
Journal - Research Article
Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., … Braithwaite, A., Poulton, R., & Craig, I. W. (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction. Biological Psychiatry, 57(10), 1117-1127.
Journal - Research Article
He, S.-J., Stevens, G., Braithwaite, A. W., & Eccles, M. R. (2005). Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin-induced cytotoxicity. Molecular Cancer Therapeutics, 4(6), 996-1003.
Journal - Research Article
Homer, C., Knight, D. A., Hananeia, L., Sheard, P., Risk, J., Lasham, A., Royds, J. A., & Braithwaite, A. W. (2005). Y-box factor YB1 controls p53 apoptotic function. Oncogene, 24, 8314-8325. Retrieved from http://www.nature.com/onc/journal/v24/n56/abs/1208998a.html
Journal - Research Article
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., … Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-389. doi: 10.1126/science.1083968
Journal - Research Article
Edwards, S. J., Hananeia, L., Eccles, M. R., Zhang, Y.-F., & Braithwaite, A. (2003). The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions. Oncogene, 22(29), 4517-4523.
Journal - Research Article
Hall, R. J., Merriman, M. E., Green, R. A., Markham, V. H., Smyth, D. J., Heward, J. M., … Braithwaite, A., … Darlow, B. A., … Harrison, A. A., Highton, J., Hunt, P. J., Manning, P. J., … Scott, R. S., Taylor, B. J., Willis, J., … Merriman, T. R. (2003). The Deleted in Colorectal Carcinoma (DCC) gene 201 R → G polymorphism: No evidence for genetic association with autoimmune disease. European Journal of Human Genetics, 11, 840-844.
Journal - Research Article
Lasham, A., Moloney, S., Hale, T., Homer, C., Zhang, Y. F., Murison, J. G., Braithwaite, A. W., & Watson, J. (2003). The Y-box-binding protein, YB1, is a potential negative regulator of the p53 tumor suppressor. Journal of Biological Chemistry, 278(37), 35516-35523.
Journal - Research Article
Zhang, Y.-F., Homer, C., Edwards, S. J., Hananeia, L., Lasham, A., Royds, J., Sheard, P., & Braithwaite, A. W. (2003). Nuclear localization of Y-box factor YB1 requires wild-type p53. Oncogene, 22, 2782-2794. doi: 10.1038/sj.onc.1206357
Journal - Research Article
Edwards, S. J., Dix, B. R., Myers, C. J., Dobson-Le, D., Huschtscha, L., Hibma, M., Royds, J., & Braithwaite, A. W. (2002). Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14ARF tumor suppressor genes. Journal of Virology, 76(24), 12483-12490. doi: 10.1128/JVI.76.24.12483-12490.2002
Journal - Research Article
Mill, J. S., Caspi, A., McClay, J., Sugden, K., Purcell, S., Asherson, P., … Braithwaite, A., Poulton, R., & Moffitt, T. E. (2002). The dopamine D4 receptor and the hyperactivity phenotype: A developmental-epidemiological study. Molecular Psychiatry, 7(4), 383-391. doi: 10.1038/sj.mp.4000984
Journal - Research Article
Braithwaite, A. W., & Russell, I. A. (2001). Induction of cell death by adenoviruses. Apoptosis, 6, 359-370.
Journal - Research Article
Dix, B. R., Edwards, S. J., & Braithwaite, A. W. (2001). Does the anti-tumour adenovirus, ONYX-015/dl1520 selectively target cells defective in the p53 pathway? Journal of Virology, 75(12), 5443-5447. doi: 10.1128/JVI.75.12.5443-5447.2001
Journal - Research Article
Hibma, M., & Braithwaite, A. (2001). Viruses to the rescue: p53-based therapies in the fight against cancer. New Zealand Medical Journal, 114(1133), 266-269.
Journal - Research Article
Thomson, W. M., Edwards, S. J., Dobson-Le, D. P., Tompkins, G. R., Poulton, R., Knight, D. A., … Braithwaite, A. W. (2001). IL-1 genotype and adult periodontitis among young New Zealanders. Journal of Dental Research, 80, 1700-1703.
Journal - Research Article
Dix, B. R., O'Carroll, S. J., Myers, C. J., Edwards, S. J., & Braithwaite, A. W. (2000). Efficient induction of cell death by adenoviruses requires binding of E1B55k and p53. Cancer Research, 60, 2666-2672.
Journal - Research Article
Hale, T. K., Myers, C., Maitra, R., Kolzau, T., Nishizawa, M., & Braithwaite, A. W. (2000). Maf transcriptionally activates the mouse p53 promoter and causes a p53-dependent cell death. Journal of Biological Chemistry, 275(24), 17991-17999.
Journal - Research Article
O'Carroll, S. J., Hall, A. R., Myers, C. J., Braithwaite, A. W., & Dix, B. R. (2000). Quantifying adenoviral titers by spectrophotometry. Biotechniques, 28, 408-410.
Journal - Research Article
Hale, T. K., & Braithwaite, A. W. (1999). The adenovirus oncoprotein E1a stimulates binding of the transcription factor ETF to transcriptionally activate the p53 gene. Journal of Biological Chemistry, 274, 23777-23786. doi: 10.1074/jbc.274.34.23777
Journal - Research Article
Kolzau, T., Hansen, R. S., Zahra, D., Reddel, R. R., & Braithwaite, A. W. (1999). Inhibition of SV40 large T antigen induced apoptosis by small T antigen. Oncogene, 18(40), 5598-5603.
Journal - Research Article
Hall, A. R., O'Carroll, S. J., Dix, B. R., & Braithwaite, A. W. (1998). p53 dependent cell death/apoptosis is required for a productive adenovirus infection. Nature Medicine, 4, 1068-1072.
Journal - Research Article
Braithwaite, A., & Poulton, R. (1997). Relevance in health research funding: reality or myth? New Zealand Medical Journal, 110, 361-362.
Journal - Research Article
Hall, A. R., & Braithwaite, A. W. (1997). From clinical significance to significance in the clinic? New Zealand Medical Journal, 110, 347-348.
Journal - Research Article
Ridgway, P. J., Hall, A. R., Myers, C. J., & Braithwaite, A. W. (1997). p53/E1b58kDa complex regulates adenovirus replication. Virology, 237, 404-413.
Journal - Research Article
Hall, A. R., & Braithwaite, A. W. (1996). Culling cancer cells and completing the cell cycle with the tumour suppressor p53. New Zealand BioScience, 4(3), 41-48.
Journal - Research Article
Hansen, R. S., & Braithwaite, A. (1996). The growth inhibitory function of p53 is separable from transactivation, apoptosis and suppression of transformation by E1a and ras. Oncogene, 13(5), 995-1007.
Journal - Research Article
Sedger, L., Ramshaw, I., Condie, A., Medvecsky, J., Braithwaite, A., & Ruby, J. (1996). Vaccinia virus replication is independent of cellular HSP72 expression which is induced during virus infection. Virology, 225(2), 423-427.
Journal - Research Article
Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394
Journal - Research Other
Mehta, S., Campbell, H., Drummond, C. J., Li, K., Murray, K., Slatter, T., … Braithwaite, A. W. (2021). Adaptive homeostasis and the p53 isoform network. EMBO Reports, 22, e53085. doi: 10.15252/embr.202153085
Journal - Research Other
Braithwaite, A. W., Royds, J. A., & Jackson, P. (2005). The p53 story: Layers of complexity. Carcinogenesis, 26(7), 1161-1169.
Journal - Research Other