BSc, PGDipSci(Cant) PhD(Otago)
Aaron leads the Epigenetic and Genetic Research Unit at UOW. His laboratory investigates how environmental factors including diet and immune derived oxidants (produced during inflammation and infection) can impact on human disease progression.
Methylated cytosine is an important epigenetic regulator of gene activity and plays a dynamic process in cell growth, differentiation, migration, and overall tissue architecture. Changing the methylation patterns during DNA replication may alter gene activity and redirect cell fate, which could be an important process in understanding how genes respond to their environmental conditions and is a central question for managing health and disease. Reactive oxygen species can act as key drivers in epigenetic change. This could affect how specific proteins bind and recognise DNA and may contribute to the link between inflammation and cancer.
He also investigates how diet can alter the composition of the human gut microbiome, and the implications of this for perinatal depression.
Seddon, A., Das, A., Hampton, M., & Stevens, A. (2023). Understanding how immune oxidants can drive epigenetic change. Proceedings of the European Society of Human Genetics (ESHG) European Human Genetics Hybrid Conference. P21.003.C. Retrieved from https://www.eshg.org/home
He, Z., Wilson, A., Rich, F., Kenwright, D., Stevens, A., Low, Y. S., & Thunders, M. (2023). Chromosomal instability and its effect on cell lines. Cancer Reports, e1822. Advance online publication. doi: 10.1002/cnr2.1822
Seddon, A. R., Das, A. B., Hampton, M. B., & Stevens, A. J. (2023). Site-specific decreases in DNA methylation in replicating cells following exposure to oxidative stress. Human Molecular Genetics, 32(4), 632-648. doi: 10.1093/hmg/ddac232
Stevens, A. J., de Jong, L., & Kennedy, M. A. (2022). The dynamic regulation of G-quadruplex DNA structures by cytosine methylation. International Journal of Molecular Sciences, 23, 2407. doi: 10.3390/ijms23052407
Seddon, A. R., Liau, Y., Pace, P. E., Miller, A. L., Das, A. B., Kennedy, M. A., Hampton, M. B., & Stevens, A. J. (2021). Genome-wide impact of hydrogen peroxide on maintenance DNA methylation in replicating cells. Epigenetics & Chromatin, 14(1), 17. doi: 10.1186/s13072-021-00388-6