2023
Journal - Research Article
Wiles, A. K., Mehta, S., Millier, M., Woolley, A. G., Li, K., Parker, K., Kazantseva, M., Wilson, M., Young, K., Bowie, S., Ray, S., Slatter, T. L., Stamp, L. K., Hessian, P. A., & Braithwaite, A. W. (2023). Activated CD90/Thy-1 fibroblasts co-express the Δ133p53β isoform and are associated with highly inflamed rheumatoid arthritis. Arthritis Research & Therapy, 25, 62. doi: 10.1186/s13075-023-03040-8
2019
Journal - Research Article
Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1
Conference Contribution - Published proceedings: Abstract
Li, K., Wilson, M., Parker, K., Wiles, A., Schultz, M., Slatter, T., Baird, M., & Braithwaite, A. (2019). An Δ133p53-like isoform drives exaggerated immune responses to promote chronic inflammation. European Journal of Immunology, 49(Suppl. 3), (pp. 782). doi: 10.1002/eji.201970400
2018
Journal - Research Article
Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3
Campbell, H., Fleming, N., Roth, I., Mehta, S., Wiles, A., Williams, G., … Munro, F., McNoe, L., Black, M., McCall, J., Slatter, T. L., … Braithwaite, A. W. (2018). Δ133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling. Nature Communications, 9(1), 254. doi: 10.1038/s41467-017-02408-0
2017
Journal - Research Article
Stayner, C., Poole, C. A., McGlashan, S. R., Pilanthananond, M., Brauning, R., Markie, D., … Slobbe, L., … Parker, K., Wiles, A., … Leichter, A., Leask, M., … Jennings, M., Horsfield, J. A., Walker, R. J., & Eccles, M. R. (2017). An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations. Scientific Reports, 7, 1601. doi: 10.1038/s41598-017-01519-4
Conference Contribution - Published proceedings: Abstract
Slatter, T. L., Kazantseva, M., Eiholzer, R., Mehta, S., Wiles, A., Bowie, S., Zhou, J., … Wilson, B. K. J., … Frampton, C. M., … Royds, J. A., … Hung, N. A., & Braithwaite, A. W. (2017). Elevated Δ133p53β correlates with a high tumor-associated macrophage content in glioblastoma with a poor patient outcome. Proceedings of the 3rd International p53 Isoforms Conference. (pp. 37). Retrieved from http://www.uib.no/en/ccbio
Wiles, A., Kazantseva, M., Li, K., Williams, M., Bowie, S., Jo, S., Millier, M., Hessian, P., Stamp, L., Baird, M. A., Slatter, T., & Braithwaite, A. (2017). The presence of Δ133p53β in the autoimmune disease rheumatoid arthritis. Proceedings of the 3rd International p53 Isoform Conference. P10. Retrieved from http://www.uib.no/en/ccbio
2016
Journal - Research Article
Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., Woolley, A., … Fleming, N., Baird, M., & Braithwaite, A. W. (2016). The Δ133p53 isoform and its mouse analogue Δ122p53 promote invasion and metastasis involving pro-inflammatory molecules interleukin-6 and CCL2. Oncogene, 35, 4981-4989. doi: 10.1038/onc.2016.45
Hung, N. A., Eiholzer, R. A., Kirs, S., Zhou, J., Ward-Hartstonge, K., Wiles, A. K., Frampton, C. M., Taha, A., Royds, J. A., & Slatter, T. L. (2016). Telomere profiles and tumor-associated macrophages with different immune signatures affect prognosis in glioblastoma. Modern Pathology, 29, 212-226. doi: 10.1038/modpathol.2015.156
Thompson, C. L., Wiles, A., Poole, C. A., & Knight, M. M. (2016). Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. FASEB Journal, 30(2), 716-726. doi: 10.1096/fj.15-274944
Conference Contribution - Verbal presentation and other Conference outputs
Eiholzer, R., Zhou, J., Taha, A., Kirs, S., Wang, D., Ziad, F., … Wilson, B., … Fulton, J., … Ward-Hartstonge, K., Wiles, A., Frampton, C., Hung, N., & Slatter, T. (2016, August-September). Surgical success and response to adjuvant therapy in glioblastoma depends on telomere maintenance associated markers. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
Campbell, H., Fleming, N., Roth, I., Vennin, C., McCall, J., Mehta, S., Wiles, A., Williams, G., … Baird, M., & Braithwaite, A. W. (2016, August-September). IL-6 signalling mediates tumorigenesis, invasion and metastasis driven by the Δ133p53 isoform. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Nelson, New Zealand.
2015
Journal - Research Article
Vermunt, J., Fraser, M., Herbison, P., Wiles, A., Schlup, M., & Schultz, M. (2015). Prevalence and knowledge of hepatitis C in a middle-aged population, Dunedin, New Zealand. World Journal of Gastroenterology, 21(35), 10224-10233. doi: 10.3748/wjg.v21.i35.10224
Thompson, C. L., Yasmin, H., Varone, A., Wiles, A., Poole, C. A., & Knight, M. M. (2015). Lithium chloride prevents interleukin-1β induced cartilage degradation and loss of mechanical properties. Journal of Orthopaedic Research, 33(10), 1552-1559. doi: 10.1002/jor.22913
Conference Contribution - Poster Presentation (not in published proceedings)
Roth, I., Campbell, H., Rubio, C., Vennin, C., Wilson, M., Wiles, A., Williams, G., … Fleming, N., Baird, M., & Braithwaite, A. (2015, October). Does a variant of the tumour suppressor P53 play a role in tumour metastasis? Poster session presented at the Otago Spotlight Series: Cancer Research, Wellington, New Zealand.
