Emeritus Professor Andy Mercer

2023

Journal - Research Article

Al Daif, B. A., Mercer, A. A., & Fleming, S. B. (2023). The parapoxvirus Orf virus inhibits dsDNA-mediated type I IFN expression via STING-dependent and STING-independent signalling pathways. Journal of General Virology, 104(10), 001912. doi: 10.1099/jgv.0.001912

2021

Journal - Research Article

AlDaif, B. A., Mercer, A. A., & Fleming, S. B. (2021). The parapoxvirus Orf virus ORF116 gene encodes an antagonist of the interferon response. Journal of General Virology, 102, 001695. doi: 10.1099/jgv.0.001695

AlDaif, B. A., Mercer, A. A., & Fleming, S. B. (2021). The parapoxvirus Orf virus inhibits IFN-β expression induced by dsRNA. Virus Research, 307, 198619. doi: 10.1016/j.virusres.2021.198619

2020

Journal - Research Article

Riad, S., Xiang, Y., AlDaif, B., Mercer, A. A., & Fleming, S. B. (2020). Rescue of a vaccinia virus mutant lacking IFN resistance genes K1L and C7L by the Parapoxvirus orf virus. Frontiers in Microbiology, 11, 1797. doi: 10.3389/fmicb.2020.01797

Wise, L. M., Stuart, G. S., Jones, N. C., Fleming, S. B., & Mercer, A. A. (2020). Orf virus IL-10 and VEGF-E act synergistically to enhance healing of cutaneous wounds in mice. Journal of Clinical Medicine, 9(4), 1085. doi: 10.3390/jcm9041085

2019

Journal - Research Article

Sharif, S., Ueda, N., Nakatani, Y., Wise, L. M., Clifton, S., Lateef, Z., Mercer, A. A., & Fleming, S. B. (2019). Chemokine-binding proteins encoded by parapoxvirus of red deer of New Zealand display evidence of gene duplication and divergence of ligand specificity. Frontiers in Microbiology, 10, 1421. doi: 10.3389/fmicb.2019.01421

Lateef, Z., Stuart, G., Jones, N., Mercer, A., Fleming, S., & Wise, L. (2019). The cutaneous inflammatory response to thermal burn injury in a murine model. International Journal of Molecular Sciences, 20(3), 538. doi: 10.3390/ijms20030538

2018

Journal - Research Article

Wise, L. M., Bodaan, C. J., Stuart, G. S., Real, N. C., Lateef, Z., Mercer, A. A., … Theoret, C. L. (2018). Treatment of limb wounds of horses with orf virus IL-10 and VEGF-E accelerates resolution of exuberant granulation tissue, but does not prevent its development. PLoS ONE, 13(5), e0197223. doi: 10.1371/journal.pone.0197223

Wise, L. M., Stuart, G. S., Real, N. C., Fleming, S. B., & Mercer, A. A. (2018). VEGF receptor-2 activation mediated by VEGF-E limits scar tissue formation following cutaneous injury. Advances in Wound Care, 7(8), 283-297. doi: 10.1089/wound.2016.0721

2017

Journal - Research Article

Fleming, S. B., McCaughan, C., Lateef, Z., Dunn, A., Wise, L. M., Real, N. C., & Mercer, A. A. (2017). Deletion of the chemokine binding protein gene from the Parapoxvirus Orf virus reduces virulence and pathogenesis in sheep. Frontiers in Microbiology, 8, 46. doi: 10.3389/fmicb.2017.00046

Chen, D.-Y., Fabrizio, J.-A., Wilkins, S. E., Dave, K. A., Gorman, J. J., Gleadle, J. M., Fleming, S. B., … Mercer, A. A. (2017). Ankyrin repeat proteins of orf virus influence the cellular hypoxia response pathway. Journal of Virology, 91(1), e01430-16. doi: 10.1128/jvi.01430-16

2016

Journal - Research Article

Sharif, S., Nakatani, Y., Wise, L., Corbett, M., Real, N. C., Stuart, G. S., Lateef, Z., Krause, K., Mercer, A. A., & Fleming, S. B. (2016). A broad-spectrum chemokine-binding protein of bovine papular stomatitis virus inhibits neutrophil and monocyte infiltration in inflammatory and wound models of mouse skin. PLoS ONE, 11(12), e0168007. doi: 10.1371/journal.pone.0168007

Bodaan, C. J., Wise, L. M., Wakelin, K. A., Stuart, G. S., Real, N. C., Mercer, A. A., … Theoret, C. (2016). Short-term treatment of equine wounds with orf virus IL-10 and VEGF-E dampens inflammation and promotes repair processes without accelerating closure. Wound Repair & Regeneration, 24(6), 966-980. doi: 10.1111/wrr.12488

Wakelin, K. A., Wise, L. M., Bodaan, C. J., Mercer, A. A., Riley, C. B., & Theoret, C. L. (2016). Orf virus interleukin-10 and vascular endothelial growth factor-E modulate gene expression in cultured equine dermal fibroblasts. Veterinary Determatology, 27(5), 434-438. doi: 10.1111/vde.12370

Bennett, J. R., Lateef, Z., Fleming, S. B., Mercer, A. A., & Wise, L. M. (2016). Orf virus IL-10 reduces monocyte, dendritic cell and mast cell recruitment to inflamed skin. Virus Research, 213, 230-237. doi: 10.1016/j.virusres.2015.12.015

Conference Contribution - Published proceedings: Abstract

Wise, L., Libuda, F., Real, N., Stuart, G., Wilkins, S., Wakelin, K., Mercer, A., Clarkson, A., Walker, G., … Theoret, C. (2016). Combined delivery of orf virus proteins VEGF-E and IL-10 dampens inflammation and promotes repair processes in equine skin wounds. Proceedings of the Diagnostics, Drugs, Devices, Discovery (D4) Conference. Retrieved from http://www.otago.ac.nz/d4/index.html

Intellectual Property

Wise, L. M., Fleming, S. B., & Mercer, A. A. (2016). Combination treatments and compositions for wound healing comprising viral VEGF. (9,314,505). United States.

2015

Journal - Research Article

Harvey, R., McCaughan, C., Wise, L. M., Mercer, A. A., & Fleming, S. B. (2015). Orf virus inhibits interferon stimulated gene expression and modulates the JAK/STAT signalling pathway. Virus Research, 208, 180-188. doi: 10.1016/j.virusres.2015.06.014

Couñago, R. M., Knapp, K. M., Nakatani, Y., Fleming, S. B., Corbett, M., Wise, L. M., Mercer, A. A., & Krause, K. L. (2015). Structures of orf virus chemokine binding protein in complex with host chemokines reveal clues to broad binding specificity. Structure, 23(7), 1199-1213. doi: 10.1016/j.str.2015.04.023

Fleming, S. B., Wise, L. M., & Mercer, A. A. (2015). Molecular genetic analysis of Orf virus: A poxvirus that has adapted to skin. Viruses, 7(3), 1505-1539. doi: 10.3390/v7031505

Herbert, M. H., Squire, C. J., & Mercer, A. A. (2015). Poxviral ankyrin proteins. Viruses, 7(2), 709-738. doi: 10.3390/v7020709

