Professor Mike Eccles

2024

Journal - Research Article

Banerjee, R., Ajithkumar, P., Keestra, N., Smith, J., Gimenez, G., Rodger, E. J., Eccles, M. R., Antony, J., Weeks, R. J., & Chatterjee, A. (2024). Targeted DNA methylation editing using an all-in-one system establishes paradoxical activation of EBF3. Cancers, 16, 898. doi: 10.3390/cancers16050898

Ajithkumar, P., Gimenez, G., Stockwell, P. A., Almomani, S., Bowden, S. A., Leichter, A. L., … Pattison, S., … Frizelle, F. A., Eccles, M. R., Purcell, R. V., Rodger, E. J., & Chatterjee, A. (2024). DNA methylome and transcriptome maps of primary colorectal cancer and matched liver metastasis. Data, 9(1), 8. doi: 10.3390/data9010008

Journal - Research Other

Hossain, S. M., Carpenter, C., & Eccles, M. R. (2024). Genomic and epigenomic biomarkers of immune checkpoint immunotherapy response in melanoma: Current and future perspectives. International Journal of Molecular Sciences, 25, 7252. doi: 10.3390/ijms25137252

Li, L., Hossain, S. M., & Eccles, M. R. (2024). The role of the PAX genes in renal cell carcinoma. International Journal of Molecular Sciences, 25(12), 6730. doi: 10.3390/ijms25126730

Powell, R. M., Moravec, J. C., Jones, G. T., Bhat, B., Lin, S. M., Planer, J. D., … Pattison, S., Morison, I. M., … Eccles, M. R., & Macaulay, E. C. (2024). DNA methylation profiling of heterogeneous sporadic LAM and matched lung tissue. American Journal of Respiratory Cell & Molecular Biology, 70(1), 81-84. doi: 10.1165/rcmb.2023-0300LE

Conference Contribution - Published proceedings: Abstract

Ravindran Menon, D., Hammerlindl, H., Gimenez, G., Zuegner, E., Magens, C., Eccles, M., … Schaider, H. (2024). O-GlcNAc transferase drives the proliferative state in adaptive drug tolerance. Cancer Research, 84(7, Suppl.), LB293. doi: 10.1158/1538-7445.AM2024-LB293

Ravindran Menon, D., Hammerlindl, H., Gimenez, G., Zuegner, E., Haass, N. K., Herlyn, M., … Eccles, M., … Schaider, H. (2024). H3K4me3 remodeling induced acquired resistance through O-GicNAc transferase in melanoma. Pigment Cell & Melanoma Research, 37, (pp. 120-121). doi: 10.1111/pcmr.13152

2023

Chapter in Book - Research

Vasantharajan, S. S., Barnett, E., Gray, E. S., Rodger, E. J., Eccles, M. R., Pattison, S., Munro, F., & Chatterjee, A. (2023). Size-based method for enrichment of circulating tumor cells from blood of colorectal cancer patients. In G. J. Seymour, M. P. Cullinan, N. C. K. Heng & P. R. Cooper (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 2588). (3rd ed.) (pp. 231-248). New York, NY: Springer. doi: 10.1007/978-1-0716-2780-8_15

Journal - Research Article

Ravindran Menon, D., Hammerlindl, H., Gimenez, G., Hammerlindl, S., Zuegner, E., Torrano, J., … Eccles, M. R., … Schaider, H. (2023). H3K4me3 remodeling induced acquired resistance through O-GlcNAc transferase. Drug Resistance Updates, 71, 100993. doi: 10.1016/j.drup.2023.100993

Li, L., Li, C. G., Almomani, S. N., Hossain, S. M., & Eccles, M. R. (2023). Co-expression of multiple PAX genes in renal cell carcinoma (RCC) and correlation of high PAX expression with favorable clinical outcome in RCC patients. International Journal of Molecular Sciences, 24, 11432. doi: 10.3390/ijms241411432

Lynch-Sutherland, C. F., McDougall, L. I., Stockwell, P. A., Almomani, S. N., Weeks, R. J., Ludgate, J. L., … Chatterjee, A., … Eccles, M. R., & Macaulay, E. C. (2023). The transposable element-derived transcript of LIN28B has a placental origin and is not specific to tumours. Molecular Genetics & Genomics. Advance online publication. doi: 10.1007/s00438-023-02033-1

Keighley, L. M., Lynch-Sutherland, C. F., Almomani, S. N., Eccles, M. R., & Macaulay, E. C. (2023). Unveiling the hidden players: The crucial role of transposable elements in the placenta and their potential contribution to pre-eclampsia. Placenta. Advance online publication. doi: 10.1016/j.placenta.2023.05.017

Rodger, E. J., Gimenez, G., Ajithkumar, P., Stockwell, P. A., Almomani, S., Bowden, S. A., Leichter, A. L., Ahn, A., Pattison, S., McCall, J. L., … Frizelle, F. A., Eccles, M. R., Purcell, R. V., & Chatterjee, A. (2023). An epigenetic signature of advanced colorectal cancer metastasis. iScience, 26(6), 106986. doi: 10.1016/j.isci.2023.106986

Fitzgerald, S., Blenkiron, C., Stephens, R., Mathy, J. A., Somers-Edgar, T., Rolfe, G., … Jackson, C., Eccles, M., … Rodger, E., … Guilford, P., … Print, C. G. (2023). Dynamic ctDNA mutational complexity in patients with melanoma receiving immunotherapy. Molecular Diagnosis & Therapy. Advance online publication. doi: 10.1007/s40291-023-00651-4

Jasiak, A., Koczkowska, M., Stukan, M., Wydra, D., Biernat, W., Izycka-Swieszewska, E., … Eccles, M. R., Walker, L., … Ratajska, M. (2023). Analysis of BRCA1 and BRCA2 alternative splicing in predisposition to ovarian cancer. Experimental & Molecular Pathology, 130(104856). doi: 10.1016/j.yexmp.2023.104856

Journal - Research Other

Rodger, E. J., Stockwell, P. A., Almomani, S., Eccles, M. R., & Chatterjee, A. (2023). Protocol for generating high-quality genome-scale DNA methylation sequencing data from human cancer biospecimens. STAR Protocols, 4, 102714. doi: 10.1016/j.xpro.2023.102714

Hossain, S. M., & Eccles, M. R. (2023). Phenotype switching and the melanoma microenvironment: Impact on immunotherapy and drug resistance. International Journal of Molecular Sciences, 24, 1601. doi: 10.3390/ijms24021601

Conference Contribution - Verbal presentation and other Conference outputs

Weeks, R., Almomani, S. N., Macaulay, E., Powell, R., Bhat, B., Zuk, M., … Eccles, M. R., & Ratajska, M. (2023, August). Early detection of lung cancer and identification of potential molecular targets for novel therapies via genetic and epigenetic screening. Verbal presentation at the Queenstown Molecular Biology (QMB) Genomics Satellite, Queenstown, New Zealand.

2022

Chapter in Book - Research

Al Momani, S., Rodger, E. J., Stockwell, P. A., Eccles, M. R., & Chatterjee, A. (2022). Generating sequencing-based DNA methylation maps from low DNA input samples. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 3-21). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_1

Journal - Research Article

Hossain, S. M., Gimenez, G., Stockwell, P. A., Tsai, P., Print, C. G., Rys, J., … Jackson, C., Chatterjee, A., & Eccles, M. R. (2022). Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures. Frontiers in Immunology, 13, 955063. doi: 10.3389/fimmu.2022.955063

Vasantharajan, S. S., Barnett, E., Gray, E. S., McCall, J. L., Rodger, E. J., Eccles, M. R., Munro, F., Pattison, S., & Chatterjee, A. (2022). Assessment of a size-based method for enriching circulating tumour cells in colorectal cancer. Cancers, 14, 3446. doi: 10.3390/cancers14143446

Powell, R. M., Pattison, S., Moravec, J. C., Bhat, B., Guirguis, N., Markie, D., Jones, G. T., … Print, C. G., Morison, I. M., Gavryushkin, A., … Eccles, M. R., & Macaulay, E. C. (2022). Tuberous sclerosis complex: A complex case. Molecular Case Studies, 8, a006182. doi: 10.1101/mcs.a006182

Ahmed, F., Tseng, H.-Y., Ahn, A., Gunatilake, D., Alavi, S., Eccles, M., … Al Emran, A. (2022). Repurposing melanoma chemotherapy to activate inflammasomes in treatment of BRAF/MAPK inhibitor resistant melanoma. Journal of Investigative Dermatology, 142, 1444-1455. doi: 10.1016/j.jid.2021.09.030

Journal - Research Other

Zheng, Q., Reid, G., Eccles, M. R., & Stayner, C. (2022). Non-coding RNAs as potential biomarkers and therapeutic targets in polycystic kidney disease [Mini review]. Frontiers in Physiology, 13, 1006427. doi: 10.3389/fphys.2022.1006427

Banerjee, R., Smith, J., Eccles, M. R., Weeks, R. J., & Chatterjee, A. (2022). Epigenetic basis and targeting of cancer metastasis. Trends in Cancer, 8(3), 226-241. doi: 10.1016/j.trecan.2021.11.008

Conference Contribution - Published proceedings: Abstract

Keighley, L., Lynch-Sutherland, C., McDougall, L., Almomani, S., Weeks, R., Gamage, T., … Eccles, M., & Macaulay, E. (2022). Investigating transposable element derived genes in pre-eclampsia. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Conference Contribution - Verbal presentation and other Conference outputs

Vasantharajan, S. S., Barnett, E., Eccles, M. R., Pattison, S., Rodger, E. J., McCall, J. L., … Munro, F., & Chatterjee, A. (2022, September). Evaluation of a membrane-based method for enriching circulating tumour cells from the blood of colorectal cancer patients. Verbal presentation at the Postgraduate & Early Career Researchers Committee (PERC) & Division of Health Sciences Early & Mid-Career Researcher (EMCR) Joint Research Symposium, Dunedin, New Zealand.

Fitzgerald, S., Blenkiron, C., Somers-Edgar, T., Rolfe, G., Rykers, A., Stephens, R., … Jackson, C., Cocadiz, J. A., Zou, D., Eccles, M., Day, R., Guilford, P., … Print, C. (2022, August). Evolving genomic complexity unveiled in ctDNA analysis of melanoma patients. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Shyam, S., Eccles, M. R., Pattison, S., Rodger, E. J., McCall, J. L., Gray, E. S., & Chatterjee, A. (2022, August). Evaluation of a membrane-based method for enriching circulating tumour cells from the blood of colorectal cancer patients. Verbal presentation at the Cancer Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Banerjee, R., Smith, J., Eccles, M. R., Weeks, R. J., Antony, J., & Chatterjee, A. (2022, August). Investigating DNA methylation as a mechanism for paradoxical gene activation using targeted epigenetic editing. Verbal presentation at the CRISPR Technologies Satellite Meeting: Queenstown Research Week, Queenstown, New Zealand.

Other Research Output

Eccles, M. (2022, August). What can we learn from alterations in gene expression, changes in DNA methylation, and phenotype switching in melanoma? UOC Research Seminar Series, University of Otago, Christchurch, New Zealand. [Research Presentation].

