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Contact Details

Email
megan.leask@otago.ac.nz
Position
Pūkeka Matua | Senior Lecturer
Department
Department of Physiology
Iwi affiliations
Kāi Tahu
Research summary
Assigning function to genetic variants associated with metabolic traits

Research

My research projects aim to assign function to genetic variants that are associated with health and disease using bioinformatics, zebrafish and cell assays. I also work with Māori and Pacific genetic data to identify clinically-relevant genetic variants that are unique to Māori and Pacific people. The long-term outcomes of this work has the potential to reduce health disparities and improve genetic equity in these population groups.

Publications

Young, C. K., Darroch, H., & Leask, M. P. (2026, February). Probing the function of neural jazf1 with whole-brain imaging and RNA-seq in the larval zebrafish. Poster session presented at the Genetics Otago (GO) Annual Symposium, Dunedin, New Zealand. Conference Contribution - Poster Presentation (not in published proceedings)

Calhoun, C., Darroch, H., Hussain, R., Morice, M., Lalonde, R., Mosimann, C., Horsfield, J., & Leask, M. (2026, February). Functional characterisation of Polynesian-enriched non-coding variants utilizing a novel method of zebrafish transgenesis. Verbal presentation at the Genetics Otago (GO) Annual Symposium, Dunedin, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

Toomata, Z. L., Leask, M. P., Dalbeth, N., Stamp, L. K., de Zoysa, J., Merriman, T. R., Wilcox, P., Dewes, O., & Murphy, R. (2025). Misclassified latent autoimmune diabetes in adults within Māori and Pacific adults with type 2 diabetes in Aotearoa New Zealand. New Zealand Medical Journal/Te ara tika o te hauora hapori, 138(1626), 49-61. doi: 10.26635/6965.6989 Journal - Research Article

Lyth, D., & Leask, M. (2025). Gouty inflammation: Genetic mechanisms towards flare therapy. Current Opinion in Rheumatology. Advance online publication. doi: 10.1097/bor.0000000000001119 Journal - Research Other

Shepherd, P., Wilcox, P., Leask, M., Dissanayake, W., Murphy, R., & Watson, H. (2025, February). Metabolic Health: Overview of how integrated Metabolic Health Flagship programme works and overall progress to date. Verbal presentation at the Maurice Wilkins Centre (MWC) Research Symposium, Auckland, New Zealand. Conference Contribution - Verbal presentation and other Conference outputs

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