2014
Journal - Research Article
Hung, N., Chen, Y.-J., Taha, A., Olivecrona, M., Boet, R., Wiles, A., … Shaw, A., Eiholzer, R., Baguley, B. C., Eccles, M. R., Braithwaite, A. W., MacFarlane, M., Royds, J. A., & Slatter, T. (2014). Increased paired box transcription factor 8 has a survival function in Glioma. BMC Cancer, 14, 159. doi: 10.1186/1471-2407-14-159
2012
Conference Contribution - Verbal presentation and other Conference outputs
Poole, C. A., Stayner, C., McGlashan, S. R., Parker, K., Wiles, A., Jennings, M., … Johnstone, A. C., Walker, R. J., & Eccles, M. R. (2012, August). Primary cilia defects in the polycystic kidneys from an ovine model of Meckel Gruber syndrome. Verbal presentation at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.
Stayner, C., Lett, B., Slobbe, L., Wiles, A., Jennings, M., Markie, D., … Johnstone, A. C., Walker, R. J., Poole, C. A., & Eccles, M. (2012, August). Renal cystic disease: Developing an ovine model. Verbal presentation at the Translational Nephrology Conference: From Mechanics to Therapeutics, Queenstown, New Zealand.
2011
Journal - Research Article
Royds, J. A., Al Nadaf, S., Wiles, A. K., Chen, Y.-J., Ahn, A., Shaw, A., Bowie, S., … Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). The CDKN2A G500 allele is more frequent in GBM patients with no defined telomere maintenance mechanism tumors and is associated with poorer survival. PLoS ONE, 6(10), e26737. doi: 10.1371/journal.pone.0026737
Woolley, A. G., Algie, M., Samuel, W., Harfoot, R., Wiles, A., Hung, N. A., … Royds, J. A., Perez, D., Yoon, H.-S., … Braithwaite, A. W. (2011). Prognostic association of YB-1 expression in breast cancers: A matter of antibody. PLoS ONE, 6(6), e20603. doi: 10.1371/journal.pone.0020603
Conference Contribution - Published proceedings: Abstract
Royds, J. A., Al Nadaf, S., Ahn, A., Chen, Y.-J., Wiles, A., Jellinek, D., Braithwaite, A. W., … Hung, N. A., & Slatter, T. L. (2011). Older patients with glioma have a high frequency of a rare CDKN2A P14/16 allele. Neuro-Oncology, 13(Suppl. 2), 50, (pp. ii10). doi: 10.1093/neuonc/nor144
Conference Contribution - Poster Presentation (not in published proceedings)
Eccles, M. R., Lett, B., Stayner, C., Wiles, A., Slobbe, L., Parker, K., Johnstone, A. C., Walker, R. J., … Markie, D. (2011, October). Genetic and phenotypic characterization of an ovine large animal model of the MKS/JBTS/NPHP ciliopathy, Meckel-Gruber syndrome. Poster session presented at the 12th International Congress of Human Genetics (ICHG) and 61st Annual Meeting of the American Society of Human Genetics (ASHG), Montreal, Canada.
Poole, C. A., Stayner, C., McGlashan, S. R., Parker, K., Wiles, A., Jennings, M., … Johnstone, A. C., Walker, R. J., & Eccles, M. R. (2011, June-July). Primary cilia defects in an ovine model of Meckel Gruber syndrome. Poster session presented at the FASEB Summer Research Conference: Polycystic Kidney Disease: From Bench to Bedside, Saxtons River, Vermont.
Wiles, A., Lett, B., Stayner, C., Slobbe, L., Markie, D., McEwan, J., Johnstone, A. C., Walker, R. J., Poole, C. A., & Eccles, M. (2011, June-July). A large animal ciliopathy: Genetic characterization of an ovine model of Meckel-Gruber syndrome. Poster session presented at the FASEB Summer Research Conference: Polycystic Kidney Disease: From Bench to Bedside, Saxtons River, Vermont.