Lee, S., Chu, H. X., Kim, H. A., Real, N. C., Sharif, S., Fleming, S. B., Mercer, A. A., Wise, L. M., … Sobey, C. G. (2015). Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development. Stroke, 46, 537-544. doi: 10.1161/strokeaha.114.007298

Conference Contribution - Poster Presentation (not in published proceedings)

Lee, W. J., Fleming, S. B., Kleffmann, T., & Mercer, A. A. (2015, August-September). Identifying the interacting partner(s) of orf virus ankyrin repeat proteins. Poster session presented at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

2014

Journal - Research Article

Wise, L. M., Stuart, G. S., Real, N. C., Fleming, S. B., & Mercer, A. A. (2014). Orf virus IL-10 accelerates wound healing while limiting inflammation and scarring. Wound Repair & Regeneration, 22(3), 356-367. doi: 10.1111/wrr.12169

Intellectual Property

Weber, O., Tennagels, S. M., Siegling, A., Schlapp, T., Mercer, A. A., Fleming, S. B., & Volk, H.-D. (2014). Recombinant proteins of parapoxvirus ovis and pharmaceutical compositions therefrom. (8,852,577). United States.

2013

Journal - Research Article

Paulsen, D., Urban, A., Knorr, A., Hirth-Dietrich, C., Siegling, A., Volk, H.-D., Mercer, A. A., … Weber, O. (2013). Inactivated orf virus shows antifibrotic activity and inhibits human hepatitis B virus (HBV) and hepatitis C virus (HCV) replication in preclinical models. PLoS ONE, 8(9), e74605. doi: 10.1371/journal.pone.0074605

Weber, O., Mercer, A. A., Friebe, A., Knolle, P., & Volk, H.-D. (2013). Therapeutic immunomodulation using a virus: The potential of inactivated orf virus. European Journal of Clinical Microbiology & Infectious Diseases, 32, 451-460. doi: 10.1007/s10096-012-1780-x

Journal - Research Other

Fairley, R. A., Mercer, A. A., Copland, C. I., Craig, S. M., & Heslip, P. A. (2013). Persistent pseudocowpox virus infection of the skin of a foot in a cat. New Zealand Veterinary Journal, 61(4), 242-243. doi: 10.1080/00480169.2012.757728

Conference Contribution - Published proceedings: Abstract

Harfoot, R., Fleming, S., Braithwaite, A., & Mercer, A. A. (2013). A retinoblastoma-associated protein (pRB) binding protein from orf virus. Proceedings of the Australasian Virology Society (AVS) Meeting. Retrieved from http://www.avs.org.au/scientific-program/

Chen, D.-Y., Fleming, S. B., & Mercer, A. A. (2013). The functional analysis of ANK repeat protein family in Chordopoxviruses during virus infection. Proceedings of the Australasian Virology Society (AVS) Meeting. Retrieved from http://www.avs.org.au/scientific-program/

Wise, L. M., Real, N. C., Stuart, G. S., Fleming, S. B., & Mercer, A. A. (2013). ORF virus homologs of VEGF and IL-10 act synergistically to accelerate skin regeneration and limit scarring. Wound Repair & Regeneration, 21(2), (pp. A47). doi: 10.1111/wrr.12030

2012

Chapter in Book - Research

Skinner, M. A., Buller, R. M., Damon, I. K., Lefkowitz, E. J., McFadden, G., McInnes, C. J., Mercer, A. A., … Upton, C. (2012). Family: Poxviridae. In A. M. Q. King, M. J. Adams, E. B. Carstens & E. J. Lefkowitz (Eds.), Virus taxonomy: Classification and nomenclature of viruses: Ninth report of the International Committee on Taxonomy of Viruses. (pp. 291-309). San Diego, CA: Elsevier Academic Press.

Mercer, A., & Fleming, S. (2012). Parapoxvirus: Poxviridae, Chordopoxvirinae. In C. Tidona & G. Darai (Eds.), The Springer Index of Viruses. (pp. 1495-1504). New York: Springer. doi: 10.1007/978-0-387-95919-1_244

Journal - Research Article

D'Costa, Z. J., Jolly, C., Androphy, E. J., Mercer, A., Matthews, C. M., & Hibma, M. H. (2012). Transcriptional repression of E-cadherin by human papillomavirus type 16 E6. PLoS ONE, 7(11), e48954. doi: 10.1371/journal.pone.0048954

Mo, M., Shahar, S., Fleming, S. B., & Mercer, A. A. (2012). How viruses affect the cell cycle through manipulation of the APC/C. Trends in Microbiology, 20(9), 440-448. doi: 10.1016/j.tim.2012.05.007

Dutton, S., Fleming, S. B., Ueda, N., Heath, D. D., Hibma, M. H., & Mercer, A. A. (2012). Delivery of Echinococcus granulosus antigen EG95 to mice and sheep using recombinant vaccinia virus. Parasite Immunology, 34(6), 312-317. doi: 10.1111/j.1365-3024.2012.01360.x

Rintoul, J. L., Lemay, C. G., Tai, L.-H., Stanford, M. M., Falls, T. J., de Souza, C. T., … Mercer, A. A., … Bell, J. C. (2012). ORFV: A novel oncolytic and immune stimulating Parapoxvirus therapeutic. Molecular Therapy, 20(6), 1148-1157. doi: 10.1038/mt.2011.301

Wise, L. M., Inder, M. K., Real, N. C., Stuart, G. S., Fleming, S. B., & Mercer, A. A. (2012). The vascular endothelial growth factor (VEGF)-E encoded by orf virus regulates keratinocyte proliferation and migration and promotes epidermal regeneration. Cellular Microbiology, 14(9), 1376-1390. doi: 10.1111/j.1462-5822.2012.01802.x

Tan, J. L., Ueda, N., Heath, D., Mercer, A. A., & Fleming, S. B. (2012). Development of orf virus as a bifunctional recombinant vaccine: Surface display of Echinococcus granulosus antigen EG95 by fusion to membrane structural proteins. Vaccine, 30(2), 398-406. doi: 10.1016/j.vaccine.2011.10.079

Conference Contribution - Published proceedings: Abstract

Wise, L., Stuart, G., Real, N., Fleming, S., & Mercer, A. (2012). VEGF-E enhances wound closure by promoting re-epithelialisation and reducing granulation tissue formation. Journal of Vascular Research, 49(Suppl. 1), (pp. 37). doi: 10.1159/000334223

Wise, L., Real, N., Inder, M., Fleming, S., & Mercer, A. (2012). Dissecting the role of the VEGF receptors in VEGF-induced monocyte activation and migration. Journal of Vascular Research, 49(Suppl. 1), (pp. 36). doi: 10.1159/000334223

Wise, L., Stuart, G., Real, N., Inder, M., Fleming, S., & Mercer, A. (2012). VEGF-E enhances wound closure by promoting vascular and epidermal regeneration while limiting granulation tissue formation. Wound Repair & Regeneration, 20(5), (pp. A78). doi: 10.1111/j.1524-475X.2012.00835.x

Wise, L., Stuart, G., Real, N., Inder, M., Fleming, S., & Mercer, A. (2012). Orf virus IL-10 enhances wound resolution by limiting inflammation and granualtion tissue formation. Wound Repair & Regeneration, 20(5), (pp. A69). doi: 10.1111/j.1524-475X.2012.00835.x

Conference Contribution - Verbal presentation and other Conference outputs

Krause, K., Couñago, R., Fleming, S., Corbett, M., Wise, L., Knapp, K., & Mercer, A. (2012, November). The structure of the chemokine binding protein from orf virus reveals clues to its broad binding specificity. Verbal presentation at the 57th New Zealand Microbiological Society (NZMS) Annual Scientific Meeting, Dunedin, New Zealand.