2021

Journal - Research Article

Smith, J., Banerjee, R., Waly, R., Urbano, A., Gimenez, G., Day, R., Eccles, M. R., Weeks, R. J., & Chatterjee, A. (2021). Locus-specific DNA methylation editing in melanoma cell lines using a CRISPR-based system. Cancers, 13, 5433. doi: 10.3390/cancers13215433

McDougall, L., Kueh, J. T. B., Ward, J., Tyndall, J. D. A., Woolley, A. G., Mehta, S., Stayner, C., Larsen, D. S., & Eccles, M. R. (2021). Chemical synthesis of the PAX protein inhibitor EG1 and its ability to slow the growth of human colorectal carcinoma cells. Frontiers in Oncology, 11, 709540. doi: 10.3389/fonc.2021.709540

Ahn, A., Rodger, E. J., Motwani, J., Gimenez, G., Stockwell, P. A., Parry, M., … Chatterjee, A., & Eccles, M. R. (2021). Transcriptional reprogramming and constitutive PD-L1 expression in melanoma are associated with dedifferentiation and activation of interferon and tumour necrosis factor signalling pathways. Cancers, 13, 4250. doi: 10.3390/cancers13174250

Stockwell, P. A., Lynch-Sutherland, C. F., Chatterjee, A., Macaulay, E. C., & Eccles, M. R. (2021). RepExpress: A novel pipeline for the quantification and characterization of transposable element expression from RNA-seq data. Current Protocols, 1(8), e206. doi: 10.1002/cpz1.206

Paumann-Page, M., Kienzl, N. F., Motwani, J., Bathish, B., Paton, L. N., Magon, N. J., … Eccles, M. R., & Winterbourn, C. C. (2021). Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential. Redox Biology, 46, 102090. doi: 10.1016/j.redox.2021.102090

Motwani, J., Rodger, E. J., Stockwell, P. A., Baguley, B. C., Macaulay, E. C., & Eccles, M. R. (2021). Genome-wide DNA methylation and RNA expression differences correlate with invasiveness in melanoma cell lines. Epigenomics, 13(8), 577-598. doi: 10.2217/epi-2020-0440

McDougall, L. I., Powell, R. M., Ratajska, M., Lynch-Sutherland, C. F., Hossain, S. M., Wiggins, G. A. R., … Motwani, J., Macaulay, E. C., Reid, G., Walker, L. C., … Eccles, M. R. (2021). Differential expression of BARD1 isoforms in melanoma. Genes, 12(2), 320. doi: 10.3390/genes12020320

Shyam, S., Eccles, M. R., Rodger, E. J., Pattison, S., McCall, J. L., Gray, E. S., … Chatterjee, A. (2021). The epigenetic landscape of circulating tumour cells. Biochimica et Biophysica Acta: Reviews on Cancer, 1875(188514). doi: 10.1016/j.bbcan.2021.188514

Tran, K. B., Gimenez, G., Tsai, P., Kolekar, S., Rodger, E., Chatterjee, A., … Eccles, M. R., … Shepherd, P. R. (2021). Genomic and signalling pathway characterisation of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma. Pigment Cell & Melanoma Research, 34(1), 136-143. doi: 10.1111/pcmr.12908

Journal - Research Other

Bowden, S. A., Rodger, E. J., Chatterjee, A., Eccles, M. R., & Stayner, C. (2021). Recent discoveries in epigenetic modifications of polycystic kidney disease. International Journal of Molecular Sciences, 22(24), 13327. doi: 10.3390/ijms222413327

Motwani, J., & Eccles, M. R. (2021). Genetic and genomic pathways of melanoma development, invasion and metastasis. Gene, 12(10), 1543. doi: 10.3390/genes12101543

Hossain, S. M., Lynch-Sutherland, C., Chatterjee, A., Macaulay, E. C., & Eccles, M. R. (2021). Can immune suppression and epigenome regulation in placenta offer novel insights into cancer immune evasion and immunotherapy resistance? Epigenomes, 5, 16. doi: 10.3390/epigenomes5030016

Mainini, F., De Santis, F., Fucà, G., Di Nicola, M., Rivoltini, L., & Eccles, M. (2021). Nanobiotechnology and immunotherapy: Two powerful and cooperative allies against cancer. Cancers, 13, 3765. doi: 10.3390/cancers13153765

Conference Contribution - Published proceedings: Abstract

Paumann-Page, M., Meredith, S., Eccles, M., Hampton, M., & Winterbourn, C. (2021). Investigating the role of peroxidasin in cancer cell invasion. Proceedings of the 16th Congress of the Federation of Asian & Oceanic Biochemists & Molecular Biologists (FAOBMB). (pp. 278). Retrieved from https://www.faobmb2021.org

Shyam, S., Eccles, M., Pattison, S., Rodger, E., McCall, J., Gray, E., & Chatterjee, A. (2021). Identification of tumour specific-epigenetic signatures in circulating tumour cells to understand their role in colorectal cancer metasis. Proceedings of the Genetics Otago (GO) Annual Symposium. Retrieved from https://blogs.otago.ac.nz/go

Conference Contribution - Poster Presentation (not in published proceedings)

Banerjee, R., Smith, J., Waly, R., Antony, J., Eccles, M., Weeks, R., & Chatterjee, A. (2021, September). Investigating DNA methylation as a mechanism for paradoxical gene activation using targeted epigenetic editing. Poster session presented at the Achieving Health Equity from Research Conference [Otago Spotlight Series], Wellington, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. (2021, November). How might Māori benefit from molecular profiling for precision cancer therapies in breast cancer in NZ? Keynote presentation at the New Zealand Breast Cancer Symposium (NZBCS), [Online].

2020

Journal - Research Article

Honda, S., Chatterjee, A., Leichter, A. L., Miyagi, H., Minato, M., Fujiyoshi, S., … Eccles, M. R. (2020). A microRNA cluster in the DLK1-DIO3 imprinted region on chromosome 14q32.2 is dysregulated in metastatic hepatoblastomas. Frontiers in Oncology, 10, 513601. doi: 10.3389/fonc.2020.513601

Lynch-Sutherland, C. F., Chatterjee, A., Stockwell, P. A., Eccles, M. R., & Macaulay, E. C. (2020). Reawakening the developmental origins of cancer through transposable elements. Frontiers in Oncology, 10, 468. doi: 10.3389/fonc.2020.00468

Tiffen, J., Gallagher, S., Filipp, F., Gunatilake, D., Al Emran, A., Cullinane, C., … Chatterjee, A., Rodger, E. J., Eccles, M. R., & Hersey, P. (2020). EZH2 cooperates with DNA methylation to downregulate key tumour suppressors and IFN signatures in melanoma. Journal of Investigative Dermatology, 140, 2442-2454.e5. doi: 10.1016/j.jid.2020.02.042

Bowden, S. A., Stockwell, P. A., Rodger, E. J., Parry, M. F., Eccles, M. R., Stayner, C., & Chatterjee, A. (2020). Extensive inter-cyst DNA methylation variation in autosomal dominant polycystic kidney disease revealed by genome scale sequencing. Frontiers in Genetics, 11, 348. doi: 10.3389/fgene.2020.00348

Journal - Research Other

Mainini, F., & Eccles, M. R. (2020). Lipid and polymer-based nanoparticle siRNA delivery systems for cancer therapy. Molecules, 25(11), 2692. doi: 10.3390/molecules25112692

Smith, J., Sen, S., Weeks, R. J., Eccles, M. R., & Chatterjee, A. (2020). Promoter DNA hypermethylation and paradoxical gene activation. Trends in Cancer, 6(5), 392-406. doi: 10.1016/j.trecan.2020.02.007

Conference Contribution - Published proceedings: Abstract

Powell, R. M., Merrilees, M. J., Pattison, S., Gray, B., Jones, G. T., Eccles, M. R., & Macaulay, E. C. (2020). Epigenetic investigations in LAM: Using heritable biomarkers to trace cell lineage. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Lynch-Sutherland, C. F., Stockwell, P. A., Eccles, M. R., Chatterjee, A., & Macaulay, E. C. (2020). Reawakening the developmental origins of cancer through transposable elements. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Weeks, R. J., Smith, J., Banerjee, R., Ahn, A., Day, R., Chatterjee, A., & Eccles, M. (2020). Using novel CRISPR technology to edit DNA methylation [Invited]. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Bessemer, B., Chatterjee, A., Alsaleh, A. A., Stockwell, P. A., Ludgate, J. L., Weeks, R. J., Jones, G. T., Day, R. C., Fukazawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2020). The potential power of placental epigenetics [Invited]. Proceedings of the Genetics Otago (GO) Epigenetics User Group (EUG) Symposium. Retrieved from https://blogs.otago.ac.nz/go/2020-3/

2019

Journal - Research Article

Macdonald, C. M., Kunnen, B., Stayner, C., & Eccles, M. R. (2019). Designing phantoms to accurately replicate circular depolarization in biological scattering media. Applied Optics, 58(35), 9577-9584. doi: 10.1364/AO.58.009577

Rodger, E. J., Chatterjee, A., Stockwell, P. A., & Eccles, M. R. (2019). Characterisation of DNA methylation changes in EBF3 and TBC1D16 associated with tumour progression and metastasis in multiple cancer types. Clinical Epigenetics, 11, 114. doi: 10.1186/s13148-019-0710-5

Roy, R., Chatterjee, A., Das, D., Ray, A., Singh, R., Chattopadhyay, E., … Eccles, M., … Roy, B. (2019). Genome-wide miRNA methylome analysis in oral cancer: Possible biomarkers associated with patient survival. Epigenomics, 11(5), 473-487. doi: 10.2217/epi-2018-0078

Stayner, C., Brooke, D. G., Bates, M., & Eccles, M. R. (2019). Targeted therapies for autosomal dominant polycystic kidney disease. Current Medicinal Chemistry, 26(17), 3081-3102. doi: 10.2174/0929867325666180508095654

Journal - Research Other

Al Emran, A., Chatterjee, A., Rodger, E. J., Tiffen, J. C., Gallagher, S. J., Eccles, M. R., & Hersey, P. (2019). Targeting DNA methylation and EZH2 activity to overcome melanoma resistance to immunotherapy. Trends in Immunology, 40(4), 328-344. doi: 10.1016/j.it.2019.02.004

Conference Contribution - Published proceedings: Abstract

Lynch-Sutherland, C., Stockwell, P. A., Eccles, M. R., Chatterjee, A., & Macaulay, E. C. (2019). Good genes gone bad: Are placental genes hijacked by cancer cells to facilitate invasion? Proceedings of the 16th Asian Conference on Transcription. (pp. 77). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-02

Motwani, J., Rodger, E. J., Stockwell, P. A., & Eccles, M. R. (2019). Genome-wide DNA methylation and gene expression analysis of non-invasive and invasive melanoma cell lines. Proceedings of the 16th Asian Conference on Transcription. (pp. 68). Retrieved from https://act2019.p.events4you.currinda.com/days/2019-12-02

