Red X iconGreen tick iconYellow tick icon

Aaron Stevens

BSc, PGDipSci(Cant) PhD(Otago)


Research interests

Aaron leads the Epigenetic and Genetic Research Unit at UOW . His laboratory investigates how environmental factors including diet and immune derived oxidants (produced during inflammation and infection) can impact on human disease progression.

Methylated cytosine is an important epigenetic regulator of gene activity and plays a dynamic process in cell growth, differentiation, migration, and overall tissue architecture. Changing the methylation patterns during DNA replication may alter gene activity and redirect cell fate, which could be an important process in understanding how genes respond to their environmental conditions and is a central question for managing health and disease. Reactive oxygen species can act as key drivers in epigenetic change. This could affect how specific proteins bind and recognise DNA and may contribute to the link between inflammation and cancer.

He also investigates how diet can alter the composition of the human gut microbiome, and the implications of this for perinatal depression.


Seddon, A. R., Damiano, O., Hampton, M. B., & Stevens, A. J. (2024). Widespread genomic de novo DNA methylation occurs following CD8+ T cell activation and proliferation. Epigenetics, 19(1), 2367385. doi: 10.1080/15592294.2024.2367385 Journal - Research Article

Picard, L. C., Rich, F. J., Kenwright, D. N., & Stevens, A. J. (2024). Epigenetic changes associated with Bacillus Calmette-Guerin (BCG) treatment in bladder cancer. Biochimica et Biophysica Acta: Reviews on Cancer. Advance online publication. doi: 10.1016/j.bbcan.2024.189123 Journal - Research Article

Seddon, A., Das, A., Hampton, M., & Stevens, A. (2024). Understanding how immune oxidants can drive epigenetic change. European Journal of Human Genetics, 32(Suppl. 1), (pp. 720). doi: 10.1038/s41431-023-01482-x Conference Contribution - Published proceedings: Abstract

Yan, M. P., Wee, C. E., Yen, K. P., Stevens, A., & Wai, L. K. (2023). G-quadruplex ligands as therapeutic agents against cancer, neurological disorders and viral infections. Future Medicinal Chemistry, 15(21), 1987-2009. doi: 10.4155/fmc-2023-0202 Journal - Research Other

He, Z., Wilson, A., Rich, F., Kenwright, D., Stevens, A., Low, Y. S., & Thunders, M. (2023). Chromosomal instability and its effect on cell lines. Cancer Reports, e1822. Advance online publication. doi: 10.1002/cnr2.1822 Journal - Research Other

Back to top