Other Research Output

Mercer, A. (2012, February). Viruses and us: Is it all bad news? University of Otago, Dunedin, New Zealand. [Inaugural Professorial Lecture].

2011

Journal - Research Article

Sonnberg, S., Fleming, S. B., & Mercer, A. A. (2011). Phylogenetic analysis of the large family of poxvirus ankyrin-repeat proteins reveals orthologue groups within and across chordopoxvirus genera. Journal of General Virology, 92(11), 2596-2607. doi: 10.1099/vir.0.033654-0

Friebe, A., Friederichs, S., Scholz, K., Janssen, U., Scholz, C., Schlapp, T., Mercer, A., … Weber, O. (2011). Characterization of immunostimulatory components of orf virus (parapoxvirus ovis). Journal of General Virology, 92(7), 1571-1584. doi: 10.1099/vir.0.028894-0

Cross, M. L., Fleming, S. B., Cowan, P. E., Scobie, S., Whelan, E., Prada, D., Mercer, A. A., & Duckworth, J. A. (2011). Vaccinia virus as a vaccine delivery system for marsupial wildlife. Vaccine, 29(28), 4537-4543. doi: 10.1016/j.vaccine.2011.04.093

Conference Contribution - Published proceedings: Abstract

D'Costa, Z., Matthews, C., Mercer, A., Wise, L., & Hibma, M. (2011). Human papillomavirus type 16 E6 regulates E-cadherin in a DNA methyltransferase-dependent manner. New Zealand Medical Journal, 124(1344). Retrieved from http://journal.nzma.org.nz/journal/124-1344/4919/content.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Wise, L., Stuart, G., Real, N., Fleming, S., & Mercer, A. (2011, November-December). VEGF-E enhances wound closure by promoting re-epithelialisation and reducing granulation tissue formation. Verbal presentation at the 15th Australian and New Zealand Microcirculation Society (ANZMS) Meeting, Margaret River, Australia.

Wise, L., Real, N., Inder, M., Fleming, S., & Mercer, A. (2011, November-December). Dissecting the role of the VEGF receptors in VEGF-induced monocyte activation and migration. Verbal presentation at the 15th Australian and New Zealand Microcirculation Society (ANZMS) Meeting, Margaret River, Australia.

Krause, K. L., Counago, R., Fleming, S., & Mercer, A. (2011, September). Orf virus chemokine binding protein maintains tight binding across chemokine families. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Herbert, M. H., Baker, E. N., Mercer, A. A., & Squire, C. J. (2011, September). Hijacking ubiquitination: Orf, structure prediction, and the SCF ubiquitin ligase complex. Verbal presentation at the Queenstown Molecular Biology (QMB) Meetings, Queenstown, New Zealand.

Mercer, A. (2011, December). Mining viruses: New therapeutics from our closest enemies. Verbal presentation at the Maurice Wilkins Centre for Molecular Biodiscovery Workshop: Celebrating Collaboration in Biomedical Research, Dunedin, New Zealand.

2010

Chapter in Book - Research

Fleming, S. B., & Mercer, A. A. (2010). Orf virus. In D. Liu (Ed.), Molecular detection of human viral pathogens. (pp. 1017-1027). CRC Press.

Journal - Research Article

Mo, M., Fleming, S. B., & Mercer, A. A. (2010). Orf virus cell cycle regulator, PACR, competes with subunit 11 of the anaphase promoting complex for incorporation into the complex. Journal of General Virology, 91, 3010-3015. doi: 10.1099/vir.0.026054-0

Couñago, R. M., Fleming, S. B., Mercer, A. A., & Krause, K. L. (2010). Crystallization and preliminary X-ray analysis of the chemokine-binding protein from orf virus (Poxviridae). Acta Crystallographica Section F, F66, 819-823. doi: 10.1107/S1744309110018166

Hautaniemi, M., Ueda, N., Tuimala, J., Mercer, A. A., Lahdenperä, J., & McInnes, C. J. (2010). The genome of pseudocowpoxvirus: Comparison of a reindeer isolate and a reference strain. Journal of General Virology, 91(6), 1560-1576. doi: 10.1099/vir.0.018374-0

Lateef, Z., Baird, M. A., Wise, L. M., Young, S., Mercer, A. A., & Fleming, S. B. (2010). The chemokine binding protein encoded by the poxvirus orf virus inhibits recruitment of dendritic cells to sites of skin inflammation and migration to peripheral lymph nodes. Cellular Microbiology, 12(5), 665-676. doi: 10.1111/j.1462-5822.2009.01425.x

Journal - Research Other

Mo, M., Fleming, S. B., & Mercer, A. A. (2010). Changing pace: Viral mimicry of an anaphase promoting complex subunit [Editorial]. Cell Cycle, 9(4), 632-633.

Conference Contribution - Published proceedings: Abstract

Gallina, L., Mercer, A., Lavazza, A., & Scagliarini, A. (2010). Investigation of the role of F1L protein in orf virus structure and morphogenesis using a deleted mutant virus. Journal of Biotechnology, 150(Suppl. 1), (pp. 532-533). doi: 10.1016/j.jbiotec.2010.09.867

Conference Contribution - Verbal presentation and other Conference outputs

Mercer, A. (2010, March). A virus-based vaccine delivery platform for use in production animals. Verbal presentation at the NZBIO Conference: Advancing a bio-based economy, Auckland, New Zealand.

2009

Journal - Research Article

Mo, M., Fleming, S. B., & Mercer, A. A. (2009). Cell cycle deregulation by a poxvirus partial mimic of anaphase-promoting complex subunit 11. PNAS, 106(46), 19527-19532. doi: 10.1073/pnas.0905893106

Westphal, D., Ledgerwood, E. C., Tyndall, J. D. A., Hibma, M. H., Ueda, N., Fleming, S. B., & Mercer, A. A. (2009). The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis, 14(11), 1317-1330. doi: 10.1007/s10495-009-0403-1

Sonnberg, S., Fleming, S. B., & Mercer, A. A. (2009). A truncated two-α-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex. Journal of General Virology, 90, 1224-1228. doi: 10.1099/vir.0.009324-0

Chang, S.-J., Hsiao, J.-C., Sonnberg, S., Chiang, C.-T., Yang, M.-H., Tzou, D.-L., Mercer, A. A., & Chang, W. (2009). Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-κB activation by tumor necrosis factor alpha but is independent of its host range function. Journal of Virology, 83(9), 4140-4152. doi: 10.1128/jvi.01835-08