Conference Contribution - Verbal presentation and other Conference outputs
Stayner, C., Lett, B., Slobbe, L., Wiles, A., Markie, D., McEwan, J., … Walker, R. J., Poole, C. A., & Eccles, M. (2011, September). Novel missense mutations in an ovine model of Meckel-Gruber Syndrome. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
2010
Journal - Research Article
Slatter, T., Gifford-Garner, J., Wiles, A., Tan, X., Chen, Y.-J., MacFarlane, M., Sullivan, M., Royds, J., & Hung, N. (2010). Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres. American Journal of Pathology, 177(6), 2694-2700. doi: 10.2353/ajpath.2010.100468
Conference Contribution - Poster Presentation (not in published proceedings)
Poole, T., McGlashan, S., Jensen, C., Eccles, M., Lett, B., Stayner, C., … Jennings, M., Wiles, A., & Walker, R. (2010, August-September). Primary cilia defects in an ovine model of Meckel-Gruber Syndrome. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Poole, C. A., McGlashan, S. R., Jensen, C. G., Eccles, M. R., Lett, B., Stayner, C., Johnstone, A. C., Jennings, M., Wiles, A., & Walker, R. J. (2010, July). Primary cilia defects on an ovine model of Meckel-Gruber Syndrome. Poster session presented at the FASEB Summer Research Conference: The Biology of Cilia and Flagella, Saxtons River, Vermont.
Conference Contribution - Verbal presentation and other Conference outputs
Eccles, M., Lett, B., Wiles, A., Jennings, M., Slobbe, L., Walker, R., Poole, A., & Stayner, C. (2010, August-September). A novel primary cilia phenotype characterizes an ovine polycystic kidney disease that maps to the Meckel syndrome gene, MKS3. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.
Poole, C. A., Jennings, M., & Wiles, A. (2010, December). The Matrix - Cilium - Golgi Continuum: Models and mutants. Verbal presentation at the 2nd Annual Mechanobiology Symposium, Auckland, New Zealand.
Eccles, M., Lett, B., Wiles, A., Jennings, M., Slobbe, L., Poole, A., Stayner, C., & Walker, R. (2010, November-December). Primary cilia abnormalities characterize an ovine polycystic kidney disease that maps to the Meckel syndrome gene, MKS3. Verbal presentation at the Medical Sciences Congress: A New Decade of Discovery (MedSciNZ), Queenstown, New Zealand.
2009
Journal - Research Article
Hibma, M. H., Real, N. C., Wiles, A., Dobson-Le, D., Dix, B. R., Wynford-Thomas, D., Braithwaite, A. W., & Royds, J. A. (2009). Increased apoptosis and reduced replication efficiency of the E3 region-modified dl309 adenovirus in cancer cells. Virus Research, 145(1), 112-120. doi: 10.1016/j.virusres.2009.06.016
2008
Journal - Research Article
Chen, Y.-J., Campbell, H. G., Wiles, A. K., Eccles, M. R., Reddel, R. R., Braithwaite, A. W., & Royds, J. A. (2008). PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Research, 68(14), 5724-5732. doi: 10.1158/0008-5472.CAN-08-0058
Macartney-Coxson, D. P., Hood, K. A., Shi, H.-j., Ward, T., Wiles, A., O'Connor, R., … Royds, J. A., Stubbs, R. S., & Rooker, S. (2008). Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer, 8, 187. doi: 10.1186/1471-2407-8-187
2007
Conference Contribution - Poster Presentation (not in published proceedings)
Chen, Y.-J., Wiles, A., Braithwaite, A., Eccles, M., Baguley, B., & Royds, J. A. (2007, August). PAX provides molecular clues to gliomagenesis. Poster session presented at the Inaugural Queenstown Molecular Biology Cancer Satellite Meeting, Queenstown, New Zealand.
Conference Contribution - Verbal presentation and other Conference outputs
Wiles, A., Hibma, M., Russell, A., Braithwaite, A., & Royds, J. A. (2007, December). Factors affecting efficiency of Onco-viral therapy involving the adenovirus ONYX-015. Verbal presentation at the 4th Australian Virology Group Meeting, Fraser Island, Australia.
2006
Journal - Research Article
Royds, J. A., Hibma, M., Dix, B. R., Hananeia, L., Russell, I. A., Wiles, A., … Braithwaite, A. W. (2006). p53 promotes adenoviral replication and increases late viral gene expression. Oncogene, 25, 1509-1520.
Conference Contribution - Published proceedings: Abstract
Macartney, D. P., Gibson, A., Hood, K. A., Croft, A., Shi, H. J., Young, D., Wiles, A., Royds, J., … Stubbs, R. S., & Rooker, S. (2006). Gene expression and mutational analysis of a minimal region of human chromosome 8p specifically disrupted in colorectal liver metastases. Proceedings of the 11th International Congress of Human Genetics. Retrieved from http://www.ichg2006.com/abstract/771.htm
2001
Conference Contribution - Published proceedings: Abstract
Wiles, A., Hibma, M. H., Wynford-Thomas, D., Royds, J. A., & Braithwaite, A. (2001). p53 co-operates with adenovirus early protein E1b 55k to induce cell death. Lorne Conference. [Abstract]
Royds, J. A., Hibma, M. H., Wiles, A., Jales, L., Wynford-Thomas, D., & Braithwaite, A. (2001). Adenovirus early proten -E1b 55k, p53 and cell death. Lorne Conference. [Abstract]
Conference Contribution - Verbal presentation and other Conference outputs
Hibma, M. H., Wiles, A., Jales, L., Wynford-Thomas, D., & Braithwaite, A. (2001). The influence of p53 and E1b55k on cell cycle following adenovirus type 5 infection. Verbal presentation at the DNA Tumour Virus Meeting, UK.
