Profile

Professor Ian Morison

Contact Details

Phone: +64 3 479 7170
Email: ian.morison@otago.ac.nz

University Links

Position: Professor
Department: Department of Pathology (Dunedin)
Qualifications: BMedSc MB ChB FRCPA PhD
Research summary: Epigenetics and genetics of blood disorders and development and laboratory haematology

Research

Ian is a research haematologist, combining careers in diagnostic haematology and basic haematology research. His research interests include childhood acute lymphoblastic leukaemia (epigenetics), epigenetics of development (IVF and placental), genomic imprinting, genetics of blood disorders, and others.

Childhood Acute Lymphoblastic Leukaemia

There is strong influence that environmental factors contribute to the incidence of childhood ALL (Acute Lymphoblastic Leukaemia). It is hypothesised that epigenetic events (DNA-methylation) contribute to the onset of ALL. Ian has used medium-throughput techniques to identify genes that are highly methylated leading to gene silencing in ALL. Functional studies are being performed to characterise candidate genes.

Epigenetics of Development

As a member of the National Research Centre for Growth and Development, Ian is determining the frequency with which epigenetic errors occur by children conceived by in vitro fertilisation.

The placenta appears to be more labile epigenetically than somatic tissues. The Centre is using high-throughput techniques to identify genes that are specifically methylated or unmethylated in the placenta and will determine the functional significance of this epigenetic change.

Genomic Imprinting

The Department of Pathology hosts and maintains the Catalogue of Parent of Origin Effects. This database is the most comprehensive database of parent of origin effects in animals. It includes documentation of all know imprinted genes in mammals.

Familial Thrombocytopenia

Linkage and mutation screening on a unique New Zealand family with thrombocytopenia, lead to the identification of the first reported mutation of human cytochrome c. This mutation enhances the activity of cytochrome c within the cell death pathway. By dysregulating platelet production in the bone marrow, the mutant protein causes premature release of platelets into the marrow space instead of into the circulation. In collaboration with Dr Liz Ledgerwood, Ian is characterising the biochemical mechanism of this pro-apoptotic cytochrome c.

Publications

Dunnet, M. J., Ortega-Recalde, O. J., Waters, S. A., Weeks, R. J., Morison, I. M., & Hore, T. A. (2022). Leukocyte-specific DNA methylation biomarkers and their implication for pathological epigenetic analysis. Epigenetics Communications, 2, 5. doi: 10.1186/s43682-022-00011-z

Ravichandran, M., Rafalski, D., Davies, C. I., Ortega-Recalde, O., Nan, X., Glanfield, C. R., … Mayyas, I. M., Kardailsky, O., … Morison, I. M., Hore, T. A., & Jurkowski, T. P. (2022). Pronounced sequence specificity of the TET enzyme catalytic domain guides its cellular function. Science Advances, 8, eabm2427. doi: 10.1126/sciadv.abm2427

Powell, R. M., Pattison, S., Moravec, J. C., Bhat, B., Guirguis, N., Markie, D., Jones, G. T., … Print, C. G., Morison, I. M., Gavryushkin, A., … Eccles, M. R., & Macaulay, E. C. (2022). Tuberous sclerosis complex: A complex case. Molecular Case Studies, 8, a006182. doi: 10.1101/mcs.a006182

Dunstan-Harrison, C., Morison, I. M., & Ledgerwood, E. C. (2022). A novel frameshift GP1BB mutation causes autosomal dominant macrothrombocytopenia with decreased vWF receptor expression but normal platelet aggregation. Platelets, 33(2), 324-327. doi: 10.1080/09537104.2021.1909716

Tschirley, A. M., Stockwell, P. A., Rodger, E. J., Eltherington, O., Morison, I. M., Christensen, N., Chatterjee, A., & Hibma, M. (2021). The mouse papillomavirus epigenetic signature is characterised by DNA hypermethylation after lesion regression. Viruses, 13, 2045. doi: 10.3390/v13102045