Lateef, Z., Baird, M. A., Wise, L. M., Mercer, A. A., & Fleming, S. B. (2009). Orf virus-encoded chemokine-binding protein is a potent inhibitor of inflammatory monocyte recruitment in a mouse skin model. Journal of General Virology, 90(6), 1477-1482. doi: 10.1099/vir.0.009589-0

Tan, J. L., Ueda, N., Mercer, A. A., & Fleming, S. B. (2009). Investigation of orf virus structure and morphogenesis using recombinants expressing FLAG-tagged envelope structural proteins: Evidence for wrapped virus particles and egress from infected cells. Journal of General Virology, 90(3), 614-625. doi: 10.1099/vir.0.005488-0

Deane, D., Ueda, N., Wise, L. M., Wood, A. R., Percival, A., Jepson, C., … Fleming, S. B., Mercer, A. A., & McInnes, C. J. (2009). Conservation and variation of the parapoxvirus GM-CSF-inhibitory factor (GIF) proteins. Journal of General Virology, 90, 970-977. doi: 10.1099/vir.0.006692-0

Conference Contribution - Published proceedings: Abstract

Inder, M., Dryden, N., Mercer, A., Fleming, S., & Wise, L. (2009). VEGF-E induces keratinocyte proliferation and migration via VEGFR-2. Journal of Vascular Research, 46(Suppl. 2), (pp. 30). doi: 10.1159/000230992

Corbett, M., Real, N., Fleming, S., Mercer, A., & Wise, L. (2009). Natural variation in ligand binding by parapoxvirus chemokine binding proteins. Journal of Vascular Research, 46(Suppl. 2), (pp. 28). doi: 10.1159/000230992

Wise, L., Li, K., van de Vrie, M., Real, N., Fleming, S., & Mercer, A. (2009). Regulation of dendritic cell function by a viral vascular endothelial growth factor. Journal of Vascular Research, 46(Suppl. 2), (pp. 20). doi: 10.1159/000230992

Corbett, M., Real, N., Fleming, S., Mercer, A., & Wise, L. (2009). The orf virus chemokine binding protein is a novel broad-spectrum chemokine inhibitor. New Zealand Medical Journal, 122(1306). Retrieved from http://journal.nzma.org.nz/journal/122-1306/3899/content.pdf

Mo, M., Fleming, S. B., & Mercer, A. A. (2009). Upping the pace: Manipulation of the cell cycle by PACR, a viral homologue of anaphase promoting complex subunit 11. Proceedings of the ComBio2009 Conference. [CD-ROM] [Abstract]

Inder, M., Dryden, N., Mercer, A., Fleming, S., & Wise, L. (2009). VEGF-E induces keratinocyte proliferation and migration via VEGFR-2. In C. Matthewson & M. Taumoepeau (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices VI. (pp. 25). Dunedin, New Zealand: Pacific Islands Centre, University of Otago. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Inder, M., Dryden, N., Mercer, A., Fleming, S., & Wise, L. (2009, September). VEGF induces keratinocyte proliferation and migration via VEGFR-2. Poster session presented at the Third Annual Division of Health Sciences Research Forum, Wellington, New Zealand.

2008

Chapter in Book - Research

Haig, D., & Mercer, A. A. (2008). Parapoxviruses. In B. W. J. Mahy & M. H. V. van Regenmortel (Eds.), Encyclopedia of virology. (3rd ed.) (pp. 57-63). Elsevier. doi: 10.1016/B978-012374410-4.00461-1

Journal - Research Article

Fairley, R. A., Whelan, E. M., Pesavento, P. A., & Mercer, A. A. (2008). Recurrent localised cutaneous parapoxvirus infection in three cats. New Zealand Veterinary Journal, 56(4), 196-201.

Vijaysri, S., Jentarra, G., Heck, M. C., Mercer, A. A., McInnes, C. J., & Jacobs, B. L. (2008). Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Intra-nasal vaccination. Vaccine, 26(5), 664-676. doi: 10.1016/j.vaccine.2007.11.045

Cébe-Suarez, S., Grünewald, F. S., Jaussi, R., Li, X., Claesson-Welsh, L., Spillmann, D., Mercer, A. A., … Ballmer-Hofer, K. (2008). Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR. FASEB Journal, 22(8), 3078-3086. doi: 10.1096/fj.08-107219

Sonnberg, S., Seet, B. T., Pawson, T., Fleming, S. B., & Mercer, A. A. (2008). Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. PNAS, 105(31), 10955-10960. doi: 10.1073/pnas.0802042105

Inder, M. K., Wise, L. M., Fleming, S. B., & Mercer, A. A. (2008). The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1. FEBS Journal, 275(1), 207-217. doi: 10.1111/j.1742-4658.2007.06189.x

Conference Contribution - Published proceedings: Abstract

Inder, M., Dryden, N., Mercer, A., Fleming, S., & Wise, L. (2008). VEGF-E induces keratinocyte proliferation and migration via VEGFR-2. In C. Matthewson & M. Taumoepeau (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices V. (pp. 21). Dunedin, New Zealand: Pacific Islands Centre, University of Otago. [Abstract]

Lateef, Z., Baird, M., Wise, L., Mercer, A., & Fleming, S. (2008). The characterisation of orf virus chemokine binding protein using murine models. New Zealand Medical Journal, 121(1278). Retrieved from http://journal.nzma.org.nz/journal/121-1278/3179/content.pdf

Mo, M., Fleming, S., & Mercer, A. (2008). Deregulation of cell cycle progression by a parapoxvirus mimic of anaphase promoting complex subunit 11. New Zealand Medical Journal, 121(1278). Retrieved from http://journal.nzma.org.nz/journal/121-1278/3179/content.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Hibma, M., Dillon, S., Sasagawa, T., Heinemann, L., Woodfield, L., Crawford, A., … Prestidge, J., Inder, M., Jerram, J., & Mercer, A. (2008, June). Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. Verbal presentation at the Australian Society for Immunology New Zealand Branch Meeting, Wellington, New Zealand.

Leong, C.-M., Doorbar, J., Yoon, H.-S., Mercer, A., & Hibma, M. (2008, November). Human papillomavirus regulation of Langerhans cell density occurs in types from the α, μ and γ genera but not in types from the β genus. Verbal presentation at the Virology Theme Meeting, Dunedin, New Zealand.

2007

Edited Book - Research

Mercer, A. A., Schmidt, A., & Weber, O. (Eds.). (2007). Poxviruses. Basel, Switzerland: Birkhäuser, 441p.

Chapter in Book - Research

Fleming, S. B., & Mercer, A. A. (2007). Genus Parapoxvirus. In A. A. Mercer, A. Schmidt & O. Weber (Eds.), Poxviruses. (pp. 127-166). Basel, Switzerland: Birkhäuser.

Journal - Research Article

Fleming, S. B., Anderson, I. E., Thomson, J., Deane, D. L., McInnes, C. J., McCaughan, C. A., Mercer, A. A., & Haig, D. M. (2007). Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factor. Journal of General Virology, 88, 1922-1927.

