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Health Sciences profile

Dr Marina Kazantseva

PositionResearch Fellow
DepartmentDepartment of Pathology (Dunedin)
QualificationsBSc(Hons)(Otago) PhD (Otago)
Research summaryGenetic and epigenetic mechanisms in cancer
Teaching
  • Research student supervisor 2 Summer Students, 2 PhD candidates
  • Tutor for ELM2, ELM3 (Pathology and Chemical Pathology), Māori ELM2 (Physiology)
Memberships
  • Maurice Wilkins Centre for Molecular Biodiscovery, New Zealand, 2016-present
  • European Association for Cancer Research: Young Investigator, 2018-present
  • Australian Epigenetics Alliance AEpiA – member, 2019-present

Research

My specific interests include:

  1. Factors that contribute to change in epigenetic fate to induce more robust and drug-tolerant cancer cells
  2. The roles of the p53 isoforms in regulation of tumour immune suppression (novel anti-AXL and -PDL1 therapeutic strategies)

Our research combines CRISPR/Cas9 genome editing, cancer biology, bioinformatics, cancer cell and mouse models to study the genetic and epigenetic mechanisms of oncogene regulation.

Additional details

There are several research projects available, ranging from honours / masters to PhD. Interested graduate and postgraduate students are encouraged to make contact to further discuss these projects.

  1. Project Title: Exploring emerging roles of p53 isoforms in epigenetic dysregulation in cancer. Using CRISPR to reactivate tumour suppressor genes in cancer cells.
    Level: honours / master's
  2. Project Title: Roles of p53 isoforms in cancer cell reprogramming and drug resistance.
    Level: honours / master's, PhD
  3. Project Title: Investigating the role of p53 isoforms in regulation of the receptor tyrosine kinase signalling in cancer cells.
    Level: honours / master's

Funding

Funding of my research has been provided by:

Publications

Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111

Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3

Journal - Research Article

Knoepp, F., Ashley, Z., Barth, D., Baldin, J.-P., Jennings, M., Kazantseva, M., Saw, E. L., Katare, R., … Fronius, M. (2020). Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. PNAS, 117(1), 717-726. doi: 10.1073/pnas.1911243117

Eiholzer, R. A., Mehta, S., Kazantseva, M., Drummond, C. J., McKinney, C., Young, K., … Fleming, N., Morrin, H. R., Reader, K., Royds, J. A., Landmann, M., Petrich, S., … Taha, A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2020). Intronic TP53 polymorphisms are associated with increased Δ133TP53 transcript, immune infiltration and cancer risk. Cancers, 12(9), 2472. doi: 10.3390/cancers12092472

Kazantseva, M., Mehta, S., Eiholzer, R. A., Gimenez, G., Bowie, S., Campbell, H., Reily-Bell, A. L., … Ray, S., Drummond, C. J., Reid, G., … Wiles, A., Morrin, H. R., Reader, K. L., Hung, N. A., Baird, M. A., Slatter, T. L., & Braithwaite, A. W. (2019). The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer. Cell Death & Disease, 10, 631. doi: 10.1038/s41419-019-1861-1

Kazantseva, M., Eiholzer, R. A., Mehta, S., Taha, A., Bowie, S., Roth, I., Zhou, J., … Royds, J. A., Hung, N. A., Slatter, T. L., & Braithwaite, A. W. (2018). Elevation of the TP53 isoform Δ133p53β in glioblastomas: An alternative to mutant p53 in promoting tumour development. Journal of Pathology, 246(1), 77-88. doi: 10.1002/path.5111

Kazantseva, M., Mehta, S., Eiholzer, R. A., Hung, N., Wiles, A., Slatter, T. L., & Braithwaite, A. W. (2018). A mouse model of the Δ133p53 isoform: Roles in cancer progression and inflammation. Mammalian Genome, 29, 831-842. doi: 10.1007/s00335-018-9758-3

Kazantseva, M., Hung, N. A., Mehta, S., Roth, I., Eiholzer, R., Rich, A. M., Seo, B., Baird, M. A., Braithwaite, A. W., & Slatter, T. L. (2017). Tumor protein 53 mutations are enriched in diffuse large B-cell lymphoma with irregular CD19 marker expression. Scientific Reports, 7, 1566. doi: 10.1038/s41598-017-01800-6

Kazantseva, M. G., Hung, N. A., Highton, J., & Hessian, P. A. (2013). MMP expression in rheumatoid inflammation: The rs11568818 polymorphism is associated with MMP-7 expression at an extra-articular site. Genes & Immunity, 14(3), 162-169. doi: 10.1038/gene.2012.65

Kazantseva, M. G., Highton, J., Stamp, L. K., & Hessian, P. A. (2012). Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. Arthritis Research & Therapy, 14, R208. doi: 10.1186/ar4046

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