Chatterjee, A., Rodger, E. J., Morison, I. M., Eccles, M. R., & Stockwell, P. A. (2017). Tools and strategies for analysis of genome-wide and gene-specific DNA methylation patterns. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 249-277). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_15

Chapter in Book - Research

Chatterjee, A., Rodger, E. J., Stockwell, P. A., Le Mée, G., & Morison, I. M. (2017). Generating multiple base-resolution DNA methylomes using reduced representation bisulfite sequencing. In G. J. Seymour, M. P. Cullinan & N. C. K. Heng (Eds.), Oral biology: Molecular techniques and applications: Methods in molecular biology (Vol. 1537). (2nd ed.) (pp. 279-298). New York, NY: Springer. doi: 10.1007/978-1-4939-6685-1_16

Chapter in Book - Research

Morison, I. M., & Reik, W. (2010). Nutrition, environment and epigenetics. In M. E. Symonds & M. M. Ramsay (Eds.), Maternal-fetal nutrition during pregnancy and lactation. (pp. 180-195). Cambridge University Press.

Chapter in Book - Research

Glaser, R. L., & Morison, I. M. (2009). Equality of the sexes? Parent-of-origin effects on transcription and de novo mutations. In S. Krawetz (Ed.), Bioinformatics for systems biology. (pp. 485-513). New York: Springer. doi: 10.1007/978-1-59745-440-7_26

Chapter in Book - Research

Journal - Research Article

Almomani, S. N., Alsaleh, A. A., Weeks, R. J., Chatterjee, A., Day, R. C., Honda, I., … Fukuzawa, R., Slatter, T. L., Hung, N. A., Devenish, C., Morison, I. M., & Macaulay, E. C. (2021). Identification and validation of DNA methylation changes in pre-eclampsia. Placenta, 110, 16-23. doi: 10.1016/j.placenta.2021.05.005

Journal - Research Article

Mayyas, I. M., Weeks, R. J., Day, R. C., Magrath, H. E., O’Connor, K. M., Kardailsky, O., Hore, T. A., Hampton, M. B., & Morison, I. M. (2021). Hairpin-bisulfite sequencing of cells exposed to decitabine documents the process of DNA demethylation. Epigenetics, 16(11), 1251-1259. doi: 10.1080/15592294.2020.1861169

Journal - Research Article

Sneyd, M. J., Gray, A. R., & Morison, I. M. (2021). Trends in survival from myeloma, 1990-2015: A competing risks analysis. BMC Cancer, 21, 821. doi: 10.1186/s12885-021-08544-7

Journal - Research Article

Sneyd, M. J., Gray, A., & Morison, I. M. (2021). Regional distribution of myeloma in New Zealand. New Zealand Medical Journal, 134(1531), 11-22. Retrieved from https://www.nzma.org.nz/journal

Journal - Research Article

Weeks, R. J., Ludgate, J. L., Le Mée, G., Khanal, R., Mehta, S., Williams, G., Slatter, T. L., Braithwaite, A. W., & Morison, I. M. (2020). Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice. Scientific Reports, 10, 16255. doi: 10.1038/s41598-020-73229-3

Journal - Research Article

Sneyd, M. J., Cox, B., & Morison, I. M. (2019). Trends in myeloma incidence, mortality and survival in New Zealand (1985–2016). Cancer Epidemiology, 60, 55-59. doi: 10.1016/j.canep.2019.03.006

Journal - Research Article

Falisse, E., Ducos, B., Stockwell, P. A., Morison, I. M., Chatterjee, A., & Silvestre, F. (2018). DNA methylation and gene expression alterations in zebrafish early-life stages exposed to the antibacterial agent triclosan. Environmental Pollution, 243(Part B), 1867-1877. doi: 10.1016/j.envpol.2018.10.004

Journal - Research Article

Halliday, B. J., Fukuzawa, R., Markie, D. M., Grundy, R. G., Ludgate, J. L., Black, M. A., … Weeks, R. J., … Morison, I. M. (2018). Germline mutations and somatic inactivation of TRIM28 in Wilms tumour. PLoS Genetics, 14(6), e1007399. doi: 10.1371/journal.pgen.1007399

