Dr Kevin Ly
Contact Details
- kevin.ly@otago.ac.nz
University Links
- Position
- Postdoctoral Fellow
- Department
- Department of Pathology (Dunedin)
- Qualifications
- MSc PhD
- Research summary
- P53 isoforms in cancer, IBD and obesity
- Memberships
- Affiliate of the Maurice Wilkins Centre New Zealand
- Australia and New Zealand Society for Immunology
Research
My research investigates the effect of an Δ133p53-like isoform on the anti-tumour immunotherapy response.
Immunotherapy aims to use the patient’s immune system to treat cancer by inducing the immune system to attack the tumour. However, this type of therapy is not always effective and some patients develop resistance to the treatment.
In recent studies from the Braithwaite laboratory, over-expression of a tumour suppressor variant known as Δ133p53 has been found in some cancers to be associated with poor outcomes. My project aims to find out how the Δ133p53 variant affects the immune response in the tumour and the effectiveness of immunotherapies, in the context of colorectal cancer.
My research aims to identify Δ133p53 as a marker for predicting the patient’s response to immunotherapy. It also aims to provide information for improving immune-targeted therapies for solid cancers.
Additional details
Dr Ly’s research is supported by a Cancer Society of New Zealand Postdoctoral Fellowship.
Publications
Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394
Zhang, J., Burn, C., Young, K., Wilson, M., Ly, K., Budhwani, M., Tschirley, A., Braithwaite, A., Baird, M., & Hibma, M. (2018). Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports, 8, 2373. doi: 10.1038/s41598-018-20779-2
Jemon, K., Leong, C.-M., Ly, K., Young, S. L., McLellan, A. D., & Hibma, M. H. (2016). Suppression of the CD8 T cell response by human papillomavirus type 16 E7 occurs in Langerhans cell-depleted mice. Scientific Reports, 6, 34789. doi: 10.1038/srep34789
Liu, Y. F., Swart, M., Ke, Y., Ly, K., & McDonald, F. J. (2013). Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel. American Journal of Physiology: Renal Physiology, 305(1), F80-F89. doi: 10.1152/ajprenal.00158.2013
Ly, K., McIntosh, C. J., Biasio, W., Liu, Y., Ke, Y., Olson, D. R., … McDonald, F. J. (2013). Regulation of the delta and alpha epithelial sodium channel (ENaC) by ubiquitination and Nedd8. Journal of Cellular Physiology, 228, 2190-2201. doi: 10.1002/jcp.24390
Zhang, J., Burn, C., Young, K., Wilson, M., Ly, K., Budhwani, M., Tschirley, A., Braithwaite, A., Baird, M., & Hibma, M. (2018). Microparticles produced by human papillomavirus type 16 E7-expressing cells impair antigen presenting cell function and the cytotoxic T cell response. Scientific Reports, 8, 2373. doi: 10.1038/s41598-018-20779-2
Journal - Research Article
Jemon, K., Leong, C.-M., Ly, K., Young, S. L., McLellan, A. D., & Hibma, M. H. (2016). Suppression of the CD8 T cell response by human papillomavirus type 16 E7 occurs in Langerhans cell-depleted mice. Scientific Reports, 6, 34789. doi: 10.1038/srep34789
Journal - Research Article
Liu, Y. F., Swart, M., Ke, Y., Ly, K., & McDonald, F. J. (2013). Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel. American Journal of Physiology: Renal Physiology, 305(1), F80-F89. doi: 10.1152/ajprenal.00158.2013
Journal - Research Article
Ly, K., McIntosh, C. J., Biasio, W., Liu, Y., Ke, Y., Olson, D. R., … McDonald, F. J. (2013). Regulation of the delta and alpha epithelial sodium channel (ENaC) by ubiquitination and Nedd8. Journal of Cellular Physiology, 228, 2190-2201. doi: 10.1002/jcp.24390
Journal - Research Article
Chang, T., Ke, Y., Ly, K., & McDonald, F. J. (2011). COMMD1 regulates the delta epithelial sodium channel (δENaC) through trafficking and ubiquitination. Biochemical & Biophysical Research Communications, 411(3), 506-511. doi: 10.1016/j.bbrc.2011.06.149
Journal - Research Article
Wiemuth, D., Lott, J. S., Ly, K., Ke, Y., Teesdale-Spittle, P., Snyder, P. M., & McDonald, F. J. (2010). Interaction of Serum- and Glucocorticoid regulated Kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS ONE, 5(8), e12163. doi: 10.1371/journal.pone.0012163
Journal - Research Article
Li, K., Ly, K., Mehta, S., & Braithwaite, A. (2022). Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis. Clinical & Translational Immunology, 11, e1394. doi: 10.1002/cti2.1394
Journal - Research Other