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Health Sciences profile

Dr Luke Wilson

PositionSenior Research Fellow
DepartmentDepartment of Medicine (Dunedin)
QualificationsPhD
Research summaryIntegrative human physiology
TeachingELM2 - Integrated Cases Tutor
MembershipsAustralian and New Zealand Society of Nephrology (ANZSN)

Research

I am an integrative human physiologist primarily focusing on cerebro-, cardiovascular, respiratory and neurophysiology, with applications in health (resting and imposed stressors such as exercise, mental and thermal) and in those with disease (diabetes, cardiovascular and chronic kidney disease).

Additional details

Convenor of the Kidney in Health and Disease Research Network

Publications

Pradhan, S., Duffull, S. B., Wilson, L. C., Kuan, I. H. S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease? British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14919

Gibbons, T. D., Ainslie, P. N., Thomas, K. N., Wilson, L. C., Akerman, A. P., Donnelly, J., Campbell, H. A., & Cotter, J. D. (2021). Influence of the mode of heating on cerebral blood flow, non-invasive intracranial pressure and thermal tolerance in humans. Journal of Physiology. Advance online publication. doi: 10.1113/jp280970

Kuan, I. H. S., Wilson, L. C., Leishman, J. C., Cosgrove, S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Metformin doses to ensure efficacy and safety in patients with reduced kidney function. PLoS ONE, 16(2), e0246247. doi: 10.1371/journal.pone.0246247

Van der Giessen, H., Wilson, L. C., Coffey, S., & Whalley, G. A. (2020). Review: Detection of patient foramen ovale using transcranial Doppler or standard echocardiography. Australasian Journal of Ultrasound in Medicine, 23(4), 210-219. doi: 10.1002/ajum.12232

Shoemaker, L. N., Wilson, L. C., Lucas, S. J. E., Machado, L., Walker, R. J., & Cotter, J. D. (2020). Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults. Journal of Physiology. Advance online publication. doi: 10.1113/jp280118

Gibbons, T. D., Ainslie, P. N., Thomas, K. N., Wilson, L. C., Akerman, A. P., Donnelly, J., Campbell, H. A., & Cotter, J. D. (2021). Influence of the mode of heating on cerebral blood flow, non-invasive intracranial pressure and thermal tolerance in humans. Journal of Physiology. Advance online publication. doi: 10.1113/jp280970

Journal - Research Article

Kuan, I. H. S., Wilson, L. C., Leishman, J. C., Cosgrove, S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Metformin doses to ensure efficacy and safety in patients with reduced kidney function. PLoS ONE, 16(2), e0246247. doi: 10.1371/journal.pone.0246247

Journal - Research Article

Pradhan, S., Duffull, S. B., Wilson, L. C., Kuan, I. H. S., Walker, R. J., Putt, T. L., Schollum, J. B. W., & Wright, D. F. B. (2021). Does the intact nephron hypothesis provide a reasonable model for metformin dosing in chronic kidney disease? British Journal of Clinical Pharmacology. Advance online publication. doi: 10.1111/bcp.14919

Journal - Research Article

Akerman, A. P., Walker, R. J., Schollum, J. B. W., Putt, T. L., & Wilson, L. C. (2020). Refinement of a protocol to induce reliable muscle cramps in the abductor hallucis. Physiological Measurement, 41, 055003. doi: 10.1088/1361-6579/ab8855

Journal - Research Article

Gibbons, T. D., Tymko, M. M., Thomas, K. N., Wilson, L. C., Stembridge, M., Caldwell, H. G., … Cotter, J. D. (2020). Global REACH 2018: The influence of acute and chronic hypoxia on cerebral haemodynamics and related functional outcomes during cold and heat stress. Journal of Physiology, 598(2), 265-284. doi: 10.1113/jp278917

Journal - Research Article

Moharram, M. A., Wilson, L. C., Williams, M. J. A., & Coffey, S. (2020). Beat-to-beat blood pressure measurement using a cuffless device does not accurately reflect invasive blood pressure. International Journal of Cardiology Hypertension, 5, 100030. doi: 10.1016/j.ijchy.2020.100030