Journal - Research Article

Sharp, P. A., Clarkson, R., Hussain, A., Weeks, R. J., & Morison, I. M. (2018). DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression. PLoS ONE, 13(5), e0197863. doi: 10.1371/journal.pone.0197863

Journal - Research Article

Chatterjee, A., Macaulay, E. C., Ahn, A., Ludgate, J. L., Stockwell, P. A., Weeks, R. J., Parry, M. F., Foster, T. J., … Eccles, M. R., & Morison, I. M. (2017). Comparative assessment of DNA methylation patterns between reduced representation bisulfite sequencing and Sequenom EpiTyper methylation analysis. Epigenomics, 9(6), 823-832. doi: 10.2217/epi-2016-0176

Journal - Research Article

Fukuzawa, R., Anaka, M. R., Morison, I. M., & Reeve, A. E. (2017). The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour. PLoS ONE, 12(10), e0186333. doi: 10.1371/journal.pone.0186333

Journal - Research Article

Ludgate, J. L., Wright, J., Stockwell, P. A., Morison, I. M., Eccles, M. R., & Chatterjee, A. (2017). A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA. BMC Medical Genomics, 10, 54. doi: 10.1186/s12920-017-0290-1

Journal - Research Article

Macaulay, E. C., Chatterjee, A., Cheng, X., Baguley, B. C., Eccles, M. R., & Morison, I. M. (2017). The genes of life and death: A potential role for placental-specific genes in cancer: Active retrotransposons in the placenta encode unique functional genes that may also be used by cancer cells to promote malignancy. BioEssays, 39(11), 1700091. doi: 10.1002/bies.201700091

Journal - Research Article

Ong, L., Morison, I. M., & Ledgerwood, E. C. (2017). Megakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes. British Journal of Haematology, 176(2), 268-279. doi: 10.1111/bjh.14421

Journal - Research Article

Chatterjee, A., Macaulay, E. C., Rodger, E. J., Stockwell, P. A., Parry, M. F., Roberts, H. E., Slatter, T. L., Hung, N. A., Devenish, C. J., & Morison, I. M. (2016). Placental hypomethylation is more pronounced in genomic loci devoid of retroelements. Genes Genomes Genetics, 6(7), 1911-1921. doi: 10.1534/g3.116.030379

Journal - Research Article

Chatterjee, A., Stockwell, P. A., Rodger, E. J., & Morison, I. M. (2016). Genome-scale DNA methylome and transcriptome profiling of human neutrophils. Scientific Data, 3, 160019. doi: 10.1038/sdata.2016.19

Journal - Research Article

Weeks, R. J., Ludgate, J. L., LeMée, G., & Morison, I. M. (2016). TESTIN induces rapid death and suppresses proliferation in childhood B acute lymphoblastic leukaemia cells. PLoS ONE, 11(3), e0151341. doi: 10.1371/journal.pone.0151341

Journal - Research Article

Chatterjee, A., Stockwell, P. A., Rodger, E. J., Duncan, E. J., Parry, M. F., Weeks, R. J., & Morison, I. M. (2015). Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation. Scientific Reports, 5, 17328. doi: 10.1038/srep17328

Journal - Research Article

Hodgson, T. O., Ruskova, A., Shugg, C. J., McCallum, V. J., & Morison, I. M. (2015). Green neutrophil and monocyte inclusions: Time to acknowledge and report. British Journal of Haematology, 170, 229-235. doi: 10.1111/bjh.13434

Journal - Research Article

Josephs, T. M., Hibbs, M. E., Ong, L., Morison, I. M., & Ledgerwood, E. C. (2015). Interspecies variation in the functional consequences of mutation of cytochrome c. PLoS ONE, 10(6), e0130292. doi: 10.1371/journal.pone.0130292

Journal - Research Article

Josephs, T. M., Morison, I. M., Day, C. L., Wilbanks, S. M., & Ledgerwood, E. C. (2014). Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: Implications for the peroxidase mechanism and cytochrome c release. Biochemical Journal, 458(2), 259-265. doi: 10.1042/BJ20131386

