Division of Health Sciences

Fagerlund, R. D., Ferguson, T. J., Maxwell, H. W. R., Opel-Reading, H. K., Krause, K. L., & Fineran, P. C. (2019). Reconstitution of CRISPR adaptation in vitro and its detection by PCR. In S. Bailey (Ed.), Methods in enzymology (Vol. 616: CRISPR-Cas enzymes). (pp. 411-433). Cambridge, MA: Academic Press. doi: 10.1016/bs.mie.2018.10.024

Chapter in Book - Research

Jowsey, W. J., Morris, C. R. P., Hall, D. A., Sullivan, J. T., Fagerlund, R. D., Eto, K. Y., … Ronson, C. W. (2023). DUF2285 is a novel helix-turn-helix domain variant that orchestrates both activation and antiactivation of conjugative element transfer in proteobacteria. Nucleic Acids Research, gkad457. Advance online publication. doi: 10.1093/nar/gkad457

Journal - Research Article

Birkholz, N., Jackson, S. A., Fagerlund, R. D., & Fineran, P. C. (2022). A mobile restriction-modification system provides phage defence and resolves an epigenetic conflict with an antagonistic endonuclease. Nucleic Acids Research, 50(6), 3348-3361. doi: 10.1093/nar/gkac147

Journal - Research Article

Mayo-Muñoz, D., Smith, L. M., Garcia-Doval, C., Malone, L. M., Harding, K. R., Jackson, S. A., Hampton, H. G., Fagerlund, R. D., Gumy, L. F., & Fineran, P. C. (2022). Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection. Molecular Cell, 82, 4471-4486.e9. doi: 10.1016/j.molcel.2022.10.028

Journal - Research Article

Schwartz, E. A., McBride, T. M., Bravo, J. P. K., Wrapp, D., Fineran, P. C., Fagerlund, R. D., & Taylor, D. W. (2022). Structural rearrangements allow nucleic acid discrimination by type I-D Cascade. Nature Communications, 13, 2829. doi: 10.1038/s41467-022-30402-8

Journal - Research Article

Usher, B., Birkholz, N., Beck, I. N., Fagerlund, R. D., Jackson, S. A., Fineran, P. C., & Blower, T. R. (2021). Crystal structure of the anti-CRISPR repressor Aca2. Journal of Structural Biology, 213, 107752. doi: 10.1016/j.jsb.2021.107752

Journal - Research Article

Fagerlund, R. D., Forsman, J. A., Biswas, S., Vass, I., Davies, F. K., Summerfield, T. C., & Eaton-Rye, J. J. (2020). Stabilization of Photosystem II by the PsbT protein impacts photodamage, repair and biogenesis. Biochimica et Biophysica Acta: Bioenergetics, 1861, 148234. doi: 10.1016/j.bbabio.2020.148234

Journal - Research Article

Forsman, J. A., Fagerlund, R. D., Biswas, S., Summerfield, T. C., & Eaton-Rye, J. J. (2020). The PsbT protein modifies the bicarbonate-binding environment of Photosystem II. New Zealand Journal of Botany, 58(4), 406-421. doi: 10.1080/0028825X.2020.1772320

Journal - Research Article

McBride, T. M., Schwartz, E. A., Kumar, A., Taylor, D. W., Fineran, P. C., & Fagerlund, R. D. (2020). Diverse CRISPR-Cas complexes require independent translation of small and large subunits from a single gene. Molecular Cell, 80, 971-979. doi: 10.1016/j.molcel.2020.11.003

Journal - Research Article

Pinilla-Redondo, R., Shehreen, S., Marino, N. D., Fagerlund, R. D., Brown, C. M., Sørensen, S. J., Fineran, P. C., & Bondy-Denomy, J. (2020). Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements. Nature Communications, 11(1), 5652. doi: 10.1038/s41467-020-19415-3

Journal - Research Article

Birkholz, N., Fagerlund, R. D., Smith, L. M., Jackson, S. A., & Fineran, P. C. (2019). The autoregulator Aca2 mediates anti-CRISPR repression. Nucleic Acids Research, 47(18), 9658-9665. doi: 10.1093/nar/gkz721

Journal - Research Article

Greisch, J.-F., Tamara, S., Scheltema, R. A., Maxwell, H. W. R., Fagerlund, R. D., Fineran, P. C., … Heck, A. J. R. (2019). Expanding the mass range for UVPD-based native top-down mass spectrometry. Chemical Science, 10, 7163-7171. doi: 10.1039/c9sc01857c