Chatterjee, A., Rodger, E. J., Ahn, A., Stockwell, P. A., Parry, M., Gallagher, S., … Eccles, M. (2019). Methylome and transcriptome programme segregates PD-L1 expressing and non-expressing melanoma. Proceedings of the 16th Asian Conference on Transcription. (pp. 38-39). Retrieved from http://act2019.p.events4you.currinda.com/days/2019-12-02/

Chatterjee, A., Ahn, A., Rodger, E. J., Stockwell, P. A., Parry, M., Motwani, J., … Eccles, M. R. (2019). Global DNA methylation levels regulate PD-L1 expression in melanoma. Cancer Research, 79(13, Suppl.). doi: 10.1158/1538-7445.Am2019-826

Bowden, S., Rodger, E. J., Bates, M., Chatterjee, A., Eccles, M. R., & Stayner, C. (2019). Global methylome analysis of single cysts in human ADPKD. Kidney International Reports, 4(7, Suppl.), (pp. S47). doi: 10.1016/j.ekir.2019.05.125

Conference Contribution - Poster Presentation (not in published proceedings)

Stayner, C., Bowden, S., Rodger, E. J., Bates, M., McDougall, L., Perreau, T., Chatterjee, A., & Eccles, M. R. (2019, August-September). Do epigenetic events underpin potential new treatment targets in cystic kidney disease? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Lynch-Sutherland, C. F., Stockwell, P. A., Eccles, M. R., Chatterjee, A., & Macaulay, E. C. (2019, August-September). Good genes gone bad: Are placental genes hijacked by cancer cells to facilitate invasion? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Macaulay, E. C., Almomani, S., Lynch-Sutherland, C. F., Chatterjee, A. C., Stockwell, P. A., Alsaleh, A. A., Wilson, J. L., Weeks, R. J., Day, R. C., Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Eccles, M. R. (2019, August-September). The placental potential: Harnessing insights from placental epigenetics to predict disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2018

Chapter in Book - Research

Chatterjee, A., Ahn, A., Rodger, E. J., Stockwell, P. A., & Eccles, M. R. (2018). A guide for designing and analyzing RNA-Seq data. In N. Raghavachari & N. Garcia-Reyero (Eds.), Gene expression analysis: Methods in molecular biology (Vol. 1783). (pp. 35-80). New York, NY: Humana Press. doi: 10.1007/978-1-4939-7834-2_3

Journal - Research Article

Bowden, S. A., Rodger, E. J., Bates, M., Chatterjee, A., Eccles, M. R., & Stayner, C. (2018). Genome-scale single nucleotide resolution analysis of DNA methylation in human autosomal dominant polycystic kidney disease. American Journal of Nephrology, 48(6), 415-424. doi: 10.1159/000494739

Chatterjee, A., Rodger, E. J., Ahn, A., Stockwell, P. A., Parry, M., Motwani, J., … Eccles, M. R., & Hersey, P. (2018). Marked global DNA hypomethylation is associated with constitutive PD-L1 expression in melanoma. iScience, 4, 312-325. doi: 10.1016/j.isci.2018.05.021

Kaur, G., Li, C. G., Chantry, A., Stayner, C., Horsfield, J., & Eccles, M. R. (2018). SMAD proteins directly suppress PAX2 transcription downstream of transforming growth factor-beta 1 (TGF-β1) signalling in renal cell carcinoma. Oncotarget, 9(42), 26852-26867. doi: 10.18632/oncotarget.25516

Chatterjee, A., Rodger, E. J., & Eccles, M. R. (2018). Epigenetic drivers of tumourigenesis and cancer metastasis. Seminars in Cancer Biology, 51, 149-159. doi: 10.1016/j.semcancer.2017.08.004

Journal - Research Other

Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. (2018). MIS416 as a siRNA delivery system with the ability to target antigen-presenting cells [Brief communication]. Nucleic Acid Therapeutics, 28(4), 225-232. doi: 10.1089/nat.2017.0695

Conference Contribution - Published proceedings: Abstract

Paumann-Page, M., Bathish, B., Eccles, M., & Winterbourn, C. (2018). Peroxidasin, a newly identified peroxidase, and its role in invasive metastatic melanoma. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Fitzgerald, S., Lasham, A., Blenkiron, C., Shields, P., Rolfe, G., Stephens, R., … Jackson, C., Rodger, E., Eccles, M., Day, R., Guilford, P., … Print, C. (2018). Development of plasma genomic biomarkers for mutation detection and monitoring in New Zealand cancer patients. Proceedings of the New Zealand Society for Oncology (NZSO) Conference. Retrieved from http://www.nzsoncology.org.nz/

Conference Contribution - Poster Presentation (not in published proceedings)

Ahn, A., Rodger, E. J., Stockwell, P. A., Parry, M., Motwani, J., Gallagher, S. J., … Chatterjee, A., & Eccles, M. R. (2018, August). Investigating the role of DNA methylation, gene expression, long non-coding RNA and transposable elements in constitutive PD-L1 expression in melanoma cell lines. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Eccles, M., Rodger, E., Chatterjee, A., & Stockwell, P. (2018, August). Is EBF3 promotor hypermethylation an oncogenic epi-mutation in multiple cancer types? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Fitzgerald, S., Lasham, A., Blenkiron, C., Shields, P., Rolfe, G., Stephens, R., … Jackson, C., Rodger, E., Eccles, M., Day, R., Guilford, P., … Print, C. (2018, August). Development of plasma genomic biomarkers for mutation detection and monitoring in New Zealand cancer patients. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Henderson, L., Mehta, S., Fleming, N., Eccles, M., Chatterjee, A., Print, C., … Braithwaite, A. (2018, August). p63 promotes proliferation in melanoma cell lines via regulation of AQP3. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

McDougall, L., Eccles, M., & Stayner, C. (2018, August). Using novel compounds to delay cyst growth in polycystic kidney disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Chatterjee, A., Rodger, E., Ahn, A., Stockwell, P., Parry, M., Motwani, J., … Eccles, M., & Hersey, P. (2018, August). Striking loss of global DNA methylation levels and constitutive PD-L1 expression in melanoma. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2017

Chapter in Book - Research

Chatterjee, A., Rodger, E. J., Morison, I. M., Eccles, M. R., & Stockwell, P. A. (2017). Tools and strategies for analysis of genome-wide and gene-specific DNA methylation patterns. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 249-277). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_15

Journal - Research Article

Macaulay, E. C., Chatterjee, A., Cheng, X., Baguley, B. C., Eccles, M. R., & Morison, I. M. (2017). The genes of life and death: A potential role for placental-specific genes in cancer: Active retrotransposons in the placenta encode unique functional genes that may also be used by cancer cells to promote malignancy. BioEssays, 39(11), 1700091. doi: 10.1002/bies.201700091

Ludgate, J. L., Wright, J., Stockwell, P. A., Morison, I. M., Eccles, M. R., & Chatterjee, A. (2017). A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA. BMC Medical Genomics, 10, 54. doi: 10.1186/s12920-017-0290-1

Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176

Stayner, C., Poole, C. A., McGlashan, S. R., Pilanthananond, M., Brauning, R., Markie, D., … Slobbe, L., … Parker, K., Wiles, A., … Leichter, A., Leask, M., … Jennings, M., Horsfield, J. A., Walker, R. J., & Eccles, M. R. (2017). An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations. Scientific Reports, 7, 1601. doi: 10.1038/s41598-017-01519-4

Leichter, A. L., Sullivan, M. J., Eccles, M. R., & Chatterjee, A. (2017). MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours. Molecular Cancer, 16(1), 15. doi: 10.1186/s12943-017-0584-0

Chatterjee, A., Stockwell, P. A., Ahn, A., Rodger, E. J., Leichter, A. L., & Eccles, M. R. (2017). Genome-wide methylation sequencing of paired primary and metastatic cell lines identifies common DNA methylation changes and a role for EBF3 as a candidate epigenetic driver of melanoma metastasis. Oncotarget, 8(4), 6085-6101. doi: 10.18632/oncotarget.14042

Journal - Research Other

Eccles, M. R., Chatterjee, A., & Rodger, E. J. (2017). Identifying drivers of metastasis; towards a systematic approach. Translational Cancer Research, 6(Suppl. 7), S1273-S1276. doi: 10.21037/tcr.2017.09.52

Ahn, A., Chatterjee, A., & Eccles, M. R. (2017). The slow cycling phenotype: A growing problem for treatment resistance in melanoma. Molecular Cancer Therapeutics, 16(6), 1002-1009. doi: 10.1158/1535-7163.mct-16-0535

Conference Contribution - Poster Presentation (not in published proceedings)

Eccles, M. R., Chatterjee, A., Rodger, E. J., Ahn, A., Leichter, A., Motwani, J., Stockwell, P., & Parry, M. (2017, September). Epigenetic drivers of melanoma metastasis identified by genome-wide reduced-representation bisulphite sequencing (RRBS) analysis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Ahn, A., Rodger, E. J., Eccles, M. R., & Chatterjee, A. (2017, September). Stratification of melanoma patients according to PD-L1 expression, CpG methylation and presence of tumourinfiltrating lymphocytes. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Eccles, M. R., Chatterjee, A., Rodger, E. J., Ahn, A., Leichter, A., Motwani, J., Stockwell, P., & Parry, M. (2017, September). Epigenetic driver of melanoma metastasis identified by genome-wide analysis. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Leichter, A. L., Day, R. C., Stockwell, P. A., Wilson, M., Guilford, P., Eccles, M. R., & Chatterjee, A. (2017, September). Development of single-cell methodologies to interrogate DNA methylation patterns at a whole genome scale. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. R., Chatterjee, A., Rodger, E. J., Ahn, A., Leichter, A., Motwani, J., Stockwell, P., Parry, M., … Gardner, J., … Sarwar, M., … multiple other members of The Maurice Wilkins Centre. (2017, September). Can research involving NZ melanoma patient participation and extensive networking by researchers help reduce the melanoma burden in NZ? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Chatterjee, A., Stockwell, P. A., Leichter, A. L., Ahn, A., Rodger, E. J., & Eccles, M. R. (2017, September). Epigenetic driver of melanoma metastasis and a clue for novel methylation mediated gene activation mechanism? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Ahn, A., Euan, R. J., Chatterjee, A., & Eccles, M. (2017, September). Stratification of TCGA melanoma patients according to TIL and PD-L1 expression using RNA-seq data. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2016

Journal - Research Article

Moktefi, A., Zhang, S.-Y., Vachin, P., Ory, V., Henique, C., Audard, V., … Eccles, M., … Pawlak, A. (2016). Repression of CMIP transcription by WT1 is relevant to podocyte health. Kidney International, 90(6), 1298-1311. doi: 10.1016/j.kint.2016.07.016

Chatterjee, A., Stockwell, P. A., Rodger, E. J., Parry, M. F., & Eccles, M. R. (2016). scan_tcga tools for integrated epigenomic and transcriptomic analysis of tumor subgroups. Epigenomics, 8(10), 1315-1330. doi: 10.2217/epi-2016-0063

Jones, A. M., Ferguson, P., Gardner, J., Rooker, S., Sutton, T., Ahn, A., Chatterjee, A., … Sarwar, M., Emanuel, P., Kenwright, D., … Eccles, M. R. (2016). NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand. Oncotarget, 7(27), 41017-41030. doi: 10.18632/oncotarget.9351

Conference Contribution - Published proceedings: Abstract

Quon, J., Chatterjee, A., & Eccles, M. (2016). Effect of DNA methylation on expression of genes related to PD-L1 expression in melanoma. New Zealand Medical Journal, 129(1441), (pp. 107). Retrieved from http://www.nzma.org.nz/journal

Conference Contribution - Poster Presentation (not in published proceedings)

Bowden, S., Bates, M., Chatterjee, A., Rodger, E. J., Eccles, M. R., & Stayner, C. (2016, August-September). CpG DNA hypomethylation occurs in human Autosomal Dominant Polycystic Kidney Disease. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Bowden, S., Bates, M., Chatterjee, A., Rodger, E. J., Eccles, M. R., & Stayner, C. (2016, August-September). CpG DNA hypomethylation occurs in human Autosomal Dominant Polycystic Kidney Disease. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

Chatterjee, A., Stockwell, P. A., Ahn, A., Rodger, E. J., Leichter, A., & Eccles, M. R. (2016, August-September). A framework and example for identifying epigenetic drivers of cancer metastasis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.