Journal - Research Article

Lander, R. L., Bailey, K. B., Lander, A. G., Alsaleh, A. A., Costa-Ribeiro, H. C., Mattos, A. P., … Houghton, L. A., Morison, I. M., Williams, S. M., & Gibson, R. S. (2014). Disadvantaged pre-schoolers attending day care in Salvador, Northeast Brazil have a low prevalence of anaemia and micronutrient deficiencies. Public Health Nutrition, 19(9), 1984-1992. doi: 10.1017/s1368980013002310

Journal - Research Article

Macaulay, E. C., Roberts, H. E., Cheng, X., Jeffs, A. R., Baguley, B. C., & Morison, I. M. (2014). Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene. PLoS ONE, 9(4), e95840. doi: 10.1371/journal.pone.0095840

Journal - Research Article

Rodger, E. J., Chatterjee, A., & Morison, I. M. (2014). 5-hydroxymethylcytosine: A potential therapeutic target in cancer. Epigenomics, 6(5), 503-514. doi: 10.2217/epi.14.39

Journal - Research Article

Stockwell, P. A., Chatterjee, A., Rodger, E. J., & Morison, I. M. (2014). DMAP: Differential methylation analysis package for RRBS and WGBS data. Bioinformatics, 30(13), 1814-1822. doi: 10.1093/bioinformatics/btu126

Journal - Research Article

Chatterjee, A., Ozaki, Y., Stockwell, P. A., Horsfield, J. A., Morison, I. M., & Nakagawa, S. (2013). Mapping the zebrafish brain methylome using reduced representation bisulfite sequencing. Epigenetics, 8(9), 979-989. doi: 10.4161/epi.25797

Journal - Research Article

Ludgate, J. L., Le Mée, G., Fukuzawa, R., Rodger, E. J., Weeks, R. J., Reeve, A. E., & Morison, I. M. (2013). Global demethylation in loss of imprinting subtype of Wilms tumor. Genes Chromosomes & Cancer, 52(2), 174-184. doi: 10.1002/gcc.22017

Journal - Research Article

Chatterjee, A., Rodger, E. J., Stockwell, P. A., Weeks, R. J., & Morison, I. M. (2012). Technical considerations for reduced representation bisulfite sequencing with multiplexed libraries. Journal of Biomedicine & Biotechnology, 2012, 741542. doi: 10.1155/2012/741542

Journal - Research Article

Chatterjee, A., Stockwell, P. A., Rodger, E. J., & Morison, I. M. (2012). Comparison of alignment software for genome-wide bisulphite sequence data. Nucleic Acids Research, 40(10), e79. doi: 10.1093/nar/gks150

Journal - Research Article

Miller, J. C., Thomson, C. D., Williams, S. M., van Havre, N., Wilkins, G. T., Morison, I. M., Ludgate, J. L., & Skeaff, C. M. (2012). Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: A randomized controlled trial. American Journal of Clinical Nutrition, 96, 923-931. doi: 10.3945/ajcn.112.043125

Journal - Research Article

Oliver, V. F., Miles, H. L., Cutfield, W. S., Hofman, P. L., Ludgate, J. L., & Morison, I. M. (2012). Defects in imprinting and genome-wide DNA methylation are not common in the in vitro fertilization population. Fertility & Sterility, 97(1), 147-153.e7. doi: 10.1016/j.fertnstert.2011.10.027

Journal - Research Article

Rodger, E. J., & Morison, I. M. (2012). Myelodysplastic syndrome in New Zealand and Australia. Internal Medicine Journal, 42(11), 1235-1242. doi: 10.1111/j.1445-5994.2011.02619.x

Journal - Research Article

Bordé, E. C., Ouzegdouh, Y., Ledgerwood, E. C., & Morison, I. M. (2011). Congenital thrombocytopenia and cytochrome c mutation: A matter of birth and death. Seminars in Thrombosis & Hemostasis, 37(6), 664-672. doi: 10.1055/s-0031-1291376

