Dr Jim Smith
Contact Details
- Position
- Honorary Research Fellow
- Department
- Department of Pathology (Dunedin)
- Qualifications
- MBChB BMedSc(Hons)
- Research summary
- I am involved in molecular profiling of human cancers with the aim of clinical biomarker development
Research
Jim is a dual MBChB and BMedSc(Hons) graduate with several years’ experience in the field of cancer epigenomics. He completed his BMedSc(Hons) with the Chatterjee Laboratory in 2018, which involved establishing targeted DNA methylation editing of cell line models in New Zealand using CRISPR-based systems.
Alongside his clinical work as a junior doctor, Jim remains an active member of the Chatterjee Laboratory. His current research involves genomic and epigenomic profiling of clinical prostate cancer samples, with the aim of identifying molecular biomarkers to improve prostate cancer screening, diagnosis, and disease monitoring in New Zealand populations.
Publications
Zhang, X., Barnett, E., Smith, J., Wilkinson, E., Subramaniam, R. M., Zarrabi, A., Rodger, E. J., & Chatterjee, A. (2023). Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications. In International review of cell and molecular biology. Elsevier. doi: 10.1016/bs.ircmb.2023.06.002
Smith, J., Barnett, E., Rodger, E. J., Chatterjee, A., & Subramaniam, R. M. (2023). Neuroendocrine neoplasms: Genetics and epigenetics. PET Clinics, 18, 169-187. doi: 10.1016/j.cpet.2022.11.003
Hall, Y., Smith, J., Turner, R. M., Greco, P., Hau, K., & Barak, Y. (2022). Creating opportunities to improve detection of older adult abuse: A national interRAI study. BMC Geriatrics, 22, 220. doi: 10.1186/s12877-022-02938-3
Smith, J., Day, R. C., & Weeks, R. J. (2022). Next-generation bisulfite sequencing for targeted DNA methylation analysis. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 47-62). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_3
Smith, J., Whittington, F., Ackermann, C., Clarke, R., Hoten-Walker, G., Kubba, Y., Low, C., Partridge, K., Wang, C., Dockerty, J. D., … Hale, L., & Waters, D. L. (2022). Impact of the 2020 New Zealand COVID-19 lockdown on participants in a community-based, peer-led fall prevention program. Australasian Journal on Ageing, 41, e240-e248. doi: 10.1111/ajag.13040
Zhang, X., Barnett, E., Smith, J., Wilkinson, E., Subramaniam, R. M., Zarrabi, A., Rodger, E. J., & Chatterjee, A. (2023). Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications. In International review of cell and molecular biology. Elsevier. doi: 10.1016/bs.ircmb.2023.06.002
Chapter in Book - Research
Smith, J., Banerjee, R., Weeks, R. J., & Chatterjee, A. (2022). Editing of DNA methylation patterns using CRISPR-based tools. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 63-74). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_4
Chapter in Book - Research
Smith, J., Day, R. C., & Weeks, R. J. (2022). Next-generation bisulfite sequencing for targeted DNA methylation analysis. In J. Horsfield & J. Marsman (Eds.), Chromatin: Methods and protocols: Methods in molecular biology (Vol. 2458). (pp. 47-62). New York, NY: Springer. doi: 10.1007/978-1-0716-2140-0_3
Chapter in Book - Research
Smith, J., Barnett, E., Rodger, E. J., Chatterjee, A., & Subramaniam, R. M. (2023). Neuroendocrine neoplasms: Genetics and epigenetics. PET Clinics, 18, 169-187. doi: 10.1016/j.cpet.2022.11.003
Journal - Research Article
Hall, Y., Smith, J., Turner, R. M., Greco, P., Hau, K., & Barak, Y. (2022). Creating opportunities to improve detection of older adult abuse: A national interRAI study. BMC Geriatrics, 22, 220. doi: 10.1186/s12877-022-02938-3
Journal - Research Article
Smith, J., Whittington, F., Ackermann, C., Clarke, R., Hoten-Walker, G., Kubba, Y., Low, C., Partridge, K., Wang, C., Dockerty, J. D., … Hale, L., & Waters, D. L. (2022). Impact of the 2020 New Zealand COVID-19 lockdown on participants in a community-based, peer-led fall prevention program. Australasian Journal on Ageing, 41, e240-e248. doi: 10.1111/ajag.13040
Journal - Research Article
Smith, J., Banerjee, R., Waly, R., Urbano, A., Gimenez, G., Day, R., Eccles, M. R., Weeks, R. J., & Chatterjee, A. (2021). Locus-specific DNA methylation editing in melanoma cell lines using a CRISPR-based system. Cancers, 13, 5433. doi: 10.3390/cancers13215433
Journal - Research Article
Banerjee, R., Smith, J., Eccles, M. R., Weeks, R. J., & Chatterjee, A. (2022). Epigenetic basis and targeting of cancer metastasis. Trends in Cancer, 8(3), 226-241. doi: 10.1016/j.trecan.2021.11.008
Journal - Research Other
Smith, J., & McIntyre, P. (2022). Bacille Calmette-Guérin vaccination site abscess: When is it a problem? Journal of Paediatrics & Child Health, 58, 715-716. doi: 10.1111/jpc.15635
Journal - Research Other
Smith, J., Sen, S., Weeks, R. J., Eccles, M. R., & Chatterjee, A. (2020). Promoter DNA hypermethylation and paradoxical gene activation. Trends in Cancer, 6(5), 392-406. doi: 10.1016/j.trecan.2020.02.007
Journal - Research Other
Urbano, A., Smith, J., Weeks, R. J., & Chatterjee, A. (2019). Gene-specific targeting of DNA methylation in the mammalian genome. Cancers, 11(10), 1515. doi: 10.3390/cancers11101515
Journal - Research Other