2015

Journal - Research Article

Mainini, F., Larsen, D. S., Webster, G. A., Young, S. L., & Eccles, M. R. (2015). Bridging small molecules to modified bacterial microparticles using a disulphide linkage: MIS416 as a cargo delivery system. PLoS ONE, 10(12), e0145403. doi: 10.1371/journal.pone.0145403

Leichter, A. L., Purcell, R. V., Sullivan, M. J., Eccles, M. R., & Chatterjee, A. (2015). Multi-platform microRNA profiling of hepatoblastoma patients using formalin fixed paraffin embedded archival samples. GigaScience, 4, 54. doi: 10.1186/s13742-015-0099-9

Pinnapureddy, A. R., Stayner, C., McEwan, J., Baddeley, O., Forman, J., & Eccles, M. R. (2015). Large animal models of rare genetic disorders: Sheep as phenotypically relevant models of human genetic disease. Orphanet Journal of Rare Diseases, 10, 107. doi: 10.1186/s13023-015-0327-5

Chatterjee, A., Leichter, A. L., Fan, V., Tsai, P., Purcell, R. V., Sullivan, M. J., & Eccles, M. R. (2015). A cross comparison of technologies for the detection of microRNAs in clinical FFPE samples of hepatoblastoma patients. Scientific Reports, 5, 10438. doi: 10.1038/srep10438

Kunnen, B., Macdonald, C., Doronin, A., Jacques, S., Eccles, M., & Meglinski, I. (2015). Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media. Journal of Biophotonics, 8(4), 317-323. doi: 10.1002/jbio.201400104

Journal - Professional & Other Non-Research Articles

Chatterjee, A., & Eccles, M. R. (2015). DNA methylation and epigenomics: New technologies and emerging concepts. Genome Biology, 16(1), 103. doi: 10.1186/s13059-015-0674-5

Conference Contribution - Poster Presentation (not in published proceedings)

Chatterjee, A., Stockwell, P. A., Rodger, E. J., & Eccles, M. R. (2015, August-September). Flexible analysis of TCGA DNA methylation and gene expression data using UNIX tools. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Bates, M. C., Stayner, C., & Eccles, M. R. (2015, August-September). Is methylation a potential second hit mechanism in polycystic kidney disease? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Chatterjee, A., Stockwell, P. A., Ahn, A., Rodger, E. J., Leichter, A. L., & Eccles, M. R. (2015, November). The epigenetic basis of melanoma metastasis. Verbal presentation at the Toxicology Symposium: Toxicology for the Modern Researcher, Dunedin, New Zealand.

Chatterjee, A., Ahn, A., Stockwell, P. A., Rodger, E. J., Leichter, A., & Eccles, M. R. (2015, August-September). Analysis of paired primary and metastatic cell lines identifies common DNA methylation changes in melanoma metastasis. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Eccles, M., and contributors to MelNet Research Stocktake. (2015, November). National approach to melanoma translational research in New Zealand. Workshop presentation at the New Zealand Melanoma Summit, Auckland, New Zealand.

2014

Journal - Research Article

Stevens, A. J., Stuffrein-Roberts, S., Cree, S. L., Gibb, A., Miller, A. L., Doudney, K., Aitchison, A., Eccles, M. R., Joyce, P. R., … Kennedy, M. A. (2014). G-quadruplex structures and CpG methylation cause drop-out of the maternal allele in polymerase chain reaction amplification of the imprinted MEST gene promoter. PLoS ONE, 9(12), e113955. doi: 10.1371/journal.pone.0113955

Eccles, M. R., & Stayner, C. A. (2014). Polycystic kidney disease: Where gene dosage counts. F1000Prime Reports, 6, 24. doi: 10.12703/p6-24

Hung, N., Chen, Y.-J., Taha, A., Olivecrona, M., Boet, R., Wiles, A., … Shaw, A., Eiholzer, R., Baguley, B. C., Eccles, M. R., Braithwaite, A. W., MacFarlane, M., Royds, J. A., & Slatter, T. (2014). Increased paired box transcription factor 8 has a survival function in Glioma. BMC Cancer, 14, 159. doi: 10.1186/1471-2407-14-159

Conference Contribution - Published proceedings: Full paper

Meglinski, I., Macdonald, C., Doronin, A., Kunnen, B., & Eccles, M. (2014). Polarized light biosensing. Proceedings of the Asia Communications and Photonics Conference. Optical Society of America. doi: 10.1364/ACPC.2014.ATh2G.2

MacDonald, C., Doronin, A., Peña Delgado, A. F., Meglinski, I., & Eccles, M. (2014). Diffusing-wave polarimetry for tissue diagnostics. Proceedings of SPIE (Vol. 8940): Optical Biopsy XII. 894007. doi: 10.1117/12.2038658

Conference Contribution - Poster Presentation (not in published proceedings)

Motwani, J., & Eccles, M. (2014, August). Characterization of epigenetic changes that underpin metastasis in melanoma. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Leichter, A. L., Chatterjee, A., & Eccles, M. R. (2014, August). A cross comparison of technologies to investigate microRNA expression patterns in hepatoblastoma. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. (2014, October). Genetic analysis of South Island malignant melanoma cases. Verbal presentation at the New Zealand Society for Oncology (NZSO) Conference, Tauranga, New Zealand.

Eccles, M. (2014, August). Genetic and epigenetic changes in the progression of melanoma. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2013

Journal - Research Article

Eccles, M. R., He, S., Ahn, A., Slobbe, L. J., Jeffs, A. R., Yoon, H.-S., & Baguley, B. C. (2013). MITF and PAX3 play distinct roles in melanoma cell migration: Outline of a “genetic switch” theory involving MITF and PAX3 in proliferative and invasive phenotypes of melanoma. Frontiers in Oncology, 3, 229. doi: 10.3389/fonc.2013.00229

Wu, M. K., Sabbaghian, N., Xu, B., Addidou-Kalucki, S., Bernard, C., Zou, D., Reeve, A. E., Eccles, M. R., … Foulkes, W. D. (2013). Biallelic DICER1 mutations occur in Wilms tumours. Journal of Pathology, 230(2), 154-164. doi: 10.1002/path.4196

Journal - Research Other

Eccles, M. R. (2013). Melanoma Genetics/Genomics. Frontiers in Oncology, 3, 309. doi: 10.3389/fonc.2013.00309

Ahn, A., & Eccles, M. R. (2013). Targeted therapy: From advanced melanoma to the adjuvant setting. Frontiers in Oncology, 3. doi: 10.3389/fonc.2013.00205

Conference Contribution - Published proceedings: Abstract

Stevens, A. J., Stuffrein-Roberts, S., Macmil, S., Gibb, A., Doudney, K., Miller, A. L., Bagshaw, A., Aitchison, A., Eccles, M. R., Joyce, P. R., … Kennedy, M. A. (2013). Allelic-dropout during PCR of the imprinted MEST promoter caused by interaction between G-quadruplex structures and DNA methylation. Proceedings of the 4th International Meeting on G-quadruplex Nucleic Acids: From Structure to Chemistry and Biology. 83. Retrieved from http://www.g4meeting2013.com/

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M., & Sneyd, M. J. (2013, April). National research strategy for melanoma. Workshop presentation at the New Zealand Melanoma Summit, Wellington, New Zealand.

2012

Journal - Research Article

McEwan, M. V., Eccles, M. R., & Horsfield, J. A. (2012). Cohesin is required for activation of MYC by estradiol. PLoS ONE, 7(11), e49160. doi: 10.1371/journal.pone.0049160

Li, C. G., & Eccles, M. R. (2012). PAX genes in cancer: Friends or foes? Frontiers in Genetics, 3, 6. doi: 10.3389/fgene.2012.00006

Ineson, J., Stayner, C., Hazlett, J., Slobbe, L., Robson, E., Legge, M., & Eccles, M. R. (2012). Somatic reactivation of expression of the silent maternal Mest allele and acquisition of normal reproductive behaviour in a colony of Peg1/Mest mutant mice. Journal of Reproduction & Development, 58(4), 490-500.

Stayner, C., Shields, J., Slobbe, L., Shillingford, J. M., Weimbs, T., & Eccles, M. R. (2012). Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1^-/- mutant mouse embryos: An investigation of the feasibility of renal cyst prevention in the foetus. Nephrology, 17(8), 739-747. doi: 10.1111/j.1440-1797.2012.01639.x

Burger, M. C., Brucker, D. P., Baumgarten, P., Ronellenfitsch, M. W., Wanka, C., Hasselblatt, M., Eccles, M. R., … Steinbach, J. P. (2012). PAX2 is an antiapoptotic molecule with deregulated expression in medulloblastoma. International Journal of Oncology, 41(1), 235-241. doi: 10.3892/ijo.2012.1446

Bower, M., Salomon, R., Allanson, J., Antignac, C., Benedicenti, F., Benetti, E., … Dixon, J., … Eccles, M., … Heidet, L. (2012). Update of PAX2 mutations in renal coloboma syndrome and establishment of locus-specific database. Human Mutation, 33(3), 457-466. doi: 10.1002/humu.22020

Conference Contribution - Poster Presentation (not in published proceedings)

Stevens, A., Stuffrein-Roberts, S., Miller, A., Gibb, A., Doudney, K., Bagshaw, A., Aitchison, A., Eccles, M., … Kennedy, M. (2012, August). G-quadruplex DNA structures, genomic imprinting and allelic drop-out in PCR. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Mainini, F., Eccles, M., Young, S., Larsen, D., & Webster, G. (2012, August). Development of a new microparticle vaccine adjuvant with the ability to deliver peptides to dendritic cells. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Pilanthananond, M., Stayner, C., Horsfield, J., & Eccles, M. (2012, August). Pathogenicity studies of a ciliopathy gene, mks3, in zebrafish embryos. Poster session presented at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Stevens, A. J., Stuffrein-Roberts, S., Miller, A. L., Gibb, A., Doudney, K., Bagshaw, A., Aitchison, A., Eccles, M. R., … Kennedy, M. A. (2012, August). G-quadruplex DNA structures, genomic imprinting and allelic drop-out in PCR. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

McEwan, M. V., Eccles, M., & Horsfield, J. A. (2012, August). Cohesin is required for activation of MYC by estradiol. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Poole, C. A., Stayner, C., McGlashan, S. R., Parker, K., Wiles, A., Jennings, M., … Johnstone, A. C., Walker, R. J., & Eccles, M. R. (2012, August). Primary cilia defects in the polycystic kidneys from an ovine model of Meckel Gruber syndrome. Verbal presentation at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.