Journal - Research Article

Macaulay, E. C., Weeks, R. J., Andrews, S., & Morison, I. M. (2011). Hypomethylation of functional retrotransposon-derived genes in the human placenta. Mammalian Genome, 22, 722-735. doi: 10.1007/s00335-011-9355-1

Journal - Research Article

Bell, C. G., Finer, S., Lindgren, C. M., Wilson, G. A., Rakyan, V. K., Teschendorff, A. E., … Morison, I. M., … Hitman, G. A. (2010). Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO Type 2 diabetes and obesity susceptibility locus. PLoS ONE, 5(11), e14040. doi: 10.1371/journal.pone.0014040

Journal - Research Article

Weeks, R. J., Kees, U. R., Song, S., & Morison, I. M. (2010). Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Molecular Cancer, 9, 163. doi: 10.1186/1476-4598-9-163

Journal - Research Article

Fukuzawa, R., Anaka, M. R., Weeks, R. J., Morison, I. M., & Reeve, A. E. (2009). Canonical WNT signalling determines lineage specificity in Wilms tumour. Oncogene, 28(8), 1063-1075. doi: 10.1038/onc.2008.455

Journal - Research Article

Ledgerwood, E. C., & Morison, I. M. (2009). Targeting the apoptosome for cancer therapy. Clinical Cancer Research, 15(2), 420-424. doi: 10.1158/1078-0432.CCR-08-1172

Journal - Research Article

Fukuzawa, R., Anaka, M. R., Heathcott, R. W., McNoe, L. A., Morison, I. M., Perlman, E. J., & Reeve, A. E. (2008). Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes. Journal of Pathology, 215(4), 377-387. doi: 10.1002/path.2366

Journal - Research Article

Krueger, C., & Morison, I. M. (2008). Random monoallelic expression: Making a choice. Trends in Genetics, 24(6), 257-259.

Journal - Research Article

Morison, I. M., Cramer Bordé, E. M., Cheesman, E. J., Cheong, P. L., Holyoake, A. J., Fichelson, S., Weeks, R. J., Lo, A., Davies, S. M. K., Wilbanks, S. M., Fagerlund, R. D., Ludgate, M. W., da Silva Tatley, F. M., Coker, M. S. A., Bockett, N. A., Hughes, G., Pippig, D. A., Smith, M. P., … Ledgerwood, E. C. (2008). A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nature Genetics, 40(4), 387-389. doi: 10.1038/ng.103

Journal - Research Article

Cutfield, W. S., Hofman, P. L., Mitchell, M., & Morison, I. M. (2007). Could epigenetics play a role in the developmental origins of health and disease? Pediatric Research, 61(5), 68R-75R.

Journal - Research Article

Glaser, R. L., Ramsay, J. P., & Morison, I. M. (2006). The imprinted gene and parent-of-origin effect database now includes parental origin of de novo mutations. Nucleic Acids Research, 34(Database), D29-D31.

Journal - Research Article

Slatter, T. L., Williams, M. J. A., Frikke-Schmidt, R., Tybjærg-Hansen, A., Morison, I. M., & McCormick, S. P. A. (2006). Promoter haplotype of a new ABCA1 mutant influences expression of familial hypoalphalipoproteinemia. Atherosclerosis, 187, 393-400.

Journal - Research Article

Weeks, R. J., & Morison, I. M. (2006). Detailed methylation analysis of CpG islands on human chromosome region 9p21. Genes Chromosomes & Cancer, 45(4), 357-364.

Journal - Research Article

Fukuzawa, R., Heathcott, R. W., Morison, I. M., & Reeve, A. E. (2005). Imprinting, expression, and localisation of DLK1 in Wilms tumours. Journal of Clinical Pathology, 58, 145-150.

Journal - Research Article

Morison, I. M., Ramsay, J. P., & Spencer, H. G. (2005). A census of mammalian imprinting. Trends in Genetics, 21(8), 457-465.