Journal - Research Article

Hampton, H. G., Jackson, S. A., Fagerlund, R. D., Vogel, A. I. M., Dy, R. L., Blower, T. R., & Fineran, P. C. (2018). AbiEi binds cooperatively to the Type IV abiE toxin-antitoxin operator via a positively-charged surface and causes DNA bending and negative autoregulation. Journal of Molecular Biology, 430(8), 1141-1156. doi: 10.1016/j.jmb.2018.02.022

Journal - Research Article

Fagerlund, R. D., Wilkinson, M. E., Klykov, O., Barendregt, A., Pearce, F. G., Kieper, S. N., Maxwell, H. W. R., … Krause, K. L., Bostina, M., … Staals, R. H. J., & Fineran, P. C. (2017). Spacer capture and integration by a type I-F Cas1–Cas2-3 CRISPR adaptation complex. PNAS, 114(26), E5122-E5128. doi: 10.1073/pnas.1618421114

Journal - Research Article

Jackson, S. A., McKenzie, R. E., Fagerlund, R. D., Kieper, S. N., Fineran, P. C., & Brouns, S. J. J. (2017). CRISPR-Cas: Adapting to change. Science, 356(6333), eaal5056. doi: 10.1126/science.aal5056

Journal - Research Article

Fagerlund, R. D., Perederina, A., Berezin, I., & Krasilnikov, A. S. (2015). Footprinting analysis of interactions between the largest eukaryotic RNase P/MRP protein Pop1 and RNase P/MRP RNA components. RNA, 21, 1591-1605. doi: 10.1261/rna.049007.114

Journal - Research Article

Fagerlund, R. D., Staals, R. H. J., & Fineran, P. C. (2015). The Cpf1 CRISPR-Cas protein expands genome-editing tools. Genome Biology, 16, 251. doi: 10.1186/s13059-015-0824-9

Journal - Research Article

Luo, H., Jackson, S. A., Fagerlund, R. D., Summerfield, T. C., & Eaton-Rye, J. J. (2014). The importance of the hydrophilic region of PsbL for the plastoquinone electron acceptor complex of Photosystem II. Biochimica et Biophysica Acta: Bioenergetics, 1837(9), 1435-1446. doi: 10.1016/j.bbabio.2014.02.015

Journal - Research Article

Bricker, T. M., Roose, J. L., Fagerlund, R. D., Frankel, L. K., & Eaton-Rye, J. J. (2012). The extrinsic proteins of Photosystem II. Biochimica et Biophysica Acta: Bioenergetics, 1817(1), 121-142. doi: 10.1016/j.bbabio.2011.07.006

Journal - Research Article

Fagerlund, R. D., Ooi, P. L., & Wilbanks, S. M. (2012). Soluble expression and purification of tumor suppressor WT1 and its zinc finger domain. Protein Expression & Purification, 85(2), 165-172. doi: 10.1016/j.pep.2012.08.002

Journal - Research Article

Fagerlund, R. D., & Eaton-Rye, J. J. (2011). The lipoproteins of cyanobacterial photosystem II. Journal of Photochemistry & Photobiology B, 104(1-2), 191-203. doi: 10.1016/j.jphotobiol.2011.01.022

Journal - Research Article

Liptak, M. D., Fagerlund, R. D., Ledgerwood, E. C., Wilbanks, S. M., & Bren, K. (2011). The proapoptotic G41S mutation to human cytochrome c alters the heme electronic structure and increases the electron self-exchange rate. Journal of the American Chemical Society, 133(5), 1153-1155. doi: 10.1021/ja106328k

Journal - Research Article

Jackson, S. A., Fagerlund, R. D., Wilbanks, S. M., & Eaton-Rye, J. J. (2010). Crystal structure of PsbQ from Synechocystis sp. PCC 6803 at 1.8 Å: Implications for binding and function in cyanobacterial photosystem II. Biochemistry, 49(13), 2765-2767. doi: 10.1021/bi100217h

Journal - Research Article

Morison, I. M., Cramer Bordé, E. M., Cheesman, E. J., Cheong, P. L., Holyoake, A. J., Fichelson, S., Weeks, R. J., Lo, A., Davies, S. M. K., Wilbanks, S. M., Fagerlund, R. D., Ludgate, M. W., da Silva Tatley, F. M., Coker, M. S. A., Bockett, N. A., Hughes, G., Pippig, D. A., Smith, M. P., … Ledgerwood, E. C. (2008). A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nature Genetics, 40(4), 387-389. doi: 10.1038/ng.103

Journal - Research Article

McBride, T. M., Cameron, S. C., Fineran, P. C., & Fagerlund, R. D. (2023). The biology and type I/III hybrid nature of type I-D CRISPR-Cas systems. Biochemical Journal, 480(7), 471-488. doi: 10.1042/bcj20220073

Journal - Research Other