Westphal, D., Ledgerwood, E. C., Hibma, M. H., Fleming, S. B., Whelan, E. M., & Mercer, A. A. (2007). A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus orf virus. Journal of Virology, 81(13), 7178-7188.

Wise, L. M., Savory, L. J., Dryden, N. H., Whelan, E. M., Fleming, S. B., & Mercer, A. A. (2007). Major amino acid sequence variants of viral vascular endothelial growth factor are functionally equivalent during Orf virus infection of sheep skin. Virus Research, 128, 115-125.

Wise, L., McCaughan, C., Tan, C. K., Mercer, A. A., & Fleming, S. B. (2007). Orf virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes, but only partially impairs their proliferation. Journal of General Virology, 88, 1677-1682.

Snell, A. E., Graves, S., Kane, R., Ward, V., Slaney, D., Mercer, A., … Weinstein, P. (2007). Pilot testing a genus wide PCR-based system for arbovirus detection in mosquitoes in New Zealand. Weta, 33, 6-13.

Ueda, N., Inder, M. K., Wise, L. M., Fleming, S. B., & Mercer, A. A. (2007). Parapoxvirus of red deer in New Zealand encodes a variant of viral vascular endothelial growth factor. Virus Research, 124, 50-58.

Hyun, J.-K., Coulibaly, F., Turner, A. P., Baker, E. N., Mercer, A. A., & Mitra, A. K. (2007). The structure of a putative scaffolding protein of immature poxvirus particles as determined by electron microscopy suggests similarity with capsid proteins of large icosahedral DNA viruses. Journal of Virology, 81(20), 11075-11083.

Inder, M. K., Ueda, N., Mercer, A. A., Fleming, S. B., & Wise, L. M. (2007). Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2. Journal of General Virology, 88, 781-791.

Dillon, S., Sasagawa, T., Crawford, A., Prestidge, J., Inder, M. K., Jerram, J., Mercer, A. A., & Hibma, M. (2007). Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. Journal of General Virology, 88, 803-813.

Conference Contribution - Published proceedings: Abstract

Mo, M., Whelan, E., Fleming, S. B., & Mercer, A. A. (2007). De-regulation of cell cycle progression by a viral mimic of anaphase promoting complex subunit 11. Proceedings of the American Society for Cell Biology's 47th Annual Meeting. ASCB. Retrieved from http://www.abstractsonline.com/

Inder, M. K., Wise, L. M., Fleming, S. B., & Mercer, A. A. (2007). The conserved O-glycosylated C-terminus of the Parapoxvirus VEGF family member, ORFV_NZ2VEGF, plays a role in its unique receptor-binding profile. In C. Matthewson & M. Taumoepeau (Eds.), Proceedings of the Pacific Postgraduate Symposium: Pacific Voices IV. (pp. 19). Dunedin, New Zealand: Pacific Islands Centre, University of Otago. [Abstract]

Sonnberg, S., Fleming, S., & Mercer, A. (2007). Poxvirus ankyrin repeat proteins represent a novel class of F-box proteins that associate with functional cellular ubiquitination ligases. New Zealand Medical Journal, 120(1262). Retrieved from http://journal.nzma.org.nz/journal/120-1262/2740/content.pdf

Westphal, D., Ledgerwood, E., Fleming, S., & Mercer, A. (2007). The orf virus protein ORFV125 acts in a Bcl-2-like manner to inhibit apoptosis. New Zealand Medical Journal, 120(1262). Retrieved from http://journal.nzma.org.nz/journal/120-1262/2740/content.pdf

Conference Contribution - Verbal presentation and other Conference outputs

Mercer, A. (2007, April). Insights from the virus-host interface: De-regulation of cell cycle progression by a viral mimic of anaphase promoting complex subunit 11. Verbal presentation at the Webster Centre for Molecular Research in Infectious Diseases Symposium, Dunedin, New Zealand.

Leong, C. M., Doorbar, J., Yoon, H.-S., Mercer, A., & Hibma, M. (2007, November). Human papillomavirus E6 regulation of Langerhans Cell density via E-cadherin is conserved in types from the A, C and E supergenera but not in types 5 and 8 from the B supergenus. Verbal presentation at the 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China.

2006

Journal - Research Article

Chan, A., Baird, M., Mercer, A. A., & Fleming, S. B. (2006). Maturation and function of human dendritic cells are inhibited by orf virus-encoded interleukin-10. Journal of General Virology, 87, 3177-3181.

Mercer, A. A., Ueda, N., Friederichs, S.-M., Hofmann, K., Fraser, K. M., Bateman, T., & Fleming, S. B. (2006). Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation. Virus Research, 116, 146-158.

Conference Contribution - Published proceedings: Abstract

Westphal, D., Fleming, S. B., Ledgerwood, E. C., & Mercer, A. A. (2006). The orf virus protein ORFV125 is a potent inhibitor of apoptosis. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2062/content.pdf

Sonnberg, S., Fleming, S. B., & Mercer, A. A. (2006). The ankyrin repeat proteins of Orf virus are a novel class of F-box proteins and associate with components of the cellular ubiquitination system. New Zealand Medical Journal, 119(1237). Retrieved from http://journal.nzma.org.nz/journal/119-1237/2062/content.pdf

Intellectual Property

Wise, L. M., Mercer, A. A., Savory, L. J., & Fleming, S. B. (2006). Vascular endothelial growth factor-like protein from ORF virus NZ10 binds and activates mammalian VEGF receptor-2. (EP 1 126 863).

2005

Chapter in Book - Research

Buller, R. M., Arif, B. M., Black, D. N., Dumbell, K. R., Esposito, J. J., Lefkowitz, E. J., … Mercer, A. A., … Tripathy, D. N. (2005). Family Poxviridae. In C. M. Fauquet, M. A. Mayo, J. Maniloff, U. Desselberger & L. A. Ball (Eds.), Virus taxonomy: Classification and nomenclature of viruses: Eighth report of the International Committee on Taxonomy of Viruses. (pp. 117-133). San Diego, California: Elsevier Academic Press.

Journal - Research Article

Mercer, A. A., Fleming, S. B., & Ueda, N. (2005). F-box-like domains are present in most poxvirus ankyrin repeat proteins. Virus Genes, 31(2), 127-133.

Conference Contribution - Published proceedings: Abstract

Wise, L. M., McCaughan, C. A., Lateef, Z. I., Inder, M. K., Mercer, A. A., & Fleming, S. B. (2005). Manipulation of immune cell migration and pro-inflammatory cytokine expression by Orf virus-encoded virulence factors. Inflammatory Research. 54(Suppl.2), (pp. S132). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Fleming, S. B., Seet, B. T., Haig, D., McCaughan, C. A., Baird, M., Imlach, W., Lateef, Z., Wise, L. M., … Mercer, A. A. (2005, November). Immune evasion strategies of the Parapoxvirus Orf virus. Verbal presentation at the SBMB New Zealand and the NZMS Conference, Dunedin, New Zealand.

Mercer, A. A., Sonnberg, S., & Fleming, S. B. (2005, November). Presence of an F-box-like domain is a feature of poxvirus ankyrin repeat proteins and suggests this family of proteins has a role in ubiquitin-mediated proteolysis. Verbal presentation at the SBMB New Zealand and the NZMS Conference: Celebrating 50 years of Microbial Interactions, Dunedin, New Zealand.