Eccles, M., Stayner, C., Shields, J., Slobbe, L., Shillingford, J., & Weimbs, T. (2012, August). Sirolimus can inhibit cyst growth in utero in Pkd1^-/- mutant mice, but rodents are perhaps not the best model in which to study treatments for kidney disease. Verbal presentation at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.

Stayner, C., Lett, B., Slobbe, L., Wiles, A., Jennings, M., Markie, D., … Johnstone, A. C., Walker, R. J., Poole, C. A., & Eccles, M. (2012, August). Renal cystic disease: Developing an ovine model. Verbal presentation at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.

2011

Chapter in Book - Research

Yoon, H.-S., & Eccles, M. R. (2011). Mild forms of Alport syndrome: Hereditary nephropathy in the absence of extra-renal features. In S. S. Prabhakar (Ed.), An update of glomerulopathies: Clinical and treatment aspects. (pp. 417-436). Rijeka, Croatia: InTech. Retrieved from http://www.intechopen.com

Journal - Research Article

Otto, E. A., Ramaswami, G., Janssen, S., Chaki, M., Allen, S. J., Zhou, W., … and the GPN Study Group, including Eccles, M. (2011). Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy. Journal of Medical Genetics, 48, 105-116. doi: 10.1136/jmg.2010.082552

Li, C. G., Nyman, J. E., Braithwaite, A. W., & Eccles, M. R. (2011). PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein. Oncogene, 30, 4824-4834. doi: 10.1038/onc.2011.190

He, S., Li, C. G., Slobbe, L., Glover, A., Marshall, E., Baguley, B. C., & Eccles, M. R. (2011). PAX3 knockdown in metastatic melanoma cell lines does not reduce MITF expression. Melanoma Research, 21(1), 24-34. doi: 10.1097/CMR.0b013e328341c7e0

Journal - Research Other

Eccles, M. (2011). Is cancer the next of kin to the developing foetus? Australasian Science, 32(10), 26-27.

Bower, M., Eccles, M., Heidet, L., & Schimmenti, L. A. (2011). Clinical utility gene card for: Renal coloboma (Papillorenal) syndrome. European Journal of Human Genetics, 19(9). doi: 10.1038/ejhg.2011.16

Duncan, G., Stevens, G., Boberg, C., Harman, R., Eccles, M., Marshall, B., … Rademaker, M. (2011). Melanoma Summit highlights best practice and priorities for action [Letter]. New Zealand Medical Journal, 124(1334). Retrieved from http://journal.nzma.org.nz/journal/124-1334/4670/content.pdf

Conference Contribution - Published proceedings: Abstract

Yoon, H.-S., & Eccles, M. (2011). A mild form of Alport syndrome: hereditary nephropathy in the absence of extra-renal features. Virchows Archiv, 459(Suppl. 1), (pp. S46-S47). doi: 10.1007/s00428-011-1113-y

Eccles, M. R., Li, C. G., Nyman, J. E., & Braithwaite, A. W. (2011). A role for PAX8 in promoting tumor cell type-specific proliferation through positively regulating E2F1 transcription and stabilizing RB protein. Proceedings of the American Association for Cancer Research (AACR) 102nd Annual Meeting. Retrieved from http://www.abstractsonline.com/plan/AdvancedSearch.aspx

Eccles, M., Print, C., Jeffs, A., He, S., Slobbe, L., & Baguley, B. (2011). Plasticity of melanoma cell differentiation state and switching of migratory potential. Proceedings of the Inaugural International Cancer Symposium. Retrieved from http://www.wnmeds.ac.nz/cancersymposium/programme.html

Conference Contribution - Poster Presentation (not in published proceedings)

Eccles, M. R., Lett, B., Stayner, C., Wiles, A., Slobbe, L., Parker, K., Johnstone, A. C., Walker, R. J., … Markie, D. (2011, October). Genetic and phenotypic characterization of an ovine large animal model of the MKS/JBTS/NPHP ciliopathy, Meckel-Gruber syndrome. Poster session presented at the 12th International Congress of Human Genetics (ICHG) and 61st Annual Meeting of the American Society of Human Genetics (ASHG), Montreal, Canada.

Kaur, G., Horsfield, J., & Eccles, M. R. (2011, September). Transcriptional regulation of PAX2 in cancer cells by transforming growth factor beta (TGF-β): Direct binding of R-SMADs to the PAX2 promoter? Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Poole, C. A., Stayner, C., McGlashan, S. R., Parker, K., Wiles, A., Jennings, M., … Johnstone, A. C., Walker, R. J., & Eccles, M. R. (2011, June-July). Primary cilia defects in an ovine model of Meckel Gruber syndrome. Poster session presented at the FASEB Summer Research Conference: Polycystic Kidney Disease: From Bench to Bedside, Saxtons River, Vermont.

Wiles, A., Lett, B., Stayner, C., Slobbe, L., Markie, D., McEwan, J., Johnstone, A. C., Walker, R. J., Poole, C. A., & Eccles, M. (2011, June-July). A large animal ciliopathy: Genetic characterization of an ovine model of Meckel-Gruber syndrome. Poster session presented at the FASEB Summer Research Conference: Polycystic Kidney Disease: From Bench to Bedside, Saxtons River, Vermont.

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. (2011, March). MITF knockdown and the phenotype switching model in melanoma. Verbal presentation at the New Zealand/Singapore Cancer Symposium, Dunedin, New Zealand.

Stayner, C., Lett, B., Slobbe, L., Wiles, A., Markie, D., McEwan, J., … Walker, R. J., Poole, C. A., & Eccles, M. (2011, September). Novel missense mutations in an ovine model of Meckel-Gruber Syndrome. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kaur, G., Horsfield, J., & Eccles, M. R. (2011, September). Transcriptional regulation of PAX2 in cancer cells by transforming growth factor beta (TGF-β): Direct binding of R-SMADs to the PAX2 promoter? Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2010

Journal - Research Article

He, S., Yoon, H.-S., Suh, B.-J., & Eccles, M. R. (2010). PAX3 is extensively expressed in benign and malignant tissues of the melanocytic lineage in humans [Letter]. Journal of Investigative Dermatology, 130, 1465-1468. doi: 10.1038/jid.2009.434

Conference Contribution - Published proceedings: Abstract

Yoon, H.-S., Wilson, J. C., Walker, R. J., & Eccles, M. R. (2010). A novel CYS1638TYR NC1 domain substitution in α5 (IV) collagen causes Alport syndrome with late onset renal failure without hearing loss or eye abnormalities. Histopathology. 57(Suppl. 1), (pp. 237). doi: 10.1111/j.1365-2559.2010.03637.x

Mönnich, M., Dickinson, E., Doidge, Z., Print, C., Eccles, M., Robertson, S., & Horsfield, J. (2010). Modelling human "Cohesinopathies" in zebrafish. American Journal of Medical Genetics Part A, (7), 152A, (pp. 1637). doi: 10.1002/ajmg.a.33439

Conference Contribution - Poster Presentation (not in published proceedings)

Poole, T., McGlashan, S., Jensen, C., Eccles, M., Lett, B., Stayner, C., … Jennings, M., Wiles, A., & Walker, R. (2010, August-September). Primary cilia defects in an ovine model of Meckel-Gruber Syndrome. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Poole, C. A., McGlashan, S. R., Jensen, C. G., Eccles, M. R., Lett, B., Stayner, C., Johnstone, A. C., Jennings, M., Wiles, A., & Walker, R. J. (2010, July). Primary cilia defects on an ovine model of Meckel-Gruber Syndrome. Poster session presented at the FASEB Summer Research Conference: The Biology of Cilia and Flagella, Saxtons River, Vermont.

Kaur, G., Horsfield, J., & Eccles, M. (2010, August-September). Regulation of paired box factor 2 (PAX2) by transforming growth factor beta (TGF-β). Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Kaur, G., Horsfield, J., & Eccles, M. (2010, September). The role of transforming growth factor beta (TGF- ) in regulating paired box factor 2 (PAX2)? Poster session presented at the Fourth Annual Division of Health Sciences Research Forum, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M., Lett, B., Wiles, A., Jennings, M., Slobbe, L., Walker, R., Poole, A., & Stayner, C. (2010, August-September). A novel primary cilia phenotype characterizes an ovine polycystic kidney disease that maps to the Meckel syndrome gene, MKS3. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Eccles, M. (2010, August-September). The effects of MITF knockdown on cell growth support the phenotype switching model in melanoma. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Stayner, C., Shields, J., Shillingford, J. M., Weimbs, T., & Eccles, M. R. (2010, November-December). Rapamycin treatment suppresses renal cyst formation in PKD1^-/- embryos. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Eccles, M., Lett, B., Wiles, A., Jennings, M., Slobbe, L., Poole, A., Stayner, C., & Walker, R. (2010, November-December). Primary cilia abnormalities characterize an ovine polycystic kidney disease that maps to the Meckel syndrome gene, MKS3. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.

Meglinski, I., Jacobs, G., & Eccles, M. (2010, October). e-Melanoma database: A tool for study and research [Internet Report]. Verbal presentation at the International School for Junior Scientists and Students on Optics, Laser Physics and Biophysics: Saratov Fall Meeting, Saratov, Russia.

Eccles, M. (2010, May). Clinical molecular cancer research on a large scale. Verbal presentation at the New Zealand Society for Oncology (NZSO) Annual Meeting, Auckland, New Zealand.

