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Contact Details

Phone
64 3 479 7877
Email
sarah.hook@otago.ac.nz
Position
Professor and Research Infrastructure Centre Manager
Qualifications
BSc(Hons) PhD(Otago)
Research summary
Vaccine formulation and delivery
Teaching
Immunology and infectious diseases to undergraduate and postgraduate students

Research

My area of interest is in the development and testing (physical, chemical and immunological) of novel vaccine formulations for the prevention and treatment of both communicable and non-communicable disease. My specific areas of interest are in the development of one-shot sustained release vaccines and in needle-free (transdermal or oral) vaccines for the treatment of tuberculosis and cancer.

My research focuses on:

  • Sustained release vaccines
  • Needle free vaccines
  • Therapeutic cancer vaccines
  • Identification and formulation of novel adjuvants

Professor Hook on Google Scholar

Publications

Ross, C. L., Lawer, A., Sircombe, K. J., Pletzer, D., Gamble, A. B., & Hook, S. (2024). Site-specific antimicrobial activity of a dual-responsive ciprofloxacin prodrug. Journal of Medicinal Chemistry. Advance online publication. doi: 10.1021/acs.jmedchem.4c00724 Journal - Research Article

Zheng, D., Fang, Y., Deng, Y., Pan, X., Gamble, A., Hook, S., & McDowell, A. (2023). Microfluidic fabrication of PLGA nanoparticles loaded with a novel fluorescent probe for application in cancer diagnosis and treatment. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home Conference Contribution - Published proceedings: Abstract

Su, S., Hook, S., Pletzer, D., & Gamble, A. (2023). Overcoming efflux-mediated multidrug resistance in Pseudomonas aeruginosa. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home Conference Contribution - Published proceedings: Abstract

Sircombe, K. J., Gamble, A., Pletzer, D., & Hook, S. (2023). Development and evaluation of controlled release responsive antibiotic delivery systems. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home Conference Contribution - Published proceedings: Abstract

Rani, P., Fairhall, J., Dadhwal, S., Hook, S., & Gamble, A. B. (2023). Dual triggered probe for improved drug delivery using TCO-peptide hydrogel. Proceedings of the New Zealand Controlled Release Society (NZCRS) Symposium. Retrieved from http://nzcrs.org.nz/#/home Conference Contribution - Published proceedings: Abstract

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