Journal - Research Article

Perry, B. G., De Hamel, T., Thomas, K. N., Wilson, L. C., Gibbons, T. D., & Cotter, J. D. (2020). Cerebrovascular haemodynamics during isometric resistance exercise with and without the Valsalva manoeuvre. European Journal of Applied Physiology, 120, 467-479. doi: 10.1007/s00421-019-04291-7

Journal - Research Article

Shoemaker, L. N., Wilson, L. C., Lucas, S. J. E., Machado, L., & Cotter, J. D. (2020). Acute exercise-related cognitive effects are not attributable to changes in end-tidal CO2 or cerebral blood velocity. European Journal of Applied Physiology, 120, 1637-1649. doi: 10.1007/s00421-020-04393-7

Journal - Research Article

Shoemaker, L. N., Wilson, L. C., Lucas, S. J. E., Machado, L., Walker, R. J., & Cotter, J. D. (2020). Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults. Journal of Physiology. Advance online publication. doi: 10.1113/jp280118

Journal - Research Article

Shoemaker, L. N., Wilson, L. C., Lucas, S. J. E., Machado, L., & Cotter, J. D. (2019). Cerebrovascular regulation is not blunted during mental stress. Experimental Physiology, 104, 1678-1687. doi: 10.1113/ep087832

Journal - Research Article

Shoemaker, L. N., Wilson, L. C., Lucas, S. J. E., Machado, L., Thomas, K. N., & Cotter, J. D. (2019). Swimming-related effects on cerebrovascular and cognitive function. Physiological Reports, 7(20), e14247. doi: 10.14814/phy2.14247

Journal - Research Article

Lucas, R. A. I., Wilson, L. C., Ainslie, P. N., Fan, J. L., Thomas, K. N., & Cotter, J. D. (2018). Independent and interactive effects of incremental heat strain, orthostatic stress, and mild hypohydration on cerebral perfusion. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 314(3), R415-R426. doi: 10.1152/ajpregu.00109.2017

Journal - Research Article

Hoye, N. A., Wilson, L. C., Wilkins, G. T., Jardine, D. L., Putt, T. L., Samaranayaka, A., Schollum, J. B. W., & Walker, R. J. (2017). Endovascular renal denervation in end-stage kidney disease patients: Cardiovascular protection: A proof-of-concept study. Kidney International Reports, 2(5), 856-865. doi: 10.1016/j.ekir.2017.04.012

Journal - Research Article

Wilson, G. A., Wilson, L. C., Lamberts, R. R., Majeed, K., Lal, S., Wilkins, G. T., & Baldi, J. C. (2017). β-adrenergic responsiveness in the type 2 diabetic heart: Effects on cardiac reserve. Medicine & Science in Sports & Exercise, 49(5), 907-914. doi: 10.1249/mss.0000000000001184

Journal - Research Article

Wilson, L. C., Peebles, K. C., Hoye, N. A., Manning, P., Sheat, C., Williams, M. J. A., Wilkins, G. T., Wilson, G. A., & Baldi, J. C. (2017). Resting heart rate variability and exercise capacity in Type 1 diabetes. Physiological Reports, 5(8), e13248. doi: 10.14814/phy2.13248

Journal - Research Article

Baldi, J. C., Wilson, G. A., Wilson, L. C., Wilkins, G. T., & Lamberts, R. R. (2016). The type 2 diabetic heart: Its role in exercise intolerance and the challenge to find effective exercise interventions. Sports Medicine, 46, 1605-1617. doi: 10.1007/s40279-016-0542-9

Journal - Research Article

Ross, E. Z., Cotter, J. D., Wilson, L., Fan, J.-L., Lucas, S. J. E., & Ainslie, P. N. (2012). Cerebrovascular and corticomotor function during progressive passive hyperthermia in humans. Journal of Applied Physiology, 112(5), 748-758. doi: 10.1152/japplphysiol.00988.2011

Journal - Research Article

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt II: Influence of age, training status and acute exercise. Experimental Gerontology, 46(1), 1-8. doi: 10.1016/j.exger.2010.06.004