Westphal, D., Ledgerwood, E. C., Whelan, E. M., Fleming, S. B., Hibma, M. H., & Mercer, A. A. (2005, November). Characterisation of a novel inhibitor of apoptosis expressed by orf virus. Verbal presentation at the SBMB New Zealand and the NZMS Conference: Celebrating 50 years of Microbial Interactions, Dunedin, New Zealand.

Min, M., Whelan, E., Kane, R., Fleming, S., & Mercer, A. (2005, November). Orf virus RING-H2 protein: Similarities to APC11 suggest a role in cell cycle control. Verbal presentation at the SBMB New Zealand and the NZMS Conference: Celebrating 50 years of Microbial Interactions, Dunedin, New Zealand.

2004

Journal - Research Article

Tikkanen, M. K., McInnes, C. J., Mercer, A. A., Büttner, M., Tuimala, J., Hirvelä-Koski, V., … Huovilainen, A. (2004). Recent isolates of parapoxvirus of Finnish reindeer (Rangifer tarandus tarandus) are closely related to bovine pseudocowpox virus. Journal of General Virology, 85, 1413-1418.

Conference Contribution - Poster Presentation (not in published proceedings)

Inder, M. K., Wise, L. M., Fleming, S. B., & Mercer, A. A. (2004, November). The structure-function analysis of a viral-encoded vascular endothelial growth factor. Poster session presented at the 14th Annual Queenstown Molecular Biology Meeting, Queenstown, New Zealand.

Conference Contribution - Verbal presentation and other Conference outputs

Mercer, A., Whelan, E., Westphal, D., Hibma, M., Fleming, S., & Ledgerwood, E. (2004, September). Inhibition of apoptosis by orf virus: Contribution of a unique, mitochondrial targeted factor. Verbal presentation at the XVth International Poxvirus and Iridovirus Conference, Oxford, England.

2003

Journal - Research Article

Marsland, B. J., Tisdall, D. J., Heath, D. D., & Mercer, A. A. (2003). Construction of a recombinant orf virus that expresses an Echinococcus granulosus vaccine antigen from a novel genomic insertion site. Archives of Virology, 148(3), 555-562. doi: 10.1007/s00705-002-0948-6

Seet, B. T., McCaughan, C. A., Handel, T. M., Mercer, A. A., Brunetti, C., McFadden, G., & Fleming, S. B. (2003). Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors. PNAS, 100(25), 15137-15142.

Wise, L., Ueda, N., Dryden, N. H., Fleming, S. B., Caesar, C., Roufail, S., … Mercer, A. A. (2003). Viral vascular endothelial growth factors vary extensively in amino acid sequence, receptor-binding specificities, and the ability to induce vascular permeability yet are uniformly active mitogens. Journal of Biological Chemistry, 278(39), 38004-38014.

Vijaysri, S., Talasela, L., Mercer, A. A., McInnes, C. J., Jacobs, B. L., & Langland, J. O. (2003). The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo. Virology, 314, 305-314.

Weber, O., Siegling, A., Friebe, A., Limmer, A., Schlapp, T., Knolle, P., Mercer, A. A., … Volk, H.-D. (2003). Inactivated parapoxvirus ovis (Orf virus) has antiviral activity against hepatitis B virus and herpes simplex virus. Journal of General Virology, 84, 1843-1852.

Lateef, Z., Fleming, S. B., Halliday, G., Faulkner, L., Mercer, A. A., & Baird, M. A. (2003). Orf virus-encoded interleukin-10 inhibits maturation, antigen presentation and migration of murine dendritic cells. Journal of General Virology, 84, 1101-1109.

Ueda, N., Wise, L., Stacker, S. A., Fleming, S. B., & Mercer, A. A. (2003). Pseudocowpox virus encodes a homolog of vascular endothelial growth factor. Virology, 305, 298-309.

Conference Contribution - Verbal presentation and other Conference outputs

Mercer, A., Wise, L., Ueda, N., Fleming, S., Achen, M., & Stacker, S. (2003, December). Functional analysis of a unique viral vascular endothelial growth factor (VEGF). Verbal presentation at the 2nd Australian Virology Group Meeting, Fraser Island, Australia.

Intellectual Property

Wise, L. M., Mercer, A. A., Savory, L. J., Fleming, S. B., & Stacker, S. (2003). Vascular endothelial growth factor-like protein from orf viruses binds and activates mammalian VEGF receptor-2, and uses thereof. United States patent (US 6,541,008 B1).

2002

Chapter in Book - Research

Mercer, A., & Fleming, S. (2002). Parapoxviruses. In Springer Index of Viruses. (pp. 896-901). Berlin: Springer Press.

Journal - Research Article

Haig, D. M., Thomson, J., McInnes, C. J., Deane, D. L., Anderson, I. E., McCaughan, C. A., Imlach, W., Mercer, A. A., & Fleming, S. B. (2002). A comparison of the anti-inflammatory and immuno-stimulatory activities of orf virus and ovine interleukin-10. Virus Research, 90(1-2), 303-316.

Mercer, A. A., Wise, L. M., Scagliarini, A., McInnes, C. J., Buttner, M., Rziha, H. J., McCaughan, C. A., Fleming, S. B., Ueda, N., & Nettleton, P. F. (2002). Vascular endothelial growth factors encoded by orf virus show surprising sequence variation but have a conserved, functionally relevant structure. Journal of General Virology, 83, 2845-2855.

Haig, D. M., Thomson, J., McInnes, C. J., McCaughan, C. A., Imlach, W., Mercer, A. A., & Fleming, S. B. (2002). Orf virus immuno-modulation and the host immune response. Veterinary Immunology & Immunopathology, 87(3-4), 395-399.

Imlach, W., McCaughan, C. A., Mercer, A. A., Haig, D. M., & Fleming, S. B. (2002). Orf virus-encoded interleukin-10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophages. Journal of General Virology, 83, 1049-1058.

Conference Contribution - Published proceedings: Abstract

Scagliarini, A., Battilani, M., Ciulli, S., Guercio, A., Prosperi, S., & Mercer, A. A. (2002). Comparative analysis of orf virus strains isolated from 'malignant' outbreaks in Italy. XIV Poxvirus Meeting. (pp. 166). [Abstract]

Wise, L. M., Ueda, N., Scagliarini, A., McInnes, C. J., Buettner, M., Rziha, H. J., … Fleming, S. B., … Mercer, A. A. (2002). Parapoxvirus-encoded vascular endothelial growth factors conserve structure and function despite extensive sequence variation. XIVth International Poxvirus and Iridovirus Symposium. (pp. 10). New York. [Abstract]

Seet, B. T., McCaughan, C. A., Hande, T., Mercer, A. A., McFadden, G., & Fleming, S. B. (2002). Orf virus encodes a chemokine binding protein with unique binding specifities. XIV Poxvirus Meeting. (pp. 81). [Abstract]

Seet, B. T., McCaughan, C. A., Mercer, A. A., Handel, T. A., Fleming, S. B., & McFadden, G. (2002). Biomolecular interaction analysis of chemokine binding protein encoded by the orf poxvirus. XIV Poxvirus Meeting. (pp. 148). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Wise, L., Ueda, N., Scagliarini, A., McInnes, C. J., Buettner, M., Rhiza, H. J., … Fleming, S. B., … Mercer, A. A. (2002). Parapoxvirus-encoded vascular endothelial growth factors conserve structure and function despite extensive sequence variation. Verbal presentation at the XIVth International Poxvirus and Iridovirus Symposium, Lake Placid, USA.