Journal - Research Article

Fukuzawa, R., Breslow, N. E., Morison, I. M., Dwyer, P., Kusafuka, T., Kobayashi, Y., … Reeve, A. E. (2004). Epigenetic differences between Wilms' tumors in white and east-Asian children. Lancet, 363, 446-451.

Journal - Research Article

Fukuzawa, R., Heathcott, R. W., Sano, M., Morison, I. M., Yun, K., & Reeve, A. E. (2004). Myogenesis in Wilms' tumors is associated with mutations of the WT1 gene and activation of Bcl-2 and the Wnt signaling pathway. Pediatric & Developmental Pathology, 7, 125-137.

Journal - Research Article

Heathcott, R. W., Morison, I. M., Gubler, M. C., Corbett, R., & Reeve, A. E. (2002). A review of the phenotypic variation due to the Denys-Drash Syndrome-associated germline WT1 mutation R362X. Human Mutation, 19(4), 462.

Journal - Research Article

Morison, I. M., Ellis, L., Teague, L. R., & Reeve, A. E. (2002). Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia. Blood, 99(1), 375-377.

Journal - Research Article

Reeve, A. E., Becroft, D. M. O., Morison, I. M., & Fukuzawa, R. (2002). IGF2 imprinting in cancer. Lancet, 359, 2050-2051.

Journal - Research Article

Tycko, B., & Morison, I. M. (2002). Physiological functions of imprinted genes. Journal of Cellular Physiology, 192, 245-258.

Journal - Research Article

Ferguson, E. L., Morison, I. M., Faed, J. M., Parnell, W. R., McKenzie, J. E., Wilson, N. C., & Russell, D. G. (2001). Dietary iron intakes and biochemical iron status of 15-49 year old women in New Zealand: Is there a cause for concern? New Zealand Medical Journal, 114, 134-148.

Journal - Research Article

Morison, I. M., Paton, C. J., & Cleverley, S. D. (2001). The imprinted gene and parent-of-origin effect database. Nucleic Acids Research, 29(1), 275-276.

Journal - Research Article

Itoh, N., Becroft, D. M. O., Reeve, A. E., & Morison, I. M. (2000). Proportion of cells with paternal 11p15 uniparental disomy correlates with organ enlargement in Wiedemann-Beckwith Syndrome. American Journal of Medical Genetics, 92, 111-116.

Journal - Research Article

Morison, I. M., Eccles, M. R., & Reeve, A. E. (2000). Imprinting of insulin-like growth factor 2 is modulated during hematopoiesis. Blood, 96(9), 3023-3028.

Journal - Research Article

Burt, M. J., Upton, J. D., Morison, I. M., Chapman, B. A., Faed, J. M., & George, P. M. (1997). Molecular analysis of HLA-H gene mutations in New Zealand patients with haemochromatosis. New Zealand Medical Journal, 110(1056), 429-432.

Journal - Research Article

Okamoto, K., Morison, I. M., Taniguchi, T., & Reeve, A. E. (1997). Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis. PNAS, 94(10), 5367-5371.

Journal - Research Article

Williams, M. J. A., Morison, I. M., Parker, J. H., & Stewart, R. A. H. (1997). Progression of the culprit lesion in unstable coronary artery disease with warfarin and aspirin versus aspirin alone: preliminary study. JACC, 30(2), 364-369.

Journal - Research Article

Morison, I. M., Becroft, D. M., Taniguchi, T., Reeve, A. E., & Woods, C. G. (1996). Somatic overgrowth associated with overexpression of insulin—like growth factor II. Nature Medicine, 2, 311-316. doi: 10.1038/nm0396-311

Journal - Research Article

Taniguchi, T., Schofield, A. E., Scarlett, J. L., Morison, I. M., Sullivan, M. J., & Reeve, A. E. (1995). Altered specificity of IGF2 promoter imprinting during fetal development and onset of Wilms tumour. Oncogene, 11, 751-756.