Journal - Research Article

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Cardiorespiratory and cerebrovascular responses to head-up tilt I: Influence of age and training status. Experimental Gerontology, 46(1), 9-17. doi: 10.1016/j.exger.2010.06.005

Journal - Research Article

Murrell, C. J., Cotter, J. D., George, K., Shave, R., Wilson, L., Thomas, K., Williams, M. J. A., & Ainslie, P. N. (2011). Syncope is unrelated to supine and postural hypotension following prolonged exercise. European Journal of Applied Physiology, 111(3), 469-476. doi: 10.1007/s00421-010-1671-8

Journal - Research Article

Lucas, R. A. I., Ainslie, P. N., Fan, J.-L., Wilson, L. C., Thomas, K. N., & Cotter, J. D. (2010). Skin cooling aids cerebrovascular function more effectively under severe than moderate heat stress. European Journal of Applied Physiology, 109, 101-108. doi: 10.1007/s00421-009-1298-9

Journal - Research Article

Wilson, L. C., Cotter, J. D., Fan, J.-L., Lucas, R. A. I., Thomas, K. N., & Ainslie, P. N. (2010). Cerebrovascular reactivity and dynamic autoregulation in tetraplegia. American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 298, R1035-R1042. doi: 10.1152/ajpregu.00815.2009

Journal - Research Article

Murrell, C. J., Cotter, J. D., George, K. P., Shave, R., Wilson, L. C., Thomas, K. N., Williams, M. J. A., … Ainslie, P. N. (2009). Influence of age on syncope following prolonged exercise: Differential responses but similar orthostatic intolerance. Journal of Physiology, 587(24), 5959-5969. doi: 10.1113/jphysiol.2009.179549

Journal - Research Article

Williams, K., Gregson, W., Robertson, C., Datson, N., Whyte, G., Murrell, C., Wilson, L., Ainslie, P., … George, K. (2009). Alterations in left ventricular function and cardiac biomarkers as a consequence of repetitive endurance cycling. European Journal of Sport Science, 9(2), 97-105. doi: 10.1080/17461390902763391

Journal - Research Article

Fan, J.-L., Cotter, J. D., Lucas, R. A. I., Thomas, K., Wilson, L., & Ainslie, P. N. (2008). Human cardiorespiratory and cerebrovascular function during severe passive hyperthermia: Effects of mild hypohydration. Journal of Applied Physiology, 105(2), 433-445.

Journal - Research Article

Lucas, S. J. E., Cotter, J. D., Murrell, C., Wilson, L., Anson, J. G., Gaze, D., … Ainslie, P. N. (2008). Mechanisms of orthostatic intolerance following very prolonged exercise. Journal of Applied Physiology, 105(1), 213-225. doi: 10.1152/japplphysiol.00175.2008

Journal - Research Article

Murrell, C., Wilson, L., Cotter, J. D., Lucas, S., Ogoh, S., George, K., & Ainslie, P. N. (2007). Alterations in autonomic function and cerebral hemodynamics to orthostatic challenge following a mountain marathon. Journal of Applied Physiology, 103(1), 88-96. doi: 10.1152/japplphysiol.01396.2006

Journal - Research Article

Gibbons, T., Thomas, K. N., & Wilson, L. C. (2020). Is all heat equal? Implications for the stimulus for adaptation in the brain. Journal of Physiology, 598(11), 2051-2052. doi: 10.1113/jp279748

Journal - Research Other

Van der Giessen, H., Wilson, L. C., Coffey, S., & Whalley, G. A. (2020). Review: Detection of patient foramen ovale using transcranial Doppler or standard echocardiography. Australasian Journal of Ultrasound in Medicine, 23(4), 210-219. doi: 10.1002/ajum.12232

Journal - Research Other

Hoye, N. A., Wilson, L. C., Jardine, D. L., & Walker, R. J. (2019). Sympathetic overactivity in dialysis patients: Underappreciated and clinically consequential. Seminars in Dialysis, 32, 255-265. doi: 10.1111/sdi.12756

Journal - Research Other

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