2009

Journal - Research Article

Jeffs, A. R., Glover, A. C., Slobbe, L. J., Wang, L., He, S., Hazlett, J. A., Awasthi, A., Woolley, A. G., … Print, C. G., … Eccles, M. R. (2009). A gene expression signature of invasive potential in metastatic melanoma cells. PLoS ONE, 4(12), e8461. doi: 10.1371/journal.pone.0008461

Hueber, P.-A., Fukuzawa, R., Elkares, R., Chu, L., Blumentkrantz, M., He, S.-J., Anaka, M. R., Reeve, A. E., Eccles, M. R., … Goodyer, P. R. (2009). PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype. Pediatric & Developmental Pathology, 12(5), 347-354. doi: 10.2350/08-05-0466.1

Mönnich, M., Banks, S., Eccles, M., Dickinson, E., & Horsfield, J. (2009). Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Gene Expression Patterns, 9(8), 586-594. doi: 10.1016/j.gep.2009.08.004

Conference Contribution - Published proceedings: Abstract

Lett, B., Stayner, C., Mahon, C., Markie, D., McEwan, J., & Eccles, M. R. (2009). Searching for a mutation in the Meckel-Gruber syndrome gene, TMEM67, in a sheep model of autosomal recessive polycystic kidney disease. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

He, S., Li, C. G., Jeffs, A., Glover, A., Yoon, H.-S., Baguley, B., & Eccles, M. R. (2009). Induction of cell death or differentiation by silencing of PAX3 is independent of MITF expression. Proceedings of the American Association for Cancer Research (AACR) 100th Annual Meeting. Retrieved from http://www.aacrmeetingabstracts.org/

Conference Contribution - Verbal presentation and other Conference outputs

Moennich, M., Dickinson, E., Doidge, Z., Print, C., Eccles, M., Robertson, S., & Horsfield, J. (2009, May). Modelling human ″cohesinopathies″ in zebrafish. Verbal presentation at the Cohesin Biology and the Cohesinopathies Second Informal Meeting, Siena, Italy.

2008

Chapter in Book - Research

Eccles, M. R. (2008). PAX2 and the Renal-Coloboma Syndrome. In C. J. Epstein, R. P. Erickson & A. Wynshaw-Boris (Eds.), Inborn errors of development: The molecular basis of clinical disorders of morphogenesis. (2nd ed.) (pp. 796-802). Oxford University Press.

Journal - Research Article

Chen, Y.-J., Campbell, H. G., Wiles, A. K., Eccles, M. R., Reddel, R. R., Braithwaite, A. W., & Royds, J. A. (2008). PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Research, 68(14), 5724-5732. doi: 10.1158/0008-5472.CAN-08-0058

Frost, V., Grocott, T., Eccles, M. R., & Chantry, A. (2008). Self-regulated Pax gene expression and modulation by the TGFβ superfamily. Critical Reviews in Biochemistry & Molecular Biology, 43(6), 371-391. doi: 10.1080/10409230802486208

Hueber, P.-A., Iglesias, D., Chu, L. L., Eccles, M., & Goodyer, P. (2008). In vivo validation of PAX2 as a target for renal cancer therapy. Cancer Letters, 265, 148-155. doi: 10.1016/j.canlet.2008.02.016

Journal - Professional & Other Non-Research Articles

Robson, E. J. D., Jeffs, A. R., & Eccles, M. R. (2008). Off-target response to decoy oligodeoxynucleotide treatment. Nature Precedings. doi: 10.1038/npre.2008.2281.1

Conference Contribution - Published proceedings: Abstract

Jeffs, A., Glover, M., He, S., Baguley, B., & Eccles, M. (2008). Gene expression signatures of invasion and survival in melanoma. Proceedings of the 8th Annual Australasian Microarray and Associated Technologies (AMATA) Conference. Retrieved from http://www.amata.org.au/index.php/resources/2008-conference-abstracts

Eccles, M., He, S., Jeffs, A., Li, C., Glover, A., Ineson, J., … Yoon, H.-S., & Baguley, B. (2008). PAX3 and MITF oppositely regulate a melanogenesis nodal point in melanoma cell lines. Proceedings of the American Society of Human Genetics 58th Annual Meeting. (pp. 264). ASHG. Retrieved from http://www.ashg.org/2008meeting/pdf/abstractbook1.pdf

Conference Contribution - Poster Presentation (not in published proceedings)

He, S., Li, C. G., Jeffs, A., Glover, A., Yoon, H.-S., Baguley, B., & Eccles, M. R. (2008, August-September). PAX3 and MITF oppositely regulate cell differentiation and independently confer cell survival. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Jeffs, A., Glover, A., He, S., Woolley, A., Eccles, M., & Baguley, B. (2008, August-September). Gene expression signatures of invasion in melanoma. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Jennings, M., Parker, K., Eccles, M., & Poole, T. (2008, August-September). Fibroblast primary cilia in a sheep model of ARPKD. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Shields, J., Eccles, M., & Stayner, C. (2008, August-September). Rapamycin treatment of Pkd1-/- embryos ameliorates the effects of renal cystic disease. Poster session presented at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Fagerlund, R. D., Eccles, M. R., & Wilbanks, S. M. (2008, November-December). Tumour suppressor WT1 binds DNA as a dimer. Poster session presented at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Fagerlund, R. D., Eccles, M. R., & Wilbanks, S. M. (2008, November-December). Tumour suppressor WT1 binds DNA as a dimer. Verbal presentation at the New Zealand Institute of Chemistry, New Zealand Society for Biochemistry and Molecular Biology and the New Zealand Society of Plant Biologists Combined Conference, Dunedin, New Zealand.

Jeffs, A., Glover, A., He, S., Eccles, M., & Baguley, B. (2008, August). Gene expression signatures of invasion in melanoma. Verbal presentation at the New Zealand Society for Oncology Conference, Christchurch, New Zealand.

Eccles, M. (2008, August-September). Molecular genetics of PAX2 and PAX8 in kidney cell development and turnover. Verbal presentation at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

Stayner, C., Shields, J., Ellis, L., Goodyer, P., Germino, G., Zhou, J., & Eccles, M. (2008, August-September). The role of PAX2 in polycystic kidney disease. Verbal presentation at the Queenstown Molecular Biology Meetings, Queenstown, New Zealand.

He, S., Jeffs, A., Li, C., Glover, A., Ineson, J., Suh, B.-J., … Yoon, H.-S., … Eccles, M. R. (2008, August). PAX3, MITF and melanoma. Verbal presentation at the New Zealand Society for Oncology Conference, Christchurch, New Zealand.

2007

Journal - Research Article

Lu, W., van Eerde, A. M., Fan, X., Quintero-Rivera, F., Kulkarni, S., Ferguson, H., … Eccles, M. R., … Maas, R. L. (2007). Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. American Journal of Human Genetics, 80(4), 616-632. doi: 10.1086/512735

Wilson, J. C., Yoon, H.-S., Walker, R. J., & Eccles, M. R. (2007). A novel Cys1638Tyr NC1 domain substitution in α5(IV) collagen causes Alport syndrome with late onset renal failure without hearing loss or eye abnormalities. Nephrology Dialysis Transplantation, 22(5), 1338-1346. doi: 10.1093/ndt/gfl793

Conference Contribution - Published proceedings: Abstract

Stayner, C., Ellis, L., Jeffs, A., McGlashan, S. R., Poole, C. A., Jensen, C. G., & Eccles, M. R. (2007). Development of immortalized fibroblast and epithelial cell lines from Pkd1/Pax2 mutant mice. Proceedings of the ISN-Nature Genetics Forefronts Symposium on Nephrogenetics: From Development to Physiology. Retrieved from http://dir.isn-online.org/ISN/forefronts/pages/abstractview.cfm?id=3&page=0

Conference Contribution - Poster Presentation (not in published proceedings)

Woolley, A., Hazlett, J., Li, G., & Eccles, M. (2007, May). Is PAX8 involved in the regulation of cell proliferation in ovarian cancer? Poster session presented at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.

Li, C., Jeffs, A., He, S., Woolley, A., & Eccles, M. (2007, May). Is there cooperation, interference, or no interaction at all between PAX genes in promoting tumorigenesis? Poster session presented at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.

Glover, A., He, S., Ineson, J., Jeffs, A., Woolley, A., Marshall, E., … Eccles, M. (2007, May). The role of PAX3 in malignant melanoma. Poster session presented at the New Zealand Society for Oncology Conference, Dunedin, New Zealand.

Eccles, M. R., He, S., Ineson, J., Yoon, H.-S., Li, C. G., Jeffs, A., … Baguley, B. (2007, October). Apoptosis induced in human melanoma cells with a PAX3 antisense oligonucleotide is associated with down-regulation of BCL2 and CDK2. Poster session presented at the American Society of Human Genetics 57th Annual Meeting, San Diego, USA.

Fagerlund, R. D., Eccles, M. R., & Wilbanks, S. M. (2007, August). Expression, purification and crystallisation of tumour suppressor WT1. Poster session presented at the 17th Queenstown Molecular Biology Meeting, Queenstown, New Zealand.

Ellis, L., Shields, J., Jeffs, A., Eccles, M., & Stayner, C. (2007, August). Development of immortalised epithelial cell lines from Pkd1/Pax2 mutant mice. Poster session presented at the 17th Queenstown Molecular Biology Meeting, Queenstown, New Zealand.

He, S., Ineson, J., Li, C. G., Jeffs, A., Marshall, E., Baguley, B., Yoon, H.-S., & Eccles, M. R. (2007, August). PAX3 is expressed in melanocytes, nevi and melanomas, and is associated with BCL-2 and CDK2-mediated cell survival. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Li, C., Jeffs, A., He, S., Marshall, E., Baguley, B., Braithwaite, A., & Eccles, M. (2007, August). Is there cooperation, interference, or no interaction at all between PAX genes in promoting tumorigenesis? Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Woolley, A., Hazlett, J., Li, C., & Eccles, M. (2007, August). Is PAX8 involved in the regulation of cell proliferation in ovarian cancer? Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Chen, Y.-J., Wiles, A., Braithwaite, A., Eccles, M., Baguley, B., & Royds, J. A. (2007, August). PAX provides molecular clues to gliomagenesis. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Sherratt, N., Eccles, M., & Legge, M. (2007, August). Thymus hyperplasia and cancer development in p53 mutant immortomice. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Selvadurai, H., Legge, M., & Eccles, M. (2007, August). A novel system for T progenitor cell identification in mice. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Glover, A., He, S., Ineson, J., Jeffs, A., Woolley, A., Marshall, E., … Eccles, M. (2007, August). The role of PAX3 in malignant melanoma. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Glover, A., He, S., Ineson, J., Jeffs, A., Woolley, A., Marshall, E., … Eccles, M. (2007, September). Expression profiling, characterisation, and the role of PAX3 in the NZM panel of metastatic melanoma cell lines. Verbal presentation at the Joint Meeting of the 10th Annual Microarray and Gene Expression Data Society (MGED) Meeting and the 7th Annual Australasian Microarray and Associated Technologies (AMATA) Conference, Brisbane, Australia.

Other Research Output

Renal coloboma syndrome [Papillorenal syndrome] in GeneReviews at GeneTests: Medical Genetics Information Resource, University of Washington, Seattle, WA. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK1451/

2006

Journal - Research Article

Utsch, B., Sayer, J. A., Attanasio, M., Pereira, R. R., Eccles, M., Hennies, H.-C., … Hildebrandt, F. (2006). Identification of the first AHI1 gene mutations in nephronophthisis-associated Joubert syndrome. Pediatric Nephrology, 21, 32-35.