Journal - Research Article

Journal - Research Other

Ludgate, J. L., Weeks, R. J., & Morison, I. M. (2021). Aberrant immunoglobulin kappa locus rearrangement in a patient with CARD11-related B cell lymphocytosis. Journal of Clinical Immunology, 41, 1943-1945. doi: 10.1007/s10875-021-01114-3

Journal - Research Other

Antony, J., Gimenez, G., Taylor, T., Khatoon, U., Day, R., Morison, I. M., & Horsfield, J. A. (2020). BET inhibition prevents aberrant RUNX1 and ERG transcription in STAG2 mutant leukaemia cells. Journal of Molecular Cell Biology, 12(5), 397-399. doi: 10.1093/jmcb/mjz114

Journal - Research Other

Chai, K. Y., Boyke Berahmana, A. A., & Morison, I. M. (2019). Haematologists usually over-estimate the percentage of CD138+ plasma cells in marrow biopsies. Pathology, 51(6), 647-648. doi: 10.1016/j.pathol.2019.05.010

Journal - Research Other

Ledgerwood, E. C., Dunstan-Harrison, C., Ong, L., & Morison, I. M. (2019). CYCS gene variants associated with thrombocytopenia. Platelets, 30(5), 672-674. doi: 10.1080/09537104.2018.1543866

Journal - Research Other

Chai, K. Y., Byrne, A. L., & Morison, I. M. (2018). Roxithromycin monotherapy inducing a partial response in a patient with myeloma: A case report. Journal of Medical Case Reports, 12, 124. doi: 10.1186/s13256-018-1636-9

Journal - Research Other

Nishina-Uchida, N., Fukuzawa, R., Hasegawa, Y., & Morison, I. M. (2015). Identification of X monosomy cells from a gonad of mixed gonadal dysgenesis with a 46,XY karyotype. Medicine, 94(14), e720. doi: 10.1097/md.0000000000000720

Journal - Research Other

Chatterjee, A., Stockwell, P. A., Horsfield, J. A., Morison, I. M., & Nakagawa, S. (2014). Base-resolution DNA methylation landscape of zebrafish brain and liver [Data in brief]. Genomics Data, 2, 342-344. doi: 10.1016/j.gdata.2014.10.008

Journal - Research Other

Chatterjee, A., & Morison, I. M. (2011). Monozygotic twins: Genes are not the destiny? [Views and challenges]. Bioinformation, 7(7), 369-370.

Journal - Research Other

Fukuzawa, R., Reeve, A. E., & Morison, I. M. (2005). Correct usage of ″Loss of imprinting″ [Correspondence]. American Journal of Medical Genetics Part A, 138A, 412.

Journal - Research Other

Wilson, J. L., & Morison, I. M. (2005). No evidence for preferential maternal origin of duplicated chromosome 14 in hyperdiploid ALL. Blood, 105(4), 1837-1838. doi: 10.1182/blood-2004-09-3804

Journal - Research Other

Fukuzawa, R., Heathcott, R. W., Morison, I. M., Reeve, A. E., & Sano, M. (2004). Reply to Dr. Sredni and colleagues. Pediatric & Developmental Pathology, 7, 670.

Journal - Research Other

Schooten, C. J. M., Ellis, L., & Morison, I. M. (2003). Reassessment of loss of heterozygosity within MLL in childhood acute lymphoblastic leukemia. Blood, 101(10), 4222.

Journal - Research Other

Morison, I. M., & Reeve, A. E. (1998). A catalogue of imprinted genes and parent-of-origin effects in humans and animals. Human Molecular Genetics, 7(10), 1599-1609. doi: 10.1093/hmg/7.10.1599

Journal - Research Other

Morison, I. M., & Reeve, A. E. (1998). Insulin-like growth factor 2 and overgrowth: Molecular biology and clinical implications. Molecular Medicine Today, 4(3), 110-115. doi: 10.1016/S1357-4310(97)01197-0

Journal - Research Other

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Professor Ian Morison

Contact Details

University Links

Research

Childhood Acute Lymphoblastic Leukaemia

Epigenetics of Development

Genomic Imprinting

Familial Thrombocytopenia

Publications