2001

Journal - Research Article

Makinen, T., Veikkola, T., Mustjoki, S., Karpanen, T., Catimel, B., Nice, E., Wise, L. M., Mercer, A. A., … Alitalo, K. (2001). Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO Journal, 20(17), 4762-4773.

Conference Contribution - Published proceedings: Abstract

Hall, D. C. A., Ward, V. K., Mercer, A. A., O'Keefe, J., & Atkinson, P. (2001). Genetic variation of Rabbit haemorrhagic disease virus (RHDV) in New Zealand since release in 1997. American Sociey of Virology 20th Annual Conference. [Abstract]

Ueda, N., Wise, L. M., Stacker, S. A., Savory, L. J., Fleming, S. B., Caesar, C., … Mercer, A. A. (2001). A vascualr endothelial growth factor (VEGF) encoded by Pseudocowpox virus. American Society of Virology 20th Annual Meeting. [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Ueda, N., Wise, L. M., Stacker, S. A., Savory, L. J., Fleming, S. B., Caesar, C., … Mercer, A. A. (2001, July). A vascular endothelial growth factor (VEGF) encoded by Pseudocowpox virus. Poster session presented at the American Society of Virology 20th Annual Meeting, Madison, USA.

2000

Journal - Research Article

Fleming, S. B., Haig, D. M., Nettleton, P., Reid, H. W., McCaughan, C. A., Wise, L. M., & Mercer, A. (2000). Sequence and functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus orf virus. Virus Genes, 21(1-2), 85-95.

Nettleton, P. F., Gilray, J. A., Reid, H. W., & Mercer, A. A. (2000). Parapoxviruses are strongly inhibited in vitro by cidofovir. Antiviral Research, 48(3), 205-208.

Fleming, S. B., Haig, D. M., Nettleton, P. F., Reid, H. W., McCaughlan, C. A., Wise, L. M., & Mercer, A. A. (2000). Sequence and functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus, orf virus. Virus Genes, 21(1/2), 85-90.

Savory, L. J., Stacker, S. A., Fleming, S. B., Niven, B. E., & Mercer, A. A. (2000). Viral vascular endothelial growth factor plays a critical role in orf virus infection. Journal of Virology, 74(22), 10699-10706.

Deane, D., McInnes, C. J., Percival, A., Wood, A. R., Thomson, J., Lear, A., … Fleming, S. B., Mercer, A. A., & Haig, D. M. (2000). Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2. Journal of Virology, 74(3), 1313-1320.

Conference Contribution - Published proceedings: Abstract

Savory, L. J., Stacker, S. A., Fleming, S. B., Lyttle, D. J., Wise, L. M., & Mercer, A. A. (2000). Functional analysis of two orf-virus encoded variants of vascular endothelial growth factor. Proceedings of XIII Poxvirus Meeting. [Abstract]

McInnes, C. J., Deane, D., Fleming, S. B., Mercer, A. A., & Haig, D. M. (2000). Orf virus encodes a novel secreted protein inhibitor of granulocyte-macrophage colony-stimulating factor and interleukin-2. XIII Poxvirus Meeting. (pp. 179). [Abstract]

Watkins, C., Nettleton, P. F., Gossner, A., Gilray, J. A., Mercer, A. A., Hopkins, J., & Harkiss, G. (2000). Pilot study: the development of a DNA vaccine against orf virus in sheep. European Virology 2000. [Abstract]

Ueda, N., Wise, L. M., Stacker, S. A., Savory, L. J., Fleming, S. B., Caesar, C., … Mercer, A. A. (2000). Pseudocowpox virus encodes a homolog of the orf virus vascular endothelial growth factor. XIIIth International Poxvirus and Iridovirus Symposium. (pp. 113). France. [Abstract]

Wise, L. M., Mercer, A. A., Savory, L. J., Fleming, S. B., Caesar, C., Vitali, A., & Stacker, S. A. (2000). Orf virus-encoded vascular endothelial growth factor: a family of varient growth factors. XIII Poxvirus Meeting. (pp. 177). [Abstract]

Haig, D. M., Imlach, W., Thomson, J., Huntley, J., McCaughan, C. A., Mercer, A. A., & Fleming, S. B. (2000). Functional activities of orf virus encoded IL-10. XIII Poxvirus Meeting. (pp. 178). [Abstract]

Conference Contribution - Poster Presentation (not in published proceedings)

Ueda, N., Wise, L. M., Stacker, S. A., Savory, L. J., Fleming, S. B., Caesar, C., … Mercer, A. A. (2000, September). Pseudocowpox virus encodes a homolog of the orf virus vascular endothelial growth factor-like proteins. Poster session presented at the XIIIth International Poxvirus and Iridovirus Symposium, Montpellier, France.

Conference Contribution - Verbal presentation and other Conference outputs

Wise, L. M., Mercer, A. A., Savory, L. J., Fleming, S. B., Caesar, C., Vitali, A., & Stacker, S. A. (2000, September). Orf virus encoded VEGF: A family of variant growth factors? Verbal presentation at the XIII International Poxvirus and Iridovirus Symposium, Montpellier.

Savory, L. J., Stacker, S. A., Fleming, S. B., Lyttle, D. J., Wise, L. M., & Mercer, A. A. (2000, September). Functional analysis of two orf virus-encoded variants of vascular endothelial growth factor (VEGF). Verbal presentation at the XIII International Poxvirus and Iridovirus Symposium, Montpellier.

1999

Chapter in Book - Research

Mercer, A. A., & Haig, D. M. (1999). Parapoxviruses. In A. Granoff & R. G. Webster (Eds.), Encyclopedia of Virology. (pp. 1140-1146). London: Academic Press.