Dziarmaga, A., Hueber, P.-A., Iglesias, D., Hache, N., Jeffs, A., Gendron, N., … Eccles, M., & Goodyer, P. (2006). Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2. American Journal of Physiology: Renal Physiology, 291, F913-F920. doi: 10.1152/ajprenal.00004.2006

Dziarmaga, A., Eccles, M., & Goodyer, P. (2006). Suppression of ureteric bud apoptosis rescues nephron endowment and adult renal function in Pax2 mutant mice. Journal of the American Society of Nephrology, 17, 1568-1575.

Hueber, P.-A., Waters, P., Clarke, P., Eccles, M., & Goodyer, P. (2006). PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells. Kidney International, 69, 1139-1145.

Stayner, C., Iglesias, D. M., Goodyer, P. R., Ellis, L., Germino, G., Zhou, J., & Eccles, M. R. (2006). Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease. Human Molecular Genetics, 15(24), 3520-3528.

Torban, E., Dziarmaga, A., Iglesias, D., Chu, L. L., Vassilieva, T., Little, M., Eccles, M., … Goodyer, P. (2006). PAX2 activates WNT4 expression during mammalian kidney development. Journal of Biological Chemistry, 281(18), 12705-12712.

Robson, E. J. D., He, S.-J., & Eccles, M. R. (2006). A PANorama of PAX genes in cancer and development. Nature Reviews Cancer, 6, 52-62.

Conference Contribution - Published proceedings: Abstract

Chen, Y.-J., Braithwaite, A. W., Eccles, M. R., & Royds, J. A. (2006). Fetal oncoproteins, PAX2 and PAX8, activate telomerase in glioma. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2062/content.pdf

Chen, Y.-J., Braithwaite, A. W., Eccles, M. R., & Royds, J. A. (2006). Upregulation of PAX2, 5, and 8 in glioma and their novel function in telomerase activation. Proceedings of the Centro Nacional de Investigaciones Oncológicas Cancer Conference. (pp. 52). Madrid, Spain: CNIO. [Abstract]

Chen, Y.-J., Eccles, M., Braithwaite, A., & Royds, J. (2006). Silencing of PAX8 transcription factor reduced the viability of glioma cells. European Journal of Cancer Supplements, 4(12), (pp. 104-105). [Abstract]

He, S., Whall, J., Li, C., Marshall, E., Baguley, B., & Eccles, M. R. (2006). Apoptosis induced in human melanoma cells by PAX3 antisense oligonucleotide is associated with down-regulation of BCL2 and CDK2. Proceedings of the 18th Lorne Cancer Conference. (pp. 85). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Chen, Y.-J., Eccles, M., Braithwaite, A., & Royds, J. (2006, May). p53 modulates the survival factor pax in gliomas. Poster session presented at the 13th International p53 Workshop, New York.

2005

Journal - Research Article

Johnstone, A. C., Davidson, B. I., Roe, A. R., Eccles, M. R., & Jolly, R. D. (2005). Congenital polycystic kidney disease in lambs. New Zealand Veterinary Journal, 53(5), 307-314.

He, S.-J., Stevens, G., Braithwaite, A. W., & Eccles, M. R. (2005). Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin-induced cytotoxicity. Molecular Cancer Therapeutics, 4(6), 996-1003.

Conference Contribution - Published proceedings: Abstract

He, S.-J., Li, C. G., Whall, J., Marshall, E., Baguley, B., & Eccles, M. (2005). Antisense cancer therapy induced cell death: How to analyze underlying mechanism. Proceedings of the SBMB New Zealand and NZMS Conference. (pp. 154). [Abstract]

Eccles, M., He, S.-J., Whall, J., Suh, B.-J., Marshall, E., & Baguley, B. (2005). PAX3 and MITF: Early markers of melanoma. Proceedings of the Keystone Symposia Stem Cells, Senescence and Cancer. (pp. 59). Singapore. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Fagerlund, R. D., Eccles, M. R., & Wilbanks, S. M. (2005, November). Oligomeric state and transcriptional function of tumour suppressor WT1. Poster session presented at the New Zealand Society for Biochemistry and Molecular Biology Conference, Dunedin, New Zealand.

2004

Chapter in Book - Research

Eccles, M. R. (2004). PAX2 and the renal-coloboma syndrome. In C. J. Epstein, R. P. Erickson & A. Wynshaw-Boris (Eds.), Inborn errors of development: The molecular basis of clinical disorders of morphogenesis. (pp. 633-642). Oxford University Press.

Journal - Research Article

Clark, P., Dziarmaga, A., Eccles, M., & Goodyer, P. (2004). Rescue of defective branching nephrogenesis in renal-coloboma syndrome by the caspase inhibitor, Z-VAD-fmk. Journal of the American Society of Nephrology, 15, 299-305.

Muratovska, A., & Eccles, M. R. (2004). Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Letters, 558, 63-68.

Filipovska, A., Eccles, M. R., Smith, R. A. J., & Murphy, M. P. (2004). Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation. FEBS Letters, 556, 180-186.

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. R., He, S. J., Braithwaite, A., Royds, J., & Baguley, B. (2004, June). A 'from the ground up' approach to the development of novel strategic genetic targets and methodologies for cancer gene therapy. Verbal presentation at the New Zealand Society for Oncology Conference, Christchurch, New Zealand.

2003

Chapter in Book - Research

Eccles, M. R., Bockett, N., & Stayner, C.-A. K. (2003). PAX2 and Renal-Coloboma Syndrome. In P. D. Vize, A. S. Woolf & J. B. L. Bard (Eds.), The kidney. (pp. 411-432). San Diego, USA: Elsevier Science.

Journal - Research Article

Fukuzawa, R., Eccles, M. R., Ikeda, M., & Hata, J.-I. (2003). Embryonal hyperplasia of Bowman's capsular epithelium in patients with WT1 mutations. Pediatric Nephrology, 18(1), 9-13.

Edwards, S. J., Hananeia, L., Eccles, M. R., Zhang, Y.-F., & Braithwaite, A. (2003). The proline-rich region of mouse p53 influences transactivation and apoptosis but is largely dispensable for these functions. Oncogene, 22(29), 4517-4523.

Muratovska, A., Zhou, C., He, S., Goodyer, P., & Eccles, M. R. (2003). Paired-box genes are frequently expressed in cancer and often required for cancer cell survival. Oncogene, 22(39), 7989-7997.

Dziarmaga, A., Clark, P., Stayner, C.-A. K., Julien, J. P., Torban, E., Goodyer, P., & Eccles, M. R. (2003). Ureteric bud apoptosis and renal hypoplasia in transgenic PAX2-Bax fetal mice mimics the renal-coloboma syndrome. Journal of the American Society of Nephrology, 14(11), 2767-2774.

Discenza, M. T., He, S., Lee, T. H., Chu, L. L., Bolon, B., Goodyer, P., Eccles, M., & Pelletier, J. (2003). WT1 is a modifier of the Pax2 mutant phenotype: Cooperation and interaction between WT1 and Pax2. Oncogene, 22(50), 8145-8155. doi: 10.1038/sj.onc.1206997

Gough, S. M., McDonald, M., Chen, X.-N., Korenberg, J. R., Neri, A., Kahn, T., Eccles, M. R., & Morris, C. M. (2003). Refined physical map of the human PAX2/HOX11/NFKB2 cancer gene region at 10q24 and relocalization of the HPV6AI1 viral integration site to 14q13.3-q21.1. BMC Genomics, 4(1), 9.

Conference Contribution - Poster Presentation (not in published proceedings)

Eccles, M., Muratovska, A., He, S., Zhou, C., & Goodyer, P. (2003, July). PAX genes are frequently expressed in cancer and often required for cancer cell survival. Poster session presented at the XIX International Congress of Genetics, Melbourne, Australia.

2002

Journal - Research Article

Eccles, M. R., He, S., Legge, M., Kumar, R., Fox, J., Zhou, C., French, M., & Tsai, R. (2002). PAX genes in development and disease: The role of PAX2 in urogenital tract development. International Journal of Developmental Biology, 46, 535-544.

Journal - Professional & Other Non-Research Articles

Gus, P. I., Giugliani, R., de Souza, C. F. M., Eccles, M. R., & Porteous, S. (2002). Papillorenal syndrome in a Brazilian family - Reply. Archives of Ophthalmology, 120, 1772-1773.

Conference Contribution - Verbal presentation and other Conference outputs

Stayner, C.-A. K., Williams, E., Lee, C., Goodyer, P., Zhou, J., & Eccles, M. (2002). A role for PAX2 in polycistic kidney disease. Verbal presentation at the 1st Canadian Developmental Biology Confernce, Quebec, Canada.

Eccles, M., Zhou, C., Kao, A., Waters, P., Torban, E., & Goodyer, P. (2002). PAX expression confers enhanced cell survival. Verbal presentation at the Lorne Cancer Conference, Lorne.

Dziarmaga, A., Eccles, M., & Goodyer, P. (2002). Renal hypoplasia in PAX2-Bax transgenic mice. Verbal presentation at the 1st Canadian Developmental Biology Conference, Quebec, Canada.

Legge, M., Fox, J., Stayner, C.-A. K., & Eccles, M. (2002). Influence of genetic background on the cellular contribution to, and the success of aggregation chimaeras. Verbal presentation at the 16th International Mammalian Genome Society Conference, San Antonio, USA.

Eccles, M. (2002). Embryology and aetiology of VUR. Verbal presentation at the XXXIII World Congress of the International College of Surgeons, Taipei.

Eccles, M. (2002). PAX2, apoptosis and morphogenesis of the renal collecting duct system. Verbal presentation at the 2nd Annual Meeting of Pediatric Urology, Taipei.

2001

Journal - Research Article

Gus, P. I., de Souza, C. F. M., Porteous, S. H., & Eccles, M. R. (2001). Renal-coloboma syndrome in a Brazilian family. Archives of Ophthalmology, 119(2), 1563-1565.

Chen, F., Colin, G. B., Liu, K. C., Beier, D. R., Eccles, M. R., Nishina, P. M., … Epstein, J. A. (2001). Characterization of the Murine Lbx2 promoter, identification of the human homologue, and evaluation as a candidate for Alstrom syndrome. Genomics, 74(2), 219-227.

Walker, R. J., Dixon, S., Ruger, B. M., Davis, P. F., Hildebrant, F., Kremer, M., Eccles, M. R., McNoe, L. A., … Reid, J. J. (2001). Familial fibronectin glomerulopathy: Analysis of chromosome 1q32 and uteroglobulin gene loci in a large New Zealand family. Nephrology, 6, 191-197.

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. R., McNoe, L. A., Torban, E., & Goodyer, P. (2001). PAX2 has a putative role in cell survival and morphogenesis of the kidney urothelium. Verbal presentation at the 8th International Workshop on Developmental Nephrology, Vancouver.

2000

Journal - Research Article

Morison, I. M., Eccles, M. R., & Reeve, A. E. (2000). Imprinting of insulin-like growth factor 2 is modulated during hematopoiesis. Blood, 96(9), 3023-3028.

Ades, L., Davies, R., Haan, E. A., Holman, K. J., Watson, K. C., Sreetharan, D., … Eccles, M. R., McNoe, L. A., & Harbord, M. (2000). Aortic dissection patent ductus arteriosus, iris hypoplasia and brachytelephalangy in a male adolescent. Clinical Dysmorphology, 8, 269-276.

