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Contact Details

Email
kevin.ly@otago.ac.nz

University Links

Position
Postdoctoral Fellow
Department
Department of Pathology (Dunedin)
Qualifications
MSc PhD
Research summary
P53 isoforms in cancer, IBD and obesity
Memberships
  • Affiliate of the Maurice Wilkins Centre New Zealand
  • Australia and New Zealand Society for Immunology

Research

My research investigates the effect of an Δ133p53-like isoform on the anti-tumour immunotherapy response.

Immunotherapy aims to use the patient’s immune system to treat cancer by inducing the immune system to attack the tumour. However, this type of therapy is not always effective and some patients develop resistance to the treatment.

In recent studies from the Braithwaite laboratory, over-expression of a tumour suppressor variant known as Δ133p53 has been found in some cancers to be associated with poor outcomes. My project aims to find out how the Δ133p53 variant affects the immune response in the tumour and the effectiveness of immunotherapies, in the context of colorectal cancer.

My research aims to identify Δ133p53 as a marker for predicting the patient’s response to immunotherapy. It also aims to provide information for improving immune-targeted therapies for solid cancers.

Additional details

Dr Ly’s research is supported by a Cancer Society of New Zealand Postdoctoral Fellowship.

Publications

Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394 Journal - Research Other

Ly, K. T. V. (2018). Investigation of RING domain E3 ubiquitin ligases in regulation of delta epithelial sodium channel (δENaC) activity (PhD). University of Otago, Dunedin, New Zealand. Retrieved from http://hdl.handle.net/10523/8143 Awarded Doctoral Degree

Hibma, M., Zhang, T., Gimenez, G., Ly, K., Burn, C., Young, K., Wilson, M., … Tschirley, A., Braithwaite, A., & Baird, M. (2018). Human papillomavirus regulation of Langerhans cell function in the skin. European Journal of Immunology, 48(Suppl. 1), (pp. 96-97). doi: 10.1002/eji.201871000 Conference Contribution - Published proceedings: Abstract

Zhang, J., Burn, C., Young, K., Wilson, M., Ly, K., Budhwani, M., Tschirley, A., Braithwaite, A., Baird, M., & Hibma, M. (2018). Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports, 8, 2373. doi: 10.1038/s41598-018-20779-2 Journal - Research Article

Zhang, T., Burn, C., Ly, K., Young, K., Wilson, M., Braithwaite, A., Baird, M., & Hibma, M. (2016). Immune modulation of Langerhans cells by microparticles from human papillomavirus type 16 E7 expressing keratinocytes. European Journal of Immunology, 46(Suppl. 1), (pp. 890-891). doi: 10.1002/eji.201670200 Conference Contribution - Published proceedings: Abstract

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