Journal - Research Article

Wise, L. M., Veikkola, T., Mercer, A. A., Savory, L. J., Fleming, S. B., Caesar, C., … Stacker, S. A. (1999). Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. PNAS, 96(6), 3071-3076. doi: 10.1073/pnas.96.6.3071

Conference Contribution - Published proceedings: Abstract

Savory, L. J., Stacker, S. A., Fleming, S. B., Lyttle, D. J., & Mercer, A. A. (1999). Deletion of the vascular endothelial growth facor gene of orf virus reduces viral virulence and lesion associated vascularisation. XIth International Congress of Virology. (pp. 394). [Abstract]

Fleming, S. B., Haig, D. M., McCaughan, C. A., Imlach, W., & Mercer, A. A. (1999). Functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus orf virus. Queenstown Molecular Biology Meeting. (pp. 36). [Abstract]

Stacker, S. A., Wise, L. M., Mercer, A. A., Stenvers, K., Caesar, C., Vitali, A., … Savory, L. J., Fleming, S. B., … Achen, M. G. (1999). Vascular endothelial growth factor (VEGF) family: their role in blood vessel growth, lymphatic development and viral infection. Queenstown Molecular Biology Meeting. (pp. 36). [Abstract]

Wise, L. M., Savory, L. J., Veikkola, T., Fleming, S. B., Caesar, C., Vitali, A., Whelan, E., … Mercer, A. A. (1999). Orf virus encodes a bioactive vascular endothelial growth factor (VEGF). Queenstown Molecular Biology Meeting. (pp. 13). [Abstract]

Wise, L. M., Veikkola, T., Mercer, A. A., Savory, L. J., Fleming, S. B., Caesar, C., … Stacker, S. A. (1999). The vascualr endothelial growth factor (VEGF)-like protein from orf virus binds and activates VEGF receptors. XIth International Congress of Virology. (pp. 152). [Abstract]

Conference Contribution - Verbal presentation and other Conference outputs

Wise, L. M., Veikkola, T., Mercer, A. A., Savory, L. J., Fleming, S. B., Caesar, C., … Stacker, S. (1999, August). The vascular endothelial growth factor (VEGF)-like protein from orf virus binds and activates VEGF receptors. Verbal presentation at the XI International Congress of Virology, Sydney, Australia.

Intellectual Property

Wise, L., Mercer, A. A., Savory, L. J., Fleming, S. B., & Stacker, S. (1999). Vascular endothelial growth factor-like protein from orf virus NZ2 binds and activates VEGF receptor-2 and uses thereof. United States patent (09/431,888).

Wise, L. M., Mercer, A. A., Savory, L. J., Fleming, S. B., & Stacker, S. (1999). Vascular endothelial growth factor -like protein from orf virus NZ2 binds and activates VEGF receptor-2 and uses thereof.. US Application 09/431,888 filed November 1999. U.S. Patent and Trademark Office.

1998

Journal - Research Article

Haig, D. M., & Mercer, A. A. (1998). Orf. Veterinary Research, 29(3-4), 311-326.

Housawi, F. M., Roberts, G. M., Gilray, J. A., Pow, I., Reid, H. W., Nettleton, P. F., … Hibma, M. H., & Mercer, A. A. (1998). The reactivity of monoclonal antibodies against orf virus with other parapoxviruses and the identification of a 39 kDa immunodominant protein. Archives of Virology, 143(12), 2289-2303.

McInnes, C. J., Wood, A., & Mercer, A. A. (1998). Orf virus encodes a homologue of the vaccinia virus interferon-resistance gene E3L. Virus Genes, 17(2), 107-115.

Haig, D. M., McInnes, C. J., Thomson, J., Bunyan, A., & Mercer, A. A. (1998). The orf virus OVIFNR gene product is involved in interferon resistance and inhibits an interferon-inducible, dsRNA-dependent kinase. Immunology, 93(3), 335-340.

Conference Contribution - Published proceedings: Abstract

McInnes, C. J., Mercer, A. A., Wood, A., Thomson, J., & Haig, D. M. (1998). Orf virus posesses an orthologue of the vaccinia virus interferon-resistance protein E3L. XII Poxvirus Meeting. [Abstract]

Savory, L. J., Fleming, S. B., Lyttle, D. J., & Mercer, A. A. (1998). Bloody, orf-full lesions: Characterisation of orf virus recombinants in which the VEGF-like gene has been inactivated. XII Poxvirus Meeting. (pp. 56). [Abstract]

1997

Journal - Research Article

Mercer, A. A., Fleming, S. B., Robinson, A., Nettelton, P., & Reid, H. W. (1997). Molecular genetic analysis of parapoxviruses pathogenic for humans. Archives of Virology, Suppl 13, 25-34.

Fleming, S. B., McCaughan, C. A., Andrews, A. E., Nash, A. D., & Mercer, A. A. (1997). A homolog of interleukin-10 is encoded by the poxvirus orf virus. Journal of Virology, 71(6), 4857-4861.

Mercer, A. A., Yirrell, D. L., Whelan, E. M., Nettleton, P. F., Pow, I., Gilray, J. A., … Robinson, A. J. (1997). A novel strategy for determining protective antigens of the parapoxvirus, orf virus. Virology, 229(1), 193-200.

Haig, D. M., McInnes, C. J., Deane, D., Reid, H. W., & Mercer, A. A. (1997). The immune and inflammatory response to orf virus. Comparative Immunology, Microbiology & Infectious Diseases, 20(3), 197-204.

Conference Contribution - Published proceedings: Abstract

Mercer, A. A., Robinson, A., Nettleton, P. F., & Reid, H. W. (1997). A novel strategy fpr determining protective antigens of the parapoxvirus, orf virus. Vaccines Beyond 2000. [Abstract]

McInnes, C. J., Mercer, A. A., Wood, A., Thomson, J., & Haig, D. M. (1997). Orf virus possesses an orthologue of the vaccinia virus interferon-resistance protein E3L. European Society for Veterinary Virology 4th International Congress. [Abstract]

1996

Journal - Research Article

Haig, D. M., McInnes, C. J., Deane, D., Lear, A., Myatt, N., Reid, H. W., … Lyttle, D. J., & Mercer, A. A. (1996). Cytokines and their inhibitors in orf virus infection. Veterinary Immunology & Immunopathology, 54(1/4), 261-267.

Mercer, A. A., Fraser, K. M., & Esposito, J. J. (1996). Gene homology between orf virus and smallpox variola virus. Virus Genes, 13(2), 175-178.

Mercer, A. A., Green, G., Sullivan, J. T., Robinson, A. J., & Drillien, R. (1996). Location, DNA sequence and transcriptional analysis of the DNA polymerase gene of orf virus. Journal of General Virology, 77, 1563-1568.

Conference Contribution - Published proceedings: Abstract

Mercer, A. A. (1996). Bloody, orf-full lesions. Microbiology Australia. 17(3), (pp. 9). [Abstract]

1995

Journal - Research Article

Mercer, A. A., Lyttle, D. J., Whelan, E., Fleming, S. B., & Sullivan, J. T. (1995). The establishment of a genetic map of orf virus reveals a pattern of genomic organisation that is highly conserved among divergent poxviruses. Virology, 212, 698-704.

Sullivan, J. T., Fleming, S. B., Robinson, A. J., & Mercer, A. A. (1995). Sequence and transcriptional analysis of a near-terminal region of the orf virus genome. Virus Genes, 11, 21-29.

Fleming, S. B., Lyttle, D. J., Sullivan, J. T., Mercer, A. A., & Robinson, A. J. (1995). Genomic analysis of transposition-deletion variant of orf virus reveals a 3.3 kbp region of non-essential DNA. Journal of General Virology, 76, 2969-2978.

1991

Journal - Research Article

McConnell, M. A., Mercer, A. A., & Tannock, G. W. (1991). Transfer of plasmid pAMβl between members of the normal microflora inhabiting the murine digestive tract and modification of the plasmid in a Lactobacillus reuteri host. Microbial Ecology in Health & Disease, 4(6), 343-355.