Eccles, M. R., & Jacobs, G. H. (2000). The genetics of primary vesico - ureteric reflux. Annals Academy Medicine Singapore, 29, 337-345.

Amiel, J., Audollent, S., Joly, D., Dureau, P., Salomon, R., Tellier, A. L., … Eccles, M. R., … Attie-Bitach, T. (2000). PAX2 mutations in renal-coloboma syndrome: Mutational hotspot and germline mosaicism. European Journal of Human Genetics, 8(11), 820-826.

Porteous, S., Torban, E., Cho, N.-P., Cunliffe, H. E., Chua, L. J., McNoe, L. A., Ward, T. A., … Yun, K., … Eccles, M. R. (2000). Primary renal hypoplasia in humans and mice with PAX2 mutations: Evidence of increased apoptosis in fetal kidneys of PAX2(1NEU)+/-mutant mice. Human Molecular Genetics, 9(1), 1-11.

Torban, E., Eccles, M. R., Favor, J., & Goodyer, P. (2000). PAX2 suppresses apoptosis in renal collecting duct cells. American Journal of Pathology, 157(3), 833-842.

Conference Contribution - Published proceedings: Abstract

Torban, E., Eccles, M. R., & Goodyer, P. (2000). PAX2 suppresses apoptosis in renal collecting duct cells. Journal of the American Society of Nephrology. 11, (pp. A2008). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. R., Porteous, S., Cho, N.-P., Torban, E., & Goodyer, P. (2000). PAX2 promotes cell survival. Verbal presentation at the New Zealand Society for Oncology Conference, Dunedin.

Eccles, M. R., Abbott, G., Tomlinson, P., & Jacobs, G. H. (2000). Molecular basis of urinary tract abnormalities. Verbal presentation at the 7th Asian Congress of Pediatric Nephrology, Singapore.

Eccles, M. R., McNoe, L., Cho, N.-P., Torban, E., & Goodyer, P. R. (2000). PAX2 is a modulator of apoptosis and extent of tissue growth. Verbal presentation at the Combio 2000 Conference, Wellington.

Eccles, M. R., Torban, E., Hudson, T., Goodyer, P., & McNoe, L. (2000). Microarray analysis of changes in gene expression associated with a PAX2 mutation: Searching for the molecular determinants of renal hypoplasia. Verbal presentation at the 7th Asian Congress of Pediatric Nephrology, Singapore.

1999

Journal - Research Article

Eccles, M. R., & Schimmenti, L. A. (1999). Renal-coloboma syndrome: a multi-system developmental disorder caused by PAX2 mutations. Clinical Genetics, 56, 1-9.

Conference Contribution - Published proceedings: Abstract

Eccles, M. R., Cho, N.-P., Torban, E., Cunliffe, H. E., Favor, J., Porteous, S., & Goodyer, P. R. (1999). Towards a molecular basis for understanding renal abnormalities and PAX2 haploinsufficiency in renal-coloboma syndrome. Journal of the American Society of Nephrology. 10(A2037), (pp. 404A). [Abstract]

Eccles, M. R., Jacobs, G. H., Choi, K.-L., French, M., McNoe, L., Goodwin, J., Edwards, S. J., … Abbott, G. D. (1999). Genome-wide linkage analysis in a New Zealand family with familial vesicoureteric reflux. American Journal of Human Genetics. 65(4), (pp. A269). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Gough, S., McDonald, M., Benjes, S., Neri, A., Kahn, T., Korenberg, J., Eccles, M., & Morris, C. (1999). Bright spots clarify 10q24 gene map. Poster session presented at the International human Genome Meeting, Brisbane, Australia.

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. R., Jacobs, G. H., Choi, K.-L., French, M., McNoe, L. A., Goodwin, J., Edwards, S. J., … Abbott, G. D. (1999). Genome-wide linkage analysis in a New Zealand family with familial vesicoureteric reflux. Verbal presentation at the American Society of Human Genetics Conference, Cambridge, UK.

Eccles, M. R., Gough, S. M., Benjes, S., McNoe, L., & Morris, C. M. (1999). An integrated physical and genetic map of the PAX2/HOX11 interval in 10q24. Verbal presentation at the 4th Chromosome 10 Mapping Workshop, Cambridge, UK.

Eccles, M. R., Cho, N.-P., Torban, E., Cunliffe, H. E., Favor, J., Porteous, S., & Goodyer, P. R. (1999). Towards a molecular basis for understanding renal abnormalities and PAX2 haploinsufficiency in renal-coloboma syndrome. Verbal presentation at the American Society of Nephrology Conference, Miami, USA.

1998

Journal - Research Article

Stayner, C. K., Cunliffe, H. E., Ward, T. A., & Eccles, M. R. (1998). Cloning and characterization of the human PAX2 promoter. Journal of Biological Chemistry, 273(39), 25472-25479.

Devriendt, K., Matthijs, G., Van Damme, B., Van Caesbroeck, D., Eccles, M. R., Vanrenterghem, Y., … Leys, A. (1998). Missense mutation and hexanucleotide duplication in the PAX2 gene in two unrelated families with renal-coloboma syndrome (MIM 120330). Human Genetics, 103, 149-153.

Choi, K.-L., McNoe, L. A., French, M. C., Guilford, P. J., & Eccles, M. R. (1998). Absence of PAX2 gene mutations in patients with primary familial vesicoureteric reflux. Journal of Medical Genetics, 35(4), 338-339. doi: 10.1136/jmg.35.4.338

Cunliffe, H. E., McNoe, L. A., Ward, T. A., Devriendt, K., Brunner, H. G., & Eccles, M. R. (1998). The prevalence of PAX2 mutations in patients with isolated colobomas or colobomas associated with urogenital anomalies. Journal of Medical Genetics, 35(10), 806-812.

Journal - Research Other

Eccles, M. R. (1998). The role of PAX2 in normal and abnormal development of the urinary tract. Pediatric Nephrology, 12, 712-720. [Review].

Conference Contribution - Verbal presentation and other Conference outputs

Stayner, C.-A. K., Ward, T. A., & Eccles, M. R. (1998). Studying human PAX2 regulation using transgenic mice. Verbal presentation at the Queenstown Molecular Biology Conference, Queenstown.

Eccles, M. R., McNoe, L. A., Norrish, J. H., McDonald, M., Kees, U., & Morris, C. M. (1998). Gene map of the chromosome band 10q24 interval involved in cancer. Verbal presentation at the New Zealand Society for Oncology Conference, Christchurch.

Porteous, S., Cho, N.-P., Cunliffe, H. E., Yoon, H.-S., Ward, T. A., Favor, J., & Eccles, M. R. (1998). Characterization of the molecular pathological basis of renal abnormalities in PAX2 haploinsufficiency syndrome. Verbal presentation at the Human Genetics Society of Australasia Conference, Christchurch.

Porteous, S., Cho, N.-P., Cunliffe, H. E., Yoon, H.-S., Ward, T. A., Favor, J., & Eccles, M. R. (1998). Characterization of the molecular pathological basis of renal abnormalities in PAX2 haploinsufficiency syndrome. Verbal presentation at the Queenstown Molecular Biology Conference, Queenstown.

1997

Journal - Research Article

McConnell, M. J., Cunliffe, H. E., Chua, L. J., Ward, T. A., & Eccles, M. R. (1997). Differential regulation of the human Wilms-tumour suppressor gene (WT1) promoter by two isoforms of PAX2. Oncogene, 14(22), 2689-2700. doi: 10.1038/sj.onc.1201114

Schimmenti, L. A., Cunliffe, H. E., McNoe, L. A., Ward, T. A., French, M., Shim, H. H., … Eccles, M. R. (1997). Further delineation of renal-coloboma syndrome in patients with extreme variability of phenotype and identical PAX2 mutations. American Journal of Human Genetics, 60(4), 869-878.

Narahara, K., Baker, E., Ito, S., Yokoyama, Y., Yu, S., Hewitt, D., … Eccles, M. R., & Richards, R. I. (1997). Localisation of a 10q breakpoint within the PAX2 gene in a patient with a de novo t(10;13) translocation and optic nerve coloboma renal disease. Journal of Medical Genetics, 34(3), 213-216.

Erickson, R. P., Stone, J. F., McNoe, L. A., & Eccles, M. R. (1997). Molecular and clinical studies of three cases of female pseudohermaphroditism with caudal dysplasia suggest multiple etiologies. Clinical Genetics, 51(5), 331-337.

Conference Contribution - Published proceedings: Abstract

Eccles, M. R., McNoe, L. A., Ward, T. A., Brunner, H. G., & Cunliffe, H. E. (1997). PAX2 mutation identified in a patient with renal-coloboma syndrome and vesicoureteric reflux (VUR): Analysis of 43 patients with coloboma and/or urogenital anomalies. American Journal of Human Genetics. 61(4), (pp. 1941). [Abstract]

Walker, R. J., Dixon, S., Ruger, B. M., Davis, P. F., Eccles, M. R., & McNoe, L. A. (1997). Familial fibronectin nephropathy. 34th Australasian and New Zealand Society of Nephrology Conference. Auckland. [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Eccles, M. R., McConnell, M., French, M., & Cunliffe, H. E. (1997). Transactivation of the WT1 promoter by PAX2, and co-expression of PAX2 and WT1 transcripts in Wilms Tumour. Verbal presentation at the Transcriptional Control of Proliferation, DIfferentiation, and Development AACR Conference, New York.

Eccles, M. R., & Stayner, C.-A. K. (1997). Characterization of the human PAX2 gene promoter. Verbal presentation at the Transcriptional Control of Proliferation, DIfferentiation, and Development AACR Conference, New York.

McNoe, L. A., Cunliffe, H. E., Ward, T. A., French, M., Brunner, H. G., Schimmenti, H. E., & Eccles, M. R. (1997). PAX2 mutation identified in a patient with renal-coloboma syndrome and vesicoureteric reflux (VUR): Analysis of 99 patients with coloboma and/or urogenital anomalies. Verbal presentation at the American Society of Human Genetics Conference, Baltimore.

McConnell, M. A., & Eccles, M. R. (1997). Differential regulation by the tumour suppressor WT1 promoter by PAX2. Verbal presentation at the EMBL Conference, Lorne La Jola.

McConnell, M., & Eccles, M. R. (1997). Differential regulation by the tumour suppressor WT1 promoter by PAX2. Verbal presentation at the 9th Lorne Cancer Conference. American Association for Cancer Research, Lorne.

1996

Journal - Research Article

Sanyanusin, P., Norrish, J. H., Ward, T. A., Nebel, A., McNoe, L. A., & Eccles, M. R. (1996). Genomic structure of the human PAX2 gene. Genomics, 35(1), 258-261.

Eccles, M. R., Bailey, R. R., Sullivan, M. J., & Abbott, G. D. (1996). Unravelling the genetics of vesicoureteric reflux: a common familial disorder. Human Molecular Genetics, 5, 1425-1429.